Lung epithelial cells release ATP during ozone exposure: Signaling for cell survival

Free Radical Biology and Medicine

Volumn 39, Issue 2, 2005, Pages 213-226

  Ahmad, Shama ^a   Ahmad, Aftab ^a   McConville, Glen ^a   Schneider, Barbara K ^a   Allen, Corrie B ^a   Manzer, Rizwan ^a   Mason, Robert J ^a   White, Carl W ^a  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

Author keywords

Akt; Apoptosis; ATP release; Cell survival; ERK; Glucose uptake; Lung epithelial cells; Ozone; Vesicular

Indexed keywords

ADENOSINE; ADENOSINE DEAMINASE; ADENOSINE TRIPHOSPHATE; APYRASE; BREFELDIN A; CIBACRON BLUE F3GA; NUCLEOTIDASE; OZONE; PURINE P2 RECEPTOR; PURINE P2Y RECEPTOR; SURAMIN; URIDINE TRIPHOSPHATE;

AIR POLLUTION; APOPTOSIS; ARTICLE; CELL DEATH; CELL PROTECTION; CELL SURVIVAL; EPITHELIUM CELL; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM; METABOLISM; PRIORITY JOURNAL; RESPIRATORY EPITHELIUM; SIGNAL TRANSDUCTION;

ADENOSINE; ADENOSINE TRIPHOSPHATE; ANIMALS; APOPTOSIS; APYRASE; BLOTTING, WESTERN; BREFELDIN A; BRONCHI; CELL LINE; CELL LINE, TUMOR; CELL SURVIVAL; DEOXYGLUCOSE; EGTAZIC ACID; EPITHELIAL CELLS; EXOCYTOSIS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GLUCOSE; HUMANS; HYDROLYSIS; LUNG; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MODELS, BIOLOGICAL; OZONE; PHOSPHORYLATION; PYROPHOSPHATASES; RATS; SIGNAL TRANSDUCTION; TIME FACTORS; TRACHEA;

EID: 20444499399     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2005.03.009     Document Type: Article

References (64)

