Is there an answer?

IUBMB Life

Volumn 57, Issue 4-5, 2005, Pages 371-373

  Ramya, T N C ^a   Surolia, Namita ^b   Surolia, Avadhesha ^a  

^a INDIAN INSTITUTE OF SCIENCE   (India)

^b JAWAHARLAL NEHRU CENTRE FOR ADVANCED SCIENTIFIC RESEARCH   (India)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; ANTIMALARIAL AGENT; FATTY ACID SYNTHASE;

CHEMICAL REACTION; CYTOSOL; DRUG TARGETING; EUKARYOTE; FATTY ACID SYNTHESIS; MALARIA; NOTE; PARASITE; PLASMODIUM FALCIPARUM; ANIMAL; ARTICLE; BIOLOGICAL MODEL; HUMAN; METABOLISM; THEORETICAL MODEL;

EUKARYOTA; PLASMODIUM FALCIPARUM;

ANIMALS; ANTIMALARIALS; FATTY ACID SYNTHETASE COMPLEX; FATTY ACIDS; HUMANS; MODELS, BIOLOGICAL; MODELS, THEORETICAL; PLASMODIUM FALCIPARUM;

EID: 21344435937     PISSN: 15216543     EISSN: None     Source Type: Journal    
DOI: 10.1080/15216540500091460     Document Type: Note

References (22)

1. Rock, C. O., and Cronan, J. E. (1996) Escherichia coli as a model for the regulation of dissociable (type II) fatty acid biosynthesis. Biochim. Biophys. Acta 1302, 1-16.
2. Reed, M. A. C., Schweizer, M., Szafranska, A. E., Arthur, C., Nicholson, T. P., Cox, R. J., Crosby, J., Crump, M. P., and Simpson, T. J. (2003) The type I rat fatty acid synthase ACP shows structural homology and analogous biochemical properties to type II ACPs. Org. Biomol. Chem. 1, 463-471.
3. World Health Organization(2002) The World Health Report 2002: Reducing risks, promoting healthy life, WHO, Geneva.
4. Holz, G. G. Jr. (1977) Lipids and the malarial parasite. Bull. World Health Organ. 55, 237-248.
5. Haldar, K., Ferguson, M. A. J., and Cross, G. A. M. (1985) Acylation of a Plasmodium falciparum merozoite surface antigen via sn-1,2-diacyl glycerol. J. Biol. Chem. 260, 4969-4974.
6. Surolia, N., and Surolia, A. (2001) Triclosan offers protection against blood stages of malaria by inhibiting enoyl-ACP reductase of Plasmodium falciparum. Nature Medicine 7, 167-173.
7. Waller, R. F., Keeling, P. J., Donald, R. G. K., Striepen, B., Handman, E., Lang-Unnasch, N., Cowman, A. F., Besra, G. S., Roos, D. S., and McFadden, G. I. (1998) Nuclear-encoded proteins target to the plastid in Toxoplasma gondii and Plasmodium falciparum. Proc. Natl. Acad. Sci. USA 95, 12352-12357.
8. Kapoor, M., Dar, M. J., Surolia, A., and Surolia, N. (2001) Kinetic determinants of the interaction of enoyl-ACP reductase from Plasmodium falciparum with its substrates and inhibitors. Biochem. Biophys. Res. Commun. 289, 832-837.
9. Sharma, S. K., Kapoor, M., Ramya, T. N. C., Kumar, S., Kumar, G., Modak, R., Sharma, S., Surolia, N., and Surolia, A. (2003) Identification, characterization and inhibition of Plasmodium falciparum β-hydroxyacyl-acyl carrier protein dehydratase (FabZ). J. Biol. Chem. 278, 45661-45671.
10. Pillai, S., Rajagopal, C., Kapoor, M., Kumar, G., Gupta, A., and Surolia, N. (2003) Functional characterization of β-ketoacyl-ACP reductase (FabG) from Plasmodium falciparum. Biochem. Biophys. Res. Commun. 303, 387-392.
11. Prigge, S. T., He, X., Gerena, L., Waters, N. C., and Reynolds, K. A. (2003) The initiating steps of a type II fatty acid synthase in Plasmodium falciparum are catalyzed by PfACP, PfMCAT and PfKASIII. Biochemistry 42, 1160-1169.
12. Waters, N. C., Kopydlowski, K. M., Guszczynski, T., Wei, L., Sellers, P., Ferlan, J. T., Lee, P. J., Li, Z., Woodard, C. L., Shallom, S. et al. (2002) Functional characterization of the acyl carrier protein (PfACP) and βketoacyl ACP synthase III (PfKASIII) from Plasmodium falciparum. Mol. Biochem. Parasitol. 123, 85-94.
13. Zuther, E., Johnson, J. J., Haselkorn, R., McLeod, R., and Gornicki, P. (1999) Growth of Toxoplasma gondii is inhibited by aryloxyphenoxypropionate herbicides targeting acetyl-CoA carboxylase. Proc. Natl. Acad. Sci. USA 96, 13387-13392.
14. Helmkamp, Jr, G. M., Brock, D. J. H., and Bloch, K. (1968) β-Hydroxydecanoyl thioester dehydrase: specificity of substrates and acetylenic inhibitors. J. Biol. Chem. 243, 3229-3232,
15. McMurry, L. M., Oethinger, M., and Levy, S. B. (1998) Triclosan targets lipid synthesis. Nature (London) 394, 531-532.
16. Parikh, S. L., Xiao, G., and Tonge, P. J. (2000) Inhibition of InhA, the enoyl reductase from Mycobacterium tuberculosis, by triclosan and isoniazid. Biochemistry 39, 7645-7650.
17. Heath, R. J., Li, J., Ronald, G. E., and Rock, C. O. (2000) Inhibition of the Staphylococcus aureus NADPH-dependent enoyl-acyl carrier protein reductase by triclosan and hexachlorophene. J. Biol. Chem. 275, 4654-4659.
18. Vance, D. E., Goldberg, I., Mitsuhashi, O., Bloch, K., Omura, S., and Nomura, S. (1972) Inhibition of fatty acid synthetases by the antibiotic cerulenin. Biochem. Biophys. Res. Commun. 48, 649-656.
19. Price, A. C., Choi, K. H., Heath, R. J., Li, Z., White, S. W., and Rock, C. O. (2001) Inhibition of β-ketoacyl-acyl carrier protein synthases by thiolactomycin and cerulenin. J. Biol. Chem. 276, 6551-6559.
20. Bhargava, H. N., and Leonard, P. A. (1996) Triclosan: applications and safety. Am. J. Infect. Control 24, 209-218.
21. Meade, M. J., Waddell, R. L., and Callahan, T. M. (2001) Soil bacteria Pseudomonas putida and Alcaligenes xylosoxidans subsp. denitrificans inactivate triclosan in liquid and solid substrates. FEMS Microbiol. Lett. 204, 45-48.
22. Surolia, A., Ramya, T. N. C., Ramya, V., and Surolia, N. (2004) FAS't inhibition of malaria. Biochem. J. 383, 1-12.