Effects of phentermine and phenformin on biomarkers of aging in rats

Gerontology

Volumn 51, Issue 1, 2005, Pages 19-28

  Anisimov, Vladimir N ^a   Ukraintseva, Svetlana V ^c   Anikin, Ivan V ^a   Popovich, Irina G ^a   Zabezhinski, Mark A ^a   Bertsein, Lev M ^a   Arutjunyan, Alexander V ^b   Ingram, Donald K ^d   Lane, Mark A ^d   Roth, George S ^d  

^a N N PETROV RESEARCH INSTITUTE OF ONCOLOGY   (Russian Federation)

^b D O OTT RESEARCH INSTITUTE OF OBSTETRICS   (Russian Federation)

^c DUKE UNIVERSITY   (United States)

^d NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Appetite; Body temperature; Caloric restriction; Caloric restriction mimetics; Reactive oxygen species

Indexed keywords

ANOREXIGENIC AGENT; ANTIDIABETIC AGENT; ANTIOXIDANT; BIOLOGICAL MARKER; CHOLESTEROL; GLUCOSE; GLUTATHIONE PEROXIDASE; GLUTATHIONE TRANSFERASE; INSULIN; LIOTHYRONINE; LOW DENSITY LIPOPROTEIN; PHENFORMIN; PHENTERMINE; PLACEBO; REACTIVE OXYGEN METABOLITE; SCHIFF BASE; SUPEROXIDE DISMUTASE; THYROXINE; TRIACYLGLYCEROL;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; BODY TEMPERATURE; BODY WEIGHT; BRAIN HOMOGENATE; BRAIN LEVEL; CALORIC INTAKE; CALORIC RESTRICTION; CHOLESTEROL BLOOD LEVEL; COMPARATIVE STUDY; CONTROLLED STUDY; ENZYME BLOOD LEVEL; FEMALE; FLUID INTAKE; FOOD INTAKE; FREE THYROXINE INDEX; GLUCOSE BLOOD LEVEL; INSULIN BLOOD LEVEL; LIPOPROTEIN BLOOD LEVEL; LIVER HOMOGENATE; LIVER LEVEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RANDOMIZATION; RAT; RECTUM TEMPERATURE; TEMPERATURE MEASUREMENT; THYROXINE BLOOD LEVEL; TRIACYLGLYCEROL BLOOD LEVEL;

AGING; ANIMALS; APPETITE DEPRESSANTS; BODY TEMPERATURE; BODY WEIGHT; BRAIN; CALORIC RESTRICTION; DRINKING; ENERGY INTAKE; FEMALE; HYPOGLYCEMIC AGENTS; LIVER; MODELS, ANIMAL; PHENFORMIN; PHENTERMINE; RANDOM ALLOCATION; RATS; RATS, WISTAR;

EID: 20844455743     PISSN: 0304324X     EISSN: None     Source Type: Journal    
DOI: 10.1159/000081430     Document Type: Article

References (57)

