메뉴 건너뛰기




Volumn 25, Issue 3 B, 2005, Pages 2161-2170

Mechanisms involved in the potentiation of paclitaxel or 5-FU by the hypoxic cytotoxin NLCQ-1 (NSC 709257) in vitro

Author keywords

5 fluorouracil; NLCQ 1; Paclitaxel

Indexed keywords

CASPASE 3; CYTOTOXIN; FLUOROURACIL; NSC 709257; PACLITAXEL; SINGLE STRANDED DNA; UNCLASSIFIED DRUG;

EID: 21344451147     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (3)

References (48)
  • 2
    • 0035925098 scopus 로고    scopus 로고
    • Tumor hypoxia: Definitions and current clinical, biologic, and molecular aspects
    • Review, and references therein
    • Hockel M and Vaupel P: Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects [Review]. J Nat Cancer Inst 93: 266-276, 2001, and references therein.
    • (2001) J Nat Cancer Inst , vol.93 , pp. 266-276
    • Hockel, M.1    Vaupel, P.2
  • 3
    • 84965808588 scopus 로고
    • Tumor-specific, schedule-dependent interaction between Tirapazamine (SR 4233) and Cisplatin
    • Dorie MJ and Brown JM: Tumor-specific, schedule-dependent interaction between Tirapazamine (SR 4233) and Cisplatin. Cancer Res 53: 4633-4636, 1993.
    • (1993) Cancer Res , vol.53 , pp. 4633-4636
    • Dorie, M.J.1    Brown, J.M.2
  • 4
    • 0028079669 scopus 로고
    • Comparison of the enhancement of tumor responses to fractionated irradiation by SR 4233 (tirapazamine) and by nicotinamide with carbogen
    • Dorie MJ, Menke D and Brown JM: Comparison of the enhancement of tumor responses to fractionated irradiation by SR 4233 (tirapazamine) and by nicotinamide with carbogen. Int J Radiat Oncol Biol Pys 28: 145-150, 1994.
    • (1994) Int J Radiat Oncol Biol Pys , vol.28 , pp. 145-150
    • Dorie, M.J.1    Menke, D.2    Brown, J.M.3
  • 5
    • 0028938970 scopus 로고
    • Chemosensitization of CCNU in KHT murine tumor cells in vivo and in vitro by the agent RB 6145 and its isomer PD 144872
    • Siemann DW: Chemosensitization of CCNU in KHT murine tumor cells in vivo and in vitro by the agent RB 6145 and its isomer PD 144872. Radiother Oncol 34: 47-53, 1995.
    • (1995) Radiother Oncol , vol.34 , pp. 47-53
    • Siemann, D.W.1
  • 6
    • 0029993225 scopus 로고    scopus 로고
    • THNLA-1 as radio/chemosensitizer of EMT-6 tumors in mice
    • Papadopoulou MV, Ji M and Bloomer WD: THNLA-1 as radio/chemosensitizer of EMT-6 tumors in mice. Br J Cancer 74(Suppl. XXVII): S267-S270, 1996.
    • (1996) Br J Cancer , vol.74 , Issue.SUPPL. XXVII
    • Papadopoulou, M.V.1    Ji, M.2    Bloomer, W.D.3
  • 7
    • 0030426530 scopus 로고    scopus 로고
    • 9-[3-(2-Nitro-1-imidazolyl)propylamino]-cyclopenteno[b]quinoline hydrochloride (NLCPQ-1). A novel DNA-affinic bioreductive agent as cytotoxin and radiosensitizer
    • Papadopoulou MV, Ji M, Rao MK and Bloomer WD: 9-[3-(2-Nitro-1-imidazolyl) propylamino]-cyclopenteno[b]quinoline hydrochloride (NLCPQ-1). A novel DNA-affinic bioreductive agent as cytotoxin and radiosensitizer. Oncol Res 8: 425-434, 1996.
    • (1996) Oncol Res , vol.8 , pp. 425-434
    • Papadopoulou, M.V.1    Ji, M.2    Rao, M.K.3    Bloomer, W.D.4
  • 8
    • 0030633994 scopus 로고    scopus 로고
    • 9-[3-(2-Nitro-1-imidazolyl) propylamino]-cyclopenteno[b]quinoline hydrochloride (NLCPQ-1): A novel DNA-affinic bioreductive agent as chemosensitizer
    • Papadopoulou MV, Ji M, Rao MK and Bloomer WD: 9-[3-(2-Nitro-1-imidazolyl) propylamino]-cyclopenteno[b]quinoline hydrochloride (NLCPQ-1): a novel DNA-affinic bioreductive agent as chemosensitizer. I Oncol Res 9: 249-257, 1997.
