Molecular tracking of antigen-specific T-cell clones during immune responses

Current Opinion in Immunology

Volumn 17, Issue 4 SPEC. ISS., 2005, Pages 441-447

  Rufer, Nathalie ^a  

^a SWISS INST FOR EXP CANCER RESEARCH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; MAJOR HISTOCOMPATIBILITY ANTIGEN; MONOCLONAL ANTIBODY; POLYMER; RECEPTOR ANTIBODY; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR BETA CHAIN; TUMOR ANTIGEN;

ANALYSIS; ANALYTICAL PARAMETERS; ANTIGEN SPECIFICITY; CELLULAR IMMUNITY; CLONAL VARIATION; DILUTION; DNA SEQUENCE; EX VIVO STUDY; EXPERIMENTAL MODEL; FLUORESCENCE; GENE AMPLIFICATION; GENE SEQUENCE; HUMAN; IMMUNE RESPONSE; IMMUNOASSAY; IMMUNOGENETICS; IMMUNOLOGICAL MONITORING; IMMUNOLOGICAL TECHNIQUE; IN VITRO STUDY; LYMPHOCYTE CLONE; LYMPHOCYTE FUNCTION; LYMPHOPROLIFERATIVE DISEASE; NONHUMAN; POLYMERASE CHAIN REACTION; RELIABILITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; STIMULATION; T LYMPHOCYTE; T LYMPHOCYTE RECEPTOR GENE;

EID: 20544465820     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2005.06.003     Document Type: Review

References (50)

