Conotruncal anomalies in the trisomy 16 mouse: An immunohistochemical analysis with emphasis on the involvement of the neural crest

Anatomical Record

Volumn 260, Issue 3, 2000, Pages 279-293

  Waller III, B R ^a   McQuinn, T ^a   Phelps, A L ^a   Markwald, R R ^a   Lo, C W ^b   Thompson, R P ^a   Wessels, A ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Congenital heart malformation; DiGeorge syndrome; Down's syndrome; Neural crest; Outflow tract; Trisomy 16

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA ARCH; AORTOPULMONARY SEPTAL DEFECT; ARTICLE; CELL FUNCTION; CELL INTERACTION; CELL SIZE; CONGENITAL HEART MALFORMATION; CONTROLLED STUDY; DIGEORGE SYNDROME; DOWN SYNDROME; EMBRYO; EXPERIMENTAL MOUSE; FALLOT TETRALOGY; HEART MUSCLE; HEART RIGHT VENTRICLE DOUBLE OUTLET; IMMUNOHISTOCHEMISTRY; MALE; MESENCHYME; MOUSE; NEURAL CREST; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; TRISOMY;

ANIMALS; CONNEXIN 43; DIGEORGE SYNDROME; DISEASE MODELS, ANIMAL; DOWN SYNDROME; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HEART DEFECTS, CONGENITAL; HEART VENTRICLES; KARYOTYPING; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; NEURAL CREST; PREGNANCY; TRISOMY; YOLK SAC;

ANIMALIA; RODENTIA;

EID: 0034331425     PISSN: 0003276X     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-0185(20001101)260:3<279::AID-AR65>3.0.CO;2-2     Document Type: Article

References (41)

1. The mouse with trisomy 16 as a model of human hearts with common atrioventricular junction
2. Genesis and systematization of cardiovascular anomalies and analysis of skeletal malformations in murine trisomy 16 and 19: Two animal models for human trisomies
3. Clinical and molecular studies in full trisomy 22: Further delineation of the phenotype and review of the literature
4. Smooth muscle cells of neural crest origin form the aorticopulmonary septum in the avian embryo
5. Abnormal interactions of embryonic mouse trisomy 16 heart fibroblasts with ecru components in vitro
6. Pax3 is required for cardiac neural crest migration in the mouse: Evidence from the splotch (Sp2H) mutant
7. Common epicardial origin of coronary vascular smooth muscle, perivascular fibroblasts, and intermyocardial fibroblasts in the avian heart
8. Heart and neural tube defects in transgenic mice overexpressing the Cx43
9. Observations on the development of the aortico-pulmonary spiral septum in the mouse
10. HIRA, a DiGeorge syndrome candidate gene, is required for cardiac outflow tract septation
11. Migration of cranial neural crest cells to the pharyngeal arches and heart in rat embryos
12. Epicardium-derived cells contribute a novel population to the myocardial wall and the atrioventricular cushions
13. Alteration in connexin 43 gap junction gene dosage impairs conotruncal heart development
14. Neural crest cells contribute to normal aorticopulmonary septation
15. Neural crest and normal development: A new perspective
16. Characterization of conotruncal malformations following ablation of 'cardiac' neural crest
17. Cellular and molecular contributions of the cardiac neural crest to cardiovascular development
18. Chamber specification of atrial myosin light chain-2 expression precedes septation during murine cardiogenesis
19. Cx43 gap junction gene expression and gap junctional communication in mouse neural crest cells
20. Cx43 gap junctions in cardiac development
21. Congenital cardiac anomalies associated with the Di George syndrome: A neonatal experience
22. Trisomy 16 in the mouse fetus associated with the generalized edema and cardiovacular and urinary tract anomalies
23. Maps of linkage and synteny homologies between mouse and man
24. Congenital heart disease in experimental (fetal) mouse trisomies: Incidence
25. Cytoplasmic stress fibers in the developing heart
26. Morphogenesis of the truncus arteriosus of the chick embryo heart: The formation and migration of mesenchymal tissue
27. Patterns of tensile stress in the developing cardiac truncus
28. Morphogenesis of the truncus arteriosus of the chick embryo heart: Movements of autoradiographic tattoos during septation
29. A computer graphic study of cardiac truncal septation
30. Morphogenesis of human cardiac outflow
31. Myocardialization of the cardiac outflow tract
32. Cardiovascular anomalies in DiGeorge syndrome and importance of neural crest as a possible pathogenetic factor
33. Cardiac neural crest cells provide new insight into septation of the cardiac outflow tract; aortic sac to ventricular septal closure
34. Cx43 expression reflect neural crest patterns during cardiovascular development
35. A novel role for cardiac neural crest in heart development
36. Cardiac morphology at late fetal stages in the mouse with trisomy 16: Consequences for different formation of the atrioventricular junction when compared to humans with trisomy
37. DiGeorge syndrome: Part of CATCH 22
38. Normal development of the outflow tract in the rat
39. Sox-4 deficiency syndrome in mice is an animal model for common trunk
40. Expression of the smooth-muscle proteins alpha-smooth-muscle actin and calponin, and of the intermediate filament protein desmin are parameters of cardiomyocyte maturation in the prenatal rat heart
41. A molecular pathway revealing a genetic basis for human cardiac and craniofacial defects