Growth of human tumor cells in macroporous microcarriers results in p53- independent, decreased cisplatin sensitivity relative to monolayers

Molecular Pharmacology

Volumn 55, Issue 5, 1999, Pages 938-947

  Maurer, Barry J ^a,d   Ihnat, Michael A ^a   Morgan, Cindy ^a   Pullman, Janice ^a   O'Brien, Craig ^a   Johnson, Steven W ^b   Rasey, Janet S ^c   Cornwell, Marilyn M ^a  

^a Fred Hutchinson Cancer Research Center   (United States)

^b FOX CHASE CANCER CENTER   (United States)

^c UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^d CHILDREN S HOSPITAL LOS ANGELES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROPEROXYCYCLOPHOSPHAMIDE; CISPLATIN; DOXORUBICIN; GELATIN; PACLITAXEL; PROTEIN P53;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DNA ADDUCT; DNA REPAIR; DRUG EFFECT; DRUG METABOLISM; DRUG SENSITIVITY; DRUG UPTAKE; HUMAN; HUMAN CELL; PRIORITY JOURNAL; TUMOR CELL; TUMOR GROWTH;

ANTINEOPLASTIC AGENTS; CELL CULTURE TECHNIQUES; CELL CYCLE; CELL DIVISION; CISPLATIN; DNA ADDUCTS; DOXORUBICIN; DRUG SCREENING ASSAYS, ANTITUMOR; GELATIN; HUMANS; KB CELLS; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEIN P53;

