Endothelin B receptor-deficient mice develop endothelial dysfunction independently of salt loading

Journal of Hypertension

Volumn 23, Issue 5, 2005, Pages 979-985

  Quaschning, Thomas ^a   Rebhan, Benjamin ^a   Wunderlich, Christoph ^a   Wanner, Christoph ^a   Richter, Claus Michael ^b   Pfab, Thiemo ^b   Bauer, Christian ^b   Kraemer Guth, Annette ^c   Galle, Jan ^a   Yanagisawa, Masashi ^d   Hocher, Berthold ^e,f  

^a UNIVERSITY HOSPITAL WÜRZBURG   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c UNIVERSITY OF FREIBURG   (Germany)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^e UNIVERSITY OF BERN   (Switzerland)

^f DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

Author keywords

Endothelin; Endothelium; Hypertension; Nitric oxide; Relaxation

Indexed keywords

CYCLO(DEXTRO TRYPTOPHYL DEXTRO ASPARTYLPROLYL DEXTRO VALYLLEUCYL); ENDOTHELIN 1; ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTHELIN B RECEPTOR; ENDOTHELIN B RECEPTOR ANTAGONIST; N (2,6 DIMETHYLPIPERIDINOCARBONYL) 4 METHYLLEUCYL DEXTRO (1 METHOXYCARBONYLTRYPTOPHANYL) DEXTRO NORLEUCINE; NITRIC OXIDE; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL FUNCTION; CONTROLLED STUDY; ENDOTHELIUM LESION; HEART RATE; HYPERTENSION; MALE; MOUSE; MUSCLE ISOMETRIC CONTRACTION; NONHUMAN; PRIORITY JOURNAL; SALT INTAKE; SALT LOADING; SYSTOLIC BLOOD PRESSURE; VASCULAR ENDOTHELIUM; VASCULAR RING;

EID: 21044434627     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.hjh.0000166838.55688.7e     Document Type: Article

References (41)

