Evidence for a gene influencing fasting LDL cholesterol and triglyceride levels on chromosome 21q

Atherosclerosis

Volumn 179, Issue 1, 2005, Pages 119-125

  North, Kari E ^a   Miller, Michael B ^b   Coon, Hilary ^c   Martin, Lisa J ^d   Peacock, James M ^b   Arnett, Donna ^b   Zhang, Binbin ^a   Province, Michael ^e   Oberman, Albert ^f   Blangero, John ^g   Almasy, Laura ^g   Ellison, R Curtis ^h   Heiss, Gerardo ^a  

^a IL   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^d CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^e WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f University of Alabama at Birmingham   (United States)

^g SOUTHWEST FOUNDATION FOR BIOMEDICAL RESEARCH   (United States)

^h BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cholesterol; Linkage (genetics); Lipids; Triglycerides

Indexed keywords

APOLIPOPROTEIN B; LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ADULT; AGED; ALCOHOL CONSUMPTION; ALLELE; ANALYSIS OF VARIANCE; ANALYTIC METHOD; ARTICLE; CALCULATION; CHOLESTEROL BLOOD LEVEL; CHROMOSOME 21Q; CHROMOSOME MARKER; DIABETES MELLITUS; ETHNOLOGY; FEMALE; GENE CONTROL; GENE FUNCTION; GENOME; HEALTH PROGRAM; HUMAN; HYPERTENSION; INFORMATION PROCESSING; LINKAGE ANALYSIS; LIPOPROTEIN BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; PHENOTYPE; PRIORITY JOURNAL; RELATIVE; SCORING SYSTEM; SIBLING; SMOKING; TRIACYLGLYCEROL BLOOD LEVEL; VARIANCE; WAIST CIRCUMFERENCE;

EID: 20844449535     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2004.09.009     Document Type: Article

References (42)