    • (1997) I Oncol Res , vol.9 , pp. 249-257
    • Papadopoulou, M.V.1    Ji, M.2    Rao, M.K.3    Bloomer, W.D.4
  • 9
    • 0031023702 scopus 로고    scopus 로고
    • Modification of the antitumor activity of chemotherapeutic drugs by the hypoxic cytotoxic agent tirapazamine
    • Dorie MJ and Brown JM: Modification of the antitumor activity of chemotherapeutic drugs by the hypoxic cytotoxic agent tirapazamine. Cancer Chemother Pharmacol 39: 361-366, 1997.
    • (1997) Cancer Chemother Pharmacol , vol.39 , pp. 361-366
    • Dorie, M.J.1    Brown, J.M.2
  • 12
    • 0031462199 scopus 로고    scopus 로고
    • Phase II study of the combination of the novel bioreductive agent, tirapazamine, with cisplatin in patients with advanced non-small-cell lung cancer
    • Miller VA, Ng KK, Grant SC, Kindler H, Pizzo B, Heelan RT, von Roemeling R and Kris MG: Phase II study of the combination of the novel bioreductive agent, tirapazamine, with cisplatin in patients with advanced non-small-cell lung cancer. Ann Oncol 8: 1269-1271, 1997.
    • (1997) Ann Oncol , vol.8 , pp. 1269-1271
    • Miller, V.A.1    Ng, K.K.2    Grant, S.C.3    Kindler, H.4    Pizzo, B.5    Heelan, R.T.6    Von Roemeling, R.7    Kris, M.G.8
  • 15
    • 6344292451 scopus 로고    scopus 로고
    • Exploiting hypoxia in solid tumors with DNA-targeted bioreductive drugs
    • Papadopoulou MV and Bloomer WD: Exploiting hypoxia in solid tumors with DNA-targeted bioreductive drugs. Drugs Future 29(8): 807-819, 2004.
    • (2004) Drugs Future , vol.29 , Issue.8 , pp. 807-819
    • Papadopoulou, M.V.1    Bloomer, W.D.2
  • 16
    • 0344629821 scopus 로고    scopus 로고
    • NLCQ-1 (NSC 709257): Exploiting hypoxia with a weak DNA-intercalating bioreductive drug
    • Papadopoulou MV and Bloomer WD: NLCQ-1 (NSC 709257): exploiting hypoxia with a weak DNA-intercalating bioreductive drug [Review] Clin Cancer Res 9: 5714-5720, 2003.
    • (2003) Clin Cancer Res , vol.9 , pp. 5714-5720
    • Papadopoulou, M.V.1    Bloomer, W.D.2
  • 17
    • 0034577002 scopus 로고    scopus 로고
    • 4-[3-(2-Nitro-1-imidazolyl)-propylamino]-7-chloroquinoline hydrochloride (NLCQ-1), a novel bioreductive compound as a hypoxia-selective cytotoxin
    • Papadopoulou MV, Ji M, Rao MK and Bloomer WD: 4-[3-(2-Nitro-1-imidazolyl) -propylamino]-7-chloroquinoline hydrochloride (NLCQ-1), a novel bioreductive compound as a hypoxia-selective cytotoxin. Oncol Res 12: 185-192, 2000.
    • (2000) Oncol Res , vol.12 , pp. 185-192
    • Papadopoulou, M.V.1    Ji, M.2    Rao, M.K.3    Bloomer, W.D.4
  • 18
    • 0345356572 scopus 로고    scopus 로고
    • Reductive activation of the nitroimidazole-based hypoxia-selective cytotoxin NLCQ-1 (NSC 709257)
    • Papadopoulou MV, Ji M, Rao MK and Bloomer WD: Reductive activation of the nitroimidazole-based hypoxia-selective cytotoxin NLCQ-1 (NSC 709257). Oncol Res 14: 21-29, 2003.
    • (2003) Oncol Res , vol.14 , pp. 21-29
    • Papadopoulou, M.V.1    Ji, M.2    Rao, M.K.3    Bloomer, W.D.4
  • 19
    • 0034571055 scopus 로고    scopus 로고
    • 4-[3-(2-Nitro-1-imidazolyl)-propylamino]-7-chloroquinoline hydrochloride (NLCQ-1). A novel bioreductive agent as radiosenitizer in vitro and in vivo. Comparison with tirapazamine
    • Papadopoulou MV, Ji M, Rao MK and Bloomer WD: 4-[3-(2-Nitro-1-imidazolyl) -propylamino]-7-chloroquinoline hydrochloride (NLCQ-1). A novel bioreductive agent as radiosenitizer in vitro and in vivo. Comparison with tirapazamine. Oncol Res 12: 325-333, 2000.
