-
3
-
-
0033611472
-
A trial of etanercept, a recombinant tumor necrosis factor receptor:Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate
-
M.E. Weinblatt, J.M. Kremer, A.D. Bankhurst, K.J. Bulpitt, R.M. Fleischmann, R.I. Fox, C.G. Jackson, M. Lange, and D.J. Burge A trial of etanercept, a recombinant tumor necrosis factor receptor:Fc fusion protein, in patients with rheumatoid arthritis receiving methotrexate N. Engl. J. Med. 340 1999 253 259
-
(1999)
N. Engl. J. Med.
, vol.340
, pp. 253-259
-
-
Weinblatt, M.E.1
Kremer, J.M.2
Bankhurst, A.D.3
Bulpitt, K.J.4
Fleischmann, R.M.5
Fox, R.I.6
Jackson, C.G.7
Lange, M.8
Burge, D.J.9
-
4
-
-
0031660364
-
Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor alpha monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis
-
R.N. Maini, F.C. Breedveld, J.R. Kalden, J.S. Smolen, D. Davis, J.D. Macfarlane, C. Antoni, B. Leeb, M.J. Elliott, J.N. Woody, T.F. Schaible, and M. Feldmann Therapeutic efficacy of multiple intravenous infusions of anti-tumor necrosis factor alpha monoclonal antibody combined with low-dose weekly methotrexate in rheumatoid arthritis Arthritis Rheum. 41 1998 1552 1563
-
(1998)
Arthritis Rheum.
, vol.41
, pp. 1552-1563
-
-
Maini, R.N.1
Breedveld, F.C.2
Kalden, J.R.3
Smolen, J.S.4
Davis, D.5
MacFarlane, J.D.6
Antoni, C.7
Leeb, B.8
Elliott, M.J.9
Woody, J.N.10
Schaible, T.F.11
Feldmann, M.12
-
5
-
-
0035056003
-
Anti-TNF alpha therapy of rheumatoid arthritis: What have we learned?
-
M. Feldmann, and R.N. Maini Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned? Annu. Rev. Immunol. 19 2001 163 196
-
(2001)
Annu. Rev. Immunol.
, vol.19
, pp. 163-196
-
-
Feldmann, M.1
Maini, R.N.2
-
6
-
-
0032428331
-
Modulation of life and death by the TNF receptor superfamily
-
S.J. Baker, and E.P. Reddy Modulation of life and death by the TNF receptor superfamily Oncogene 17 1998 3261 3270
-
(1998)
Oncogene
, vol.17
, pp. 3261-3270
-
-
Baker, S.J.1
Reddy, E.P.2
-
8
-
-
85047692516
-
Signalling pathways of the TNF superfamily: A double-edged sword
-
B.B. Aggarwal Signalling pathways of the TNF superfamily: a double-edged sword Nat. Rev., Immunol. 3 2003 745 756
-
(2003)
Nat. Rev., Immunol.
, vol.3
, pp. 745-756
-
-
Aggarwal, B.B.1
-
10
-
-
0028935270
-
Pro-inflammatory cytokines and environmental stress cause p38 MAP kinase activation by dual phosphorylation on tyrosine and threonine
-
J. Raingeaud, S. Gupta, J. Roger, M. Dickens, J. Han, R.J. Ulevitch, and R.J. Davis Pro-inflammatory cytokines and environmental stress cause p38 MAP kinase activation by dual phosphorylation on tyrosine and threonine J. Biol. Chem. 270 1995 7420 7426
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 7420-7426
-
-
Raingeaud, J.1
Gupta, S.2
Roger, J.3
Dickens, M.4
Han, J.5
Ulevitch, R.J.6
Davis, R.J.7
-
11
-
-
0242663910
-
The death domain kinase RIP1 is essential for tumor necrosis factor alpha signaling to p38 mitogen-activated protein kinase
-
T.H. Lee, Q. Huang, S. Oikemus, J. Shank, J.J. Ventura, N. Cusson, R.R. Vaillancourt, B. Su, R.J. Davis, and M.A. Kelliher The death domain kinase RIP1 is essential for tumor necrosis factor alpha signaling to p38 mitogen-activated protein kinase Mol. Cell. Biol. 23 2003 8377 8385
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 8377-8385
-
-
Lee, T.H.1
Huang, Q.2
Oikemus, S.3
Shank, J.4
Ventura, J.J.5
Cusson, N.6
Vaillancourt, R.R.7
Su, B.8
Davis, R.J.9
Kelliher, M.A.10
-
12
-
-
0041660960
-
Mechanism of p38 MAP kinase activation in vivo
-
D. Brancho, N. Tanaka, A. Jaeschke, J.J. Ventura, N. Kelkar, Y. Tanaka, M. Kyuuma, T. Takeshita, R.A. Flavell, and R.J. Davis Mechanism of p38 MAP kinase activation in vivo Genes Dev. 17 2003 1969 1978
-
(2003)
Genes Dev.
