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Volumn 11, Issue 8, 1999, Pages 345-357

Mechanisms involved in the potentiation of melphalan by the bioreductive bompound THNLA-1 in Vitro

Author keywords

Bioreductive drugs; Chemotherapy; Mechanisms; Potentiation; THNLA I

Indexed keywords

9 (3 (2 NITRO 1 IMIDAZOLYL)PROPYLAMINO) 1,2,3,4 TETRAHYDROACRIDINE; 9-(3-(2-NITRO-1-IMIDAZOLYL)PROPYLAMINO)-1,2,3,4-TETRAHYDROACRIDINE; ALKYLATING AGENT; BUTHIONINE SULFOXIMINE; DNA; DRUG DERIVATIVE; GLUTATHIONE; MELPHALAN; PROTEIN; RADIOSENSITIZING AGENT; RNA; TACRINE;

EID: 0033289801     PISSN: 09650407     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (8)

References (43)
  • 1
    • 0023082510 scopus 로고
    • Tumor hypoxia; its impact on cancer therapy
    • Moulder, J. E.; Rockwell, S. Tumor hypoxia; its impact on cancer therapy. Cancer Metastasis Rev. 5:313-341; 1987.
    • (1987) Cancer Metastasis Rev. , vol.5 , pp. 313-341
    • Moulder, J.E.1    Rockwell, S.2
  • 2
    • 0025807618 scopus 로고
    • Oxygénations of human tumors: Evaluation of tissue oxygen distribution in breast cancers by computerized O, tension measurements
    • Vaupel, P.; Schlenger, K.; Knoop, C.; Hockel, M. Oxygénations of human tumors: Evaluation of tissue oxygen distribution in breast cancers by computerized O, tension measurements. Cancer Res. 51:3316-3322; 1991.
    • (1991) Cancer Res. , vol.51 , pp. 3316-3322
    • Vaupel, P.1    Schlenger, K.2    Knoop, C.3    Hockel, M.4
  • 5
    • 0021216039 scopus 로고
    • Modification of chemotherapy by nitroimidazoles
    • Siemann, D. W. Modification of chemotherapy by nitroimidazoles. Int. J. Radiât. Oncol. Biol. Phys. 10:1585-1594; 1984.
    • (1984) Int. J. Radiât. Oncol. Biol. Phys. , vol.10 , pp. 1585-1594
    • Siemann, D.W.1
  • 6
    • 0024207211 scopus 로고
    • Effect of cancer chemotherapy on the hypoxic fraction of a solid tumor measured using a local tumor control assay
    • Grau, C.; Overgaard, J. Effect of cancer chemotherapy on the hypoxic fraction of a solid tumor measured using a local tumor control assay. Radiother. Oncol. 13:301-309; 1988.
    • (1988) Radiother. Oncol. , vol.13 , pp. 301-309
    • Grau, C.1    Overgaard, J.2
  • 7
    • 0023555121 scopus 로고
    • Hypoxie cells as specific drug targets for chemotherapy
    • Kennedy, K. A. Hypoxie cells as specific drug targets for chemotherapy. Anticancer Drug Des. 2:181-194; 1987.
    • (1987) Anticancer Drug Des. , vol.2 , pp. 181-194
    • Kennedy, K.A.1
  • 8
    • 0023902264 scopus 로고
    • Therapeutic attack of hypoxic cells of solid tumors: Presidential address
    • Sartorelli, A. C. Therapeutic attack of hypoxic cells of solid tumors: Presidential address. Cancer Res. 48:775-778; 1988.
    • (1988) Cancer Res. , vol.48 , pp. 775-778
    • Sartorelli, A.C.1
  • 9
    • 0026513038 scopus 로고
    • Enhancement of alkylating agent activity by SR-4233 in FSalIC murine fibrosarcoma
    • Holden, S. A.; Teicher, B. A.; Ara, G.; Herman, T. S.; Coleman, C. N. Enhancement of alkylating agent activity by SR-4233 in FSalIC murine fibrosarcoma. J. Natl. Cancer Inst. 84:187-193; 1992.
