Acquisition, transport, and storage of iron by pathogenic fungi

Clinical Microbiology Reviews

Volumn 12, Issue 3, 1999, Pages 394-404

  Howard, Dexter H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXAMIC ACID; IRON; OXIDOREDUCTASE; POLYPHOSPHATE; SIDEROPHORE;

ARTICLE; CANDIDA ALBICANS; CRYPTOCOCCUS NEOFORMANS; GEOTRICHUM CANDIDUM; IRON METABOLISM; IRON STORAGE; IRON TRANSPORT; NONHUMAN; SACCHAROMYCES CEREVISIAE; TRANSPORT KINETICS;

CANDIDA ALBICANS; FILOBASIDIELLA NEOFORMANS; FUNGI; GALACTOMYCES GEOTRICHUM; GEOTRICHUM; SACCHAROMYCES CEREVISIAE;

EID: 0032808171     PISSN: 08938512     EISSN: None     Source Type: Journal    
DOI: 10.1128/cmr.12.3.394     Document Type: Article

References (104)

1. Adjimani, J. P., and E. Owusu. 1997. Nonenzymatic NADH/FMN-dependent reduction of ferric siderophores. J. Inorg. Biochem. 66:247-252.
2. An, Z., B. Mei, W. M. Yuan, and S. A. Leong. 1997. The distal GATA sequences of the sid1 promoter of Ustilago maydis mediate iron repression of siderophore production and interact directly with Urbs1, a GATA family transcription factor. EMBO J. 16:1742-1750.
3. An, Z., Q. Zhao, J. McEvoy, W. M. Yuan, J. L. Markley, and S. A. Leong. 1997. The second finger of Urbs1 is required for iron-mediated repression of sid1 in Ustilago maydis. Proc. Natl. Acad. Sci. USA 94:5882-5887.
4. Ardon, O., R. Nudelman, C. Caris, J. Libman, A. Shanzer, Y. Chen, and Y. Hadar. 1998. Iron uptake in Ustilago maydis: tracking the iron path. J. Bacteriol. 180:2021-2026.
5. Ardon, O., H. Weizman, J. Libman, A. Shanzer, Y. Chen, and Y. Hadar. 1997. Iron uptake in Ustilago maydis: studies with fluorescent ferrichrome analogues. Microbiology 143:3625-3631.
6. Barash, I., G. Pupkin, D. Netzer, and Y. Kashman. 1982. A novel enolic β-ketoaldehyde phytotoxin produced by Stemphylium botryosum f. sp. lycopersici. Plant Physiol. 69:23-27.
7. Barash, I., S. Dori, H. Mor, and S. Manulis. 1993. Role of iron in fungal phytopathologies, p. 251-267. In Iron chelation in plants and soil microorganisms. Academic Press, Inc., New York, N.Y.
8. Bentley, M. D., R. J. Anderegg, P. J. Szaniszlo, and R. F. Davenport. 1986. Isolation and identification of the principal siderophore of the dermatophyte Microsporum gypseum. Biochemistry 25:1455-1457.
9. Boelaert, J. R., M. de Locht, J. Van Cutsem, V. Kerrels, B. Cantinieaux, A. Verdonck, H. W. Van Landuty, and Y.-J. Schneider. 1993. Mucormycosis during deferoxamine therapy is a siderophore-mediated infection. J. Clin. Investig. 91:1979-1986.
10. Böhnke, R., and B. F. Matzanke. 1395. The mobile ferrous iron pool in Escherichia coli is bound to a phosphorylated sugar derivative. BioMetals 8:223-230.
11. Burnham, B. F., and J. B. Neilands. 1961. Studies on the metabolic function of the ferrichrome compounds. J. Biol. Chem. 236:554-559.
12. Burt, W. R. 1982. Identification of ccprogen B and its breakdown products from Histoplasma capsulatum. Infect. Immun. 35:990-996.