1. M.M. Davis, and P.J. Bjorkman T-cell antigen receptor genes and T-cell recognition Nature 334 1988 395 402
2. J. Nikolich-Zugich, M.K. Slifka, and I. Messaoudi The many important facets of T-cell repertoire diversity Nat Rev Immunol 4 2004 123 132 This review focuses on several recent advances that address diversity in the generation of an optimal immune response.
3. P.A. Moss, R.J. Moots, W.M. Rosenberg, S.J. Rowland-Jones, H.C. Bodmer, A.J. McMichael, and J.I. Bell Extensive conservation of alpha and beta chains of the human T-cell antigen receptor recognizing HLA-A2 and influenza A matrix peptide Proc Natl Acad Sci USA 88 1991 8987 8990
4. P.J. Lehner, E.C. Wang, P.A. Moss, S. Williams, K. Platt, S.M. Friedman, J.I. Bell, and L.K. Borysiewicz Human HLA-A0201-restricted cytotoxic T lymphocyte recognition of influenza A is dominated by T cells bearing the V beta 17 gene segment J Exp Med 181 1995 79 91
5. G.B. Stewart-Jones, A.J. McMichael, J.I. Bell, D.I. Stuart, and E.Y. Jones A structural basis for immunodominant human T cell receptor recognition Nat Immunol 4 2003 657 663
6. A.M. Deckhut, W. Allan, A. McMickle, M. Eichelberger, M.A. Blackman, P.C. Doherty, and D.L. Woodland Prominent usage of V beta 8.3 T cells in the H-2Db-restricted response to an influenza A virus nucleoprotein epitope J Immunol 151 1993 2658 2666
7. + T-cell repertoire in longitudinal studies.
8. W. Zhong, and E.L. Reinherz In vivo selection of a TCR Vbeta repertoire directed against an immunodominant influenza virus CTL epitope Int Immunol 16 2004 1549 1559
9. D. Valmori, V. Dutoit, D. Lienard, F. Lejeune, D. Speiser, D. Rimoldi, V. Cerundolo, P.Y. Dietrich, J.C. Cerottini, and P. Romero Tetramer-guided analysis of TCR beta-chain usage reveals a large repertoire of melan-A-specific CD8+ T cells in melanoma patients J Immunol 165 2000 533 538
10. P.Y. Dietrich, P.R. Walker, A.L. Quiquerez, G. Perrin, V. Dutoit, D. Lienard, P. Guillaume, J.C. Cerottini, P. Romero, and D. Valmori Melanoma patients respond to a cytotoxic T lymphocyte-defined self-peptide with diverse and nonoverlapping T-cell receptor repertoires Cancer Res 61 2001 2047 2054
11. D. Valmori, V. Dutoit, V. Schnuriger, A.L. Quiquerez, M.J. Pittet, P. Guillaume, V. Rubio-Godoy, P.R. Walker, D. Rimoldi, and D. Lienard Vaccination with a Melan-A peptide selects an oligoclonal T cell population with increased functional avidity and tumour reactivity J Immunol 168 2002 4231 4240
12. P.Y. Dietrich, F.A. Le Gal, V. Dutoit, M.J. Pittet, L. Trautman, A. Zippelius, I. Cognet, V. Widmer, P.R. Walker, and O. Michielin Prevalent role of TCR alpha-chain in the selection of the preimmune repertoire specific for a human tumour-associated self-antigen J Immunol 170 2003 5103 5109
13. G. Pantaleo, J.F. Demarest, H. Soudeyns, C. Graziosi, F. Denis, J.W. Adelsberger, P. Borrow, M.S. Saag, G.M. Shaw, and R.P. Sekaly Major expansion of CD8+ T cells with a predominant V beta usage during the primary immune response to HIV Nature 370 1994 463 467
14. T. Dong, G. Stewart-Jones, N. Chen, P. Easterbrook, X. Xu, L. Papagno, V. Appay, M. Weekes, C. Conlon, and C. Spina HIV-specific cytotoxic T cells from long-term survivors select a unique T cell receptor J Exp Med 200 2004 1547 1557
15. J.D. Wilson, G.S. Ogg, R.L. Allen, P.J. Goulder, A. Kelleher, A.K. Sewell, C.A. O'Callaghan, S.L. Rowland-Jones, M.F. Callan, and A.J. McMichael Oligoclonal expansions of CD8(+) T cells in chronic HIV infection are antigen specific J Exp Med 188 1998 785 790
16. D.C. Douek, M.R. Betts, J.M. Brenchley, B.J. Hill, D.R. Ambrozak, K.L. Ngai, N.J. Karandikar, J.P. Casazza, and R.A. Koup A novel approach to the analysis of specificity, clonality, and frequency of HIV-specific T cell responses reveals a potential mechanism for control of viral escape J Immunol 168 2002 3099 3104
17. D.A. Price, S.M. West, M.R. Betts, L.E. Ruff, J.M. Brenchley, D.R. Ambrozak, Y. Edghill-Smith, M.J. Kuroda, D. Bogdan, and K. Kunstman T cell receptor recognition motifs govern immune escape patterns in acute SIV infection Immunity 21 2004 793 803 This paper describes, for the first time, the presence of highly conserved identical BV-CDR3 sequences in multiple macaques during SIV infection. The paper is based on the analysis of more than 3400 SIV-specific TCR sequences.