, vol.17
, pp. 1969-1978
-
-
Brancho, D.1
Tanaka, N.2
Jaeschke, A.3
Ventura, J.J.4
Kelkar, N.5
Tanaka, Y.6
Kyuuma, M.7
Takeshita, T.8
Flavell, R.A.9
Davis, R.J.10
-
13
-
-
0032780309
-
Activation of the AP-1 transcription factor by inflammatory cytokines of the TNF family
-
J.M. Kyriakis Activation of the AP-1 transcription factor by inflammatory cytokines of the TNF family Gene Expression 7 1999 217 231
-
(1999)
Gene Expression
, vol.7
, pp. 217-231
-
-
Kyriakis, J.M.1
-
14
-
-
0142026209
-
P38 MAP kinases: Key signalling molecules as therapeutic targets for inflammatory diseases
-
S. Kumar, J. Boehm, and J.C. Lee p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases Nat. Rev., Drug Discov. 2 2003 717 726
-
(2003)
Nat. Rev., Drug Discov.
, vol.2
, pp. 717-726
-
-
Kumar, S.1
Boehm, J.2
Lee, J.C.3
-
15
-
-
0038179379
-
Inhibitors of p38 mitogen-activated protein kinase for the treatment of rheumatoid arthritis
-
C. Pargellis, and J. Regan Inhibitors of p38 mitogen-activated protein kinase for the treatment of rheumatoid arthritis Curr. Opin. Investig. Drugs 4 2003 566 571
-
(2003)
Curr. Opin. Investig. Drugs
, vol.4
, pp. 566-571
-
-
Pargellis, C.1
Regan, J.2
-
16
-
-
0034121690
-
Disease-modifying activity of SB 242235, a selective inhibitor of p38 mitogen-activated protein kinase, in rat adjuvant-induced arthritis
-
A.M. Badger, D.E. Griswold, R. Kapadia, S. Blake, B.A. Swift, S.J. Hoffman, G.B. Stroup, E. Webb, D.J. Rieman, M. Gowen, J.C. Boehm, J.L. Adams, and J.C. Lee Disease-modifying activity of SB 242235, a selective inhibitor of p38 mitogen-activated protein kinase, in rat adjuvant-induced arthritis Arthritis Rheum. 43 2000 175 183
-
(2000)
Arthritis Rheum.
, vol.43
, pp. 175-183
-
-
Badger, A.M.1
Griswold, D.E.2
Kapadia, R.3
Blake, S.4
Swift, B.A.5
Hoffman, S.J.6
Stroup, G.B.7
Webb, E.8
Rieman, D.J.9
Gowen, M.10
Boehm, J.C.11
Adams, J.L.12
Lee, J.C.13
-
17
-
-
0028605318
-
A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
-
J.C. Lee, T. Laydon, P.C. McDonnell, T.F. Gallagher, S. Kumar, D. Gree, D. McNulty, M.J. Blumenthal, J.R. Heys, S.W. Landvatter, J.E. Strickler, M.M. McLaughlin, I.R. Siemens, S.M. Fisher, G.P. Livi, J.R. White, J.L. Adams, and P.R. Young A protein kinase involved in the regulation of inflammatory cytokine biosynthesis Nature 372 1994 739 746
-
(1994)
Nature
, vol.372
, pp. 739-746
-
-
Lee, J.C.1
Laydon, T.2
McDonnell, P.C.3
Gallagher, T.F.4
Kumar, S.5
Gree, D.6
McNulty, D.7
Blumenthal, M.J.8
Heys, J.R.9
Landvatter, S.W.10
Strickler, J.E.11
McLaughlin, M.M.12
Siemens, I.R.13
Fisher, S.M.14
Livi, G.P.15
White, J.R.16
Adams, J.L.17
Young, P.R.18
-
18
-
-
0032525233
-
Interferon-γ expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway
-
M. Rincón, H. Enslen, J. Raingeaud, M. Recht, T. Zapton, M.S.-S. Su, L.A. Penix, R.J. Davis, and R.A. Flavell Interferon-γ expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway EMBO J. 17 1998 2817 2829
-
(1998)
EMBO J.