13. Burt, W. R. 1983. Isolation of hydroxamic acids from Blastomyces dermatitidis, abstr. F17, p. 385. In Abstracts of the Annual Meeting of the American Society for Microbiology 1983. American Society for Microbiology, Washington, D.C.
14. Byers, B. R., and J. E. L. Arceneaux 1998. Microbial iron transport: iron acquisition by pathogenic microorganisms. Metal Ions Biol. Syst. 35:37-66.
15. Caldwell, C. W., and R. F. Sprouse. 1982. Iron and host resistance in histoplasmosis. Am. Rev. Respir. Dis. 125:674-677.
16. Carrano, C. J., and K. N. Raymond. 1978. Coordination chemistry of microbial iron transport compounds: rhodotorulic acid and iron uptake in Rhodotorula pilimanae. J. Bacteriol. 136:69-74.
17. Carrano, C. J., R. Böhnke, and B. F. Matzanke. 1996. Fungal ferritins: the ferritin from mycelia of Absidia spinosa is a bacterioferritin. FEBS Lett. 390:261-264.
18. Casanova, M., A. M. Cervera, D. Gozalbo, and P. Martinez. 1997. Hemin induces germ tube formation in Candida albicans. Infect. Immun. 65:4360-4364.
19. Castaneda, E., E. Brummer, A. M. Perlman, J. G. McEwen, and D. A. Stevens. 1988. A culture medium for Paracoccidioides brasiliensis with high plating efficiency, and the effect of siderophores. J. Med. Vet. Mycol. 26: 351-358.
20. Charlang, G., B. Ng, N. H. Horowitz, and R. M. Horowitz. 1981. Cellular and extracellular siderophores of Aspergillus nidulans and Penicillium chrysogenum. Mol. Cell. Biol. 1:94-100.
21. Chung, T. D. Y., B. F. Matzanke, G. Winkelmann, and K. N. Raymond. 1986. Inhibitory effect of the partially resolved coordination isomers of chromic desferricoprogen on coprogen uptake in Neurospora crassa. J. Bacteriol. 165:283-287.
22. Coulanges, V., P. Andere, O. Ziegler, L. Buchheit, and D. J.-M. Vidon. 1997. Utilization of iron-catecholamine complexes involving ferric reductase activity in Listeria monocytogenes. Infect. Immun. 65:2778-2785.
23. Cox, C. D. 1994. Deferration of laboratory media and assays for ferric and ferrous iron. Methods Enzymol. 235:315-329.
24. Crosa, J. H. 1997. Signal transduction and transcriptional and posttranscriptional control of iron-regulated genes in bacteria. Microbiol. Mol. Biol. Rev. 61:319-336.
25. Cutler, J. E., and Y. Han. 1996. Fungal factors implicated in pathogenesis, p. 3-29. In K. Esser and P. A. Lemke (ed.), The Mycota, vol. VI. Human and animal relationships. Springer-Verlag KG, Berlin, Germany.
26. de Hoog, G. S., F. D. Marvin-Sikkema, G. A. Lahpoor, J. G. Gottschall, R. A. Prins, and E. Guého. 1994. Ecology and physiology of the emerging opportunistic fungi Pseudallescheria boydii and Scedosporium prolificans. Mycoses 37:71-78.
27. Drechsel, H., A. Thieken, R. Reissbrodt, G. Jung, and G. Winkelmann. 1993. α ketoacids are novel siderophores in the genera Proteus, Providencia, and Morganella and are produced by amino acid diaminases. J. Bacteriol. 175:2727-2733.
28. Eide, D., and M. L. Guerinot. 1997. Metal ion uptake in eukaryotes. ASM News 63:199-205.
29. Fekete, F. A. 1993. Assays for microbial siderophores, p. 399-417. In Iron chelation in plants and soil microorganisms. Academic Press, Inc., New York, N.Y.
30. Fekete, F. A., V. Chandhoke, and J. Jellison. 1989. Iron-binding compounds produced by wood-decaying basidiomycetes. Appl. Environ. Microbiol. 55: 2720-2722.
