Inhibitory effect of genistein on mouse colon cancer MC-26 cells involved TGF-β1/Smad pathway

Biochemical and Biophysical Research Communications

Volumn 333, Issue 3, 2005, Pages 827-832

  Yu, Zengli ^a   Tang, Yunan ^b   Hu, Dongsheng ^a   Li, Juan ^a  

^a ZHENGZHOU UNIVERSITY   (China)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Colon cancer; Genistein; MC 26 cells; Smad proteins; TGF 1

Indexed keywords

ADENOVIRUS VECTOR; CASPASE 3; GENISTEIN; MESSENGER RNA; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; PROTEIN P21; SMAD PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA ANTIBODY; TRANSFORMING GROWTH FACTOR BETA1;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CELL ASSAY; COLON CANCER; CONTROLLED STUDY; DNA PROTEIN COMPLEX; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; ENZYME LINKED IMMUNOSORBENT ASSAY; GEL MOBILITY SHIFT ASSAY; GENE OVEREXPRESSION; GROWTH INHIBITION; MOUSE; NITROBLUE TETRAZOLIUM TEST; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

ANIMALS; CELL DIVISION; CELL LINE, TUMOR; COLONIC NEOPLASMS; DNA-BINDING PROTEINS; GENISTEIN; MICE; PHOSPHORYLATION; SIGNAL TRANSDUCTION; SMAD PROTEINS; TRANS-ACTIVATORS; TRANSFORMING GROWTH FACTOR BETA;

ADENOVIRIDAE; ANIMALIA; GLYCINE MAX;

EID: 20744456762     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.05.177     Document Type: Article

References (37)

