Structure - Activity relationships in 2,2-diphenyl-2-ethylthioacetic acid esters: Unexpected agonistic activity in a series of muscarinic antagonists

Bioorganic and Medicinal Chemistry

Volumn 9, Issue 5, 2001, Pages 1165-1174

  Scapecchi, S ^a   Marucci, G ^b   Matucci, R ^a   Angeli, P ^b   Bellucci, C ^a   Buccioni, M ^b   Dei, S ^a   Gualtieri, F ^a   Manetti, D ^a   Romanelli, M N ^a   Teodori, E ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b UNIVERSITY OF CAMERINO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 (4 PHENYLPYPERAZINYL)ETHYL 2,2 DIPHENYL 2 ETHYLTHIOACETATE; 2 (4 PHENYLPYPERAZINYL)ETHYL 2,2 DIPHENYL 2 ETHYLTHIOACETATE METHYLIODIDE; 2,2 DIPHENYL 2 ETHYLTHIOACETIC ACID; 3 (4 PHENYLPYPERAZINYL)PROPYL 2,2 DIPHENYL 2 ETHYLTHIOACETATE; 4 (4 PHENYLPYPERAZINYL)BUTYL 2,2 DIPHENYL 2 ETHYLTHIOACETATE; 5,5 DIPHENYL 5 ETHYLTHIO 2 PENTYNAMINE DERIVATIVE; ACETIC ACID DERIVATIVE; ATROPINE; MUSCARINIC AGENT; MUSCARINIC RECEPTOR BLOCKING AGENT; N,N DIETHYL N METHYL(5 ETHYLTHIO 5,5 DIPHENYLPENT 2 YNYL)AMONIUM IODIDE; N,N DIETHYL(5 ETHYLTHIO 5,5 DIPHENYLPENT 2 YNYL)AMINE; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTICHOLINERGIC EFFECT; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SYNTHESIS; MALE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ALKYNES; ANIMALS; ATROPINE; CEREBRAL CORTEX; GUINEA PIGS; ILEUM; LUNG; MALE; MUSCARINIC AGONISTS; MUSCARINIC ANTAGONISTS; MYOCARDIUM; RABBITS; RATS; RECEPTOR, MUSCARINIC M1; RECEPTOR, MUSCARINIC M2; RECEPTOR, MUSCARINIC M3; RECEPTORS, MUSCARINIC; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE; VAS DEFERENS;

EID: 0034996496     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(00)00332-1     Document Type: Article

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