31. Fekete, F. A., J. T. Spence, and T. Emery. 1983. A rapid and sensitive paper electrophoresis assay for detection of microbial siderophores elicited in solid-plating culture. Anal. Biochem. 131:516-519.
32. Fleischmann, J., and R. I. Lehrer. 1985. Phagocytic mechanisms in host response, p. 123-149. In D. H. Howard (ed.), Fungi pathogenic for humans and animals. B. Pathogenicity and detection: II. Marcel Dekker, Inc., New York, N.Y.
33. Frederick, C. B., P. J. Szaniszlo, P. E. Vickrey, M. D. Bentley, and W. Shive. 1981. Production and isolation of siderophores from the soil fungus Epicoccum purpurescens. Biochemistry 20:2432-2436.
34. Garcia-del Portillo, F., J. W. Foster, M. E. Maguire, and B. B. Finlay. 1992. Characterization of the micro-environment of Salmonella typhimurium-containing vacuoles within MDCK epithelial cells. Mol. Microbiol. 6:3289-3297.
35. Gobin, J., C. H. Moore, J. R. Reeve, Jr., D. K. Wong, B. W. Gibson, and M. A. Horwitz. 1995. Iron acquisition by Mycobacterium tuberculosis: isolation and characterization of a family of iron-binding exochelins. Proc. Natl. Acad. Sci. USA 92:5189-5193.
36. Griffiths, E., and J. Humphreys. 1980. Isolation of enterochelin from the peritoneal washings of guinea pigs lethally infected with Escherichia coli. Infect. Immun. 28:286-289.
37. Guerinot, M. L. 1994. Microbial iron transport. Annu. Rev. Microbiol. 48:743-772.
38. Haas, B., J. Kraut, J. Marks, S. C. Zanker, and D. Castignetti. 1991. Siderophore presence in sputa of cystic fibrosis patients. Infect. Immun. 59:3997-4000.
39. Höfte, M. 1993. Classes of microbial siderophores, p. 3-26. In L. L. Barton (ed.), Iron chelation in plants and soil microorganisms. Academic Press, Inc., New York, N.Y.
40. Holzberg, M., and W. M. Artis. 1983. Hydroxamate siderophore production by opportunistic and systemic fungal pathogens. Infect. Immun. 40:1134-1139.
41. Howard, D. H. 1981. Mechanisms of resistance in the systemic mycoses, p. 475-494. In A. J. Nahmias and R. J. O'Reilly (ed.), Immunology of human infection. Plenum Press, New York, N.Y.
42. Ismail, A., G. W. Bedell, and D. M. Lupan. 1985. Siderophore production by the pathogenic yeast, Candida albicans. Biochem. Biophys. Res. Commun. 130:885-891.
43. Jacobson, E. S., and M. J. Petro. 1987. Extracellular iron chelation in Cryptococcus neoformans. J. Med. Vet. Mycol. 25:415-418.
44. Jacobson, E. S., A. P. Goodner, and K. J. Nyhus. 1998. Ferrous iron uptake in Cryptococcus neoformans. Infect. Immun. 66:4169-4175.
45. Jalal, M. A. F., and D. van der Helm. 1991. Isolation and spectroscopic identification of fungal siderophores, p. 235-269. In G. Winkelmann (ed.), Handbook of microbial iron chelates. CRC Press, Inc., Boca Raton, Fla.
46. Jellison, J., and B. Goodell. 1988. Immunological detection of decay in wood. Wood Sci. Technol. 22:293-297.
47. Jellison, J., and B. Goodell. 1989. Inhibitory effects of undecayed wood and the detection of Postia placenta using the enzyme-linked immunosorbent assay. Wood Sci. Technol. 23:13-20.
48. Jellison, J., V. Chandhoke, B. Goodell, and F. A. Fekete. 1991. The isolation and immunolocalization of iron-binding compounds produced by Gloeophyllum trabeum. Appl. Biotechnol. Microbiol. 35:805-809.
