The expression of selected non-ribosomal peptide synthetases in Aspergillus fumigatus is controlled by the availability of free iron

FEMS Microbiology Letters

Volumn 248, Issue 1, 2005, Pages 83-91

  Reiber, Kathrin ^a   Reeves, Emer P ^a   Neville, Claire M ^a   Winkler, Robert ^a,b   Gebhardt, Peter ^a,b   Kavanagh, Kevin ^a   Doyle, Sean ^a  

^a NATIONAL UNIVERSITY OF IRELAND   (Ireland)

^b HANS KNÖLL INSTITUTE   (Germany)

Author keywords

4 PPTase; Iron; MALDI ToF; NRPS; Proteomics; Secondary metabolites; Siderophore

Indexed keywords

FUNGAL PROTEIN; IRON; PEPTIDE SYNTHASE; SIDEROPHORE;

ARTICLE; ASPERGILLUS FUMIGATUS; CONTROLLED STUDY; CULTURE MEDIUM; FUNGAL GENE; FUNGAL METABOLISM; FUNGUS CULTURE; GENE EXPRESSION; GENE IDENTIFICATION; IRON DEPLETION; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MYCELIUM; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIDC GENE; SIDD GENE; SIDE GENE;

ASPERGILLUS FUMIGATUS; IRON; PEPTIDE SYNTHASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIDEROPHORES; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

ASPERGILLUS FUMIGATUS; FUNGI;

EID: 20444435018     PISSN: 03781097     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.femsle.2005.05.028     Document Type: Article

References (34)