1. J. Raju, and R.P. Bird Energy restriction reduces the number of advanced aberrant crypt foci and attenuates the expression of colonic transforming growth factor beta and cyclooxygenase isoforms in Zucker obese (fa/fa) rats Cancer Res. 63 2003 6595 6601
2. J. Massague, S.W. Blain, and R.S. Lo TGFbeta signaling in growth control, cancer, and heritable disorders Cell 103 2000 295 309
3. K. Miyazono, P. ten Dijke, and C.H. Heldin TGF-beta signaling by Smad proteins Adv. Immunol. 75 2000 115 157
4. L. Attisano, and J.L. Wrana Signal transduction by the TGF-beta superfamily Science 296 2002 1646 1647
5. A. Mehra, L. Attisano, and J.L. Wrana Characterization of Smad phosphorylation and Smad-receptor interaction Methods Mol. Biol. 142 2000 67 78
6. M. Lutz, and P. Knaus Integration of the TGF-beta pathway into the cellular signalling network Cell Signal. 14 2002 977 988
7. J. Massague How cells read TGF-beta signals Nat. Rev. Mol. Cell Biol. 1 2000 169 178
8. A. Moustakas, S. Souchelnytskyi, and C.H. Heldin Smad regulation in TGF-beta signal transduction J. Cell Sci. 114 2001 4359 4369
9. Y. Shi, Y.F. Wang, L. Jayaraman, H. Yang, J. Massague, and N.P. Pavletich Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling Cell 94 1998 585 594
10. L. Zawel, J.L. Dai, P. Buckhaults, S. Zhou, K.W. Kinzler, B. Vogelstein, and S.E. Kern Human Smad3 and Smad4 are sequence-specific transcription activators Mol. Cell 1 1998 611 617
11. V. Mostert, S. Wolff, I. Dreher, J. Kohrle, and J. Abel Identification of an element within the promoter of human selenoprotein P responsive to transforming growth factor-beta Eur. J. Biochem. 268 2001 6176 6181
12. J.N. Topper, J.X. Cai, Y. Qiu, K.R. Anderson, Y.Y. Xu, J.D. Deeds, R. Feeley, C.J. Gimeno, E.A. Woolf, O. Tayber, G.G. Mays, B.A. Sampson, F.J. Schoen, M.A. Gimbrone, and D. Falb Proc. Natl. Acad. Sci. USA 94 1997 9314 9319
13. T. Miura, L. Yuan, B. Sun, H. Fujii, M. Yoshida, K. Wakame, and K. Kosuna Isoflavone aglycon produced by culture of soybean extracts with basidiomycetes and its anti-angiogenic activity Biosci. Biotechnol. Biochem. 66 2002 2626 2631
14. L.R. Ferguson, N. Karunasinghe, and M. Philpott Epigenetic events and protection from colon cancer in New Zealand Environ. Mol. Mutagen. 44 2004 36 43
15. A. Constantinou, and E. Huberman Genistein, an inducer of tumor cell differentiation: possible mechanisms of action Proc. Soc. Exp. Biol. Med. 208 1995 109 115
16. S.M. Kuo Antiproliferative potency of structurally distinct dietary flavonoids on human colon cancer cells Cancer Lett. 110 1996 41 48
17. K. Shimokado, K. Umezawa, and J. Ogata Tyrosine kinase inhibitors inhibit multiple steps of the cell cycle of vascular smooth muscle cells Exp. Cell Res. 220 1995 266 273
18. Z. Yu, W. Li, and F. Liu Inhibition of proliferation and induction of apoptosis by genistein in colon cancer HT-29 cells Cancer Lett. 215 2004 159 166
19. J.P. Morgenstern, and H. Land Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line Nucleic Acids Res. 18 1990 3587 3596
20. X. Liu, J. Lee, M. Cooley, E. Bhogte, S. Hartley, and A. Glick Smad7 but not Smad6 cooperates with oncogenic ras to cause malignant conversion in a mouse model for squamous cell carcinoma Cancer Res. 63 2003 7760 7768
21. M. Fujii, K. Takeda, T. Imamura, H. Aoki, T.K. Sampath, S. Enomoto, M. Kawabata, M. Kato, H. Ichijo, and K. Miyazono Roles of bone morphogenetic protein type I receptors and Smad proteins in osteoblast and chondroblast differentiation Mol. Biol. Cell 10 1999 3801 3813
22. J.D. Lambert, J. Hong, G.Y. Yang, J. Liao, and C.S. Yang Inhibition of carcinogenesis by polyphenols: evidence from laboratory investigations Am. J. Clin. Nutr. 81 Suppl. 1 2005 284S 291S
23. D. Altavilla, A. Crisafulli, H. Marini, M. Esposito, R. D'Anna, F. Corrado, A. Bitto, and F. Squadrito Cardiovascular effects of the phytoestrogen genistein Curr. Med. Chem. Cardiovasc. Hematol. Agents 2 2004 179 186
24. A. Cotter, and K.D. Cashman Genistein appears to prevent early postmenopausal bone loss as effectively as hormone replacement therapy Nutr. Rev. 61 2003 346 351
25. X. Huang, S. Chen, L. Xu, Y. Liu, D.K. Deb, L.C. Platanias, and R.C. Bergan Genistein inhibits p38 map kinase activation, matrix metalloproteinase type 2, and cell invasion in human prostate epithelial cells Cancer Res. 65 2005 3470 3478
26. S.A. Vantyghem, S.M. Wilson, C.O. Postenka, W. Al-Katib, A.B. Tuck, and A.F. Chambers Dietary genistein reduces metastasis in a postsurgical orthotopic breast cancer model Cancer Res. 65 2005 3396 3403
27. M.F. Aguero, M.M. Facchinetti, Z. Sheleg, and A.M. Senderowicz Phenoxodiol, a novel isoflavone, induces G1 arrest by specific loss in cyclin-dependent kinase 2 activity by p53-independent induction of p21WAF1/CIP1 Cancer Res. 65 2005 3364 3373
28. T. Valachovicova, V. Slivova, and D. Sliva Cellular and physiological effects of soy flavonoids Mini. Rev. Med. Chem. 4 2004 881 887
29. A.B. Glick TGFbeta1, back to the future: revisiting its role as a transforming growth factor Cancer Biol. Ther. 3 2004 276 283
30. J. Gong, S. Ammanamanchi, T.C. Ko, and M.G. Brattain Transforming growth factor beta 1 increases the stability of p21/WAF1/CIP1 protein and inhibits CDK2 kinase activity in human colon carcinoma FET cells Cancer Res. 63 2003 3340 3346
31. O. Kolek, B. Gajkowska, M.M. Godlewski, and T. Motyl Antiproliferative and apoptotic effect of TGF-beta 1 in bovine mammary epithelial BME-UV1 cells Comp. Biochem. Physiol. C Toxicol. Pharmacol. 134 2003 417 430
32. P. Singh, J.P. Walker, C.M. Townsend Jr., and J.C. Thompson Role of gastrin and gastrin receptors on the growth of a transplantable mouse colon carcinoma (MC-26) in BALB/c mice Cancer Res. 46 1986 1612 1616
33. F. Li, Y. Cao, C.M. Townsend Jr., and T.C. Ko TGF-beta signaling in colon cancer cells World J. Surg. 29 2005 306 311
34. H. Ijichi, T. Ikenoue, N. Kato, Y. Mitsuno, G. Togo, J. Kato, F. Kanai, Y. Shiratori, and M. Omata Systematic analysis of the TGF-beta-Smady signaling pathway in gastrointestinal cancer cells Biochem. Biophys. Res. Commun. 289 2001 350 357
35. R. Derynck, R.J. Akhurst, and A. Balmain TGF-beta signaling in tumor suppression and cancer progression Nat. Genet. 29 2001 117 129
36. R.J. Akhurst, and R. Derynck TGF-beta signaling in cancer-a double-edged sword Trends Cell Biol. 11 2001 S44 S51
37. H. Ayashi, S. Abdollah, Y. Qiu, J. Cai, Y.Y. Xu, B.W. Grinnell, M.A. Richardson, J.N. Topper, M.A. Gimbrone, J.L. Wrana Jr., and D. Falb The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling Cell 9 1997 1165 1173