Restoration of DSCR1 to disomy in the trisomy 16 mouse model of Down syndrome does not correct cardiac or craniofacial development anomalies

Developmental Dynamics

Volumn 233, Issue 3, 2005, Pages 954-963

  Lange, Alexander W ^a   Rothermel, Beverly A ^b   Yutzey, Katherine E ^a,c  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c Cincinnati Children's Medical Center ML 7020   (United States)

Author keywords

Congenital heart defects; Craniofacial malformations; Down syndrome; DSCR1; Trisomy 16 mice

Indexed keywords

CALCINEURIN; COMPLEMENTARY DNA; LUCIFERASE; RNA; TRANSCRIPTION FACTOR NFAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHROMOSOME 16; CHROMOSOME 21; CONGENITAL HEART MALFORMATION; CRANIOFACIAL MALFORMATION; DISOMY; DOWN SYNDROME; DSCR1 GENE; EMBRYO; GENE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRISOMY 16;

ANIMALS; BRAIN; CHROMOSOMES, MAMMALIAN; CRANIOFACIAL ABNORMALITIES; DIPLOIDY; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; DOWN SYNDROME; EMBRYO; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEART DEFECTS, CONGENITAL; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE; MUSCLE PROTEINS; MYOCARDIUM; NFATC TRANSCRIPTION FACTORS; NUCLEAR PROTEINS; PROTEIN ISOFORMS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRISOMY;

MURINAE;

EID: 20744431729     PISSN: 10588388     EISSN: None     Source Type: Journal    
DOI: 10.1002/dvdy.20433     Document Type: Article

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