    • (1992) J. Natl. Cancer Inst. , vol.84 , pp. 187-193
    • Holden, S.A.1    Teicher, B.A.2    Ara, G.3    Herman, T.S.4    Coleman, C.N.5
  • 10
    • 84982712502 scopus 로고
    • Potentiation of antineoplastic drugs in vitro and in vivo by intercalating bioreductive agents
    • Papadopoulou, M. V.; Miller, A.; Seskey, T.; Epperly, M. W.; Bloomer, W. D. Potentiation of antineoplastic drugs in vitro and in vivo by intercalating bioreductive agents. Radiât. Oncol. Invest. 1:206-217; 1993.
    • (1993) Radiât. Oncol. Invest. , vol.1 , pp. 206-217
    • Papadopoulou, M.V.1    Miller, A.2    Seskey, T.3    Epperly, M.W.4    Bloomer, W.D.5
  • 11
    • 84965808588 scopus 로고
    • Tumor-specific, schedule-dependent interaction between tirapazamine SR 4233} and cisplatin
    • Doric, M. J.; Brown, J. M. Tumor-specific, schedule-dependent interaction between tirapazamine (SR 4233} and cisplatin. Cancer Res. 53:4633-4636; 1993.
    • (1993) Cancer Res. , vol.53 , pp. 4633-4636
    • Doric, M.J.1    Brown, J.M.2
  • 12
    • 0028938970 scopus 로고
    • Chemosensitization of CCNU in KHT murine tumor cells in vivo and in vitro by the agent RB 6145 and its isomer PD 144872
    • Siemann, D. W. Chemosensitization of CCNU in KHT murine tumor cells in vivo and in vitro by the agent RB 6145 and its isomer PD 144872. Radiother. Oncol. 34:47-53; 1995.
    • (1995) Radiother. Oncol. , vol.34 , pp. 47-53
    • Siemann, D.W.1
  • 13
    • 0029938276 scopus 로고    scopus 로고
    • THNLA-1: A DNA-targeted bioreductive agent as chcmosensitizer m
    • Papadopoulou, M. V.; Ji, M.; Bloomer, W. D. THNLA-1: A DNA-targeted bioreductive agent as chcmosensitizer m vitro and in vivo. In vivo 10:49-58; 1996.
    • (1996) Vitro and in Vivo. in Vivo , vol.10 , pp. 49-58
    • Papadopoulou, M.V.1    Ji, M.2    Bloomer, W.D.3
  • 14
    • 0029993225 scopus 로고    scopus 로고
    • THNLA-1 as radio/ chcmoscnsilizer of EMT-6 tumors in mice
    • Papadopoulou, M. V.; Ji, M.; Bloomer, W. D. THNLA-1 as radio/ chcmoscnsilizer of EMT-6 tumors in mice. Dr. J. Cancer 74(Suppl. XXVII):S267-S270; 1996.
    • (1996) Dr. J. Cancer , vol.74 , Issue.27 SUPPL.
    • Papadopoulou, M.V.1    Ji, M.2    Bloomer, W.D.3
  • 15
    • 0030633994 scopus 로고    scopus 로고
    • -cyclopenteno[b]quinoline hydrochloridc (NLCPQ-1). A novel DNA-affinic bioreductive agent as chcmosensitizer
    • -cyclopenteno[b]quinoline hydrochloridc (NLCPQ-1). A novel DNA-affinic bioreductive agent as chcmosensitizer. I. Oncol. Res. 9:249-257; 1997.
    • (1997) I. Oncol. Res. , vol.9 , pp. 249-257
    • Papadopoulou, M.V.1    Ji, M.2    Rao, M.K.3    Bloomer, W.D.4
  • 16
    • 0031773145 scopus 로고    scopus 로고
    • NLCQ-1, a novel hypoxic cytotoxin: Potentiation of mclphalan, rJ.cDDP and cyclophosphamide
    • 199S.
    • Papadopoulou, M. V; Ji, M.; Bloomer, W. D. NLCQ-1, a novel hypoxic cytotoxin: Potentiation of mclphalan, rJ.cDDP and cyclophosphamide in vivo. Int. J. Radial. Oncol. Biol. Phys. 42:775-779; 199S.
    • In Vivo. Int. J. Radial. Oncol. Biol. Phys. , vol.42 , pp. 775-779
    • Papadopoulou, M.V.1    Ji, M.2    Bloomer, W.D.3
  • 17
    • 0010695956 scopus 로고    scopus 로고
    • Tirapazaminc plus cisplatin in the treatment of patients with breast cancer and other platinum resistant tumors. A phase II clinical trial
    • Marshall, J. L.; Figueira, M.; Dahut, W.; Rizvi, N.; Roemcling, R.; Hawkins M. J. Tirapazaminc plus cisplatin in the treatment of patients with breast cancer and other platinum resistant tumors. A phase II clinical trial. Cancer Thcr. l(4):237-243; 1998.
