An investigation of inhaled ozone dose and the magnitude of airway inflammation in healthy adults

American Journal of Respiratory and Critical Care Medicine

Volumn 169, Issue 10, 2004, Pages 1089-1095

  Mudway, Ian S ^a   Kelly, Frank J ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

OZONE;

ADULT; BREATHING PATTERN; BRONCHOSCOPY; COMPARATIVE STUDY; CONCENTRATION RESPONSE; CONFIDENCE INTERVAL; DATA ANALYSIS; DISEASE ASSOCIATION; ENVIRONMENTAL EXPOSURE; EXERCISE; FEMALE; HUMAN; HUMAN EXPERIMENT; HUMIDIFIER; LUNG FUNCTION; LUNG LAVAGE; MALE; NEUTROPHIL; NEUTROPHILIA; NORMAL HUMAN; PRIORITY JOURNAL; REGRESSION ANALYSIS; RESPIRATORY FUNCTION; RESPIRATORY TRACT INFLAMMATION; REVIEW;

EID: 2442581585     PISSN: 00030805     EISSN: None     Source Type: Journal    
DOI: 10.1164/rccm.200309-1325pp     Document Type: Review

References (46)

1. Thurston GD, Ito K. Epidemiological studies of acute ozone exposures and mortality. J Expo Anal Environ Epidemiol 2001;11:286-294.
2. Kinney PL, Thurston GD, Raizenne M. The effects of ambient ozone on lung function in children: a reanalysis of six summer camp studies. Environ Health Perspect 1996;104:170-174.
3. Romieu I, Meneses F, Ramirez M, Ruiz S, Perez Padilla R, Sienra JJ, Gerber M, Grievink L, Dekker R, Waida I, et al. Antioxidant supplementation and respiratory functions among workers exposed to high levels of ozone. Am J Respir Crit Care Med 1998;158:226-232.
4. Peters JM, Avol E, Gauderman WJ, Linn WS, Navidi W, London SJ, Margolis H, Rappaport E, Vora H, Gong H Jr, et al. A study of twelve Southern California communities with differing levels and types of air pollution. II: effects on pulmonary function. Am J Respir Crit Care Med 1999;159:768-775.
5. Kinney PL, Nilsen DM, Lippmann M, Brescia M, Gordon T, McGovern T, El-Fawal H, Devlin RB, Rom WN. Biomarkers of lung inflammation in recreational joggers exposed to ozone. Am J Respir Crit Care Med 1996;154:1430-1435.
6. Broeckaert F, Arsalane K, Hermans C, Bergamaschi E, Brustolin A, Mutti A, Bernard A. Lung epithelial damage at low concentrations of ambient ozone. Lancet 1999;353:900-901.
7. Thurston GD, Ito K, Kinney PL, Lippmann M. A multi-year study of air pollution and respiratory hospital admissions in three New York State metropolitan areas: results for 1988 and 1989 summers. J Expo Anal Environ Epidemiol 1992;2:429-450.
8. Thurston GD, Ito K, Hayes CG, Bates DV, Lippmann M. Respiratory hospital admissions and summertime haze air pollution in Toronto, Ontario: consideration of the role of acid aerosols. Environ Res 1994;65:271-290.
9. Mustafa MG. Biochemical basis of ozone toxicity. Free Radic Biol Med 1990;9:245-265.
10. Committee of the Environmental and Occupational Health Assembly of the American Thoracic Society. Health effects of outdoor air pollution. Am J Respir Crit Care Med 1996;153:3-50.
11. Devlin RB, McDonnell WF, Mann R, Becker S, House DE, Schreinemachers D, Koren HS. Exposure of humans to ambient levels of ozone for 6.6 hours causes cellular and biochemical changes in the lung. Am J Respir Cell Mol Biol 1991;4:72-81.
12. McDonnell WF, Horstman DH, Hazucha MJ, Seal E Jr, Haak ED, Salaam SA, House DE. Pulmonary effects of ozone exposure during exercise: dose-response characteristics. J Appl Physiol 1983;54:1345-1352.
13. McDonnell WF, Stewart PW, Andreoni S, Seal E Jr, Kehrl HR, Horstman DH, Folinsbee LJ, Smith MV. Prediction of ozone-induced FEV1 changes: effects of concentration, duration, and ventilation. Am J Respir Crit Care Med 1997;156:715-722.
