The effects of NN414, a SUR1/Kir6.2 selective potassium channel opener, in healthy male subjects

Journal of Clinical Pharmacology

Volumn 45, Issue 7, 2005, Pages 763-772

  Zdravkovic, Milan ^a   Kruse, Matthias ^b   Rost, Karl Ludwig ^b   Møss, Judi ^a   Kecskes, Andrei ^b   Dyrberg, Thomas ^a  

^a NOVO NORDISK A S   (Denmark)

^b PAREXEL INTERNATIONAL   (United States)

Author keywords

Clinical trial; Diabetes; Pharmacodynamics; Pharmacokinetics; Potassium channel opener

Indexed keywords

DIAZOXIDE; GLUCAGON; GLUCOSE; GROWTH HORMONE; INSULIN; NN 414; PLACEBO; POTASSIUM CHANNEL AFFECTING AGENT; UNCLASSIFIED DRUG;

ABDOMINAL PAIN; ADULT; AREA UNDER THE CURVE; ARTICLE; ASTHENIA; BACKACHE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIARRHEA; DOUBLE BLIND PROCEDURE; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG HALF LIFE; DRUG SAFETY; DRUG TOLERABILITY; DYSPEPSIA; EDEMA; ERYTHEMA; FLATULENCE; FLU LIKE SYNDROME; GLUCAGON BLOOD LEVEL; GLUCOSE BLOOD LEVEL; GROWTH HORMONE BLOOD LEVEL; HEADACHE; HEART PALPITATION; HUMAN; INSULIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; MICTURITION DISORDER; NAUSEA; NORMAL HUMAN; ORAL GLUCOSE TOLERANCE TEST; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SINGLE DRUG DOSE; SOMNOLENCE; SWEATING; TREMOR; URINARY EXCRETION;

ADULT; ATP-BINDING CASSETTE TRANSPORTERS; BICYCLO COMPOUNDS, HETEROCYCLIC; BLOOD GLUCOSE; CYCLIC S-OXIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN; ISLETS OF LANGERHANS; MALE; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; RECEPTORS, DRUG;

EID: 21044441532     PISSN: 00912700     EISSN: None     Source Type: Journal    
DOI: 10.1177/0091270005276947     Document Type: Article

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