    • (2000) Oncol Res , vol.12 , pp. 325-333
    • Papadopoulou, M.V.1    Ji, M.2    Rao, M.K.3    Bloomer, W.D.4
  • 20
    • 21344456979 scopus 로고    scopus 로고
    • NLCQ-1 (NSC 709257) in combination with radiation against human glioma U251 xenografts
    • Papadopoulou MV, Bloomer WD and Hollingshead MG: NLCQ-1 (NSC 709257) in combination with radiation against human glioma U251 xenografts. Anticancer Res 25(3): 1865-1870, 2005.
    • (2005) Anticancer Res , vol.25 , Issue.3 , pp. 1865-1870
    • Papadopoulou, M.V.1    Bloomer, W.D.2    Hollingshead, M.G.3
  • 22
    • 0031773145 scopus 로고    scopus 로고
    • NLCQ-1, a novel hypoxic cytotoxin: Potentiation of melphalan, cisDDP and cyclophosphamide in vivo
    • Papadopoulou MV, Ji M and Bloomer WD: NLCQ-1, a novel hypoxic cytotoxin: potentiation of melphalan, cisDDP and cyclophosphamide in vivo. Int J Radiat Oncol Biol Phys 42: 775-779, 1998.
    • (1998) Int J Radiat Oncol Biol Phys , vol.42 , pp. 775-779
    • Papadopoulou, M.V.1    Ji, M.2    Bloomer, W.D.3
  • 23
    • 0036733699 scopus 로고    scopus 로고
    • Enhancement of the antitumor effect of cyclophosphamide with the hypoxia-selective cytotoxin NLCQ-1 against murine tumors and human xenografts
    • Papadopoulou MV, Ji M, Bloomer WD and Hollingshead MG: Enhancement of the antitumor effect of cyclophosphamide with the hypoxia-selective cytotoxin NLCQ-1 against murine tumors and human xenografts. J Exp Ther Oncol 2(5): 298-305, 2002.
    • (2002) J Exp Ther Oncol , vol.2 , Issue.5 , pp. 298-305
    • Papadopoulou, M.V.1    Ji, M.2    Bloomer, W.D.3    Hollingshead, M.G.4
  • 24
    • 0036452676 scopus 로고    scopus 로고
    • Therapeutic advantage from combining paclitaxel with the hypoxia-selective cytotoxin NLCQ-1 in murine tumor- or human xenograft-bearing mice
    • Papadopoulou MV, Ji M, Ji X, Bloomer WD and Hollingshead MG: Therapeutic advantage from combining paclitaxel with the hypoxia-selective cytotoxin NLCQ-1 in murine tumor- or human xenograft-bearing mice. Cancer Chem Pharmacol 50: 501-508, 2002.
    • (2002) Cancer Chem Pharmacol , vol.50 , pp. 501-508
    • Papadopoulou, M.V.1    Ji, M.2    Ji, X.3    Bloomer, W.D.4    Hollingshead, M.G.5
  • 25
    • 0036368672 scopus 로고    scopus 로고
    • Synergistic enhancement of the antitumor effect of taxol by the bioreductive compound NLCQ-1, in vivo. Comparison with tirapazamine
    • Papadopoulou MV, Ji M, Ji X and Bloomer WD: Synergistic enhancement of the antitumor effect of taxol by the bioreductive compound NLCQ-1, in vivo. Comparison with tirapazamine. Oncol Res 13: 47-54, 2002.
    • (2002) Oncol Res , vol.13 , pp. 47-54
    • Papadopoulou, M.V.1    Ji, M.2    Ji, X.3    Bloomer, W.D.4
  • 26
    • 0036387403 scopus 로고    scopus 로고
    • Therapeutic advantage from combining 5-Fluorouracil with the hypoxia-selective cytotoxin NLCQ-1 in vivo. Comparison with tirapazamine
    • Papadopoulou MV, Ji M, Ji X and Bloomer WD: Therapeutic advantage from combining 5-Fluorouracil with the hypoxia-selective cytotoxin NLCQ-1 in vivo. Comparison with tirapazamine. Cancer Chem Pharmacol 50: 291-298, 2002.
