Melanoma patients respond to a cytotoxic T lymphocyte-defined self-peptide with diverse and nonoverlapping T-cell receptor repertoires

Cancer Research

Volumn 61, Issue 5, 2001, Pages 2047-2054

  Dietrich, Pierre Yves ^a   Walker, Paul R ^a   Quiquerez, Anne Lise ^a   Perrin, Gaelle ^a   Dutoit, Valerie ^b   Liénard, Danielle ^b   Guillaume, Philippe ^a,b   Cerottini, Jean Charles ^b   Romero, Pedro ^b   Valmori, Danila ^b  

^a UNIVERSITY HOSPITAL   (Switzerland)

^b LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; HLA A2 ANTIGEN; MELAN A; T LYMPHOCYTE RECEPTOR; T LYMPHOCYTE RECEPTOR BETA CHAIN; TETRAMER; TUMOR ANTIGEN;

ARTICLE; CELL SPECIFICITY; COMPLEMENTARITY DETERMINING REGION; CYTOTOXIC T LYMPHOCYTE; HUMAN; HUMAN CELL; LYMPHOCYTE CLONE; MELANOMA; PRIORITY JOURNAL; VIRUS INFECTION;

AMINO ACID SEQUENCE; ANTIGENS, NEOPLASM; BASE SEQUENCE; COMPLEMENTARITY DETERMINING REGIONS; EPITOPES, T-LYMPHOCYTE; HLA-A2 ANTIGEN; HUMANS; IMMUNODOMINANT EPITOPES; IMMUNOGLOBULIN VARIABLE REGION; LYMPH NODES; MELANOMA; MOLECULAR SEQUENCE DATA; NEOPLASM PROTEINS; PEPTIDE FRAGMENTS; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0035266395     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Induction of tumor-reactive CTL from peripheral blood and tumor-infiltrating lymphocytes of melanoma patients by in vitro stimulation with an immunodominant peptide of the human melanoma antigen MART-1
2. CTL specific for the tyrosinase autoantigen can be induced from healthy donor blood to lyse melanoma cells
3. High frequencies of naive Melan-A/MART-1-specifc CD8+ T cells in a large proportion of HLA-A2 individuals
4. An innate sense of danger
5. Extensive conservation of α and β chains of the human T-cell antigen receptor recognizing HLA-A2 and influenza A matrix peptide
6. Dominant selection of an invariant T cell antigen receptor in response to persistent infection by Epstein-Barr virus
7. Multiple specificities in the repertoire of a melanoma patient's cytolytic T lymphocytes directed against tumor antigen MAGE-1.A1
8. Cytotoxic T-lymphocyte clones from different patients display limited T-cell-receptor variable-region gene usage in HLA-A2-restricted recognition of the melanoma antigen Melan-A/MART-1
9. Cytolytic T lymphocyte recognition of the immunodominant HLA-A*0201-restricted Melan-A/MART-1 antigenic peptide in melanoma
10. T-cell repertoire diversity and clonal expansions in normal and clinical samples
11. In situ T cell responses against melanoma comprise high numbers of locally expanded T cell clonotypes
12. A new gene coding for a differentiation antigen recognized by autologous cytolytic T lymphocytes on HLA-A2 melanomas
13. Cloning of the gene coding for a shared human melanoma antigen recognized by autologous T cells infiltrating into tumor
14. Identification of the immunodominant peptides of the MART-1 human melanoma antigen recognized by the majority of HLA-A2-restricted tumor infiltrating lymphocytes
15. Ex vivo staining of metastatic lymph nodes by class I major histocompatibility complex tetramers reveals high numbers of antigen-experienced tumor-specific cytolytic T lymphocytes
16. Diversity of the fine specificity displayed by HLA-A*0201-restricted CTL specific for the immunodominant Melan-A/MART-1 antigenic peptide
17. Phenotypic analysis of antigen-specifc T lymphocytes
18. Enhanced generation of specific tumor-reactive CTL in vitro by selected Melan-A/MART-1 immunodominant peptide analogs
19. Astrocytoma infiltrating lymphocytes include major T cell clonal expansions confined to the CD8 subset
20. An experimentally validated panel of subfamily-specific oligonucleotide primers (V α 1-w29/V β 1-w24) for the study of human T cell receptor variable V gene segment usage by polymerase chain reaction
21. Recurrent T cell receptor rearrangements in the cytotoxic T lymphocyte response in vivo against the P815 murine tumor
22. Different TCRBV genes generate biased patterns of V-D-J diversity in human T cells
23. T-cell repertoires in healthy and diseased human tissues analysed by T-cell receptor β-chain CDR3 size determination: Evidence for oligoclonal expansions in tumours and inflammatory diseases
24. + T cells in melanoma patients
25. CD4+ tumor-infiltrating lymphocytes in cervical cancer recognize HLA-DR-restricted peptides provided by human papillomavirus-E7
26. Analysis of TCR usage in human tumors - A new tool for assessing tumor-specific immune responses
27. Human HLA-A0201-restricted cytotoxic T lymphocyte recognition of influenza A is dominated by T cells bearing the Vβ17 gene segment
28. Conservation of T cell receptor usage by HLA B27-restricted influenza-specific cytotoxic T lymphocytes suggests a general pattern for antigen-specific major histocompatibility complex class I-restricted responses
29. Individual variations in the murine T cell response to a specific peptide reflect variability in naive repertoires
30. Analysis of the cytolytic T lymphocyte response of melanoma patients to the naturally HLA-A*0201-associated tyrosinase peptide 368-376
31. + T cell response to the cancer testis antigen NY-ESO-1 in melanoma patients
32. (27-35)
33. The peptide ligands mediating positive selection in the thymus control T cell survival and homeostatic proliferation in the periphery
34. Designing and maintaining the mature TCR repertoire: The continuum of self-peptide:self-MHC complex recognition
35. Direct evidence for thymic function in adult humans
36. A direct estimate of the human αβ T cell receptor diversity