Cytokines induce nitric oxide-mediated mtDNA damage and apoptosis in oligodendrocytes: Protective role of targeting 8-oxoguanine glycosylase to mitochondria

Journal of Biological Chemistry

Volumn 280, Issue 22, 2005, Pages 21673-21679

  Druzhyna, Nadiya M ^a   Musiyenko, Sergyi I ^a   Wilson, Glenn L ^a   LeDoux, Susan P ^a  

^a UNIVERSITY OF SOUTH ALABAMA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; CELLS; DNA; ENZYMES; MOLECULAR BIOLOGY; PATHOLOGY; TUMORS;

MITOCHONDRIA; NITRIC OXIDE (NO); OLIGODENDROCYTES; TUMOR NECROSIS;

CYTOLOGY;

8 HYDROXYGUANINE; CASPASE 9; CYTOKINE; DNA GLYCOSYLTRANSFERASE; GAMMA INTERFERON; INDUCIBLE NITRIC OXIDE SYNTHASE; MITOCHONDRIAL DNA; NITRIC OXIDE; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; RECOMBINANT PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; APOPTOSIS; ARTICLE; BIOSYNTHESIS; BRAIN MITOCHONDRION; CELL STIMULATION; CELL SURVIVAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DNA DAMAGE; ENZYME ACTIVATION; ENZYME ACTIVITY; GENETIC TRANSFECTION; GLIA CELL; MULTIPLE SCLEROSIS; NERVE CELL CULTURE; NEUROPROTECTION; NONHUMAN; OLIGODENDROGLIA; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; RAT; SOUTHERN BLOTTING; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; BRAIN; CASPASE 8; CASPASE 9; CASPASES; CELL SURVIVAL; CYTOKINES; CYTOSOL; DNA DAMAGE; DNA GLYCOSYLASES; DNA, MITOCHONDRIAL; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; INFLAMMATION; INTERFERON TYPE II; MITOCHONDRIA; MULTIPLE SCLEROSIS; NEUROGLIA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; OLIGODENDROGLIA; RATS; RECOMBINANT PROTEINS; RNA; TIME FACTORS; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 20444430445     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M411531200     Document Type: Article

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