Glutamine protects mitochondrial structure and function in oxygen toxicity

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 280, Issue 4 24-4, 2001, Pages

  Ahmad, Shama ^a   White, Carl W ^a,b   Chang, Ling Yi ^a   Schneider, Barbara K ^a   Allen, Corrie B ^a  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

^b NONE   (United States)

Author keywords

Adenosine 5 triphosphate; ke toglutarate dehydrogenase; Airway; Epithelium; Human; Mitochondrial membrane potential

Indexed keywords

ADENOSINE TRIPHOSPHATE; GLUTAMINE; GLUTATHIONE; OXOGLUTARATE DEHYDROGENASE; OXYGEN;

ARTICLE; CELL DAMAGE; CELL LINE; CELL PROLIFERATION; CELL PROTECTION; CELL STRUCTURE; CONTROLLED STUDY; DRUG MECHANISM; ELECTRON MICROSCOPY; EPITHELIUM CELL; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; HYPEROXIA; LUNG ALVEOLUS EPITHELIUM; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; OXYGEN CONSUMPTION; OXYGEN TOXICITY; PRIORITY JOURNAL;

EID: 0035024641     PISSN: 10400605     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajplung.2001.280.4.l779     Document Type: Article

References (54)

1. Abcouwer SF, Schwarz C, and Meguid RA. Glutamine deprivation induces the expression of GADD45 and GADD153 primarily by mRNA stabilization. J Biol Chem 274: 28645-28651, 1999.
2. Aksenov MY, Aksenova MV, Carney JM, and Butterfield DA. Oxidative modification of glutamine synthetase by amyloid beta peptide. Free Radic Res 27: 267-281, 1997.
3. Allen CB, Guo XL, and White CW. Changes in pulmonary expression of hexokinase and glucose transporter mRNAs in rats adapted to hyperoxia. Am J Physiol Lung Cell Mol Physiol 274: L320-L329, 1998.
4. Allen CB and White CW. Glucose modulates cell death due to normobaric hyperoxia by maintaining cellular ATP. Am J Physiol Lung Cell Mol Physiol 274: L159-L164, 1998.
5. Ames BN, Shigenaga MK, and Hagen TM. Mitochondrial decay in aging. Biochim Biophys Acta 1271: 165-170, 1995.
6. Amores-Sanchez MI and Medina MA. Glutamine, as a precursor of glutathione, and oxidative stress. Mol Genet Metab 67: 100-105, 1999.
7. Anderson ME. Determination of glutathione and glutathione disulfide in biological samples. Methods Enzymol 113: 548-555, 1985.
8. Balentine JD. Ultrastructural pathology of hyperbaric oxygenation in the central nervous system. Observations in anterior horn gray matter. Lab Invest 31: 580-592, 1974.
9. Bergmeyer HU. Methods of Enzymatic Analysis. New York: Academic, 1974, p. 1981-1987.
10. Buckley S, Driscoll B, Barsky L, Weinberg K, Anderson K, and Warburton D. ERK activation protects against DNA damage and apoptosis in hyperoxic rat AEC2. Am J Physiol Lung Cell Mol Physiol 277: L159-L166, 1999.
11. Collins CL, Wasa M, Souba WW, and Abcouwer SF. Determinants of glutamine dependence and utilization by normal and tumor-derived breast cell lines. J Cell Physiol 176: 166-178, 1998.
12. Crapo JD, Barry BE, Foscue HA, and Shelburne J. Structural and biochemical changes in rat lungs occurring during exposures to lethal and adaptive doses of oxygen. Am Rev Respir Dis 122: 123-143, 1980.
13. κB and elevation of MnSOD gene expression by thiol reducing agents in lung adenocarcinoma (A549) cells. Am J Physiol Lung Cell Mol Physiol 269: L588-L602, 1995.
14. Deneke SM and Fanburg BL. Regulation of cellular glutathione. Am J Physiol Lung Cell Mol Physiol 257: L163-L173, 1989.
15. Deneke SM, Steiger V, and Fanburg BL. Effect of hyperoxia on glutathione levels and glutamic acid uptake in endothelial cells. J Appl Physiol 63: 1966-1971, 1987.