18. J.D. Altman, P.A. Moss, P.J. Goulder, D.H. Barouch, M.G. McHeyzer-Williams, J.I. Bell, A.J. McMichael, and M.M. Davis Phenotypic analysis of antigen-specific T lymphocytes Science 274 1996 94 96
19. P. Romero, P.R. Dunbar, D. Valmori, M. Pittet, G.S. Ogg, D. Rimoldi, J.L. Chen, D. Lienard, J.C. Cerottini, and V. Cerundolo Ex vivo staining of metastatic lymph nodes by class I major histocompatibility complex tetramers reveals high numbers of antigen-experienced tumour-specific cytolytic T lymphocytes J Exp Med 188 1998 1641 1650
20. P.C. Doherty, and J.P. Christensen Accessing complexity: the dynamics of virus-specific T cell responses Annu Rev Immunol 18 2000 561 592
21. C. Pannetier, J. Even, and P. Kourilsky T-cell repertoire diversity and clonal expansions in normal and clinical samples Immunol Today 16 1995 176 181
22. C. Genevee, A. Diu, J. Nierat, A. Caignard, P.Y. Dietrich, L. Ferradini, S. Roman-Roman, F. Triebel, and T. Hercend An experimentally validated panel of subfamily-specific oligonucleotide primers (V alpha 1-w29/V beta 1-w24) for the study of human T cell receptor variable V gene segment usage by polymerase chain reaction Eur J Immunol 22 1992 1261 1269
23. K. Maslanka, T. Piatek, J. Gorski, and M. Yassai Molecular analysis of T cell repertoires. Spectratypes generated by multiplex polymerase chain reaction and evaluated by radioactivity or fluorescence Hum Immunol 44 1995 28 34
24. P. Bousso, A. Casrouge, J.D. Altman, M. Haury, J. Kanellopoulos, J.P. Abastado, and P. Kourilsky Individual variations in the murine T cell response to a specific peptide reflect variability in naive repertoires Immunity 9 1998 169 178
25. M.Y. Lin, and R.M. Welsh Stability and diversity of T cell receptor repertoire usage during lymphocytic choriomeningitis virus infection of mice J Exp Med 188 1998 1993 2005
26. S.J. Turner, K. Kedzierska, N.L. La Gruta, R. Webby, and P.C. Doherty Characterization of CD8+ T cell repertoire diversity and persistence in the influenza A virus model of localized, transient infection Semin Immunol 16 2004 179 184
27. B. Arden, S.P. Clark, D. Kabelitz, and T.W. Mak Human T-cell receptor variable gene segment families Immunogenetics 42 1995 455 500
28. G. Folch, and M.P. Lefranc The human T cell receptor beta variable (TRBV) genes Exp Clin Immunogenet 17 2000 42 54
29. A. Lim, V. Baron, L. Ferradini, M. Bonneville, P. Kourilsky, and C. Pannetier Combination of MHC-peptide multimer-based T cell sorting with the Immunoscope permits sensitive ex vivo quantitation and follow-up of human CD8+ T cell immune responses J Immunol Methods 261 2002 177 194
30. J.L. Maryanski, C.V. Jongeneel, P. Bucher, J.L. Casanova, and P.R. Walker Single-cell PCR analysis of TCR repertoires selected by antigen in vivo: a high magnitude CD8 response is comprised of very few clones Immunity 4 1996 47 55
31. S.J. Turner, G. Diaz, R. Cross, and P.C. Doherty Analysis of clonotype distribution and persistence for an influenza virus-specific CD8+ T cell response Immunity 18 2003 549 559
32. •].
33. • ] used 5′ RACE and cDNA sequencing to follow the persistence of adoptively transferred tumour-specific T-cell clones in melanoma patients. These reports describe a novel approach to address the complexity of TCR repertoires.
34. C.L. O'Keefe, M. Plasilova, M. Wlodarski, A.M. Risitano, A.R. Rodriguez, E. Howe, N.S. Young, E. Hsi, and J.P. Maciejewski Molecular analysis of TCR clonotypes in LGL: a clonal model for polyclonal responses J Immunol 172 2004 1960 1969
35. M. Plasilova, A.M. Risitano, C.L. O'Keefe, A. Rodriguez, M. Wlodarski, N.S. Young, and J. Maciejewski Shared and individual specificities of immunodominant cytotoxic T-cell clones in paroxysmal nocturnal hemoglobinuria as determined by molecular analysis Exp Hematol 32 2004 261 269