1. Weindruch R, Walford R: The Retardation of Aging and Disease by Dietary Restriction. Springfield, Thomas, 1988.
2. Yu BP: Modulation of Aging Processes by Dietary Restriction. Boca Raton, CRC Press, 1994.
3. Roth GS, Ingram DK, Lane MA: Calorie restriction in primates: Will it work and how will we know? J Am Geriatr Soc 1999;47:896-903.
4. Roth GS, Ingram DK, Black A, Lane MA: Effects of reduced energy intake on the biology of aging: The primate model. Eur J Clin Nutr 2000;54(Suppl 3):S15-S20.
5. Lane MA, Ball SS, Ingram DK, Cutler RG, Engel J, Read V, Roth GS: Diet restriction in rhesus monkeys lowers fasting and glucose-stimulated glucoregulatory end points. Am J Physiol 1995;268(5 Pt 1):E941-E948.
6. Lane MA, Ingram DK, Ball SS, Roth GS: Dehydroepiandrosterone sulfate: A biomarker of primate aging slowed by calorie restriction. J Clin Endocrinol Metab 1997;82:2093-2096.
7. Ramsey JJ, Harper ME, Weindruch R: Restriction of energy intake, energy expenditure, and aging. Free Radic Biol Med 2000;29:946-968.
8. Lane MA, Ingram DK, Roth GS: 2-Deoxy-D-glucose feeding in rats mimics physiological effects of calorie restriction. J Antiaging Med 1998;1:327-337.
9. Hadley EC, Dutta C, Finkelstein J, Harris TB, Lane MA, Roth GS, Sherman SS, Starke-Reed PE: Human implications of caloric restriction's effect on aging in laboratory animals: An overview of opportunities for research. J Gerontol A Biol Sci Med Sci 2001;56(Spec No 1):5-6.
10. Mattson MP, Duan W, Lee J, Guo Z, Roth GS, Ingram DK, Lane MA: Progress in the development of caloric restriction mimetic dietary supplements. J Antiaging Med 2001;4:225-232.
11. Facchini FS, Hua NW, Reaven GM, Stoohs RA: Hyperinsulinemia: The missing link among oxidative stress and age-related diseases? Free Radic Biol Med 2000;29:1302-1306.
12. Dilman VM: Development, Aging and Disease: A New Rationale for an Intervention Strategy. Chur, Harwood, 1994.
13. Ulrich P, Cerami A: Protein glycation, diabetes, and aging. Recent Prog Horm Res 2001;56:1-21.
14. Verzijl N, DeGroot J, Bank RA, Bayliss MT, Bijlsma JW, Lafeber FE, Maroudas A, TeKoppele JM: Age-related accumulation of the advanced glycation endproduct pentosidine in human articular cartilage aggrecan: The use of pentosidine levels as a quantitative measure of protein turnover. Matrix Biol 2001;20:409-417.
15. Sell DR, Lane MA, Johnson WA, Masoro EJ, Mock OB, Reiser KM, Fogarty JF, Cutler RG, Ingram DK, Roth GS, Monnier VM: Longevity and the genetic determination of collagen glycoxidation kinetics in mammalian senescence. Proc Natl Acad Sci U S A 1996;93:485-490.
16. Clancy DJ, Gems D, Harshman LG, Oldham S, Stocker H, Hafen E, Leevers SJ, Partridge L: Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science 2001;292:104-106.
17. Tatar M, Kopelman A, Epstein D, Tu MP, Yin CM, Garofalo RS: A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroenodcrine function. Science 2001;292:107-110.
18. Lane MA, Tilmont EM, De Angelis H, Handy A, Ingram DK, Kemnitz JW, Roth GS: Short-term calorie restriction improves disease-related markers in older male rhesus monkeys (Macaca mulatta). Mech Ageing Dev 2000;112:185-196.
19. Duan W, Mattson MP: Dietary restriction and 2-deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parkinson's disease. J Neurosci Res 1999;57:195-206.
20. Lee J, Bruce-Keller AJ, Kruman Y, Chan SL, Mattson MP: 2-Deoxy-D-glucose protects hippocampal neurons against excitotoxic and oxidative injury: Evidence for the involvement of stress proteins. J Neurosci Res 1999;57:48-61.
21. Dilman VM: Age-associated elevation of hypothalamic threshold to feedback control and its role in development, ageing, and disease. Lancet 1971;1:1211-1219.
22. Dilman VM, Anisimov VN: Effect of treatment with phenformin, dyphenylhydantoin or L-dopa on life span and tumour incidence in C3H/Sn mice. Gerontology 1980;26:241-246.
23. Anisimov VN: Effect of buformin and diphenylhydantoin on the life span, estrous function and spontaneous tumor incidence in rats (in Russian). Vopr Onkol 1980;26:42-48.
24. Anisimov VN: Effect of phenformin on life span, estrus function and incidence of spontaneous tumors in rats. Farmakol Toksikol 1982;45:127.
25. Anisimov VN: Carcinogenesis and Aging. Boca Raton, CRC Press, 1987.
26. American Society of Health-System Pharmacists: American Hospital Formulary Service Drug Information. Bethesda, ASHSP, 1998.
27. Cho AK, Segal DS (eds): Amphetamines and Its Analogs: Psychopharmacology, Toxicology and Abuse. New York, Academic Press, 1994.
28. Katzung BG (ed): Basic and Clinical Pharmacology, ed 8. Norwalk, Appleton & Lange, 2001.
29. Alger SA, Malone M, Cerulli J, Fein S, Howard L: Beneficial effects of pharmacotherapy on weight loss, depressive symptoms, and eating patterns in obese binge eaters and non-binge eaters. Obes Res 1999;7:469-476.
30. Cordero-MacIntyre ZR, Lohman TG, Rosen J, Peters W, Espana RC, Dickinson B, Reid PM, Howell WH, Fernandez ML: Weight loss is correlated with an improved lipoprotein profile in obese postmenopausal women. J Am Coll Nutr 2000;19:275-284.