16. Doverskog M, Ljunggren J, Ohman L, and Haggstrom L. Physiology of cultured animal cells. J Biotechnol 59: 103-115, 1997.
17. Esteve JM, Mompo J, Garcia de la Asuncion J, Sastre J, Asensi M, Boix J, Vina JR, Vina J, and Pallardo FV. Oxidative damage to mitochondrial DNA and glutathione oxidation in apoptosis: studies in vivo and in vitro. FASEB J 13: 1055-1064, 1999.
18. Freeman BA and Crapo JD. Hyperoxia increases oxygen radical production in rat lungs and lung mitochondria. J Biol Chem 256: 10986-10992, 1981.
19. Gardner PR, Nguyen DD, and White CW. Aconitase is a sensitive and critical target of oxygen poisoning in cultured mammalian cells and in rat lungs. Proc Natl Acad Sci USA 91: 12248-12252, 1994.
20. Gardner PR, Raineri I, Epstein LB, and White CW. Superoxide radical and iron modulate aconitase activity in mammalian cells. J Biol Chem 270: 13399-13405, 1995.
21. Gorman L, Mercer LP, and Hennig B. Growth requirements of endothelial cells in culture: variations in serum and amino acid concentrations. Nutrition 12: 266-270, 1996.
22. Harris JB, Chang LY, and Crapo JD. Rat lung alveolar type I epithelial cell injury and response to hyperoxia. Am J Respir Cell Mol Biol 4: 115-125, 1991.
23. Jobe AJ. The new BPD: an arrest of lung development. Pediatr Res 46: 641-643, 1999.
24. Joenje H, Gille JJ, Oostra AB, and Van der Valk P. Some characteristics of hyperoxia-adapted HeLa cells. A tissue culture model for cellular oxygen tolerance. Lab Invest 52: 420-428, 1985.
25. Kang YJ, Feng Y, and Hatcher EL. Glutathione stimulates A549 cell proliferation in glutamine-deficient culture: the effect of glutamate supplementation. J Cell Physiol 161: 589-596, 1994.
26. Komadina KH, Duncan CA, Bryan CL, and Jenkinson SG. Protection from hyperbaric oxidant stress by administration of buthionine sulfoximine. J Appl Physiol 71: 352-358, 1991.
27. Lelli JL Jr, Becks LL, Dabrowska MI, and Hinshaw DB. ATP converts necrosis to apoptosis in oxidant-injured endothelial cells. Free Radic Biol Med 25: 694-702, 1998.
28. Lemasters JJ, Qian T, Bradham CA, Brenner DA, Cascio WE, Trost LC, Nishimura Y, Nieminen AL, and Herman B. Mitochondrial dysfunction in the pathogenesis of necrotic and apoptotic cell death. J Bioenerg Biomembr 31: 305-319, 1999.
29. Linsinger G, Wilhelm S, Wagner H, and Hacker G. Uncouplers of oxidative phosphorylation can enhance a Fas death signal. Mol Cell Biol 19: 3299-3311, 1999.
30. Macho A, Decaudin D, Castedo M, Hirsch T, Susin SA, Zamzami N, and Kroemer G, Chloromethyl-X-rosamine is an aldehyde-fixable potential-sensitive fluorochrome for the detection of early apoptosis. Cytometry 25: 333-340, 1996.
31. Macho A, Hirsch T, Marzo I, Marchetti P, Dallaporta B, Susin SA, Zamzami N, and Kroemer G. Glutathione depletion is an early and calcium elevation is a late event of thymocyte apoptosis. J Immunol 158: 4612-4619, 1997.
32. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 4: 239-248, 1999.
33. Moore S and Stein WH. Chromatographic determination of amino acids by the use of automatic recording equipment. Methods Enzymol 6: 819-831, 1963.
34. Morgan DM. Tetrazolium (MTT) assay for cellular viability and activity. Methods Mol Biol 79: 179-183, 1998.
35. Morton RL, Ikle D, and White CW. Loss of lung mitochondrial aconitase activity due to hyperoxia in bronchopulmonary dysplasia in primates. Am J Physiol Lung Cell Mol Physiol 274: L127-L133, 1998.
36. Neermann J and Wagner R. Comparative analysis of glucose and glutamine metabolism in transformed mammalian cell lines, insect and primary liver cells. J Cell Physiol 166: 152-169, 1996.
