The conformation and movement of Na+ channel inactivation gate peptide in linker between domain III and IV during inactivation by NMR spectroscopy and molecular modeling study

Journal of Peptide Research

Volumn 63, Issue 3, 2004, Pages 313-323

  Lou, B S ^a   Lin, T H ^b,c   Lo, C Z ^c  

^a CHANG GUNG UNIVERSITY   (Taiwan)

^b TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Local anesthetic drugs; Molecular modeling; Na+ channel inactivation gate; NMR spectroscopy

Indexed keywords

BIPHENYL; BUFFER; DIHEXANOYLPHOSPHOCHOLINE; DIMYRISTOYLPHOSPHATIDYLCHOLINE; LOCAL ANESTHETIC AGENT; PEPTIDE DERIVATIVE; PHENYTOIN; PHOSPHATE; PHOSPHOLIPID; POLYPEPTIDE; SODIUM CHANNEL INACTIVATION GATE PEPTIDE; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL;

ARTICLE; CARBOXY TERMINAL SEQUENCE; MICELLE; MOLECULAR MODEL; MOLECULAR RECOGNITION; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN LIPID INTERACTION; PROTEIN STABILITY; SIGNAL TRANSDUCTION;

ANESTHETICS, LOCAL; ANIMALS; COMPUTATIONAL BIOLOGY; ION CHANNEL GATING; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; OLIGOPEPTIDES; PEPTIDES; PHENYTOIN; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; RATS; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS;

EID: 1942534146     PISSN: 1397002X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1399-3011.2004.00154.x     Document Type: Article

References (37)