49. Kaplan, J., and T. V. O'Halloran. 1996. Iron metabolism in eukaryotes: Mars and Venus at it again. Science 271:1510-1512.
50. Kosman, D. J. 1994. Transition metal ion uptake in yeasts and filamentous fungi, p. 1-38. In G. Winkelmann and D. R. Winge (ed.), Metal ions in fungi, vol. 11. Marcel Dekker, Inc., New York, N.Y.
51. Kwon-Chung, K. J., and J. E. Bennett. 1992. Medical mycology. Lea & Febiger, Philadelphia, Pa.
52. Labbe-Bois, R., and J.-M. Camadro. 1994. Ferrochelatase in Saccharomyces cerevisiae, p. 413-453. In G. Winkelmann and D. R. Winge (ed.). Metal ions in fungi, vol. 11. Marcel Dekker, Inc., New York, N.Y.
53. Leong, S. A., and G. Winkelmann. 1998. Molecular biology of iron transport in fungi. Metal Ions Biol. Syst. 35:147-186.
54. Lesuisse, E., and P. Labbe. 1994. Reductive iron assimilation in Saccharomyces cerevisiae. p. 149-178. In G. Winkelmann and D. R. Winge (ed.), Metal ions in fungi, vol. 11. Marcel Dekker, Inc., New York, N.Y.
55. Liles, M. R., and N. P. Cianciotto. 1996. Absence of siderophore-like activity in Legionella pneumophila supernatants. Infect. Immun. 64:1873-1876.
56. Liu, L., K. Wakamatsu, S. Iton, and P. Williamson. 1999. Catecholamine oxidative products, but not melanin, are produced by Cryptococcus neoformans during neuropathogenesis in mice. Infect. Immun. 67:108-112.
57. Loper, J. E., and J. S. Buyer. 1991. Siderophores in microbial interactions on plant surfaces. Mol. Plant-Microbe Interact. 4:5-13.
58. Manulis, S., Y. Kashman, and I. Barash. 1987. Identification of siderophores and siderophore-mediated uptake of iron in Stemphylium botryosum. Phytochemistry 26:1317-1320.
59. Manulis, S., Y. Kashman, D. Netzer, and I. Barash. 1984. Phytotoxins from Stemphylium botryosum: structural determination of stemphyloxin II, production in culture and interaction with iron. Phytochemistry 23:2193-2198.
60. Matzanke, B. F. 1987. Mossbauer spectroscopy of microbial iron uptake and metabolism, p. 252-284. In G. Winkelmann, D. van der Helm, and J. B. Neilands (ed.), Iron transport in microbes, plants and animals. VCH Publishers, Weinheim, Germany.
61. Matzanke, B. F. 1991. Structures, coordination chemistry and functions of microbial iron chelates, p. 15-64. In G. Winkelmann (ed.), Handbook of microbial iron chelates. CRC Press, Inc., Boca Raton, Fla.
62. Matzanke, B. F. 1994. Iron storage in fungi, p. 179-214. In G. Winkelmann and D. R. Winge (ed.), Metal ions in fungi, vol. 11. Marcel Dekker, Inc., New York, N.Y.
63. Matzanke, B. F. 1994. Iron transport: siderophores, p. 1915-1933. In R. B. King (ed.), Encyclopedia of inorganic chemistry, vol. 4, Iro-Met. John Wiley & Sons, Inc., New York, N.Y.
64. Matzanke, B. F. 1997. Iron storage in Microorganisms, p. 117-157. In G. Winkelmann and C. J. Carrano (ed.), Transition metals in microbial metabolism. Harwood Academic Publishers, Australia.
65. 57Fe-labeled coprogen in Neurospora crassa. An in vivo Mossbauer study. Eur. J. Biochem. 162:643-650.
66. Matzanke, B. F., E. Bill, A. X. Trautwein, and G. Winkelmann. 1988. Ferricrocin functions as the main intracellular iron-storage compound in mycelia of Neurospora crassa. Biol. Metals 1:18-25.