EID: 0032938310     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Akiyama S, Fojo A, Hanover JA, Pastan I and Gottesman MM (1992) Isolation and genetic characterization of human KB cell lines resistant to multiple drugs Som Cell Mol Genet 11:117-126
2. Butz K, Shahabeddin L, Geisen C, Spitkovsky D, Ullmann A and Hoppe-Seyler F (1995) Functional p63 protein in human papillomavirus-positive cancer cells Oncogene 10:927-936.
3. Casciari JJ, Hollingshead MG, Alley MC Mayo JG, Malspeis L, Miyauchi S, Grever MR and Weinstein JN (1997) Growth and chemotherapeutic response of cells in a hollow-fiber in vitro solid tumor model. J Natl Cancer Inst 86:1846-1852.
4. Durand RE (1990) Multicell spheroids as a model for cell kinetic studies Cell Tissue Kinet 23:141-159.
5. Erlichman C and Wu A (1992) Resistance of MGH-U1 bladder cancer spheroids to vincristine. Anticancer Res 12:1233-1236.
6. Evan GI, Brown L, Whyte M and Harrington E (1995) Apoptosis and the cell cycle Curr Opin Cell Biol 7:825-834.
7. Fan S, El-Deiry WS, Bae I, Freeman J, Jondle D, Bhatia K, Fornace AJ Jr, Magrath I, Kohn KW and O'Connor PM (1994) p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents Cancer Res 54:5824-5830.
8. Fan S, Smith ML, Rivet DJ, Duba D, Zhan Q, Kohn KW, Fornace AJ, Jr. and O'Connor PM (1995) Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxyphylline. Cancer Res 55:1649-1654
9. Frankel A, Buckman R and Kerbel RS (1997) Abrogation of taxol-induced G2-M arrest and apoptosis in human ovarian cancer cells grown as multicellular tumor spheroids. Cancer Res 57:2388-2393.
10. Fujiwara T, Grimm EA, Mukhopadhyay T, Zhang WW, Owen-Schaub LB and Roth JA (1994) Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene. Cancer Res 54:2287-2291.
11. Hawkins DS, Demers GW and Galloway DA (1996) Inactivation of p53 enhances sensitivity to multiple chemotherapeutic agents. Cancer Res 56:892-898.
12. Hoffman RM (1993) To do tissue culture in two or three dimensions? That is the question. Stem Cells (Dayton) 11:105-111.
13. Johnson SW, Perez RP, Godwin AK, Yeung AT, Handel LM, Ozols RF and Hamilton TC (1994) Role of platinum-DNA adduct formation and removal in cisplatin resistance in human ovarian cancer cell lines. Biochem Pharmacol 47:689-697.
14. Kawasaki T, Tomita Y, Bilim V, Takeda M, Takahashi K and Kumanishi T (1996) Abrogation of apoptosis induced by DNA-damaging agents in human bladder-cancer cell lines with p21WAF1/CIP1 and/or p53 gene alterations. Int J Cancer 68:501-505.
15. Kobayashi H, Man S, Graham CH, Kapitain SJ, Teicher BA and Kerbel RS (1993) Acquired multicellular-mediated resistance to alkylating agents in cancer. Proc Natl Acad Sci USA 90:3294-3298.
16. Luk CK and Tannock IF (1989) Flow cytometric analysis of doxorubicin accumulation in cells from human and rodent cell lines. J Natl Cancer Inst 81:55-59.
17. McGown AT, Ward TH and Fox BW (1983) Comparative studies of the uptake of daunorubicin in sensitive and resistant P388 cell lines by flow cytometry and biochemical extraction procedures. Cancer Chemother Pharmacol 11:113-116.
18. Nikolai TJ and Hu W-S (1992) Cultivation of mammalian cells on macroporous microcarriers. Enzyme Microb Technol 14:203-208.
19. Olive PL, Banath JP and Evans HH (1993) Cell killing and DNA damage by etoposide in Chinese hamster V79 monolayers and spheroids: Influence of growth kinetics, growth environment and DNA packaging. Br J Cancer 67:522-530.
20. Olive PL and Durand RE (1994) Drug and radiation resistance in spheroids: Cell contact and kinetics. Cancer Metast Rev 13:121-138.
21. Piovesan B, Pennel N and Berinstein NL (1998) Human lymphoblastoid cell lines expressing mutant p53 exhibit decreased sensitivity to cisplatin-induced cytotoxicity. Oncogene 17:2339-2350.
22. Polyak K, Kato JY, Solomon MJ, Sherr CJ, Massague J, Roberts JM and Koff A (1994) p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest. Genes Dev 8:9-22.
23. Ramachandran C, Mead D, Wellham LL, Sauerteig A and Krishan A (1995) Expression of drug resistance-associated mdr-1, GST pi, and topoisomerase II genes during cell cycle traverse. Biochem Pharmacol 49:545-552.
24. Rasey, JS (1984) Cell-cell contact and repair of radiation damage [review], in Proc 7th Int Cong Radiat Res (Broerse JJ ed) pp 303-312, Martinus Nijhoff, New York.
25. Rasey JS, Cornwell MM, Maurer B, Boyles DJS, Hofstrand P, Chin L and Cerveny C (1996) Growth and radiation response of cells grown in macroporous gelatin microcarriers. Br J Cancer 74(Suppl):S78-S81.
26. Rolfe M, Beer-Romero P, Glass S, Eckstein J, Berdo I, Theodoras A, Pagano M and Draetta G (1995) Reconstitution of p53-ubiquitinylation reactions from purified components: The role of human ubiquitin-conjugating enzyme UBC4 and E6-associated protein (E6AP). Proc Natl Acad Sci USA 92:3264-3268
27. Russell KJ, Wiens LW, Demers GW, Galloway DA, Plon SE and Groudine M (1995) Abrogation of the G2 checkpoint results in differential radiosensitization of G1 checkpoint-deficient and G1 checkpoint-competent cells. Cancer Res 55:1639-1642.
28. Sakata K, Kwok TT, Gordon GR, Waleh NS and Sutherland RM (1994) Resistance to verapamil sensitization of multidrug-resistant cells grown as multicellular spheroids. Int J Cancer 59:282-286.
29. Scheffher M, Werness BA, Huibregtse JM, Levine AJ and Howley PM (1990) The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 63:1129-1136.
30. Sorenson CM and Eastman A (1988) Mechanism of cis-diamminedichloroplatinum(II)-induced cytotoxicity: Role of G2 arrest and DNA double-strand breaks. Cancer Res 48:4484-4488.
31. Sorenson CM, Barry MA and Eastman A (1990) Analysis of events associated with cell cycle arrest at G2 phase and cell death induced by cisplatin. J Natl Cancer Inst 82:749-765.
32. St. Croix BS, Florenes VA, Rak JW, Flanagan M, Bhattacharya N, Slingerland JM and Kerbel RS (1996a) Impact of the cyclin-dependent kinase inhibitor p27Kip1 on resistance of tumor cells to anticancer agents. Nat Med 2:1204-1210.
33. St. Croix BS, Rak JW, Kapitain SJ, Sheehan C, Graham CH and Kerbel RS (1996b) Reversal by hyaluronidase of adhesion-dependent multicellular drug resistance in mammary carcinoma cells. J Natl Cancer Inst 88:1285-1296.
34. Sutherland RM (1988) Cell and environment interactions in tumor microregions: The multicell spheroid model. Science 240:177-184.
35. Sutherland RM, Bareham BJ and Reich KA (1980) Cytotoxicity of hypoxic cell sensitizers in multicell spheroids. Cancer Clin Trials 3:73-83.
36. Sutherland RM, Eddy HA, Bareham B, Reich K and Vanantwerp D (1979) Resistance to adriamycin in multicellular spheroids. Int J Radiat Biol Phys 5:1225-1230.
37. Twentyman PR (1980) Response to chemotherapy of EMT6 spheroids as measured by growth delay and cell survival. Br J Cancer 42:297-304.
38. Vescio RA, Connors KM, Kubota T and Hoffman RM (1991) Correlation of histology and drug response of human tumors grown in native-state three-dimensional histoculture and in nude mice. Proc Natl Acad Sci USA 88:5163-5166.
39. Willingham MC, Cornwell MM, Cardarelli CO, Gottesman MM and Pastan I (1986) Single cell analysis of daunomycin uptake and efflux in multidrug-resistant and -sensitive KB cells: Effects of verapamil and other drugs. Cancer Res 46:5941-5946.