    • (2002) Cancer Chem Pharmacol , vol.50 , pp. 291-298
    • Papadopoulou, M.V.1    Ji, M.2    Ji, X.3    Bloomer, W.D.4
  • 27
    • 0034905940 scopus 로고    scopus 로고
    • Schedule-dependent potentiation of chemotherapeutic drugs by the bioreductive compounds NLCQ-1 and Tirapazamine against EMT6 tumors in mice
    • Papadopoulou MV, Ji M and Bloomer WD: Schedule-dependent potentiation of chemotherapeutic drugs by the bioreductive compounds NLCQ-1 and Tirapazamine against EMT6 tumors in mice. Cancer Chem Pharmacol 48(2): 160-168, 2001.
    • (2001) Cancer Chem Pharmacol , vol.48 , Issue.2 , pp. 160-168
    • Papadopoulou, M.V.1    Ji, M.2    Bloomer, W.D.3
  • 28
    • 0025010717 scopus 로고
    • Concepts for describing the interaction of two agents
    • Zaider M: Concepts for describing the interaction of two agents. Radiat Res 123: 257-262, 1990.
    • (1990) Radiat Res , vol.123 , pp. 257-262
    • Zaider, M.1
  • 29
    • 0033136316 scopus 로고    scopus 로고
    • Apoptosis induced by granzyme B-glycosaminoglycan complexes: Implications for granule-mediated apoptosis in vivo
    • Galvin J, Spaeny-Dekking LHA, Wang B, Seth P, Hack CE and Froelich CJ: Apoptosis induced by granzyme B-glycosaminoglycan complexes: Implications for granule-mediated apoptosis in vivo. J Immunol 162: 5345-50, 1999.
    • (1999) J Immunol , vol.162 , pp. 5345-5350
    • Galvin, J.1    Spaeny-Dekking, L.H.A.2    Wang, B.3    Seth, P.4    Hack, C.E.5    Froelich, C.J.6
  • 30
    • 0028986423 scopus 로고
    • Detection of hypoxia by measurement of DNA damage in individual cells from spheroids and murine tumours exposed to bioreductive drugs. I. Tirapazamine
    • Olive PL: Detection of hypoxia by measurement of DNA damage in individual cells from spheroids and murine tumours exposed to bioreductive drugs. I. Tirapazamine. Br J Cancer 71: 529-536, 1995.
    • (1995) Br J Cancer , vol.71 , pp. 529-536
    • Olive, P.L.1
  • 31
    • 0033289801 scopus 로고    scopus 로고
    • Mechanistic studies regarding the potentiation of melphalan by the bioreductive compound THNLA-1 in vitro
    • Papadopoulou MV, Ji M, Khan SH and Bloomer WD: Mechanistic studies regarding the potentiation of melphalan by the bioreductive compound THNLA-1 in vitro. Oncol Res 11: 345-357, 1999.
    • (1999) Oncol Res , vol.11 , pp. 345-357
    • Papadopoulou, M.V.1    Ji, M.2    Khan, S.H.3    Bloomer, W.D.4
  • 32
    • 0027358748 scopus 로고
    • Induction and rejoining of radiation-induced DNA single-strand breaks: 'Tail moment' as a function of position in the cell cycle
    • Olive PL and Banath JP: Induction and rejoining of radiation-induced DNA single-strand breaks: 'tail moment' as a function of position in the cell cycle. Mutation Res 294: 275-283, 1993.
    • (1993) Mutation Res , vol.294 , pp. 275-283
    • Olive, P.L.1    Banath, J.P.2
  • 34
    • 0027220561 scopus 로고
    • Overview of paclitaxel (taxol) in advanced lung cancer
    • Etlinger DS: Overview of paclitaxel (taxol) in advanced lung cancer. Semin Oncol 20: 46-49, 1993.
    • (1993) Semin Oncol , vol.20 , pp. 46-49
    • Etlinger, D.S.1
  • 35
    • 0027337806 scopus 로고
    • Use of paclitaxel (taxol) in squamous cell carcinoma of the head and neck
    • Forastiere AA: Use of paclitaxel (taxol) in squamous cell carcinoma of the head and neck. Semin Oncol 20: 56-60, 1993.
    • (1993) Semin Oncol , vol.20 , pp. 56-60
    • Forastiere, A.A.1
  • 37
    • 0028346310 scopus 로고
    • Sequence dependence of paclitaxel (taxol) combined with cisplatin or alkylators in human cancer cells
    • Liebmann JE, Fisher J, Teague D and Cook JA: Sequence dependence of paclitaxel (taxol) combined with cisplatin or alkylators in human cancer cells. Oncol Res 6: 25-31, 1994.
