Gender differences in hepatic ischemic reperfusion injury in rats are associated with endothelial cell nitric oxide synthase-derived nitric oxide

World Journal of Gastroenterology

Volumn 11, Issue 22, 2005, Pages 3441-3445

  Lü, Ping ^a   Liu, Fang ^a   Wang, Chun You ^a   Chen, Dao Da ^a   Yao, Zhong ^b   Tian, Yuan ^a   Zhang, Jing Hui ^a   Wu, Yi Hua ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

Author keywords

Endothelial constitutive nitric oxide synthase; Gender identity; Liver; Reperfusion injury

Indexed keywords

ALANINE AMINOTRANSFERASE; ESTRADIOL; ESTROGEN; MALONALDEHYDE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; TUMOR NECROSIS FACTOR ALPHA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DISEASE SEVERITY; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME BLOOD LEVEL; FEMALE; LAPAROTOMY; LIVER ISCHEMIA; LIVER PROTECTION; MALE; NONHUMAN; QUANTITATIVE ANALYSIS; RANDOMIZATION; RAT; RAT STRAIN; REPERFUSION INJURY; SEX DIFFERENCE; SURVIVAL RATE;

EID: 21044450671     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v11.i22.3441     Document Type: Article

References (31)

1. Arranz J, Soriano A, Garcia I, Garcia I, Concepcion MT, Navarro J, Arteaga A, Filella X, Gonzalez F, Fernandez C, Barrera M, Munoz L, Perera AJ, Pozo JL, Jimenez A, Macia M, Arteaga I. Association between anatomopathologic graft disorders during reperfusion and vena cava sIL-2r in orthotopic liver transplantation. Transplant Proc 2003; 35: 1880-1883
2. Shearman AM, Cupples LA, Demissie S, Peter I, Schmid CH, Karas RH, Mendelsohn ME, Housman DE, Levy D. Association between estrogen receptor alpha gene variation and cardiovascular disease. JAMA 2003; 290: 2263-2270
3. Dubey RK, Oparil S, Imthurn B, Jackson EK. Sex hormones and hypertension. Cardiovasc Res 2002; 53: 688-708
4. Hayward CS, Kalnins WV, Kelly RP. Gender-related differences in left ventricular chamber function. Cardiovasc Res 2001; 49: 340-350
5. Jain A, Reyes J, Kashyap R, Dodson SF, Demetris AJ, Ruppert K, Abu-Elmagd K, Marsh W, Madariaga J, Mazariegos G, Geller D, Bonham CA, Gayowski T, Cacciarelli T, Fontes P, Starzl TE, Fung JJ. Long-term survival after liver transplantation in 4,000 consecutive patients at a single center. Ann Surg 2000; 232: 490-500
6. Lee CC, Chau GY, Lui WY, Tsay SH, King KL, Loong CC, Hshia CY, Wu CW. Better post-resectional survival in female cirrhotic patients with hepatocellular carcinoma. Hepatogastroenterology 2000; 47: 446-449
7. Sakamoto N, Sun Z, Brengman ML, Maemura K, Ozaki M, Bulkley GB, Klein AS. Hepatic reticuloendothelial system dysfunction after ischemia-reperfusion: role of P-selectin-mediated neutrophil accumulation. Liver Transpl 2003; 9: 940-948
8. Khandoga A, Biberthaler P, Enders G, Teupser D, Axmann S, Luchting B, Hutter J, Messmer K, Krombach F. P-selectin mediates platelet-endothelial cell interactions and reperfusion injury in the mouse liver in vivo. Shock 2002; 18: 529-535
9. Mendelsohn ME. Genomic and nongenomic effects of estrogen in the vasculature. Am J Cardiol 2002; 90: 3-6
10. Spyridopoulos I, Sullivan AB, Kearney M, Isner JM, Losordo DW. Estrogen-receptor-mediated inhibition of human endothelial cell apoptosis. Estradiol as a survival factor. Circulation 1997; 95: 1505-1514
11. Li L, Haynes MP, Bender JR. Plasma membrane localization and function of the estrogen receptor alpha variant (ER46) in human endothelial cells. Proc Natl Acad Sci USA 2003; 100: 4807-4812
12. Hodges YK, Tung L, Yan XD, Graham JD, Horwitz KB, Horwitz LD. Estrogen receptors alpha and beta: prevalence of estrogen receptor beta mRNA in human vascular smooth muscle and transcriptional effects. Circulation 2000; 101: 1792-1798
13. Simoncini T, Genazzani AR, Liao JK. Nongenomic mechanisms of endothelial nitric oxide synthase activation by the selective estrogen receptor modulator raloxifene. Circulation 2002; 105: 1368-1373