1. P. Bodin, and G. Burnstock Purinergic signalling: ATP release Neurochem. Res. 26 2001 959 969
2. E.M. Schwiebert, and A. Zsembery Extracellular ATP as a signaling molecule for epithelial cells Biochim. Biophys. Acta 1615 2003 7 32
3. I. Novak ATP as a signaling molecule: the exocrine focus News Physiol. Sci. 18 2003 12 17
4. E. Gerasimovskaya, S. Ahmad, C.W. White, P.L. Jones, T.C. Carpenter, and K.R. Stenmark Extracellular ATP is an autocrine/paracrine regulator of hypoxia-induced adventitial fibroblast growth. Signaling through extracellular signal-regulated kinase-1/2 and the Egr-1 transcription factor J. Biol. Chem. 277 2002 44638 44650
5. T.K. Aalto, and K.O. Raivio Adenine nucleotide depletion from endothelial cells exposed to xanthine oxidase Am. J. Physiol. 259 1990 C883 C888
6. T.K. Aalto, and K.O. Raivio Mechanisms of adenine nucleotide depletion from endothelial cells exposed to reactive oxygen metabolites Free Radic. Biol. Med. 14 1993 177 183
7. T.K. Aalto, and K.O. Raivio Metabolism of extracellular nucleotides by human endothelial cells exposed to reactive oxygen metabolites Am. J. Physiol. 264 1993 C282 C286
8. S. Ahmad, A. Ahmad, M. Ghosh, C.C. Leslie, and C.W. White Extracellular ATP-mediated signaling for survival in hyperoxia-induced oxidative stress J. Biol. Chem. 279 2004 16317 16325
9. G.D. Thurston, and D.V. Bates Air pollution as an underappreciated cause of asthma symptoms JAMA 290 2003 1915 1916
10. C.H. Goss, S.A. Newsom, J.S. Schildcrout, L. Sheppard, and J.D. Kaufman Effect of ambient air pollution on pulmonary exacerbations and lung function in cystic fibrosis Am. J. Respir. Crit. Care Med. 169 2004 816 821
11. I.S. Mudway, and F.J. Kelly An investigation of inhaled ozone dose and the magnitude of airway inflammation in healthy adults Am. J. Respir. Crit. Care Med. 169 2004 1089 1095
12. C. Uhlson, K. Harrison, C.B. Allen, S. Ahmad, C.W. White, and R.C. Murphy Oxidized phospholipids derived from ozone-treated lung surfactant extract reduce macrophage and epithelial cell viability Chem. Res. Toxicol. 15 2002 896 906
13. L.J. Dobbs, and R.J. Mason Pulmonary alveolar type II cells isolated from rats. Release of phosphatidylcholine in response to beta-adrenergic stimulation J. Clin. Invest. 63 1979 378 387
14. J.M. Shannon, R.J. Mason, and S.D. Jennings Functional differentiation of alveolar type II epithelial cells in vitro: effects of cel shape, cell-matrix interactions and cell-cell interactions Biochim. Biophys. Acta 931 1987 143 156
15. L.G. Dobbs, M.C. Wlliams, and R. Gonzalez Monoclonal antibodies specific to apical surfaces of rat alveolar type I cells bind to surfaces of cultured, but not freshly isolated, type II cells Biochim. Biophys. Acta 970 1988 146 156
16. S.I. Danto, S.M. Zabski, and E.D. Crandall Reactivity of alveolar epithelial cells in primary culture with type I cell monoclonal antibodies Am. J. Respir. Cell. Mol. Biol. 6 1992 296 306
17. A.L. Cozens, M.J. Yezzi, K. Kunzelmann, T. Ohrui, L. Chin, K. Eng, W.E. Finkbeiner, J.H. Widdicombe, and D.C. Gruenert CFTR expression and chloride secretion in polarized immortal human bronchial epithelial cells Am. J. Respir. Cell. Mol. Biol. 6 1994 38 47
18. C.B. Allen An automated system for exposure of cultured cells and other materials to ozone Inhal. Toxicol. 15 2003 1039 1052
19. C.B. Allen, X.L. Guo, and C.W. White Changes in pulmonary expression of hexokinase and glucose transporter mRNAs in rats adapted to hyperoxia Am. J. Physiol. 274 1998 L320 L329
20. C.B. Allen, and C.W. White Glucose modulates cell death due to normobaric hyperoxia by maintaining cellular ATP Am. J. Physiol. 274 1998 L159 L164
21. S. Ahmad, A. Ahmad, E. Gerasimovskaya, K.R. Stenmark, C.B. Allen, and C.W. White Hypoxia protects human lung microvascular endothelial and epithelial-like cells against oxygen toxicity: role of phosphatidylinositol 3-kinase Am. J. Respir. Cell Mol. Biol. 28 2003 179 187
22. Ballinger, C. A.; Cueto, R.; Squadrito, G.; Coffin, J. F.; Velsor, L. W.; Pryor, W. A.; Postlethwait, E. M. Antioxidant-mediated augmentation of ozone-induced membrane oxidation. Free Radic. Biol. Med., in press.
