Chronic psychosocial stress in tree shrews: Effect of the substance P (NK1 receptor) antagonist L-760735 and clomipramine on endocrine and behavioral parameters

Psychopharmacology

Volumn 181, Issue 2, 2005, Pages 207-216

  Van Der Hart, Marieke G C ^a,b   De Biurrun, Gabriel ^a   Czéh, Boldizsár ^a   Rupniak, Nadia M J ^c   Den Boer, Johan A ^b   Fuchs, Eberhard ^a  

^a GERMAN PRIMATE CENTER   (Germany)

^b UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Affective disorders; Animal model; Antidepressant; Behavior; HPA axis; Substance P; Tree shrew

Indexed keywords

5 [[2 [1 [3,5 BIS(TRIFLUOROMETHYL)PHENYL]ETHOXY] 3 (4 FLUOROPHENYL) 4 MORPHOLINYL]METHYL] N,N DIMETHYL 1H 1,2,3 TRIAZOLE 4 METHANAMINE; CLOMIPRAMINE; SUBSTANCE P RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; GROOMING; HYDROCORTISONE URINE LEVEL; LOCOMOTION; MALE; NEUROENDOCRINE SYSTEM; NONHUMAN; NORADRENALIN BLOOD LEVEL; PRIMATE; PRIORITY JOURNAL; SOCIAL PSYCHOLOGY; URINALYSIS; VIDEOTAPE;

ADRENAL GLANDS; ANIMALS; BEHAVIOR, ANIMAL; CLOMIPRAMINE; ENDOCRINE SYSTEM; EPIDIDYMIS; GROOMING; HYDROCORTISONE; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MALE; MORPHOLINES; MOTOR ACTIVITY; NOREPINEPHRINE; ORGAN SIZE; RECEPTORS, NEUROKININ-1; STRESS, PSYCHOLOGICAL; SUBSTANCE P; SYMPATHETIC NERVOUS SYSTEM; TUPAIIDAE;

EID: 21344463477     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-005-2260-0     Document Type: Article

References (39)