67. Mezence, M. I. B., and P. Boiron. 1995. Studies on siderophore production and effect of iron deprivation on the outer membrane proteins of Madurella mycetomatis. Curr. Microbiol. 31:220-223.
68. Minnick, A. A., L. E. Eizember, J. A. McKee, E. K. Dolence, and M. J. Miller. 1991. Bioassay for siderophore utilization by Candida albicans. Anal. Biochem. 194:223-229.
69. Moore, D. G., R. J. Yancey, C. E. Lankford, and C. F. Earhart. 1980. Bacteriostatic enterochelin-specific immunoglobulin from normal human serum. Infect. Immun. 27:418-423.
70. Moors, M. A., T. L. Stull, K. J. Blank, H. R. Buckley, and D. M. Mosser. 1992. A role for complement receptor-like molecules in iron acquisition by Candida albicans. J. Exp. Med. 175:1643-1651.
71. Mor, H., Y. Kashman, G. Winkelmann, and I. Barash. 1992. Characterization of siderophores produced by different species of dermatophytic fungi Microsporum and Trichophyton. BioMetals 5:213-216.
72. Mor, H., M. Pasternak, and I. Barash. 1988. Uptake of iron by Geotrichum candidum, a non-siderophore producer. BioMetals 1:99-105.
73. Morrissey, J. A., P. H. Williams, and A. M. Cashmore. 1996. Candida albicans has a cell-associated ferric reductase activity which is regulated in response to levels of iron and copper. Microbiology 142:485-492.
74. Müller, G., S. J. Barclay, and K. N. Raymond. 1985. The mechanism and specificity of iron transport in Rhodotorula pilimanae probed by synthetic analogs of rhodotorulic acid. J. Biol. Chem. 260:13916-13920.
75. Neilands, J. B. 1994. Identification and isolation of mutants defective in iron acquisition. Methods Enzymol. 235:352-357.
76. Neilands, J. B., and K. Nakamura. 1991. Detection, determination, isolation, characterization and regulation of microbial iron chelates, p. 1-14. In G. Winkelmann (ed.), Handbook of microbial iron chelates. CRC Press, Inc., Boca Raton, Fla.
77. Newman, S. L., L. Gootee, G. Brunner, and G. S. Deepe, Jr. 1994. Chloroquine induces human macrophage killing of Histoplasma capsulatum by limiting the availability of intracellular iron and is therapeutic in a murine model of histoplasmosis. J. Clin. Investig. 93:1422-1429.
78. Newman, S. L., L. Gootee, V. Stroobant, H. van der Goot, and J. R. Boelaert. 1995. Inhibition of growth of Histoplasma capsulatum yeast cells in human macrophages by the iron chelator VUF 8514 and comparison of VUF 8514 with deteroxamine. Antimicrob. Agents Chemother. 39:1824-1829.
79. Nyhus, K. J., A. T. Wilborn, and E. S. Jacobson. 1997. Ferric iron reduction by Cryptococcus neoformans. Infect. Immun. 65:434-438.
80. Payne, S. M. 1993. Iron acquisition in microbial pathogenesis. Trends Microbiol. 1:66-68.
81. Payne, S. M. 1994. Detection, isolation, and characterization of siderophores. Methods Enzymol. 235:329-344.
82. Payne, S. M. 1994. Effects of iron deprivation in outer membrane protein expression. Methods Enzymol. 235:344-352.
83. Payne, S. M. 1994. Identification and isolation of mutants defective in iron acquisition. Methods Enzymol. 235:352-356.
84. Perry, R. D. 1993. Acquisition and storage of inorganic iron and hemin by the yersiniae. Trends Microbiol. 1:142-147.
85. Plattner, H. J., and H. Diekmann. 1994. Enzymology of siderophore biosynthesis in fungi, p. 99-116. In G. Winkelmann and D. R. Winge (ed.), Metal ions in fungi, vol. 11. Marcel Dekker, Inc., New York, N.Y.
