2,5-Diketopiperazines as potent and selective oxytocin antagonists 1: Identification, stereochemistry and initial SAR

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 10, 2005, Pages 2579-2582

  Wyatt, Paul G ^a,c   Allen, Michael J ^a   Borthwick, Alan D ^a   Davies, Dave E ^a   Exall, Anne M ^a   Hatley, Richard J D ^a   Irving, Wendy R ^a   Livermore, David G ^a   Miller, Neil D ^a   Nerozzi, Fabrizio ^a   Sollis, Steve L ^a   Szardenings, Anna Katrin ^b,d  

^a GLAXOSMITHKLINE   (United Kingdom)

^b AFFYMAX RESEARCH INSTITUTE   (United States)

^c ASTEX PHARMACEUTICALS   (United Kingdom)

^d ACTIVX BIOSCIENCES INC   (United States)

Author keywords

2,5 Diketopiperidines; Antagonists; Oxytocin; Oxytocin receptor; Pooled libraries; Preterm birth; Screening; Solid phase; Structure activity relationships; Ugi reaction; Unencoded libraries

Indexed keywords

OXYTOCIN ANTAGONIST; PIPERAZINEDIONE;

ARTICLE; DRUG ACTIVITY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; LIBRARY; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

EID: 20944434680     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.03.045     Document Type: Article

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10. The X-ray crystal structure will be published elsewhere