1. Aguiar MS, Brandão ML (1996) Effects of microinjections of the neuropeptide substance P in the dorsal periaqueductal gray on the behaviour of rats in the plus-maze test. Physiol Behav 60:1183-1186
2. Ballard TM, Sanger S, Higgins GA (2001) Inhibition of shock-induced foot tapping behaviour in the gerbil by a tachykinin NK1 receptor antagonist. Eur J Pharmacol 412:255-264
3. Beresford IJ, Birch PJ, Hagan RM, Ireland SJ (1991) Investigation into species variants in tachykinin NK1 receptors by use of the non-peptide antagonist, CP-96, 345. Br J Pharmacol 104:292-293
4. Boyce S, Smith D, Carlson E, Hewson L, Rigby M, O'Donnell R, Harrison T, Rupniak NM (2001) Intra-amygdala injection of the substance P [NK(1) receptor] antagonist L-760735 inhibits neonatal vocalisations in guinea-pigs. Neuropharmacology 41: 130-137
5. Brodin E, Rosen A, Schott E, Brodin K (1994) Effects of sequential removal of rats from a group cage, and of individual housing of rats, on substance P, cholecystokinin and somatostatin levels in the periaqueductal grey and limbic regions. Neuropeptides 26:253-260
6. Cheeta S, Tucci S, Sandhu J, Williams AR, Rupniak NM, File SE (2001) Anxiolytic actions of the substance P (NK1) receptor antagonist L- 760735 and the 5-HT1A agonist 8-OH-DPAT in the social interaction test in gerbils. Brain Res 915:170-175
7. Conley RK, Cumberbatch MJ, Mason GS, Williamson DJ, Harrison T, Locker K, Swain C, Maubach K, O'Donnell R, Rigby M, Hewson L, Smith D, Rupniak NM (2002) Substance P (neurokinin 1) receptor antagonists enhance dorsal raphe neuronal activity. J Neurosci 22:7730-7736
8. Czéh B, Michaelis T, Watanabe T, Frahm J, de Biurrun G, van Kampen M, Bartolomucci A, Fuchs E (2001) Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine. Proc Natl Acad Sci U S A 98:12796-12801
9. Dal Zotto S, Marti O, Armario A (2002) Is repeated exposure to immobilization needed to induce adaptation of the hypothalamic-pituitary-adrenal axis? Influence of adrenal factors. Behav Brain Res 129:187-195
10. Den Boer JA, Bosker FJ, Slaap BR (2000) Serotonergic drugs in the treatment of depressive and anxiety disorders. Hum Psychopharmacol 15:315-336
11. File SE (2000) NKP608, an NK1 receptor antagonist, has an anxiolytic action in the social interaction test in rats. Psychopharmacology (Berl) 152:105-109
12. Fischer HD, Heinzeller T, Raab A (1985) Gonadal response to psychosocial stress in male tree shrews (Tupaia belangeri) morphometry of testis, epididymis and prostate. Andrologia 17: 262-275
13. Flügge G, Kramer M, Rensing S, Fuchs E (1998) 5HT1A-receptors and behaviour under chronic stress: selective counteraction by testosterone. Eur J Neurosci 10:2685-2693
14. Froger N, Gardier AM, Moratalla R, Alberti I, Lena I, Boni C, De Felipe C, Rupniak NM, Hunt SP, Jacquot C, Hamon M, Lanfumey L (2001) 5-hydroxytryptamine (5-HT)1A autoreceptor adaptive changes in substance P (neurokinin 1) receptor knock-out mice mimic antidepressant-induced desensitization. J Neurosci 21:8188-8197
15. Fuchs E (1999) Tree Shrews. In: Poole T (ed) UFAW Handbook on the care and management of laboratory animals. Blackwell, Oxford, pp. 235-245
16. Fuchs E, Flügge G (2002) Social stress in tree shrews: effects on physiology, brain function, and behavior of subordinate individuals. Pharmacol Biochem Behav 73:247-258
17. Fuchs E, Kramer M, Hermes B, Netter P, Hiemke C (1996) Psychosocial stress in tree shrews: clomipramine counteracts behavioral and endocrine changes. Pharmacol Biochem Behav 54: 219-228
18. Harbuz MS, Jessop DS (2001) Stress and inflammatory disease: widening roles for serotonin and substance P. Stress 4:57-70
19. Kramer MS, Cutler N, Feighner J, Shrivastava R, Carman J, Sramek JJ, Reines SA, Liu G, Snavely D, Wyatt-Knowles E, Hale JJ, Mills SG, MacCoss M, Swain CJ, Harrison T, Hill RG, Hefti F, Scolnick EM, Cascieri MA, Chicchi GG, Sadowski S, Williams AR, Hewson L, Smith D, Rupniak NM (1998) Distinct mechanism for antidepressant activity by blockade of central substance P receptors. Science 281:1640-1645
20. Kramer M, Hiemke C, Fuchs E (1999) Chronic psychosocial stress and antidepressant treatment in tree shrews: time-dependent behavioral and endocrine effects. Neurosci Biobehav Rev 23: 937-947