31. Roth JD, Rowland NE: Efficacy of administration of dexfenfluramine and phentermine, alone and in combination, on ingestive behavior and body weight in rats. Psychopharmacology (Berl) 1998;137:99-106.
32. Anisimov VN, Pliss GB, Iogannsen MG, Popovich IG, Averianova TK, Romanov AN, Romanov KP: Spontaneous tumors in outbred LIO rats. J Exp Clin Cancer Res 1989;8:254-262.
33. Ledvina M: Estimation of β-lipoproteids in the blood serum with turbidimetric method. Lab Delo 1960;3:13-17.
34. Arutjunyan AV, Dubinina EE, Zybina NN: Methods of an Evaluation of Free Radical Oxidation and Antioxidant System of Organisms: Methodic Recommendations. St. Petersburg 2000.
35. Anisimov VN, Arutjunyan AV, Khavinson VK: Effects of pineal peptide preparation Epithalamin on free-radical processes in humans and animals. Neuroendocrinol Lett 2001;22:9-18.
36. Prokopenko VM, Arutiunian AV, Kuz'minykh TU, Govorova EE, Frolova EV: Free radical oxidation in placental tissues in preterm delivery (in Russian). Vopr Med Khim 1995;41:53-56.
37. Stalnaya IA: Determination of the level of diene conjugates and Schiff bases; in Orekhovich VN (ed): Current Methods in Biochemistry. Moscow, Meditsina Publishing, 1974, pp 63-66.
38. Burmistrov SO, Oparina TI, Prokopenko VM, Arutiunian AV: Antioxidant activity of the blood serum in pregnant and nonpregnant women: Comparison of various detection methods (in Russian). Klin Lab Diagn 1997;11:14-17.
39. Agostini A, Gerli GC, Beretta L, Bianchi M, Vignoli M, Bombelli F: Superoxide dismutase, catalase and glutathione peroxidase activities in maternal and cord blood erythrocytes. J Clin Chem Clin Biochem 1980;18:771-773.
40. Moin VM: A simple and specific method for determining glutathione peroxidase activity in erythrocytes (in Russian). Lab Delo 1986;12:724-727.
41. Goubler EV: Computing Methods of Pathology Analysis and Recognition. Leningrad, Meditsina Publishing, 1978.
42. Ames BN, Shigenaga MK, Hagen TM: Oxidants, antioxidants, and the degenerative diseases of aging. Proc Natl Acad Sci USA 1993;90:7915-7921.
43. Facchini FS, Humphreys MH, DoNascimento CA, Abbasi F, Reaven GM: Relation between insulin resistance and plasma concentrations of lipid hydroperoxides, carotenoids, and tocopherols. Am J Clin Nutr 2000;72:776-779.
44. Randle PJ, Garland PB, Newsholme EA, Hales CN: The glucose fatty acid cycle in obesity and maturity onset diabetes mellitus. Ann NY Acad Sci 1965;131:324-333.
45. Muntoni S: Inhibition of fatty acid oxidation by biguanides: Implications for metabolic physiopathology. Adv Lipid Res 1974;12:311-377.
46. Dilman VM, Berstein LM, Zabezhinski MA, Alexandrov VA, Bobrov JF, Pliss GB: Inhibition of DMBA-induced carcinogenesis by phenformin in the mammary gland of rats. Arch Geschwulstforsch 1978;48:1-8.
47. Dilman VM, Berstein LM, Ostroumova MN, Fedorov SN, Poroshina TE, Tsyrlina EV, Buslaeva VP, Semiglazov VF, Seleznev IK, Bobrov YF, Vasilyeva IA, Kondratjev VB, Nemirovsky VS, Nikiforov YF: Metabolic immunodepression and metabolic immunotherapy: An attempt of improvement in immunologic response in breast cancer patients by correction of metabolic disturbances. Oncology 1982;39:13-19.
48. Dilman VM, Berstein LM, Yevtushenko TP, Tsyrlina YV, Ostroumova MN, Bobrov YF, Revskoy SY, Kovalenko IG, Simonov NN: Preliminary evidence on metabolic rehabilitation of cancer patients. Arch Geschwulstforsch 1988;58:175-183.
49. Alexandrov VA, Anisimov VN, Belous NM, Vasilyeva IA, Mazon VB: The inhibition of the transplacental blastomogenic effect of nitrosomethylurea by postnatal administration of buformin to rats. Carcinogenesis 1980;1:975-978.
50. Anisimov VN, Pozharisskii KM, Dil'man VM: Effect of phenformin on the blastomogenic action of 1,2-dimethylhydrazine in rats (in Russian). Vopr Onkol 1980;26:54-58.
51. Anisimov VN, Belous NM, Prokudina EA: Inhibition by phenformin of the radiation carcinogenesis in female rats. Exp Onkol 1982;4:26-29.
52. Kimura KD, Tissenbaum HA, Liu Y, Ruvkun G: daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 1997;277:942-946.
53. Lin K, Dorman JB, Rodan A, Kenyon C: daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science 1997;278:1319-1322.
54. Mihaylova VT, Borland CZ, Manjarrez L, Stern MJ, Sun H: The PTEN tumor suppressor homolog in Caenorhabditis elegans regulates longevity and dauer formation in an insulin receptor-like signaling pathway. Proc Natl Acad Sci USA 1999;96:7427-7432.
55. McCarty MF: Longevity effect of chromium picolinate - 'rejuvenation' of hypothalamic function? Med Hypotheses 1994;43:253-265.
56. Cheney KE, Liu RK, Smith GS, Meredith PJ, Mickey MR, Walford RL: The effect of dietary restriction of varying duration on survival, tumor patterns, immune function, and body temperature in B10C3F1 female mice. J Gerontol 1983;38:420-430.
57. Weindruch RH, Kristie JA, Cheney KE, Walford RL: Influence of controlled dietary restriction on immunologic function and aging. Fed Proc 1979;38:2007-2016.