1. Aldrich, R.W., Corey, D.P. & Stevens, C.F. (1983) A reinterpretation of mammalian sodium channel gating based on single channel recording. Nature 306, 436-441.
2. Armstrong, C.M. (1981) Sodium channels and gating currents. Physiol Rev. 61, 644-683.
3. Armstrong, C.M. & Bezanilla, F. (1977) Inactivation of sodium channel II. Gating current experiments. J. Gen. Physiol. 70, 567-590.
4. +-channel inactivation: charge neutralizations and deletions in the III-IV linker. Proc. Natl. Sci. USA 89, 10905-10909.
5. + channel inactivation. Proc. Natl. Acad. Sci. USA 89, 10910-10914.
6. Nelson, D.L. & Cox, M.M. (2000) Biological Membranes & Transport, in Lehninger Principles of Biochemistry, 3rd edn. Worth Publishers, New York, NY, USA, pp. 389-433.
7. Smith, M.R. & Goldin, A.L. (1997) Interaction between the sodium channel inactivation linker and domain III S4-S5. Biophys J. 73, 1885-1895.
8. Mcphee, J.C., Ragsdale, D.S., Scheuer, T. & Catterall, W.A. (1998) A critical role for the S4-S5 intracellular loop in domain IV of sodium channel α-subunit in fast inactivation. J Biol Chem 27, 1121-1129.
9. Wang, S.Y. & Wang, G.K. (2003) Voltage-gated sodium channels as primary targets of diverse lipid-soluble neurotoxins. Cellular Signalling 15, 151-159.
10. + channels by local anesthetics. Science 265, 1724-1728.
11. + channels. J. Clinical Investigation 98, 2874-2886.
12. + current by diphenhydramine and other diphenyl compounds: molecular determinants of selective binding to the inactivated channels. Mol. Pharmacol. 57, 135-143.
13. Vold, R.R., Prosser, R.S. & Deese, A.J. (1997) Isotropic solutions of phospholipids bicelles: a new membrane mimetic for high-resolution NMR studies of polypeptides. J. Biomolecular NMR 9, 329-335.
14. Struppe, J., Whiles, J.A. & Vold, R.R. (2000) Acidic phospholipids bicelles: a versatile model membrane system. Biophysical J. 78, 281-289.
15. Luchette, P.A., Vetman, T.N., Prosser, R.S., Hancock, R.E., Nieh, M.P., Glinka, C.J., Krueger, S. & Katsaras, J. (2001) Morphology of fast-tumbling bicelles: a small angle neutron scattering and NMR study. Bioch. et Biophy. Acta 1513(2), 83-94.
16. Kuo, C.C. & Bean, B.P. (1994) Slow binding of phenytoin to inactivated sodium channels in rat hippocampal neurons. Mol. Pharmacol. 46, 716-725.
17. + currents: quantitative distinction from phenytoin and possible therapeutic implications. Mel. Pharmacol. 51, 1077-1083.
18. Wuthrich, K. (1986) NMR of Proteins and Nucleic Acids. Wiley, New York.
19. Wishart, D.S., Sykes, B.D. & Richards, F.M. (1991) Relationship between nuclear magnetic resonance chemical shift and protein secondary structure. J. Mol. Biol. 222, 311-333.
20. HNα for identification of helical secondary structure. J. Mol. Biol. 180, 741-751.
21. Kessler, H. (1982) Conformation and biological activity of cyclic peptides. Angew. Chem., Int. Ed. Engl. 21, 512-523.
22. Hille, B. (1992) Ionic Channels of Excitable Membranes. Sinauer Associates, Sunderland, MA, USA, pp. 390-422.
23. Stuhmer, W., Conti, F., Suzuki, H., Wang, X.O., Noda, M., Yahagi, N., Kubo, H. & Numa, S. (1989) Structural parts involved in activation and inactivation of sodium channel. Nature 339, 597-603.
24. + channel D3-S6 segment modulate both batrachotoxin and local anesthetic affinities. Biophys J. 79, 1379-1387.
25. + channels. J. Gen. Physiol. 113, 7-16.
26. Sack, J.S., Saper, M.A. & Quiocho, F.A. (1989) J. Mol. Biol. 206, 171-191.
27. + channels. Mol. Pharmacol 54, 389-396.
28. Bax, A. & Davis, D.G. (1985) MLEV-17-based two-dementional homonuclear magnetization transfer spectroscopy. J. Magn. Reson. 65, 355-360.
29. Otting, G. (1990) Zero-quantum suppression in NOESY and experiments with a z filter. J. Magn. Reson. 86, 496-508.
30. Braunschweiler, L. & Ernst, R.R. (1983) Coherence transfer by isotropic mixing: application to proton correlation spectroscopy. J. Magn. Reson. 53, 521-528.
31. Bax, A. & Davis, D.G. (1985) Practical aspects of two-dimensional transverse NOE spectroscopy. J. Magn. Reson. 63, 207-213.
32. Kessler, H., Griesinger, C. & Wagner, K. (1987) Peptide conformations. 42. conformation of side chains in peptide using heteronuclear coupling constants obtained by two-dimentional NMR spectroscopy. J. Am. Chem. Soc. 109, 6927-6933.
33. Bothner-By, A.A., Stephens, R.L., Lee, J.M., Warren, C.D. & Jeanloz, R.W. (1984) Structure determination of a tetrasaccharide: transient nuclear overhauser effects in the rotating frame. J. Am. Chem. Soc. 106, 811-813.
34. Qian, X., Kover, K.E., Shenderovich, M.D. et al. (1994) Newly discovered stereochemical requirements in the side-chain conformation of δ Opioid Agonists for Recognizing δ Opioid Receptors. J. Med. Chem. 37, 1746-1757.
35. Bystrov, V.F. (1976) Spin-spin coupling and the conformatina; states of peptide systems. Prog. NMR Spectrosc. 10, 41-81.
36. Karplus, M. & McCammon, J.A. (1983) Dynamics of proteins: elements and function. Annu. Rev. Biochem. 52, 263-300.
37. MaCammon, J.A. & Karplus, M. (1983) Dynamics of proteins structure. Acc. Chem. Res. 16, 187-193.