The interactions of phenytoin and its binding site in DI-S6 segment of Na+ channel voltage-gated peptide by NMR spectroscopy and molecular modeling study

Journal of Peptide Research

Volumn 66, Issue 1, 2005, Pages 27-38

  Lou, B S ^a   Lin, T H ^b,c   Lo, C Z ^b  

^a CHANG GUNG UNIVERSITY   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

Author keywords

310 helical conformation; Anticonvulsant diphenyl drug; Chemical shifts ( s); Molecular modeling; Nuclear magnetic resonance; Phenytoin; S6 segments; Voltaged gated Na+ channels

Indexed keywords

ACETYLGLYCYLSERYLPHENYLALANYLTYROSYLLEUCYLISOLEUCYLASPARAGINYLLEUCYLISOLEUC YLLEUCYLALANYLVALINE; ANTICONVULSIVE AGENT; ASPARAGINE; HETEROCYCLIC AMINE; LEUCINE; PEPTIDE BL DIS6; PEPTIDE DERIVATIVE; PHENYTOIN; UNCLASSIFIED DRUG; VALINE; VOLTAGE GATED SODIUM CHANNEL;

AMINO ACID SEQUENCE; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG RECEPTOR BINDING; HYDROPHOBICITY; MEASUREMENT; MOLECULAR MODEL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; RAT;

ANTICONVULSANTS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; NERVE TISSUE PROTEINS; PEPTIDE FRAGMENTS; PHENYTOIN; PROTEIN STRUCTURE, SECONDARY; PROTONS;

EID: 20844444131     PISSN: 1397002X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-3011.2005.00269.x     Document Type: Article

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