21. Kramer MS, Winokur A, Kelsey J, Preskorn SH, Rothschild AJ, Snavely D, Ghosh K, Ball WA, Reines SA, Munjack D, Apter JT, Cunningham L, Kling M, Bari M, Getson A, Lee Y (2004) Demonstration of the efficacy and safety of a novel substance P (NK(1)) receptor antagonist in major depression. Neuropsychopharmacology 29:385-392
22. Martin RD (1990) Are tree-shrews primates? In: Martin RD (ed) Primate origins and evolution a phylogenetic reconstruction. Chapman and Hall, London, pp. 191-213
23. Maubach KA, Martin K, Chicchi G, Harrison T, Wheeldon A, Swain CJ, Cumberbatch MJ, Rupniak NM, Seabrook GR (2002) Chronic substance P (NK1) receptor antagonist and conventional antidepressant treatment increases burst firing of monoamine neurones in the locus coeruleus. Neuroscience 109:609-617
24. McEwen BS (2000) The neurobiology of stress: from serendipity to clinical relevance. Brain Res 886:172-189
25. McTavish D, Benfield P (1990) Clomipramine. An overview of its pharmacological properties and a review of its therapeutic use in obsessive compulsive disorder and panic disorder. Drugs 39:136-153
26. Papp M, Vassout A, Gentsch C (2000) The NK1-receptor antagonist NKP608 has an antidepressant-like effect in the chronic mild stress model of depression in rats. Behav Brain Res 115:19-23
27. Pioro EP, Cuello AC, Mai JK (1990) Distribution of substance P-and enkephalin immunoreactive neurons and fibers. In: Paxinos G (ed) The human nervous system. Academic, San Diego, pp. 1051-1094
28. Rupniak NM (2002) New insights into the antidepressant actions of substance P (NK1 receptor) antagonists. Can J Physiol Pharmacol 80:489-494
29. Rupniak NM, Carlson EC, Harrison T, Oates B, Seward E, Owen S, De Felipe C, Hunt S, Wheeldon A (2000) Pharmacological blockade or genetic deletion of substance P (NK(1)) receptors attenuates neonatal vocalisation in guinea-pigs and mice. Neuropharmacology 39:1413-1421
30. Rupniak NM, Carlson EJ, Webb JK, Harrison T, Porsolt RD, Roux S, De Felipe C, Hunt SP, Oates B, Wheeldon A (2001) Comparison of the phenotype of NK1R-/- mice with pharmacological blockade of the substance P (NK1) receptor in assays for antidepressant and anxiolytic drugs. Behav Pharmacol 12:497-508
31. Santarelli L, Gobbi G, Debs PC, Sibille ET, Blier P, Hen R, Heath MJ (2001) Genetic and pharmacological disruption of neurokinin 1 receptor function decreases anxiety-related behaviors and increases serotonergic function. Proc Natl Acad Sci U S A 98:1912-1917
32. Sergeyev V, Hokfelt T, Hurd Y (1999) Serotonin and substance P co-exist in dorsal raphe neurons of the human brain. NeuroReport 10:3967-3970
33. Shirayama Y, Mitsushio H, Takashima M, Ichikawa H, Takahashi K (1996) Reduction of substance P after chronic antidepressants treatment in the striatum, substantia nigra and amygdala of the rat. Brain Res 739:70-78
34. Udenfriend S, Gerber LD, Brink L, Spector S (1985) Scintillation proximity radioimmunoassay utilizing 125I-labeled ligands. Proc Natl Acad Sci U S A 82:8672-8676
35. van der Hart MGC, Czéh B, de Biurrun G, Michaelis T, Watanabe T, Natt O, Frahm J, Fuchs E (2002) Substance P receptor antagonist and clomipramine prevent stress-induced alterations in cerebral metabolites, cytogenesis in the dentate gyrus and hippocampal volume. Mol Psychiatry 7:933-941
36. van Kampen M (2002) Chronic psychosocial stress in male tree shrews: an animal model for depression. University of Leide, pp. 1-154
37. van Kampen M, Schmitt U, Hiemke C, Fuchs E (2000) Diazepam has no beneficial effects on stress-induced behavioural and endocrine changes in male tree shrews. Pharmacol Biochem Behav 65:539-546
38. van Kampen M, Kramer M, Hiemke C, Flügge G, Fuchs E (2002) The chronic psychosocial stress paradigm in male tree shrews: evaluation of a novel animal model for depressive disorders. Stress 5:37-46
39. Varty GB, Cohen-Williams ME, Morgan CA, Pylak U, Duffy RA, Lachowicz JE, Carey GJ, Coffin VL (2002) The gerbil elevated plus-maze II: anxiolytic-like effects of selective neurokinin NK1 receptor antagonists. Neuropsychopharmacology 27:371-379