A longitudinal study on an autoimmune murine model of ankylosing spondylitis

Annals of the Rheumatic Diseases

Volumn 64, Issue 7, 2005, Pages 981-987

  Bardos T ^a,b   Szabo Z ^a,c   Czipri, M ^a,b   Vermes, C ^a,b   Tunyogi Csapo M ^a,b   Urban, R M ^a   Mikecz, K ^a   Glant, T T ^a  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF PÉCS   (Hungary)

^c UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

AGGRECAN; PROTEOGLYCAN;

ANIMAL MODEL; ANIMAL TISSUE; ANKYLOSING SPONDYLITIS; ARTICLE; AUTOIMMUNITY; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE ACTIVITY; DISEASE COURSE; ENTHESITIS; FEMALE; GENE LOCUS; HISTOPATHOLOGY; IMAGE ANALYSIS; INCIDENCE; LONGITUDINAL STUDY; MOUSE; NONHUMAN; PHENOMENOLOGY; PRIORITY JOURNAL; RADIODIAGNOSIS; SACROILIAC JOINT; SPONDYLOARTHROPATHY;

ANIMALS; ARTHRITIS, EXPERIMENTAL; AUTOIMMUNE DISEASES; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; FEMALE; IMMUNIZATION; INTERVERTEBRAL DISK; MICE; MICE, INBRED BALB C; MICE, INBRED DBA; MODELS, ANIMAL; PROTEOGLYCANS; SACROILIAC JOINT; SPONDYLITIS, ANKYLOSING;

EID: 21344465664     PISSN: 00034967     EISSN: None     Source Type: Journal    
DOI: 10.1136/ard.2004.029710     Document Type: Article

References (58)