1. Lüscher TF, Boulanger CM, Dohi Y, Yang ZH. Endothelium-derived contracting factors. Hypertension 1992; 19:117-130.
2. 2+ channels. J Hypertens 1988; 6(suppl):S188-S191.
3. Hirata Y, Takagi Y, Fukuda Y, Marumo F. Endothelin is a potent mitogen for rat vascular smooth muscle cells. Atherosclerosis 1989; 78:225-228.
4. Takase H, Moreau P, Lüscher TF. Endothelin receptor subtypes in small arteries. Studies with FR139317 and bosentan. Hypertension 1995; 25:739-743.
5. Arai H, Hori S, Aramori I, Ohkubo H, Nakanishi S. Cloning and expression of a cDNA encoding an endothelin receptor. Nature 1990; 348:730-732.
6. Hirata Y, Emori T, Eguchi S, Kanno K, Imai T, Ohta K, Marumo F. Endothelin receptor subtype B mediates synthesis of nitric oxide by cultured bovine endothelial cells. J Clin Invest 1993; 91:1367-1373.
7. Warner TD. Characterization of endothelin synthetic pathways and receptor subtypes: physiological and pathophysiological implications. Eur Heart J 1993; 14(suppl I):42-47.
8. Fukuroda T, Fujikawa T, Ozaki S, Ishikawa K, Yano M, Nishikibe M. Clearance of circulating endothelin-1 by ETB receptors in rats. Biochem Biophys Res Commun 1994; 199:1461-1465.
9. Morris MJ, Cox HS, Lambert GW, Kaye DM, Jennings GL, Meredith IT, Esler MD. Region-specific neuropeptide Y overflows at rest and during sympathetic activation in humans. Hypertension 1997; 29:137-143.
10. Boulanger C, Lüscher TF. Release of endothelin from the porcine aorta. Inhibition by endothelium-derived nitric oxide. J Clin Invest 1990; 85:587-590.
11. Stewart DJ, Cernacek P, Mohamed F, Biais D, Cianflone K, Monge JC. Role of cyclic nucleotides in the regulation of endothelin-1 production by human endothelial cells. Am J Physiol 1994; 266:H944-H951.
12. Lüscher TF, Richard V, Tschudi M, Yang ZH, Boulanger C. Endothelial control of vascular tone in large and small coronary arteries. J Am Coll Cardiol 1990; 15:519-527.
13. Schiffrin EL, Lariviere R, Li JS, Sventek P, Touyz RM. Deoxycorticosterone acetate plus salt induces overexpression of vascular endothelin-1 and severe vascular hypertrophy in spontaneously hypertensive rats. Hypertension 1995; 25:769-773.
14. Doucet J, Gonzalez W, Michel JB. Endothelin antagonists in salt-dependent hypertension associated with renal insufficiency. J Cardiovasc Pharmacol 1996; 27:643-651.
15. Ikeda T, Ohta H, Okada M, Kawai N, Nakao R, Siegl PK, et al. Pathophysiological roles of endothelin-1 in Dahl salt-sensitive hypertension. Hypertension 1999; 34:514-519.
16. Hocher B, George I, Rebstock J, Bauch A, Schwarz A, Neumayer HH, Bauer C. Endothelin system-dependent cardiac remodeling in renovascular hypertension. Hypertension 1999; 33:816-822.
17. Sharifi AM, He G, Touyz RM, Schiffrin EL. Vascular endothelin-1 expression and effect of an endothelin ETA antagonist on structure and function of small arteries from stroke-prone spontaneously hypertensive rats. J Cardiovasc Pharmacol 1998; 31(suppl 1):S309-S312.
18. D'Orleans-Juste P, Labonte J, Bkaily G, Choufani S, Plante M, Honore JC. Function of the endothelin(B) receptor in cardiovascular physiology and pathophysiology. Pharmacol Ther 2002; 95:221-238.
19. Berthiaume N, Yanagisawa M, D'Orleans-Juste P. Contribution of endogenous endothelin-1 and endothelin-A-receptors to the hypertensive state of endothelin-B heterozygous (+/-) knockout mice. J Cardiovasc Pharmacol 2000; 36(suppl 1):S72-S74.
20. Clouthier DE, Hosoda K, Richardson JA, Williams SC, Yanagisawa H, Kuwaki T, et al. Cranial and cardiac neural crest defects in endothelin-A receptor-deficient mice. Development 1998; 125:813-824.
21. Hosoda K, Hammer RE, Richardson JA, Baynash AG, Cheung JC, Giaid A, Yanagisawa M. Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice. Cell 1994; 79:1267-1276.
22. Gariepy CE, Ohuchi T, Williams SC, Richardson JA, Yanagisawa M. Salt-sensitive hypertension in endothelin-B receptor-deficient rats. J Clin Invest 2000; 105:925-933.
23. Gariepy CE, Williams SC, Richardson JA, Hammer RE, Yanagisawa M. Transgenic expression of the endothelin-B receptor prevents congenital intestinal aganglionosis in a rat model of Hirschsprung disease. J Clin Invest 1998; 102:1092-1101.
24. Webb DJ, Monge JC, Rabelink TJ, Yanagisawa M. Endothelin: new discoveries and rapid progress in the clinic. Trends Pharmacol Sci 1998; 19:5-8.
25. Ohuchi T, Yanagisawa M, Gariepy CE. Renal tubular effects of endothelin-B receptor signaling: its role in cardiovascular homeostasis and extracellular volume regulation. Curr Opin Nephrol Hypertens 2000; 9:435-439.
26. Ohuchi T, Laphmani H, Yamada T. Salt-sensitive hypertension in endothelin-B receptor-deficient mice due to impaired renal salt excretion. Sixth International Conference on Endothelin 1999; I:O10.
27. Nataf V, Grapin-Botton A, Champeval D, Amemiya A, Yanagisawa M, Le Douarin NM. The expression patterns of endothelin-A receptor and endothelin 1 in the avian embryo. Mech Dev 1998; 75:145-149.
28. Quaschning T, Kocak S, Bauer C, Neumayer HH, Galle J, Hocher B. Increase in nitric oxide bioavailability improves endothelial function in endothelin-1 transgenic mice. Nephrol Dial Transplant 2003; 18:479-483.
29. Quaschning T, d'Uscio LV, Shaw S, Lüscher TF. Vasopeptidase inhibition exhibits endothelial protection in salt-induced hypertension. Hypertension 2001; 37:1108-1113.
30. Lüscher TF, Barton M. Biology of the endothelium. Clin Cardiol 1997; 20(11 suppl 2):II3-II10.
31. Barton M, d'Uscio LV, Shaw S, Meyer P, Moreau P, Lüscher TF. ET(A) receptor blockade prevents increased tissue endothelin-1, vascular hypertrophy, and endothelial dysfunction in salt-sensitive hypertension. Hypertension 1998; 31:499-504.
32. Kupper TS. Adhesion molecules in scleroderma: collagen binding integrins. Int Rev Immunol 1995; 12:217-225.
33. Giardina JB, Green GM, Rinewalt AN, Granger JP, Khalil RA. Role of endothelin B receptors in enhancing endothelium-dependent nitric oxide-mediated vascular relaxation during high salt diet. Hypertension 2001; 37:516-523.
34. Antunes-Rodrigues J, Ramalho MJ, Reis LC, Picanco-Diniz DW, Favaretto AL, Gutkowska J, McCann SM. Possible role of endothelin acting within the hypothalamus to induce the release of atrial natriuretic peptide and natriuresis. Neuroendocrinology 1993; 58:701-708.
35. Ahn D, Ge Y, Stricklett PK, Gill P, Taylor D, Hughes AK, et al. Collecting duct-specific knockout of endothelin-1 causes hypertension and sodium retention. J Clin Invest 2004; 114:504-511.
36. Kohan DE. Endothelins in the normal and diseased kidney. Am J Kidney Dis 1997; 29:2-26.
37. Kohan DE, Padilla E. Osmolar regulation of endothelin-1 production by rat inner medullary collecting duct, J Clin Invest 1993; 91:1235-1240.
38. Gratton JP, Cournoyer G, Loffler BM, Sirois P, D'Orleans-Jusle P. ET(B) receptor and nitric oxide synthase blockade induce BCM 23-sensitive pressor effects in the rabbit. Hypertension 1997; 30:1204-1209.
39. Ishikawa K, Ihara M, Noguchi K, Mase T, Mino N, Saeki T, et al. Biochemical and pharmacological profile of a potent and selective endothelin B-receptor antagonist, BQ-788. Proc Natl Acad Sci USA 1994; 91:4892-4896.
40. Verhaar MC, Strachan FE, Newby DE, Cruden NL, Koomans HA, Rabelink TJ, Webb DJ. Endothelin-A receptor antagonist-mediated vasodilatation is attenuated by inhibition of nitric oxide synthesis and by endothelin-B receptor blockade. Circulation 1998; 97:752-756.
41. Berthiaume N, Yanagisawa M, Labonte J, D'Orleans-Juste P. Heterozygous knock-out of ET(B) receptors induces BQ-123-sensitive hypertension in the mouse. Hypertension 2000; 36:1002-1007.