    • (1994) Oncol Res , vol.6 , pp. 25-31
    • Liebmann, J.E.1    Fisher, J.2    Teague, D.3    Cook, J.A.4
  • 38
    • 0032032201 scopus 로고    scopus 로고
    • Cellular interactions of 5-fluorouracil and the camptothecin analogue CPT-11 (irinotecan) in a human colorectal carcinoma cell line
    • Guichard S, Hennebelle I, Bugat R and Canal P: Cellular interactions of 5-fluorouracil and the camptothecin analogue CPT-11 (irinotecan) in a human colorectal carcinoma cell line. Biochem Pharmacol 55: 667-676, 1998.
    • (1998) Biochem Pharmacol , vol.55 , pp. 667-676
    • Guichard, S.1    Hennebelle, I.2    Bugat, R.3    Canal, P.4
  • 40
    • 0031796275 scopus 로고    scopus 로고
    • 5-Fluorouracil: A pharmacological paradigm in the use of cytotoxics.
    • Review
    • Thomas DM and Zalcberg JR: 5-Fluorouracil: a pharmacological paradigm in the use of cytotoxics. [Review] Clin Experim Pharmacol Physiol 25: 887, 1998.
    • (1998) Clin Experim Pharmacol Physiol , vol.25 , pp. 887
    • Thomas, D.M.1    Zalcberg, J.R.2
  • 42
    • 0035415493 scopus 로고    scopus 로고
    • Prodrug strategies in cancer therapy
    • Review
    • Denny WA: Prodrug strategies in cancer therapy [Review]. Eur J Med Chem 36: 577-595, 2001.
    • (2001) Eur J Med Chem , vol.36 , pp. 577-595
    • Denny, W.A.1
  • 43
    • 6344269546 scopus 로고    scopus 로고
    • The involvement of DNA repair genes in the hypoxia-dependent NLCQ-1 (NSC 709257) toxicity and its synergistic interaction with cisplatin or melphalan
    • Brisbane, Australia, 17-22 August, Proceedings
    • Papadopoulou MV, Xue C and Bloomer WD: The involvement of DNA repair genes in the hypoxia-dependent NLCQ-1 (NSC 709257) toxicity and its synergistic interaction with cisplatin or melphalan. 12th Int Congress of Radiat Res, Brisbane, Australia, 17-22 August, 2003 (Proceedings).
    • (2003) 12th Int Congress of Radiat Res
    • Papadopoulou, M.V.1    Xue, C.2    Bloomer, W.D.3
  • 44
    • 11344286813 scopus 로고    scopus 로고
    • DNA damage induced by paclitaxel and DNA repair capability of peripheral blood lymphocytes as evaluated by alkaline comet assay
    • Branham MT, Nadin SB, Vargas-Roig LM and Ciocca DR: DNA damage induced by paclitaxel and DNA repair capability of peripheral blood lymphocytes as evaluated by alkaline comet assay. Mutat Res 560: 11-17, 2004.
    • (2004) Mutat Res , vol.560 , pp. 11-17
    • Branham, M.T.1    Nadin, S.B.2    Vargas-Roig, L.M.3    Ciocca, D.R.4
  • 46
    • 0029026611 scopus 로고
    • Contrasting patterns of DNA fragmentation induced by thymidylate synthase inhibitors, ZD1694 and AG-331
    • Panadero A, Yin MB, Voigt W and Rustum YM: Contrasting patterns of DNA fragmentation induced by thymidylate synthase inhibitors, ZD1694 and AG-331. Oncol Res 7: 73-81, 1995.
    • (1995) Oncol Res , vol.7 , pp. 73-81
    • Panadero, A.1    Yin, M.B.2    Voigt, W.3    Rustum, Y.M.4
  • 47
    • 0027817576 scopus 로고
    • Locus of interaction among 5-fluorouracil, leucovorin and interferon-alpha 2a in colon carcinoma cells
    • Houghton JA, Morton CL, Adkins DA and Rahman A: Locus of interaction among 5-fluorouracil, leucovorin and interferon-alpha 2a in colon carcinoma cells. Cancer Res 53: 44243-44250, 1993.
    • (1993) Cancer Res , vol.53 , pp. 44243-44250
    • Houghton, J.A.1    Morton, C.L.2    Adkins, D.A.3    Rahman, A.4
  • 48
    • 0032996680 scopus 로고    scopus 로고
    • Paclitaxel shows cytotoxicity in human hepatocellular carcinoma cell lines
    • Gagandeep S, Novikoff PM, Ott M and Gupta S: Paclitaxel shows cytotoxicity in human hepatocellular carcinoma cell lines. Cancer Let 136: 109-118, 1999.
    • (1999) Cancer Let , vol.136 , pp. 109-118
    • Gagandeep, S.1    Novikoff, P.M.2    Ott, M.3    Gupta, S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.