14. McDonnell WF, Stewart PW, Smith MV, Pan WK, Pan J. Ozone-induced respiratory symptoms: exposure-response models and association with lung function. Eur Respir J 1999;14:845-853.
15. Blomberg A, Mudway IS, Nordenhall C, Hedenstrom H, Kelly FJ, Frew AJ, Holgate ST, Sandstrom T. Ozone-induced lung function decrements do not correlate with early airway inflammatory or antioxidant responses. Eur Respir J 1999;13:1418-1428.
16. Mudway IS, Kelly FJ. Identification of the inflammatory threshold of ozone (O3) in healthy adults . Exp Lung Res 2003;29:425-427.
17. Balmes JR, Aris RM, Chen LL, Scannell C, Tager IB, Finkbeiner W, Christian D, Kelly T, Hearne PQ, Ferrando R, et al. Effects of ozone on normal and potentially sensitive human subjects. Part I: airway inflammation and responsiveness to ozone in normal and asthmatic subjects. Res Rep Health Eff Inst 1997;78:1-37.
18. Balmes JR, Chen LL, Scannell C, Tager I, Christian D, Hearne PQ, Kelly T, Aris RM. Ozone-induced decrements in FEV1 and FVC do not correlate with measures of inflammation. Am J Respir Crit Care Med 1996;153:904-909.
19. Torres A, Utell MJ, Morow PE, Voter KZ, Whitin JC, Cox C, Looney RJ, Speers DM, Tsai Y, Frampton MW. Airway inflammation in smokers and nonsmokers with varying responsiveness to ozone. Am J Respir Crit Care Med 1997;156:728-736.
20. Basha MA, Gross KB, Gwizdala CJ, Haidar AH, Popovich J Jr. Bronchoalveolar lavage neutrophilia in asthmatic and healthy volunteers after controlled exposure to ozone and filtered purified air. Chest 1994;106:1757-1765.
21. Mudway IS, Stenfors N, Blomberg A, Helleday R, Dunster C, Marklund SL, Frew AJ, Sandstrom T, Kelly FJ. Differences in basal airway antioxidant concentrations are not predictive of individual responsiveness to ozone: a comparison of healthy and mild asthmatic subjects. Free Radic Biol Med 2001;31:962-974.
22. Samet JM, Hatch GE, Horstman D, Steck-Scott S, Arab L, Bromberg PA, Levine M, McDonnell WF, Devlin RB. Effect of antioxidant supplementation on ozone-induced lung injury in human subjects. Am J Respir Crit Care Med 2001;164:819-825.
23. Krishna MT, Madden J, Teran LM, Biscione GL, Lau LC, Withers NJ, Sandstrom T, Mudway I, Kelly FJ, Walls A, et al. Effects of 0.2 ppm ozone on biomarkers of inflammation in bronchoalveolar lavage fluid and bronchial mucosa of healthy subjects. Eur Respir J 1998;11:1294-1300.
24. Schelegle ES, Siefkin AD, McDonald RJ. Time course of ozone-induced neutrophilia in normal humans. Am Rev Respir Dis 1991;143:1353-1358.
25. Jorres RA, Holz O, Zachgo W, Timm P, Koschyk S, Muller B, Grimminger F, Seeger W, Kelly FJ, Dunster C, et al. The effect of repeated ozone exposures on inflammatory markers in bronchoalveolar lavage fluid and mucosal biopsies. Am J Respir Crit Care Med 2000;161:1855-1861.
26. Seltzer J, Bigby BG, Stulbarg M, Holtzman MJ, Nadel JA, Ueki IF, Leikauf GD, Goetzl EJ, Boushey HA. O3-induced change in bronchial reactivity to methacholine and airway inflammation in humans. J Appl Physiol 1986;60:1321-1326.
27. Coffey MJ, Wheeler CS, Gross KB, Eschenbacher WL, Sporn PH, Peters-Golden M. Increased 5-lipoxygenase metabolism in the lungs of human subjects exposed to ozone. Toxicology 1996;114:187-197.
28. Hazbun ME, Hamilton R, Holian A, Eschenbacher WL. Ozone-induced increases in substance P and 8-epi-prostaglandin F2 alpha in the airways of human subjects. Am J Respir Cell Mol Biol 1993;9:568-572.
29. Silverman F, Folinsbee LJ, Barnard J, Shephard RJ. Pulmonary function changes in ozone-interaction of concentration and ventilation. J Appl Physiol 1976;41:859-864.
30. Hazucha MJ. Relationship between ozone exposure and pulmonary function changes. J Appl Physiol 1987;62:1671-1680.