36. A.M. Risitano, J.P. Maciejewski, S. Green, M. Plasilova, W. Zeng, and N.S. Young In vivo dominant immune responses in aplastic anaemia: molecular tracking of putatively pathogenetic T-cell clones by TCR beta-CDR3 sequencing Lancet 364 2004 355 364 This work provides solid evidence for the identification of dominant T-cell clones that have expanded in vivo in patients with aplastic anaemia.
37. A.M. Risitano, J.P. Maciejewski, P. Muranski, M. Wlodarski, C. O'Keefe, E.M. Sloand, and N.S. Young Large granular lymphocyte (LGL)-like clonal expansions in paroxysmal nocturnal hemoglobinuria (PNH) patients Leukemia 19 2005 217 222
38. V. Bigouret, T. Hoffmann, L. Arlettaz, J. Villard, M. Colonna, A. Ticheli, A. Gratwohl, K. Samii, B. Chapuis, and N. Rufer Monoclonal T-cell expansions in asymptomatic individuals and in patients with large granular leukemia consist of cytotoxic effector T cells expressing the activating CD94:NKG2C/E and NKD2D killer cell receptors Blood 101 2003 3198 3204
39. M.J. Pittet, D. Valmori, P.R. Dunbar, D.E. Speiser, D. Lienard, F. Lejeune, K. Fleischhauer, V. Cerundolo, J.C. Cerottini, and P. Romero High frequencies of naive Melan-A/MART-1-specific CD8(+) T cells in a large proportion of human histocompatibility leukocyte antigen (HLA)-A2 individuals J Exp Med 190 1999 705 715
40. M.J. Pittet, D.E. Speiser, D. Lienard, D. Valmori, P. Guillaume, V. Dutoit, D. Rimoldi, F. Lejeune, J.C. Cerottini, and P. Romero Expansion and functional maturation of human tumour antigen-specific CD8+ T cells after vaccination with antigenic peptide Clin Cancer Res 7 2001 796s 803s
41. M.J. Pittet, A. Zippelius, D. Valmori, D.E. Speiser, J.C. Cerottini, and P. Romero Melan-A/MART-1-specific CD8 T cells: from thymus to tumour Trends Immunol 23 2002 325 328
42. P. Romero, D. Valmori, M.J. Pittet, A. Zippelius, D. Rimoldi, F. Levy, V. Dutoit, M. Ayyoub, V. Rubio-Godoy, and O. Michielin Antigenicity and immunogenicity of Melan-A/MART-1 derived peptides as targets for tumour reactive CTL in human melanoma Immunol Rev 188 2002 81 96
43. G. Brady, and N.N. Iscove Construction of cDNA libraries from single cells Methods Enzymol 225 1993 611 623
44. N. Rufer, A. Zippelius, P. Batard, M.J. Pittet, I. Kurth, P. Corthesy, J.C. Cerottini, S. Leyvraz, E. Roosnek, and M. Nabholz Ex vivo characterization of human CD8+ T subsets with distinct replicative history and partial effector functions Blood 102 2003 1779 1787
45. N. Rufer, P. Reichenbach, and P. Romero Methods for the ex vivo characterization of human CD8+ T subsets based on gene expression and replicative history analysis Methods Mol Med 109 2005 265 284 This methodological paper describes in detail the modified RT-PCR protocol used for the detection of specific cDNAs after global amplification of expressed mRNAs at single-cell level.
46. P.G. Coulie, V. Karanikas, D. Colau, C. Lurquin, C. Landry, M. Marchand, T. Dorval, V. Brichard, and T. Boon A monoclonal cytolytic T-lymphocyte response observed in a melanoma patient vaccinated with a tumour-specific antigenic peptide encoded by gene MAGE-3 Proc Natl Acad Sci USA 98 2001 10290 10295
47. V. Karanikas, C. Lurquin, D. Colau, N. van Baren, C. De Smet, B. Lethe, T. Connerotte, V. Corbiere, M.A. Demoitie, and D. Lienard Monoclonal anti-MAGE-3 CTL responses in melanoma patients displaying tumour regression after vaccination with a recombinant canarypox virus J Immunol 171 2003 4898 4904
48. C. Lonchay, P. van der Bruggen, T. Connerotte, T. Hanagiri, P. Coulie, D. Colau, S. Lucas, A. Van Pel, K. Thielemans, and N. van Baren Correlation between tumour regression and T cell responses in melanoma patients vaccinated with a MAGE antigen Proc Natl Acad Sci USA 101 Suppl 2 2004 14631 14638
49. C. Germeau, W. Ma, F. Schiavetti, C. Lurquin, E. Henry, N. Vigneron, F. Brasseur, B. Lethe, E. De Plaen, and T. Velu High frequency of antitumor T cells in the blood of melanoma patients before and after vaccination with tumour antigens J Exp Med 201 2005 241 248
50. C. Lurquin, B. Lethe, E. De Plaen, V. Corbiere, I. Theate, N. van Baren, P.G. Coulie, and T. Boon Contrasting frequencies of antitumor and anti-vaccine T cells in metastases of a melanoma patient vaccinated with a MAGE tumour antigen J Exp Med 201 2005 249 257