Self-association properties of monomeric insulin analogs under formulation conditions

Pharmaceutical Research

Volumn 15, Issue 9, 1998, Pages 1434-1441

  Richards, Jane P ^a,b   Stickelmeyer, Mary P ^a   Flora, David B ^a   Chance, Ronald E ^a   Frank, Bruce H ^a   DeFelippis, Michael R ^a  

^a ELI LILLY AND COMPANY   (United States)

^b Baxter Hemoglobin Therapeutics Inc   (United States)

Author keywords

Analytical ultracentrifugation; Insulin association; Monomeric insulin analogs; Peptide formulation

Indexed keywords

HUMAN INSULIN; INSULIN DERIVATIVE; INSULIN LISPRO; META CRESOL; ZINC;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; DIMERIZATION; DRUG ACTIVITY; DRUG CONFORMATION; DRUG FORMULATION; MOLECULAR WEIGHT; PRIORITY JOURNAL; SEDIMENTATION RATE; STRUCTURE ACTIVITY RELATION; ULTRACENTRIFUGATION;

AMINO ACID SEQUENCE; BUFFERS; CHEMISTRY, PHARMACEUTICAL; DRUG INTERACTIONS; EXCIPIENTS; HUMANS; INSULIN; MOLECULAR SEQUENCE DATA; PHENOLSULFONPHTHALEIN; SEQUENCE HOMOLOGY, AMINO ACID; ULTRACENTRIFUGATION; ZINC;

EID: 0031751766     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011961923870     Document Type: Article

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