86. Reissbrodt, R., R. Kingsley, W. Rabsch, W. Beer, M. Roberts, and P. H. Williams. 1997. Iron-regulated excretion of α-keto acids by Salmonella typhimurium. J. Bacteriol. 179:4538-4544.
87. Riquelme, M. 1996. Fungal siderophores in plant-microbe interactions. Microbiologia 12:537-546.
88. Salvin, S. B. 1951. Hemolysin from the yeastlike phases of some pathogenic fungi. Proc. Soc. Exp. Biol. Med. 76:852-854.
89. Spiro, T. G., S. F. Allerton, J. Renner, A. Terzis, R. Bils, and P. Saltman. 1966. The hydrolytic polymerization of iron (III). J. Am. Chem. Soc. 88: 2721-2725.
90. Stearman, R., D. S. Yuan, Y. Yamaguchi-Iwai, R. D. Klausner, and A. Dancis. 1996. A permease-oxidase complex involved in high affinity iron uptake in yeast. Science 271:1552-1557.
91. Sudbery, P. 1994. The non-Saccharomyces yeasts. Yeast 10:1707-1726.
92. Sweet, S. P., and L. J. Douglas. 1991. Effect of iron concentration on siderophore synthesis and pigment production by Candida albicans. FEMS Microbiol. Lett. 80:87-92.
93. Telford, J. R., and K. N. Raymond. 1996. Siderophores, p. 245-266. In J. Latwood, J. E. D. Davis, D. D. MacNicol, and F. Vogtle (ed.), Comprehensive supramolecular chemistry, vol. 1. Elsevier Science Ltd., Oxford, United Kingdom.
94. Theil, E. C. 1987. Ferritin: structure, gene regulation, and cellular function in animals, plants, and microorganisms. Annu. Rev. Biochem. 56:289-315.
95. Tilbrook, G. S., and R. C. Hider. 1998. Iron chelators for clinical use. Metal Ions Biol. Syst. 35:691-730.
96. van der Helm, D., and G. Winkelmann. 1994. Hydroxamates and polycarboxylates as iron transport agents (siderophores) in fungi, p. 39-98. In G. Winkelmann and D. R. Winge (ed.), Metal ions in fungi, vol. 11. Marcel Dekker, Inc., New York, N.Y.
97. Vartivarian, S. E., R. E. Cowart, E. J. Anaisse, T. Tashiro, and H. A. Sprigg. 1995. Iron acquisition by Cryptococcus neoformans. J. Med. Vet. Mycol. 33:151-156.
98. Weinberg, E. D. 1993. The iron-withholding defense system. ASM News 59:559-562.
99. Wilson, M. E., R. W. Vorhies, K. A. Anderson, and B. E. Britigen. 1994. Acquisition of iron from transferrin and lactoferrin by the protozoan Leishmania chagasi. Infect. Immun. 62:3262-3269.
100. Winkelmann, G. 1979. Surface iron polymers and hydroxy acids. A model of iron supply in sideramine-free fungi. Arch. Microbiol. 121:43-51.
101. Winkelmann, G. 1991. Specificity of iron transport in bacteria and fungi, p. 65-105. In G. Winkelmann (ed.), Handbook of microbial iron chelates. CRC Press, Inc., Boca Raton, Fla.
102. Winkelmann, G. 1993. Kinetics, energetics, and mechanisms of siderophore iron transport in fungi, p. 219-239. In L. L. Barton (ed.), Iron chelation in plants and soil microorganisms. Academic Press, Inc., New York, N.Y.
103. Winkelmann, G., and H. Zahner. 1973. Stoffwechselprodukte von Mikroorganismen. 115, Mitteilung. Eisenaufnahme bei Neurospora crassa. I. Zur Spezifitat des Eisentransportes. Arch. Mikrobiol. 88:49-60.
104. Worsham, P. L., and W. E. Goldman. 1988. Quantitative plating of Histoplasma capsulatum without addition of conditioned medium or siderophores. J. Med. Vet. Mycol. 6:137-143.