1. Schlosstein L, Terasaki PI, Bluestone R, Pearson CM. High association of an HL-A antigen, W27, with ankylosing spondylitis. N Engl J Med 1973;288:704-6.
2. Robinson WP, van der Linden SM, Khan MA, Rentsch HU, Cats A, Russell A, et al. HLA-Bw60 increases susceptibility to ankylosing spondylitis in HLA-B27+ patients. Arthritis Rheum 1989;32:1135-41.
3. Said-Nahal R, Miceli-Richard C, Berthelot JM, Duche A, Dernis-Labous E, Le Blevec G, et al. The familial form of spondylarthropathy: a clinical study of 115 multiplex families. Groupe Francais d'Etude Genetique des Spondylarthropathies. Arthritis Rheum 2000;43:1356-65.
4. Brown MA, Pile KD, Kennedy LG, Campbell D, Andrew L, March R, et al. A genome-wide screen for susceptibility loci in ankylosing spondylitis. Arthritis Rheum 1998;41:588-95.
5. Laval SH, Timms A, Edwards S, Bradbury L, Brophy S, Milicic A, et al. Whole-genome screening in ankylosing spondylitis: evidence of non-MHC genetic-susceptibility loci. Am J Hum Genet 2001;68:918-26.
6. Ebringer RW, Cawdell DR, Cowling P, Ebringer A. Sequential studies in ankylosing spondylitis. Association of Klebsiella pneumoniae with active disease. Ann Rheum Dis 1978;37:146-51.
7. Hermann E, Suckè B, Droste U, Zum Büschenfelde K-HM. Klebsiella pneumoniae-reactive T cells in blood and synovial fluid of patients with ankylosing spondylitis. Arthritis Rheum 1995;38:1277-82.
8. Cancino-Diaz M, Curiel-Quesada E, Garcia-Latorre E, Jimenez-Zamudio L. Cloning and sequencing of the gene that codes for the Klebsiella pneumoniae GroEL-Tike protein associated with ankylosing spondylitis. Microb Pathog 1998;25:23-32.
9. Ebringer A, Wilson C. HLA molecules, bacteria and autoimmunity. J Med Microbiol 2000;49:305-11.
10. Nickerson CL, Hogen KL, Luthra HS, David CS. Effect of H-2 genes on expression of HLA-B27 and Yersinia-induced arthritis. Scand J Rheumatol 1990;87:85-90.
11. Ugrinovic S, Mertz A, Wu P, Braun J, Sieper J. A single nonamer from the Yersinia 60-kDa heat shock protein is the target of HLA-B27-restricted CTL response in Yersinia-induced reactive arthritis. J Immunol 1997;159:5715-23.
12. Yu D, Kuipers JG. Role of bacteria and HLA-B27 in the pathogenesis of reactive arthritis. Rheum Dis Clin North Am. 2003;29: 21-36, v-vi).
13. Schwimmbeck PL, Yu DTY, Oldstone MBA. Autoantibodies to HLA B27 in the sera of HLA B27 patients with ankylosing spondylitis and Reiter's syndrome. J Exp Med 1987;166:173-81.
14. Gonzalez-Roces S, Alvarez MV, Gonzalez S, Dieye A, Makni H, Woodfield DG, et al. HLA-B27 polymorphism and worldwide susceptibility to ankylosing spondylitis. Tissue Antigens 1997;49:116-23.
15. Glant T, Csongor J, Szücs T. Immunopathologic role of proteoglycan antigens in rheumatoid joint diseases. Scand J Immunol 1980;11:247-52.
16. Golds EE, Stephen IBM, Esdaile JM, Strawczynski H, Poole AR. Lymphocyte transformation to connective tissue antigens in adult and juvenile rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, systemic lupus eryrhematosus and a non-arthritic control population. Cell Immunol 1983;82:196-209.
17. Mikecz K, Giant TT, Baron M, Poole AR. Isolation of proteoglycan specific T-cells from patients with ankylosing spondylitis. Cell Immunol 1988;112:55-63.
18. Jobanputra P, Choy EHS, Kingsley GH, Sieper J, Palacios-Boix AA, Heinegård D, et al. Cellular immunity to cartilage proteoglycans: relevance to the pathogenesis of ankylosing spondylitis. Ann Rheum Dis 1992;51:959-62.
19. Zou J, Zhang Y, Thiel A, Rudwaleit M, Shi SL, Radbruch A, et al. Predominant cellular immune response to the cartilage autoantigenic G1 aggrecan in ankylosing spondylitis and rheumatoid arthritis. Rheumatology (Oxford) 2003;42:846-55.
20. Lipson SJ, Muir H. Vertebral osteophyte formation in experimental disc degeneration. Morphologic and proteoglycan changes over time. Arthritis Rheum 1980;23:319-24.
21. Mahowald ML, Krug H, Taurog J. Progressive ankylosis in mice. An animal model of spondylartnropathy. I. Clinical and radiographic findings. Arthritis Rheum 1988;31:1390-9.
22. Moskowitz RW, Ziv I, Denko CW, Boja B, Jones PK, Adler JH. Spondylosis in sand rats: a model of intervertebral disc degeneration and hyperostosis. J Orthop Res 1990;8:401-11.
23. 2m: an animal model of HLA-B27-associated human disorders. Cell 1990;63:1099-112.
24. Miyamoto S, Yonenobu K, Ono K. Experimental cervical spondylosis in the mouse. Spine 1991;16:S495-500.
25. 2-microglobulin: a model of numan spondyloarthropathies. J Exp Med 1995;182:1153-8.
26. Ho AM, Johnson MD, Kingsley DM. Role of the mouse ank gene in control of tissue calcification and arthritis. Science 2000;289:265-70.
27. Harmey D, Hessle L, Narisawa S, Johnson KA, Terkeltaub R, Millan JL. Concerted regulation of inorganic pyrophosphate and osteopontin by akp2, enpp1, and ank: an integrated model of the pathogenesis of mineralization disorders. Am J Pathol 2004;164:1199-209.
28. Glant TT, Mikecz K, Arzoumanian A, Poole AR. Proteoglycan-induced arthritis in BALB/c mice. Clinical features and histopathology. Arthritis Rheum 1987;30:201-12.
29. Glant TT, Bardos T, Vermes C, Chandrasekaran R, Valdéz JC, Otto JM, et al. Variations in susceptibility to proteoglycan-induced arthritis and spondylitis among C3H substrains of mice. Evidence of genetically acquired resistance to autoimmune disease. Arthritis Rheum 2001;44:682-92.
30. Giant TT, Finnegan A, Mikecz K. Proteoglycan-induced arthritis: immune regulation, cellular mechanisms and genetics. Crit Rev Immunol 2003;23:199-250.