, vol.17
, pp. 2817-2829
-
-
Rincón, M.1
Enslen, H.2
Raingeaud, J.3
Recht, M.4
Zapton, T.5
Su, M.S.-S.6
Penix, L.A.7
Davis, R.J.8
Flavell, R.A.9
-
19
-
-
0031445542
-
Th1/Th2 cytokine balance in arthritis
-
P. Miossec, and W. van den Berg Th1/Th2 cytokine balance in arthritis Arthritis Rheum. 40 1997 2105 2115
-
(1997)
Arthritis Rheum.
, vol.40
, pp. 2105-2115
-
-
Miossec, P.1
Van Den Berg, W.2
-
20
-
-
0034502224
-
Inhibition of Th1 differentiation by IL-6 is mediated by SOCS1
-
S. Diehl, J. Anguita, A. Hoffmeyer, T. Zapton, J.N. Ihle, E. Fikrig, and M. Rincon Inhibition of Th1 differentiation by IL-6 is mediated by SOCS1 Immunity 13 2000 805 815
-
(2000)
Immunity
, vol.13
, pp. 805-815
-
-
Diehl, S.1
Anguita, J.2
Hoffmeyer, A.3
Zapton, T.4
Ihle, J.N.5
Fikrig, E.6
Rincon, M.7
-
21
-
-
0036645028
-
Induction of NFATc2 expression by interleukin 6 promotes T helper type 2 differentiation
-
S. Diehl, C.W. Chow, L. Weiss, A. Palmetshofer, T. Twardzik, L. Rounds, E. Serfling, R.J. Davis, J. Anguita, and M. Rincon Induction of NFATc2 expression by interleukin 6 promotes T helper type 2 differentiation J. Exp. Med. 196 2002 39 49
-
(2002)
J. Exp. Med.
, vol.196
, pp. 39-49
-
-
Diehl, S.1
Chow, C.W.2
Weiss, L.3
Palmetshofer, A.4
Twardzik, T.5
Rounds, L.6
Serfling, E.7
Davis, R.J.8
Anguita, J.9
Rincon, M.10
-
22
-
-
0028935974
-
Independent human MAP kinase signal transduction pathways defined by MEK and MKK isoforms
-
B. Dérijard, J. Rainjeaud, T. Barret, I.-H. Wu, J. Han, R.J. Ulevitch, and R.J. Davis Independent human MAP kinase signal transduction pathways defined by MEK and MKK isoforms Science 267 1995 683 685
-
(1995)
Science
, vol.267
, pp. 683-685
-
-
Dérijard, B.1
Rainjeaud, J.2
Barret, T.3
Wu, I.-H.4
Han, J.5
Ulevitch, R.J.6
Davis, R.J.7
-
23
-
-
0030044182
-
Characterization of the structure and function of a novel MAP kinases kinases (MKK6)
-
J. Han, J.-D. Lee, Y. Jiang, Z. Li, L. Feng, and R.J. Ulevitch Characterization of the structure and function of a novel MAP kinases kinases (MKK6) J. Biol. Chem. 271 1996 2886 2891
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 2886-2891
-
-
Han, J.1
Lee, J.-D.2
Jiang, Y.3
Li, Z.4
Feng, L.5
Ulevitch, R.J.6
-
24
-
-
15844431960
-
A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3
-
T. Moriguchi, N. Kuroyanigi, K. Yamaguchi, Y. Gotoh, K. Irie, T. Kano, K. Shirakabe, Y. Muro, H. Shibuya, K. Matsumoto, B. Nishida, and M. Hagiwara A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3 J. Biol. Chem. 271 1996 13675 13679
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 13675-13679
-
-
Moriguchi, T.1
Kuroyanigi, N.2
Yamaguchi, K.3
Gotoh, Y.4
Irie, K.5
Kano, T.6
Shirakabe, K.7
Muro, Y.8
Shibuya, H.9
Matsumoto, K.10
Nishida, B.11
Hagiwara, M.12
-
25
-
-
0034548094
-
Activation of p38 MAP kinase in T cells facilitates the immune response to the influenza virus
-
D. Conze, J. Lumsden, H. Enslen, R.J. Davis, G. Le Gros, and M. Rincon Activation of p38 MAP kinase in T cells facilitates the immune response to the influenza virus Mol. Immunol. 37 2000 503 513
-
(2000)
Mol. Immunol.
