A novel mycolactone from a clinical isolate of Mycobacterium ulcerans provides evidence for additional toxin heterogeneity as a result of specific changes in the modular polyketide synthase

ChemBioChem

Volumn 6, Issue 4, 2005, Pages 643-648

  Hong, Hui ^a   Spencer, Jonathan B ^a   Porter, Jessica L ^b   Leadlay, Peter F ^a   Stinear, Tim ^b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b MONASH UNIVERSITY   (Australia)

Author keywords

Biosynthesis; Buruli ulcer; Mycobacterium; Mycolactone; Polyketides

Indexed keywords

BACTERIAL DNA; BACTERIAL TOXIN; MACROCYCLIC COMPOUND; MYCOLACTONE A; MYCOLACTONE B; POLYKETIDE; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; BURULI ULCER; CATALYSIS; CHEMICAL STRUCTURE; DNA SEQUENCE; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITE; MYCOBACTERIUM ULCERANS; NONHUMAN; PRIORITY JOURNAL; STRAIN DIFFERENCE; TOXIN ANALYSIS;

ACYLTRANSFERASES; AMINO ACID SEQUENCE; BACTERIAL TOXINS; LACTONES; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MYCOBACTERIUM ULCERANS; POLYKETIDE SYNTHASES; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

MYCOBACTERIUM; MYCOBACTERIUM ULCERANS;

EID: 21044436769     PISSN: 14394227     EISSN: None     Source Type: Journal    
DOI: 10.1002/cbic.200400339     Document Type: Article

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