31. Shi S, Ciurli C, Cartman A, Pidoux I, Poole AR, Zhang Y. Experimentol immunity to the G1 domain of the proteoglycan versican induces spondylitis and sacroiliitis, of a kind seen in human spondylarthropathies. Arthritis Rheum 2003;48:2903-15.
32. Zhang Y. Animal models of inflammatory spinal and sacroiliac joint diseases. Rheum Dis Clin North Am 2003;29:631-45.
33. Mikecz K, Giant TT, Poole AR. Immunity to cartilage proteoglycans in BALB/c mice with progressive polyarthritis and ankylosing spondylitis induced by injection of human cartilage proteoglycan. Arthritis Rheum 1987;30:306-18.
34. Glant TT, Cs-Szabó G, Nagase H, Jacobs JJ, Mikecz K. Progressive polyarthritis induced in BALB/c mice by aggrecan from human osteoarthritic cartilage. Arthritis Rheum 1998;41:1007-18.
35. Glant TT, Mikecz K. Proteoglycan aggrecan-induced arthritis: a murine autoimmune model of rheumatoid artnritis. Methods Mol Med 2004;102:313-38.
36. Otto JM, Cs-Szabó G, Gallagher J, Velins S, Mikecz K, Buzás EI, et al. Identification of multiple loci linked to inflammation and autoantibody production by a genome scan of a murine model of rheumatoid arthritis. Arthritis Rheum 1999;42;2524-31.
37. Bárdas T, Kamath RV, Mikecz K, Giant TT. Anti-inflammatory and chondroprotective effect of TSG-6 (tumor necrosis factor-α-stimulated gene-6) in murine models of experimental arthritis. Am J Pathol 2001;159:1711-21.
38. Czipri M, Otto JM, Cs-Szabo G, Kamath RV, Vermes C, Firneisz G, et al. Genetic rescue of chondrodysplasia and the perinatal lethal effect of cartilage link protein deficiency. J Biol Chem 2003;278:39214-23.
39. Kimmel CA, Trammell C. A rapid procedure for routine double staining of cartilage and bone in fetal and adult animals. Stain Technol 1981;56:271-3.
40. Bárdos T, Mikecz K, Finnegan A, Zhang J, Glant TT. T and B cell recovery in arthritis adoptively transferred to SCiD mice: antigen-specific activation is required for restoration of autopathogenic CD4+ Th1 cells in a syngeneic system. J Immunol 2002;168:6013-21.
41. Schmidt MB, Mow VC, Chun LE, Eyre DR. Effects of proteoglycan extraction on the tensile behavior of articular cartilage. J Orthop Res 1990;8:353-63.
42. Waggett AD, Ralphs JR, Kwan AP, Woodnutt D, Benjamin M. Characterization of collagens and proteoglycans at the insertion of the human Achilles tendon. Matrix Biol 1998;16:457-70.
43. Pearce RH, Grimmer BJ, Adams ME. Degeneration and the chemical composition of the human lumbar intervertebral disc. J Orthop Res 1987;5:198-205.
44. Kang JD, Stefanovic-Racic M, McIntyre LA, Georgescu HI, Evans CH. Toward a biochemical understanding of human intervertebral disc degeneration and herniation. Contributions of nitric oxide, interleukins, prostaglandin E2, and matrix metalloproteinases. Spine 1997;22:1065-73.
45. Szanto S, Bárdos T, Szabo Z, David CS, Buzás E, Mikecz K, et al. Induction of arthritis in HLA-DR4-humanized and HLA-DQ8-humanized mice by human cartilage proteoglycan aggrecan but only in the presence of an appropriate (non-MHC) genetic background. Arthritis Rheum 2004;50:1984-95.
46. Doege KJ, Sasaki M, Kimura T, Yamada Y. Complete coding sequence and deduced primary structure of the human cartilage large aggregating proteoglycan, aggrecan. Human- specific repeats, and additional alternativley spliced forms. J Biol Chem 1991;266:894-902.
47. Walcz E, Deák F, Erhardt P, Coulter SN, Fülöp C, Horváth P, et al. Complete coding sequence, deduced primary structure, chromosomal localization and structural analysis of murine aggrecan. Genomics 1994;22:364-71.
48. Kabasakal Y, Garrett SL, Calin A. The epidemiology of spondylodiscitis in ankylosing spondylitis - a controlled study. Br J Rheumatol 1996;35:660-3.
49. Braun J, Bollow M, Sieper J. Radiologic diagnosis and pathology of the spondyloarthropathies. Rheum Dis Clin North Am 1998;24:697-735.
50. Eulderink F. Pathology of ankylosing spondylitis. Spine State of the Art Reviews 1990;4:507-28.
51. Fry TR, Eurell JC, Johnson AL, Brown MD, Losonsky JM, Schaeffer DJ. Radiographic and histologic effects of chondroitinase ABC on normal canine lumbar intervertebral disc. Spine 1991;16:810-19.
52. Taurog JD, Maika SD, Satumtira N, Dorris ML, McLean IL, Yanagisawa H, et al. Inflammatory disease in HLA-B27 transgenic rats. Immunol Rev 1999;169:209-23.
53. Taurog JD, Richardson JA, Croft JT, Simmons WA, Zhou M, Fernandez-Sueiro JL, et al. The germfree state prevents development of gut and joint inflammatory disease in HLA-B27 transgenic rats. J Exp Med 1994;180:2359-64.
54. Brown MA, Brophy S, Bradbury L, Hamersma J, Timms A, Laval S, et al. Identification of major loci controlling clinical manifestations of ankylosing spondylitis. Arthritis Rheum 2003;48:2234-9.
55. Glant TT, Mikecz K, Thonar EJMA, Kuettner KE. Immune responses to cartilage proteoglycans in inflammatory animal models and human diseases. In: Woessner JF, Howell DS, eds. Cartilage degradation: basic and clinical aspects. New York: Marcel Dekker, 1992:435-73.
56. Karopoulos C, Rowley MJ, Hie MZ, Handley CJ. Presence of antibodies to native G1 domain of aggrecan core protein in synovial fluids from patients with various joint diseases. Arthritis Rheum 1996;39:1990-7.
57. Guerassimov A, Zhang YP, Banerjee S, Cartman A, Leroux JY, Rosenberg LC, et al. Cellular immunity to the G1 domain of cartilage proteoglycan aggrecan is enhanced in patients with rheumatoid arthritis but only after removal of keratan sulfate. Arthritis Rheum 1998;41:1019-25.
58. Li NL, Zhang DQ, Zhou KY, Cartman A, Leroux JY, Poole AR, et al. Isolation and characteristics of autoreactive T cells specific to aggrecan G1 domain from rheumatoid arthritis patients. Cell Res 2000;10:39-49.