37. Noronha-Dutra AA and Steen EM. Lipid peroxidation as a mechanism of injury in cardiac myocytes. Lab Invest 47: 346-353, 1982.
38. Pruijn FB, Schoonen WG, and Joenje H. Inactivation of mitochondrial metabolism by hyperoxia-induced oxidative stress. Ann NY Acad Sci 663: 453-455, 1992.
39. Rancourt RC, Staversky RJ, Keng PC, and O'Reilly MA. Hyperoxia inhibits proliferation of Mv1Lu epithelial cells independent of TGF-β signaling. Am J Physiol Lung Cell Mol Physiol 277: L1172-L1178, 1999.
40. Robinson J and Cooper JM. Method of determining oxygen concentrations in biological media, suitable for calibration of the oxygen electrode. Anal Biochem 33: 390-399, 1970.
41. Rosenbaum RM, Wittner M, and Lenger M. Mitochondrial and other ultrastructural changes in great alveolar cells of oxygen-adapted and poisoned rats. Lab Invest 20: 516-528, 1969.
42. Salotra PT and Singh VN. Regulation of glucose metabolism in the lung: hexokinase-catalyzed phosphorylation, a rate-limiting step. Life Sci 31: 791-794, 1982.
43. Sanfeliu A and Stephanopoulos G. Effect of glutamine limitation on the death of attached Chinese hamster ovary cells-Biotechnol Bioeng 64: 46-53, 1999.
44. Schoonen WG, Wanamarta AH, van der Klei-van Moorsel JM, Jakobs C, and Joenje H. Respiratory failure and stimulation of glycolysis in Chinese hamster ovary cells exposed to normobaric hyperoxia, J Biol Chem 265: 1118-1124, 1990.
45. Schoonen WG, Wanamarta AH, van der Klei-van Moorsel JM, Jakobs C, and Joenje H. Hyperoxia-induced clonogenic killing of HeLa cells associated with respiratory failure and selective inactivation of Krebs cycle enzymes. Mutat Res 237: 173-181, 1990.
46. Schoonen WG, Wanamarta AH, van der Klei-van Moorsel JM, Jakobs C, and Joenje H. Characterization of oxygen-resistant Chinese hamster ovary cells. III. Relative resistance of succinate and alpha-ketoglutarate dehydrogenases to hyperoxic inactivation. Free Radic Biol Med 10: 111-118, 1991.
47. Shenberger JS and Dixon PS. Oxygen induces S-phase growth arrest and increases p53 and p21(WAF1/CIP1) expression in human bronchial smooth-muscle cells. Am J Respir Cell Mol Biol 21: 395-402, 1999.
48. Souba WW, Herskowitz K, and Plumley DA. Lung glutamine metabolism. JPEN J Parenter Enterai Nutr 14, Suppl: 68S-70S, 1990.
49. Vander Heiden MG, Chandel NS, Williamson EK, Schumacker PT, and Thompson CB. Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria. Cell 91: 627-637, 1997.
50. Van der Valk P, Gille JJ, Oostra AB, Roubos EW, Sminia T, and Joenje H. Characterization of an oxygen-tolerant cell line derived from Chinese hamster ovary. Antioxygenic enzyme levels and ultrastructural morphometry of peroxisomes and mitochondria. Cell Tissue Res 239: 61-68, 1985.
51. Van der Valk P, Gille JJ, van der Plas LH, Jongkind JF, Verkerk A, Konings AW, and Joenje H. Characterization of oxygen-tolerant Chinese hamster ovary cells. II. Energy metabolism and antioxidant status. Free Radic Biol Med 4: 345-356, 1988.
52. Wallace DC, Shoffner JM, Trounce I, Brown MD, Ballinger SW, Corral-Debrinski M, Horton T, Jun AS, and Lott MT. Mitochondrial DNA mutations in human degenerative diseases and aging. Biochim Biophys Acta 1271: 141-151, 1995.
53. Wullner U, Seyfried J, Groscurth P, Beinroth S, Winter S, Gleichmann M, Heneka M, Loschmann P, Schulz JB, Weller M, and Klockgether T. Glutathione depletion and neuronal cell death: the role of reactive oxygen intermediates and mitochondrial function. Brain Res 826: 53-62, 1999.
54. Zielke HR, Zielke CL, and Ozand PT. Glutamine: a major energy source for cultured mammalian cells. Fed Proc 43: 121-125, 1984.