, vol.37
, pp. 503-513
-
-
Conze, D.1
Lumsden, J.2
Enslen, H.3
Davis, R.J.4
Le Gros, G.5
Rincon, M.6
-
26
-
-
0024314554
-
Inhibitory effect of TNF alpha antibodies on synovial cell interleukin-1 production in rheumatoid arthritis
-
F.M. Brennan, D. Chantry, A. Jackson, R. Maini, and M. Feldmann Inhibitory effect of TNF alpha antibodies on synovial cell interleukin-1 production in rheumatoid arthritis Lancet 2 1989 244 247
-
(1989)
Lancet
, vol.2
, pp. 244-247
-
-
Brennan, F.M.1
Chantry, D.2
Jackson, A.3
Maini, R.4
Feldmann, M.5
-
27
-
-
0043074682
-
Tumor necrosis factor alpha blockade reduces the synovial cell infiltrate early after initiation of treatment, but apparently not by induction of apoptosis in synovial tissue
-
T.J. Smeets, M.C. Kraan, M.E. van Loon, and P.P. Tak Tumor necrosis factor alpha blockade reduces the synovial cell infiltrate early after initiation of treatment, but apparently not by induction of apoptosis in synovial tissue Arthritis Rheum. 48 2003 2155 2162
-
(2003)
Arthritis Rheum.
, vol.48
, pp. 2155-2162
-
-
Smeets, T.J.1
Kraan, M.C.2
Van Loon, M.E.3
Tak, P.P.4
-
28
-
-
0037093877
-
P38 mitogen-activated protein kinase is activated and linked to TNF-alpha signaling in inflammatory bowel disease
-
G.H. Waetzig, D. Seegert, P. Rosenstiel, S. Nikolaus, and S. Schreiber p38 mitogen-activated protein kinase is activated and linked to TNF-alpha signaling in inflammatory bowel disease J. Immunol. 168 2002 5342 5351
-
(2002)
J. Immunol.
, vol.168
, pp. 5342-5351
-
-
Waetzig, G.H.1
Seegert, D.2
Rosenstiel, P.3
Nikolaus, S.4
Schreiber, S.5
-
29
-
-
0030426902
-
Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function
-
A.M. Badger, J.N. Bradbeer, B. Votta, J.C. Lee, J.L. Adams, and D.E. Griswold Pharmacological profile of SB 203580, a selective inhibitor of cytokine suppressive binding protein/p38 kinase, in animal models of arthritis, bone resorption, endotoxin shock and immune function J. Pharmacol. Exp. Ther. 279 1996 1453 1461
-
(1996)
J. Pharmacol. Exp. Ther.
, vol.279
, pp. 1453-1461
-
-
Badger, A.M.1
Bradbeer, J.N.2
Votta, B.3
Lee, J.C.4
Adams, J.L.5
Griswold, D.E.6
-
30
-
-
0024212823
-
Effect of inhibitors of eicosanoid metabolism in murine collagen-induced arthritis
-
D.E. Griswold, L.M. Hillegass, P.C. Neunier, M.J. DiMartino, and N. Hanna Effect of inhibitors of eicosanoid metabolism in murine collagen-induced arthritis Arthritis Rheumatol. 31 1988 1406 1412
-
(1988)
Arthritis Rheumatol.
, vol.31
, pp. 1406-1412
-
-
Griswold, D.E.1
Hillegass, L.M.2
Neunier, P.C.3
Dimartino, M.J.4
Hanna, N.5
-
31
-
-
0036399586
-
Immunological basis for the use of TNFalpha-blocking agents in ankylosing spondylitis and immunological changes during treatment
-
J.X. Zou, J. Braun, and J. Sieper Immunological basis for the use of TNFalpha-blocking agents in ankylosing spondylitis and immunological changes during treatment Clin. Exp. Rheumatol. 20 2002 S34 S37
-
(2002)
Clin. Exp. Rheumatol.
, vol.20
-
-
Zou, J.X.1
Braun, J.2
Sieper, J.3
|