1. W.B. Kannel, and P.W. Wilson Efficacy of lipid profiles in prediction of coronary disease Am Heart J 124 3 1992 768 774
2. P.W. Wilson, and B.F. Culleton Epidemiology of cardiovascular disease in the United States Am J Kidney Dis 32 5 Suppl. 3 1998 S56 S65
3. B.D. Mitchell Genetic and environmental contributions to cardiovascular risk factors in Mexican Americans. The San Antonio Family Heart Study Circulation 94 9 1996 2159 2170
4. J.M. Ordovas HDL genetics: candidate genes, genome wide scans and gene-environment interactions Cardiovasc Drugs Ther 16 4 2002 273 281
5. C. Ober, M. Abney, and M.S. McPeek The genetic dissection of complex traits in a founder population Am J Hum Genet 69 5 2001 1068 1079
6. H. Coon A genome-wide screen reveals evidence for a locus on chromosome 11 influencing variation in LDL cholesterol in the NHLBI Family Heart Study Hum Genet 111 3 2002 263 269
7. M.C. Mahaney A quantitative trait locus on chromosome 16q influences variation in plasma HDL-C levels in Mexican Americans Arterioscler Thromb Vasc Biol 23 2 2003 339 345
8. P. Pajukanta Combined analysis of genome scans of dutch and finnish families reveals a susceptibility locus for high-density lipoprotein cholesterol on chromosome 16q Am J Hum Genet 72 4 2003 903 917
9. A. Soro Genome scans provide evidence for low-HDL-C loci on chromosomes 8q23, 16q24.1-24.2, and 20q13.11 in Finnish families Am J Hum Genet 70 5 2002 1333 1340
10. R. Arya Linkage of high-density lipoprotein-cholesterol concentrations to a locus on chromosome 9p in Mexican Americans Nat Genet 30 1 2002 102 105
11. S.C. Elbein, and S.J. Hasstedt Quantitative trait linkage analysis of lipid-related traits in familial type 2 diabetes: evidence for linkage of triglyceride levels to chromosome 19q Diabetes 51 2 2002 528 535
12. R. Duggirala A major susceptibility locus influencing plasma triglyceride concentrations is located on chromosome 15q in Mexican Americans Am J Hum Genet 66 4 2000 1237 1245
13. H. Coon Genome-wide linkage analysis of lipids in the Hypertension Genetic Epidemiology Network (HyperGEN) Blood Pressure Study Arterioscler Thromb Vasc Biol 21 12 2001 1969 1976
14. M.C. Mahaney Plasma HDL cholesterol, triglycerides, and adiposity. A quantitative genetic test of the conjoint trait hypothesis in the San Antonio Family Heart Study Circulation 92 11 1995 3240 3248
15. L. Almasy, T.D. Dyer, and J. Blangero Bivariate quantitative trait linkage analysis: pleiotropy versus co-incident linkages Genet Epidemiol 14 6 1997 953 958
16. Multi-center genetic study of hypertension. The Family Blood Pressure Program (FBPP). Hypertension 2002;39(1):3-9.
17. R.R. Williams NHLBI family blood pressure program: methodology and recruitment in the HyperGEN network. Hypertension genetic epidemiology network Ann Epidemiol 10 6 2000 389 400
18. M.W. McGowan A peroxidase-coupled method for the colorimetric determination of serum triglycerides Clin Chem 29 3 1983 538 542
19. W.T. Friedewald, R.I. Levy, and D.S. Fredrickson Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge Clin Chem 18 6 1972 499 502
20. J. David, and N. Naito Separation of lipoprotein (Lp) fraction by the Beckman TL-100 table-top ultracentrifuge (UC) Clin Chem 32 1986 1094
21. Hinds DRN. The ASPEX package: affected sib-pair mapping, 1996.
22. G.R. Abecasis Merlin - rapid analysis of dense genetic maps using sparse gene flow trees Nat Genet 30 1 2002 97 101
23. L. Almasy, and J. Blangero Multipoint quantitative-trait linkage analysis in general pedigrees Am J Hum Genet 62 5 1998 1198 1211
24. J. Blangero, and L. Almasy Multipoint oligogenic linkage analysis of quantitative traits Genet Epidemiol 14 6 1997 959 964
25. C. Amos, M. de Andrade, and D. Zhu Comparison of multivariate tests for genetic linkage Hum Hered 51 3 2001 133 144
26. L. Almasy, T.D. Dyer, and J. Blangero Bivariate quantitative trait linkage analysis: pleiotropy versus co-incident linkages Genet Epidemiol 14 6 1997 953 958
27. S. Self, and K. Liang Asymptotic properties of maximum likelihood ratio tests under nonstandard conditions J Am Stat Assoc 82 1987 605 610
28. SAS Institute Inc., 2000. What's New for SAS Software for release 8.1. Cary, NC, 2000.
29. J. Blangero, J.T. Williams, and L. Almasy Variance component methods for detecting complex trait loci Adv Genet 42 2001 151 181
30. D.C. Rao, and M.A. Province The future of path analysis, segregation analysis, and combined models for genetic dissection of complex traits Hum Hered 50 1 2000 34 42
31. P. Pajukanta Genomewide scan for familial combined hyperlipidemia genes in finnish families, suggesting multiple susceptibility loci influencing triglyceride, cholesterol, and apolipoprotein B levels Am J Hum Genet 64 5 1999 1453 1463
32. J. Klucken ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport Proc Natl Acad Sci USA 97 2 2000 817 822
33. T. Ito Physiological function of ABCG1 Drug News Perspect 16 8 2003 490 492
34. H.B. Brewer Jr., and S. Santamarina-Fojo New insights into the role of the adenosine triphosphate-binding cassette transporters in high-density lipoprotein metabolism and reverse cholesterol transport Am J Cardiol 91 7A 2003 3E 11E
35. G. Carey Inference about genetic correlations Behav Genet 18 3 1988 329 338
36. K.L. Klos Genome-wide linkage analysis reveals evidence of multiple regions that influence variation in plasma lipid and apolipoprotein levels associated with risk of coronary heart disease Arterioscler Thromb Vasc Biol 21 6 2001 971 978
37. S. Canizales-Quinteros Locus on chromosome 6p linked to elevated HDL cholesterol serum levels and to protection against premature atherosclerosis in a kindred with familial hypercholesterolemia Circ Res 92 5 2003 569 576
38. H. Knoblauch A cholesterol-lowering gene maps to chromosome 13q Am J Hum Genet 66 1 2000 157 166
39. S. Francke A genome-wide scan for coronary heart disease suggests in Indo-Mauritians a susceptibility locus on chromosome 16p13 and replicates linkage with the metabolic syndrome on 3q27 Hum Mol Genet 10 24 2001 2751 2765
40. J. Skogsberg Characterization of the human peroxisome proliferator activated receptor delta gene and its expression Int J Mol Med 6 1 2000 73 81
41. C. Bastie Expression of peroxisome proliferator-activated receptor PPARdelta promotes induction of PPARgamma and adipocyte differentiation in 3T3C2 fibroblasts J Biol Chem 274 31 1999 21920 21925
42. J. Skogsberg Evidence that peroxisome proliferator-activated receptor delta influences cholesterol metabolism in men Arterioscler Thromb Vasc Biol 23 4 2003 637 643