    • (1998) Cancer Thcr. , vol.50 , Issue.4 , pp. 237-243
    • Marshall, J.L.1    Figueira, M.2    Dahut, W.3    Rizvi, N.4    Roemcling, R.5    Hawkins, M.J.6
  • 19
    • 0028555808 scopus 로고
    • 9-3-(2-Nitro-l-imidazolyl)propylamino-l,2,3,4-tetrahydroacridinc hydrochloride. A novel DNA-affinic hypoxic cell cytotoxin and radiosensitizer
    • Papadopoulou, M. V.; Roscnzweig, H. S.; Doddi, M.: Bloomer, W. D. 9-[3-(2-Nitro-l-imidazolyl)propylamino-l,2,3,4-tetrahydroacridinc hydrochloride. A novel DNA-affinic hypoxic cell cytotoxin and radiosensitizer. Comparison with NLA-1. Oncol. Res. 6:439-448; 1994.
    • (1994) Comparison with NLA-1. Oncol. Res. , vol.6 , pp. 439-448
    • Papadopoulou, M.V.1    Doddi M, R.H.S.2    Bloomer, W.D.3
  • 21
    • 0023124018 scopus 로고
    • Chemosensitization of L-phenyl-alaninc mustard by the thiol-modulating agent buthionine sulfoximine
    • Kramer, R. A.; Grccne, K.; Ahmad, S.; Vistica, D. T. Chemosensitization of L-phenyl-alaninc mustard by the thiol-modulating agent buthionine sulfoximine. Cancer Res. 47:1593-1597; 1987.
    • (1987) Cancer Res. , vol.47 , pp. 1593-1597
    • Kramer, R.A.1    Grccne, K.2    Ahmad, S.3    Vistica, D.T.4
  • 22
    • 0022387475 scopus 로고
    • Potentiation and protection of doxorubicin cytotoxicity by cellular glutathionc modulation
    • Russo, A.; Mitchell, J. B. Potentiation and protection of doxorubicin cytotoxicity by cellular glutathionc modulation. Cancer Treat. Rep. 69:1293-1296; 1985.
    • (1985) Cancer Treat. Rep. , vol.69 , pp. 1293-1296
    • Russo, A.1    Mitchell, J.B.2
  • 23
    • 0020665635 scopus 로고
    • Enhancement of the DNA cross-linking activity of melphalan by misonidazole
    • Murray, D.; Meyn, R. E. Enhancement of the DNA cross-linking activity of melphalan by misonidazole in vivo. Br. J. Cancer 47: 195-203; 1983.
    • (1983) In Vivo. Br. J. Cancer , vol.47 , pp. 195-203
    • Murray, D.1    Meyn, R.E.2
  • 24
    • 0020529593 scopus 로고
    • Mechanism of sensitization of Chinese hamster ovary cells to melphalan by hypoxic treatment with misonidazole
    • Taylor, Y. C.; Evans, J. W.; Brown, J. M. Mechanism of sensitization of Chinese hamster ovary cells to melphalan by hypoxic treatment with misonidazole. Cancer Res. 43:3175-3181; 1983.
    • (1983) Cancer Res. , vol.43 , pp. 3175-3181
    • Taylor, Y.C.1    Evans, J.W.2    Brown, J.M.3
  • 26
    • 0028986423 scopus 로고
    • Detection of hypoxia by measurement of DNA damage in individual cells from spheroids and murine tumours exposed to bioreduclive drugs. I. Tirapazamine
    • Olive, P. L. Detection of hypoxia by measurement of DNA damage in individual cells from spheroids and murine tumours exposed to bioreduclive drugs. I. Tirapazamine. Br. J. Cancer 71: 529-536; 1995.
    • (1995) Br. J. Cancer , vol.71 , pp. 529-536
    • Olive, P.L.1
  • 28
    • 0014481378 scopus 로고
    • Enzymic method for quantitative determination of nanogram amounts of total and oxidized glulathione: Applications to mammalian blood and other tissues
    • Tietze, F. Enzymic method for quantitative determination of nanogram amounts of total and oxidized glulathione: Applications to mammalian blood and other tissues. Anal. Biochcm. 27:502-522; 1969.