14. Hisamoto K, Ohmichi M, Kurachi H, Hayakawa J, Kanda Y, Nishio Y, Adachi K, Tasaka K, Miyoshi E, Fujiwara N, Taniguchi N, Murata Y. Estrogen induces the Akt-dependent activation of endothelial nitric-oxide synthase in vascular endothelial cells. J Biol Chem 2001; 276: 3459-3467
15. Mendelsohn ME. Nongenomic, ER-mediated activation of endothelial nitric oxide synthase: how does it work? What does it mean? Circ Res 2000; 87: 956-960
16. Sakamoto M, Uen T, Nakamura T, Hashimoto O, Sakata R, Kin M, Ogata R, Kawaguch T, Torimura T, Sata M. Estrogen upregulates nitric oxide synthase expression in cultured rat hepatic sinusoidal endothelial cells. J Hepatol 2001; 34: 858-864
17. Nuedling S, Kahlert S, Loebbert K, Doevendans PA, Meyer R, Vetter H, Grohe C. 17 Beta-estradiol stimulates expression of endothelial and inducible NO synthase in rat myocardium. in-vitro and in-vivo. Cardiovasc Res 1999; 43: 666-674
18. Lü P, Chen DD, Tian Y, Zhang JH, Wu YH. The effect of nitric oxide/endothelins system on the hepatic ischemia/reperfusion injury. J Huazhong Univ Sci Technol Med Sci 2002; 22: 216-217
19. Lü P, Chen DD, Tian Y, Zhang JH, Wu YH. The protection of the hepatic ischemic preconditioning is concerned with the NO/ET-1 system. Zhongguo Bingli Shengli Zazhi 2000; 16: 901-905
20. Camargo CA Jr, Madden JF, Gao W, Selvan RS, Clavien PA. Interleukin-6 protects liver against warm ischemia/reperfusion injury and promotes hepatocyte proliferation in the rodent. Hepatology 1997; 26: 1513-1520
21. Kleinert H, Wallerath T, Euchenhofer C, Ihrig-Biedert I, Li H, Forstermann U. Estrogens increase transcription of the human endothelial NO synthase gene: analysis of the transcription factors involved. Hypertension 1998; 31: 582-588
22. Haynes MP, Li L, Sinha D, Russell KS, Hisamoto K, Baron R, Collinge M, Sessa WC, Bender JR. Src kinase mediates phosphatidylinositol 3-kinase/Akt-dependent rapid endothelial nitric-oxide synthase activation by estrogen. J Biol Chem 2003; 278: 2118-2123
23. Wink DA, Miranda KM, Espey MG, Pluta RM, Hewett SJ, Colton C, Vitek M, Feelisch M, Grisham MB. Mechanisms of the antioxidant effects of nitric oxide. Antioxid Redox Signal 2001; 3: 203-213
24. Grisham MB, Jourd'Heuil D, Wink DA. Nitric oxide. I. Physiological chemistry of nitric oxide and its metabolites:implications in inflammation. Am J Physiol 1999; 276(2 Pt 1): G315-321
25. Haynes MP, Sinha D, Russell KS, Collinge M, Fulton D, Morales-Ruiz M, Sessa WC, Bender JR. Membrane estrogen receptor engagement activates endothelial nitric oxide synthase via the PI3-kinase-Akt pathway in human endothelial cells. Circ Res 2000; 87: 677-682
26. Huang PL. Endothelial nitric oxide synthase and endothelial dysfunction. Curr Hypertens Rep 2003; 5: 473-480
27. Iwasaki Y, Tagaya N, Hattori Y, Yamaguchi K, Kubota K. Protective effect of ischemic preconditioning against intermittent warm-ischemia-induced liver injury. J Surg Res 2002; 107: 82-92
28. Wen Y, Yang S, Liu R, Perez E, Yi KD, Koulen P, Simpkins JW. Estrogen attenuates nuclear factor-kappa B activation induced by transient cerebral ischemia. Brain Res 2004; 1008: 147-154
29. Rai RM, Lee FY, Rosen A, Yang SQ, Lin HZ, Koteish A, Liew FY, Zaragoza C, Lowenstein C, Diehl AM. Impaired liver regeneration in inducible nitric oxide synthasedeficient mice. Proc Natl Acad Sci USA 1998; 95: 13829-13834
30. Knoferl MW, Diodato MD, Angele MK, Ayala A, Cioffi WG, Bland KI, Chaudry IH. Do female sex steroids adversely or beneficially affect the depressed immune responses in males after trauma-hemorrhage? Arch Surg 2000; 135: 425-433
31. Nascimento CA, Kauser K, Rubanyi GM. Effect of 17beta-estradiol in hypercholesterolemic rabbits with severe endothelial dysfunction. Am J Physiol 1999; 276(5 Pt 2): H1788-H1794