23. T.J. Cheng, H.P. Kao, C.C. Chan, and W.P. Chang Effects of ozone on DNA single-strand breaks and 8-oxoguanine formation in A549 cells Environ. Res. 93 2003 279 284
24. P.R. Gardner, D.D. Nguyen, and C.W. White Aconitase is a sensitive and critical target of oxygen poisoning in cultured mammalian cells and in rat lungs Proc. Natl. Acad. USA 91 1994 12248 12252
25. J.D. Crapo, B.E. Barry, H.E. Foscue, and J. Shelburne Structural and biochemical changes in rat lungs occurring during exposures to lethal and adaptive doses of oxygen Am. Rev. Respir. Dis. 122 1980 123 143
26. S. Ahmad, C.W. White, L.Y. Chang, B.K. Schneider, and C.B. Allen Glutamine protects mitochondrial structure and function in oxygen toxicity Am. J. Physiol.: Lung Cell. Mol. Biol. 280 2001 L779 L791
27. 3-induced formation of bioactive lipids: estimated surface concentrations and lining layer effects Am. J. Physiol. 274 1998 L1006 L1016
28. G. Valacchi, E. Pagnin, A.M. Carbacho, E. Olano, P.A. Davis, L. Packer, and C.E. Cross In vivo ozone exposure induces oxidant/stress-related responses in murine lung and skin Free Radic. Biol. Med. 36 2004 673 681
29. A. Van der Vliet, C.A. O'Neil, J.P. Eiserich, and C.E. Cross Oxidative damage to extracellular fluids by ozone and possible protective effects of thiols Arch. Biochem. Biophys. 321 1995 43 50
30. M.K. Pulfer, C. Taube, E. Gelfand, and R.C. Murphy Ozone exposure in vivo and formation of biologically active oxysterols in the lung J. Pharmacol. Exp. Ther. 2004 Aug 17 Epub ahead of print
31. M.K. Pulfer, and R.C. Murphy Formation of biologically active oxysterols during ozonlysis of cholesterol present in lung surfactant J. Biol. Chem. 279 2004 26331 26338
32. J.M. Cheek, A.R. Buckpit, C. Li, B.K. Tarkington, and C.G. Plopper Ozone injury to alveolar epithelium in vitro does not reflect loss of antioxidant defenses Toxicol. Appl. Pharmacol. 112 1994 64 72
33. R.M. Kafoury, W.A. Pryor, G.L. Squadrito, M.G. Salgo, X. Zou, and M. Friedman Induction of inflammatory mediators in human airway epithelial cells by lipid ozonation products Am. J. Respir. Crit. Care Med. 160 1999 1934 1942
34. G.L. Squadrito, M.G. Salgo, F.R. Fronczek, and W.A. Pryor Synthesis of inflammatory signal transduction species formed during ozonation and/or peroxidation of tissue lipids Methods Enzymol. 319 2000 570 582
35. L.M. Connor, C.A. Ballinger, T.B. Albrecht, and E.M. Postlethwait Interfacial phospholipids inhibit ozone-reactive absorption-mediated cytotoxicity in vitro Am. J. Physiol.: Lung Cell. Mol. Physiol. 286 2004 L1169 L1178
36. W.A. Pryor, G.L. Squadrito, and M. Friedman The cascade mechanism to explain ozone toxicity: the role of lipid ozonation products Free Radic. Biol. Med. 19 1995 935 941
37. E.M. Postlethwait, J.P. Joad, D.M. Hyde, E.S. Schelegle, J.M. Bric, A.J. Weir, L.F. Putney, V.J. Wong, L.W. Velsor, and C.G. Plopper Three-dimensional mapping of ozone-induced acute cytotoxicity in tracheobronchial airways of isolated perfused rat lung Am. J. Respir. Cell Mol. Biol. 22 2000 191 199
38. S.F. Ferng Ozone-induced DNA single strand-breaks in guinea pig tracheobronchial epithelial cells in vivo Inhal. Toxicol. 14 2002 621 633
39. P.A. Bromberg, V. Ranga, and M.J. Stutts Effects of ozone on airway epithelial permeability and ion transport Res. Rep. Health Eff. Inst. 48 1991 1 22
40. E.R. Lazarowski, R. Tarran, B.R. Grubb, C.A. van Heusden, S. Okada, and R.C. Boucher Nucleotide release provides a mechanism for airway surface liquid homeostasis J. Biol. Chem. 279 2004 36855 36864
41. S. Diaz-Llera, Y. Gonzalez-Hernandez, E.A. Prieto-Gonzalez, and A. Azoy Genotoxic effect of ozone in human peripheral blood leukocytes Mutat. Res. 517 2002 13 20
42. E.W. Gabrielson, X.Y. Yu, and E.W. Spannhake Comparison of the toxic effects of hydrogen peroxide and ozone on cultured human bronchial epithelial cells Environ. Health Perspect. 102 1994 972 974
43. 2 and protects Sertoli cells against lipoperoxidation and cellular injury Free Radic. Res. 38 2004 37 47