    • (1969) Anal. Biochcm. , vol.27 , pp. 502-522
    • Tietze, F.1
  • 29
    • 0028144364 scopus 로고
    • The role of apoptosis in cell killing by cisplatin: A flow cylometry study
    • Ormerod, M. G.; Orr, R. M.; Peacock, J. H. The role of apoptosis in cell killing by cisplatin: A flow cylometry study. Br. J. Cancer 69:93-100; 1994.
    • (1994) Br. J. Cancer , vol.69 , pp. 93-100
    • Ormerod, M.G.1    Orr, R.M.2    Peacock, J.H.3
  • 30
    • 0017186787 scopus 로고
    • Fractionation of DNA from mammalian cells by alkaline elution
    • Kohn, K. W.; Erickson, L. C.; Ewig, R. A. G.; Friedman, C. A. Fractionation of DNA from mammalian cells by alkaline elution. Biochemistry 15:4629-4637; 1976.
    • (1976) Biochemistry , vol.15 , pp. 4629-4637
    • Kohn, K.W.1    Erickson, L.C.2    Ewig, R.A.G.3    Friedman, C.A.4
  • 31
    • 0028024162 scopus 로고
    • The kinetics of cellular recovery in exponential and plateau growth phase human glioma cells following y-irradiation
    • Heller, D. P.; Raaphorst, G. P. The kinetics of cellular recovery in exponential and plateau growth phase human glioma cells following y-irradiation. Int. J. Radiât. Oncol. Biol. Phys. 30:383-390; 1994.
    • (1994) Int. J. Radiât. Oncol. Biol. Phys. , vol.30 , pp. 383-390
    • Heller, D.P.1    Raaphorst, G.P.2
  • 32
    • 0028923172 scopus 로고
    • Detection of hypoxia by measurement of DNA damage in individual cells from spheroids and murine tumours exposed to bioreduclive drugs. II. RSU 1069
    • Olive, P. L. Detection of hypoxia by measurement of DNA damage in individual cells from spheroids and murine tumours exposed to bioreduclive drugs. II. RSU 1069. Br. J. Cancer 71:537-542; 1995.
    • (1995) Br. J. Cancer , vol.71 , pp. 537-542
    • Olive, P.L.1
  • 33
    • 0018102806 scopus 로고
    • Differences between melphalan and nitrogen mustard in the formation and removal of DNA cross-links
    • Ross, W. E.; Ewig, R. A. G.; Kohn, K. W. Differences between melphalan and nitrogen mustard in the formation and removal of DNA cross-links. Cancer Res. 38:1502-1506; 1978.
    • (1978) Cancer Res. , vol.38 , pp. 1502-1506
    • Ross, W.E.1    Ewig, R.A.G.2    Kohn, K.W.3
  • 35
    • 0021878218 scopus 로고
    • Augmentation of adriamycin, melphalan and cisplatin cytotoxicity in drug-resistant and -sensitive human ovarian cancer cell lines by buthionine sulfoximine mediated glutathione depletion
    • Hamilton, T. C.; Winker, M. A.; Louie, K. G.; Batist, G.; Bohrens, B. C; Tsuruo, T.; Grotzinger, K. R.; McKoy, W. M.; Young, R. C.; Ozols, R. F. Augmentation of adriamycin, melphalan and cisplatin cytotoxicity in drug-resistant and -sensitive human ovarian cancer cell lines by buthionine sulfoximine mediated glutathione depletion. Biochcm. Pharmacol. 34:2583-2586; 1985.
    • (1985) Biochcm. Pharmacol. , vol.34 , pp. 2583-2586
    • Hamilton, T.C.1    Winker, M.A.2    Louie, K.G.3    Batist, G.4    Bohrens, B.C.5    Tsuruo, T.6    Grotzinger, K.R.7    McKoy, W.M.8    Young, R.C.9    Ozols, R.F.10
  • 36
    • 49149136604 scopus 로고
    • Metabolism and function of glutathione
    • Meister, A. Metabolism and function of glutathione. Trends Biochem. Sci. 6:231-234, 1981.
    • (1981) Trends Biochem. Sci. , vol.6 , pp. 231-234
    • Meister, A.1
  • 37
    • 0025219192 scopus 로고
    • Chemosensitivity correlation between the primary tumors and simultaneous metastatic lymph node of patients evaluated by DNA synthesis inhibition assay
    • Nio, Y.; Imai, S.; Shiraishi T.; Tsubono, M.; Morimoto, H.; Tseng, C.; Tobe, T. Chemosensitivity correlation between the primary tumors and simultaneous metastatic lymph node of patients evaluated by DNA synthesis inhibition assay. Cancer 65:1273-1278; 1990.