1. D.P. Kontoyiannis, and G.P. Bodey Invasive aspergillosis in 2002: an update Eur. J. Clin. Microbiol. Infect. Dis. 21 2002 161 172
2. J.E. Mabey, M.J. Anderson, P.F. Giles, C.J. Miller, T.K. Attwood, N.W. Paton, E. Bornberg-Bauer, G.D. Robson, S.G. Oliver, and D.W. Denning CADRE: the Central Aspergillus Data REpository Nucleic Acids Res. 32 2004 401 405
3. M. Schrettl, E. Bignell, C. Kragl, C. Joechl, T. Rogers, H.N. Arst Jr., K. Haynes, and H. Haas Siderophore biosynthesis but not reductive iron assimilation is essential for Aspergillus fumigatus virulence J. Exp. Med. 200 2004 1213 1219
4. B. Liebmann, M. Muller, A. Braun, and A.A. Brakhage The cyclic AMP-dependent protein kinase a network regulates development and virulence in Aspergillus fumigatus Infect. Immun. 72 2004 5193 5203
5. R. Bhabhra, M.D. Miley, E. Mylonakis, D. Boettner, J. Fortwendel, J.C. Panepinto, M. Postow, J.C. Rhodes, and D.S. Askew Disruption of the Aspergillus fumigatus gene encoding nucleolar protein CgrA impairs thermotolerant growth and reduces virulence Infect. Immun. 72 2004 4731 4740
6. A.H.T. Hissen, J.M.T. Chow, L.J. Pinto, and M.M. Moore Survival of Aspergillus fumigatus in serum involves removal of iron from transferrin: the role of siderophores Infect. Immun. 72 2004 1402 1408
7. D.H. Howard Acquistion, transport, and storage of iron by pathogenic fungi Clin. Microbiol. Rev. 12 1999 394 404
8. H.J. Plattner, and H. Diekmann Enzymology of siderophore biosynthesis in fungi G. Winkelmann D.R. Winge Metal Ions in Fungi 1994 Decker New York 99 117
9. M. Eisendle, H. Oberegger, I. Zadra, and H. Haas The siderophore system is essential for viability of Aspergillus nidulans: functional analysis of two genes encoding 1-ornithine N 5-monooxygenase (sidA) and a non-ribosomal peptide synthetase (sidC) Mol. Microbiol. 49 2003 359 375
10. F. Lipmann Non-ribosomal polypeptide synthesis Acta Endocrinol. Suppl. (Copenh) 180 1973 294 300
11. H. Kleinkauf, and H. von Döhren Nonribosomal biosynthesis of peptide antibiotics Eur. J. Biochem. 192 1990 1 15
12. T.A. Keating, and C.T. Walsh Initiation, elongation and termination strategies in polyketide and polypeptide antibiotic biosynthesis Curr. Opin. Chem. Biol. 3 1999 598 606
13. D.E. Cane A special thematic issue on polyketide and nonribosomal polypeptide biosynthesis Chem. Rev. 97 1997 2463 2706
14. H. Haas Molecular genetics of fungal siderophore biosynthesis and uptake: the role of siderophores in iron uptake and storage Appl. Microbiol. Biotechnol. 62 2003 316 330
15. B. Mei, A.D. Budde, and S.A. Leong sid1, a gene initiating siderophore biosynthesis in Ustilago maydis: molecular characterisation, regulation by iron, and role in phytopathogenicity Proc. Natl. Acad. Sci. USA 90 1993 903 907
16. W.M. Yuan, G.D. Gentil, A.D. Budde, and S.A. Leong Characterization of the Ustilago maydis sid2 gene, encoding a multidomain peptide synthetase in the ferrichrome biosynthetic gene cluster J. Bacteriol. 183 2001 4040 4051
17. C.M. Neville, A. Murphy, K. Kavanagh, and S. Doyle A 4′- phosphopantetheinyl transferase mediates non-ribosomal peptide synthetase activation in Aspergillus fumigatus ChemBioChem 6 2005 679 685
18. B. Schwyn, and J.B. Neilands Universal chemical assay for the detection and determination of siderophores Anal. Biochem. 160 1987 47 56
19. A.M. Milagres, A. Machuca, and D. Napoleaco Detection of siderophore production from several fungi and bacteria by a modification of chrome azurol S (CAS) agar plate assay J. Microbiol. Meth. 37 1999 1 6
20. C. Burns, R. Geraghty, C. Neville, A. Murphy, K. Kavanagh, and S. Doyle Identification, cloning and functional expression of three glutathione transferase genes from Aspergillus fumigatus Fungal Genet. Biol. 42 2005 319 327
21. B. Romero, G. Turner, I. Olivas, F. Laborda, and J.R. De Lucas The Aspergillus nidulans alcA promoter drives tightly regulated conditional gene expression in Aspergillus fumigatus permitting validation of essential genes in this human pathogen Fungal Genet. Biol. 40 2003 103 114
22. L.M. Machesky, E. Reeves, F. Wientjes, F.J. Mattheyse, A. Grogan, N.F. Totty, A.L. Burlingame, J.J. Hsuan, and A.W. Segal Mammalian actin-related protein 2/3 complex localizes to regions of lamellipodial protrusion and is composed of evolutionarily conserved proteins Biochem. J. 15 1997 105 112
23. M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal. Biochem. 72 1976 248 254
24. U.K. Laemmli Cleavage of structural proteins during the assembly of the head of bacteriophage T4 Nature 227 1970 680 685
25. D. Suckau, A. Resemann, M. Schuerenberg, P. Hufnagel, J. Franzen, and A. Holle A novel MALDI LIFT-ToF/ToF mass spectrometer for proteomics Anal. Bioanal. Chem. 376 2003 952 965
26. H. von Döhren, R. Dickmann, and M. Pavela-Vrancic The nonribosomal code Chem. Biol. 6 1999 273 279
27. T. Stachelhaus, H.D. Mootz, and M.A. Marahiel The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases Chem. Biol. 6 1999 493 505
28. G.L. Challis, J. Ravel, and C.A Townsend Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains Chem. Biol. 7 2000 211 224
29. R.S. Gokhale, and C. Khosla Role of linkers in communication between protein modules Curr. Opin. Chem. Biol. 4 2000 22 27
30. K. Reiber, T. Neuhof, J.H. Ozegowski, H. von Dohren, and T. Schwecke A nonribosomal peptide synthetase involved in the biosynthesis of ampullosporins in Sepedonium ampullosporum J. Pept. Sci. 9 2003 701 713
31. T. Correia, N. Grammel, I. Ortel, U. Keller, and P. Tudzynski Molecular cloning and analysis of the ergopeptine assembly system in the ergot fungus Claviceps purpurea Chem. Biol. 10 2003 1281 1292
32. A.M. Nilius, and S.G. Farmer Identification of extracellular siderophores of pathogenic strains of Aspergillus fumigatus J. Med. Vet. Mycol. 28 1990 395 403
33. H. Oberegger, M. Schoeser, I. Zadra, B. Abt, and H. Haas SREA is involved in regulation of siderophore biosynthesis, utilization and uptake in Aspergillus nidulans Mol. Microbiol. 41 2001 1077 1089
34. J.J. La Clair, T.L. Foley, T.R. Schegg, C.M. Regan, and M.D. Burkart Manipulation of carrier proteins in antibiotic biosynthesis Chem. Biol. 11 2004 195 201