44. D. Gatof, G. Kilic, and J.G. Fitz Vesicular exocytosis contributes to volume-sensitive ATP release in biliary cells Am. J. Physiol.: Gastrointest. Liver Physiol. 286 2004 G538 G546
45. R.D. Burgoyne, and M.J. Clague Calcium and calmodulin in membrane fusion Biochim. Biophys. Acta 1641 2003 137 143
46. D. Reigada, and C.H. Mitchell Release of ATP from RPE cells involves both CFTR and vesicular transport Am. J. Physiol.: Cell Physiol. Sept. 15 2004 Epub ahead of print
47. M. Hirakawa, M. Oike, Y. Karashima, and Y. Ito Sequential activation of RhoA and FAK/paxillin leads to ATP release and actin reorganization in human endothelium J. Physiol. 558 2004 479 488
48. T. van der Wijk, S.F. Tomassen, A.B. Houtsmuller, H.R. de Jonge, and B.C. Tilly Increased vesicle recycling in response to osmotic cell swelling. Cause and consequence of hypotonicity-provoked ATP release J. Biol. Chem. 278 2003 40020 40025
49. D.D. Dawicki, J. McGowan-Jordan, S. Bullard, S. Pond, and S. Rounds Extracellular nucleotides stimulate leukocyte adherence to cultured pulmonary artery endothelial cells Am. J. Physiol.: Lung Cell. Mol. Physiol. 268 1995 L666 L673
50. N.E. Chorna, L.I. Santiago-Perez, L. Erb, C.I. Seye, J.T. Neary, G.Y. Sun, G.A. Weisman, and F.A. Gonzales P2Y receptors activate neuroprotective mechanisms in astrocytic cells J. Neurochem. 91 2004 119 132
51. S. Buckley, B. Driscoll, L. Barsky, K. Weinberg, K. Anderson, and D. Warburton ERK activation protects against DNA damage and apoptosis in hyperoxic rat AEC2 Am. J. Physiol. 277 1999 L159 L166
52. J.T. Neary, M. McCarthy, Y. Kang, and S. Zuniga Mitogenic signaling from P1 and P2 purinergic receptors to mitogen-activated protein kinase in human fetal astrocyte cultures Neurosci. Lett. 242 1998 159 162
53. T. Markou, G. Vassort, and A. Lazou Regulation of MAPK pathways in response to purinergic stimulation of adult rat cardiac myocytes Mol. Cell. Biochem. 242 2003 163 171
54. P.A. Wilden, Y.M. Agazie, R. Kaufman, and S.M. Halenda ATP-stimulated smooth muscle cell proliferation requires independent ERK and PI3K signaling pathways Am. J. Physiol. 275 1998 H1209 H1215
55. Y. Tesfaigzi Processes involved in the repair of injured airway epithelia Arch. Immunol. Ther. Exp. (Warsz.) 51 2003 283 288
56. J.T. Neary, Y. Kang, K.A. Willoughby, and E.F. Ellis Activation of extracellular signal-regulated kinase by stretch-induced injury in astrocytes involves extracellular ATP and P2 purinergic receptors J. Neurosci. 23 2003 2348 2356
57. D. Communi, P. Paindavoine, G.A. Place, M. Parmentier, and J.M. Boeynaems Expression of P2Y receptors in cell lines derived from the human lung Br. J. Pharmacol. 127 1999 562 568
58. W.R. Rice, and F.M. Singleton P2Y-purinoceptor regulation of surfactant secretion from rat isolated alveolar type II cells is associated with mobilization of intrcellular calcium Br. J. Pharmacol. 91 1987 833 838
59. W.R. Rice, and F.M. Singleton Reactive blue 2 selectively inhibits P2Y-purinoceptor-stimulated surfactant phosopholipid secretion from rat isolated alveolar type II cells Br. J. Pharmacol. 97 1989 158 162
60. P.V. Usatyuk, and V. Natarajan Role of mitogen-activated protein kinases in 4-hydroxy-2-nonenal-induced actin remodeling and barrier function in endothelial cells J. Biol. Chem. 279 2004 11789 11797
61. A.H. Khan, and J.E. Pessin Insulin regulation of glucose uptake: a complex interplay of intracellular signalling pathways Diabetologia 45 2002 1475 1483
62. A. Huwiler, W. Rolz, S. Dorsch, S. Ren, and J. Pfeilschifter Extracellular ATP and UTP activate the protein kinase B/Akt cascade via the P2Y(2) purinoceptor in renal mesangial cells Br. J. Pharmacol. 136 2002 520 529
63. M.C. Jacques-Silva, R. Rodnight, G. Lenz, Z. Liao, Q. Kong, M. Tran, Y. Kang, F.A. Gonzalez, G.A. Weisman, and J.T. Neary P2X7 receptors stimulate AKT phosphorylation in astrocytes Br. J. Pharmacol. 141 2004 1106 1117
64. A. Muscella, M.G. Elia, S. Greco, C. Storelli, and S. Marsigliante Activation of P2Y2 receptor induces c-FOS protein through a pathway involving mitogen-activated protein kinases and phosphoinositide 3-kinases in HeLa cells J. Cell. Physiol. 195' 2003 234 240