    • (1990) Cancer , vol.65 , pp. 1273-1278
    • Nio, Y.1    Imai, S.2    Shiraishi, T.3    Tsubono, M.4    Morimoto, H.5    Tseng, C.6    Tobe, T.7
  • 38
    • 0028346310 scopus 로고
    • Sequence dependence of paclitaxel (taxol) combined with cisplatin or alkylators in human cancer cells
    • Liebmann, J. E.; Fisher, J.; Teague, D.; Cook, J. A. Sequence dependence of paclitaxel (taxol) combined with cisplatin or alkylators in human cancer cells. Oncol. Res. 6:25-31; 1994.
    • (1994) Oncol. Res. , vol.6 , pp. 25-31
    • Liebmann, J.E.1    Fisher, J.2    Teague, D.3    Cook, J.A.4
  • 39
    • 0029561580 scopus 로고
    • Effect of melphalan and hypcrthermia on cell cycle progression and cyclin Bl expression in human melanoma cells
    • Orlandi, L.; Zaffaroni, N.; Bearzatto, A.; Costa, A.; Supino, R.; Vaglini, M.; Silvestrini, R. Effect of melphalan and hypcrthermia on cell cycle progression and cyclin Bl expression in human melanoma cells. Cell Prolif. 28:617-630; 1995.
    • (1995) Cell Prolif. , vol.28 , pp. 617-630
    • Orlandi, L.1    Zaffaroni, N.2    Bearzatto, A.3    Costa, A.4    Supino, R.5    Vaglini, M.6    Silvestrini, R.7
  • 40
    • 0025952852 scopus 로고
    • Interphase cell death as related to the cell cycle of melphalan-treatcd human myeloma cells
    • Fernberg, J. O.; Lcwensohn, R.; Skog, S. Interphase cell death as related to the cell cycle of melphalan-treatcd human myeloma cells. Med. Oncol. Tumor Pharmacother. 8:63-67; 1991.
    • (1991) Med. Oncol. Tumor Pharmacother. , vol.8 , pp. 63-67
    • Fernberg, J.O.1    Lcwensohn, R.2    Skog, S.3
  • 41
    • 0027261147 scopus 로고
    • The cell cycle related differences in susceptibility of HL-60 cells to apoptosis induced by various antitumor agents
    • Gorczyca, W.; Gong, J.; Ardelt, B.; Traganos, F.; Darzynkiewicz, Z. The cell cycle related differences in susceptibility of HL-60 cells to apoptosis induced by various antitumor agents. Cancer Res. 53:3186-3192; 1993.
    • (1993) Cancer Res. , vol.53 , pp. 3186-3192
    • Gorczyca, W.1    Gong, J.2    Ardelt, B.3    Traganos, F.4    Darzynkiewicz, Z.5
  • 42
    • 0022482922 scopus 로고
    • Comparative studies of total cross-linking, cell survival and cell cycle perturbations in Chinese hamster cells treated with alkylating agents
    • Millar, B. C; Tilby, M. J.; Ormcrod, M. G.; Payne, A. W.; Jinks, S.; Loverock, P. S. Comparative studies of total cross-linking, cell survival and cell cycle perturbations in Chinese hamster cells treated with alkylating agents in vitro. Biochem. Pharmacol. 35: 1163-1169; 1986.
    • (1986) In Vitro. Biochem. Pharmacol. , vol.35 , pp. 1163-1169
    • Millar, B.C.1    Tilby, M.J.2    Ormcrod, M.G.3    Payne, A.W.4    Jinks, S.5    Loverock, P.S.6
  • 43
    • 0025768599 scopus 로고
    • Cell cycle arrest and DNA damage after melphalan treatment of the human myeloma cell line RPMI 8226
    • Fcrnbcrg, J. O.; Lewensohn, R.; Skog, S. Cell cycle arrest and DNA damage after melphalan treatment of the human myeloma cell line RPMI 8226. Eur. J. Haematol. 47:161-167; 1991.
    • (1991) Eur. J. Haematol. , vol.47 , pp. 161-167
    • Fcrnbcrg, J.O.1    Lewensohn, R.2    Skog, S.3


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