31. Hazucha MJ, Folinsbee LJ, Seal E. Effects of steady-state and variable ozone concentration profiles on pulmonary function. Am Rev Respir Dis 1992;146:1487-1493.
32. Koren HS, Devlin RB, Graham DE, Mann R, McGee MP, Horstman DH, Kozumbo WJ, Becker S, House DE, McDonnell WF, et al. Ozone-induced inflammation in the lower airways of human subjects. Am Rev Respir Dis 1989;139:407-415.
33. Hatch GE, Slade R, Harris LP, McDonnell WF, Devlin RB, Koren HS, Costa DL, McKee J. Ozone dose and effect in humans and rats: a comparison using oxygen-18 labeling and bronchoalveolar lavage. Am J Respir Crit Care Med 1994;150:676-683.
34. Christian DL, Chen LL, Scannell CH, Ferrando RE, Welch BS, Balmes JR. Ozone-induced inflammation is attenuated with multiday exposure. Am J Respir Crit Care Med 1998;158:532-537.
35. Weinmann GG, Liu MC, Proud D, Weidenbach-Gerbase M, Hubbard W, Frank R. Ozone exposure in humans: inflammatory, small and peripheral airway responses. Am J Respir Crit Care Med 1995;152: 1175-1182.
36. Aris RM, Christian D, Hearne PQ, Kerr K, Finkbeiner WE, Balmes JR. Ozone-induced airway inflammation in human subjects as determined by airway lavage and biopsy. Am Rev Respir Dis 1993;148:1363-1372.
37. Devlin RB, McDonnell WF, Becker S, Madden MC, McGee MP, Perez R, Hatch G, House DE, Koren HS. Time-dependent changes of inflammatory mediators in the lungs of humans exposed to 0.4 ppm ozone for 2 hr: a comparison of mediators found in bronchoalveolar lavage fluid 1 and 18 hr after exposure. Toxicol Appl Pharmacol 1996;138:176-185.
38. Koren HS, Devlin RB, Becker S, Perez R, McDonnell WF. Time-dependent changes of markers associated with inflammation in the lungs of humans exposed to ambient levels of ozone. Toxicol Pathol 1991; 19:406-411.
39. Stenfors N, Pourazar J, Blomberg A, Krishna MT, Mudway I, Helleday R, Kelly FJ, Frew AJ, Sandstrom T. Effect of ozone on bronchial mucosal inflammation in asthmatic and healthy subjects. Respir Med 2002;96:352-358.
40. McConnell R, Berhane K, Gilliland F, London SJ, Islam T, Gauderman WJ, Avol E, Margolis HG, Peters JM. Asthma in exercising children exposed to ozone: a cohort study. Lancet 2002;359:386-391.
41. Schwartz J. Lung function and chronic exposure to air pollution: a cross-sectional analysis of NHANES II. Environ Res 1989;50:309-321.
42. Schelegle ES, Miller LA, Gershwin LJ, Fanucchi MV, Van Winkle LS, Gerriets JE, Walby WF, Mitchell V, Tarkington BK, Wong VJ, et al. Repeated episodes of ozone inhalation amplifies the effects of allergen sensitization and inhalation on airway immune and structural development in Rhesus monkeys. Toxicol Appl Pharmacol 2003;191:74-85.
43. Holz O, Jorres RA, Timm P, Mucke M, Richter K, Koschyk S, Magnussen H. Ozone-induced airway inflammatory changes differ between individuals and are reproducible. Am J Respir Crit Care Med 1999;159: 776-784.
44. Nightingale JA, Rogers DF, Barnes PJ. Effect of inhaled ozone on exhaled nitric oxide, pulmonary function, and induced sputum in normal and asthmatic subjects. Thorax 1999;54:1061-1069.
45. Hiltermann JT, Lapperre TS, van Bree L, Steerenberg PA, Brahim JJ, Sont JK, Sterk PJ, Hiemstra PS, Stolk J. Ozone-induced inflammation assessed in sputum and bronchial lavage fluid from asthmatics: a new noninvasive tool in epidemiologic studies on air pollution and asthma. Free Radic Biol Med 1999;27:1448-1454.
46. Krishna MT, Blomberg A, Biscione GL, Kelly F, Sandstrom T, Frew A, Holgate S. Short-term ozone exposure upregulates P-selectin in normal human airways. Am J Respir Crit Care Med 1997;155:1798-1803.