Structure-activity relationship studies optimizing the antiproliferative activity of novel cyclic somatostatin analogues containing a restrained cyclic β-amino acid

Journal of Medicinal Chemistry

Volumn 48, Issue 8, 2005, Pages 2916-2926

  Sukopp, Martin ^a   Schwab, Richard ^b   Marinelli, Luciana ^c   Biron, Eric ^a   Heller, Markus ^a   Várkondi, Edit ^b   Pap, Ákos ^b   Novellino, Ettore ^c   Kéri, György ^b   Kessler, Horst ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b SEMMELWEIS UNIVERSITY   (Hungary)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 3,5 DIMETHYL 2 CYCLOHEX 3 ENECARBOXYLIC ACID; BETA AMINO ACID; CARBOXYLIC ACID DERIVATIVE; CYCLIC BETA AMINO ACID; CYCLO(CYCLIC BETA AMINO ACID TYROSYL DEXTRO TRYPTOPHYLNORLEUCYLTHREONYLTRIPHENYLMETHYL) AMIDE; CYCLO(PROLYLPHENYLALANYL DEXTRO TRYPTOPHYLLYSYLTHREONYLPHENYLALANYL); CYCLOHEXIMIDE; GLUCAGON; GROWTH HORMONE; HEXAPEPTIDE; INSULIN; PHENYLALANINE; PROLINE; SOMATOSTATIN DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CONFORMATION; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE; SQUAMOUS CELL CARCINOMA; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

AMINO ACIDS, CYCLIC; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; PEPTIDE FRAGMENTS; PEPTIDES, CYCLIC; SOMATOSTATIN; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 20944435317     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm049500j     Document Type: Article

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