-
1
-
-
0033600763
-
Development of substituted benzo[c]quinolizinium compounds as novel activators of the cystic fibrosis chloride channel
-
F. Becq, Y. Mettey, M.A. Gray, L.J.V. Galietta, R.L. Dormer, M. Merton, M. Metaye, V. Chappe, C. Marvingt-Mounir, O. Zegarra-Moran, R. Tarran, L. Bulteau, R. Derand, M.M.C. Pereira, M.A. Mcpherson, C. Rogier, M. Joffre, B.E. Argent, D. Sarrouilhe, W. Kammouni, C. Figarella, B. Verrier, M. Gola, and J.M. Vierfond Development of substituted benzo[c]quinolizinium compounds as novel activators of the cystic fibrosis chloride channel J. Biol. Chem. 274 1999 27415 27425
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 27415-27425
-
-
Becq, F.1
Mettey, Y.2
Gray, M.A.3
Galietta, L.J.V.4
Dormer, R.L.5
Merton, M.6
Metaye, M.7
Chappe, V.8
Marvingt-Mounir, C.9
Zegarra-Moran, O.10
Tarran, R.11
Bulteau, L.12
Derand, R.13
Pereira, M.M.C.14
McPherson, M.A.15
Rogier, C.16
Joffre, M.17
Argent, B.E.18
Sarrouilhe, D.19
Kammouni, W.20
Figarella, C.21
Verrier, B.22
Gola, M.23
Vierfond, J.M.24
more..
-
3
-
-
17044448151
-
CFTR activation in human bronchial epithelial cells by novel benzoflavone and benzimidazolone compounds
-
E. Caci, C. Folli, O. Zegarra-Moran, T. Ma, M.F. Springsteel, R.E. Sammelson, M.H. Nantz, M.J. Kurth, A.S. Verkman, and L.J.V. Galietta CFTR activation in human bronchial epithelial cells by novel benzoflavone and benzimidazolone compounds Am. J. Physiol. 285 2003 L180 L188
-
(2003)
Am. J. Physiol.
, vol.285
-
-
Caci, E.1
Folli, C.2
Zegarra-Moran, O.3
Ma, T.4
Springsteel, M.F.5
Sammelson, R.E.6
Nantz, M.H.7
Kurth, M.J.8
Verkman, A.S.9
Galietta, L.J.V.10
-
4
-
-
0034810492
-
- channels in human lung epithelia: Activation by arachidonic acid, amidation, and acid activated omeprazole
-
- channels in human lung epithelia: activation by arachidonic acid, amidation, and acid activated omeprazole Am. J. Physiol. 281 2001 C46 C54
-
(2001)
Am. J. Physiol.
, vol.281
-
-
Cuppoletti, J.1
Tewara, K.P.2
Sherry, A.M.3
Kupert, E.Y.4
Malinowska, D.H.5
-
5
-
-
0038630416
-
Benzoquinolines and chloride secretion in murine colonic epithelium
-
A.W. Cuthbert Benzoquinolines and chloride secretion in murine colonic epithelium Br. J. Pharmacol. 138 2003 1528 1534
-
(2003)
Br. J. Pharmacol.
, vol.138
, pp. 1528-1534
-
-
Cuthbert, A.W.1
-
6
-
-
0041769470
-
Mechanisms of anion secretion in Calu-3 human epithelial cells by 7,8-benzoquinoline
-
A.W. Cuthbert, and L.J. MacVinish Mechanisms of anion secretion in Calu-3 human epithelial cells by 7,8-benzoquinoline Br. J. Pharmacol. 140 2003 81 90
-
(2003)
Br. J. Pharmacol.
, vol.140
, pp. 81-90
-
-
Cuthbert, A.W.1
MacVinish, L.J.2
-
7
-
-
0042856296
-
Bicarbonate-dependent chloride secretion in Calu-3 epithelia in response to 7,8-benzoquinoline
-
A.W. Cuthbert, C.T. Supuran, and L.J. MacVinish Bicarbonate-dependent chloride secretion in Calu-3 epithelia in response to 7,8-benzoquinoline J. Physiol. 551 2003 79 92
-
(2003)
J. Physiol.
, vol.551
, pp. 79-92
-
-
Cuthbert, A.W.1
Supuran, C.T.2
MacVinish, L.J.3
-
8
-
-
17144453452
-
Comparative pharmacology of the activity of wild-type and G551D mutated CFTR chloride channel: Effect of the benzimidazolone derivative NS004
-
R. Dearand, L. Bulteau-Pignoix, and F. Becq Comparative pharmacology of the activity of wild-type and G551D mutated CFTR chloride channel: effect of the benzimidazolone derivative NS004 J. Membr. Biol. 194 2003 109 117
-
(2003)
J. Membr. Biol.
, vol.194
, pp. 109-117
-
-
Dearand, R.1
Bulteau-Pignoix, L.2
Becq, F.3
-
9
-
-
0026781952
-
Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitive
-
G.M. Denning, M.P. Anderson, J.F. Amara, J. Marshall, A.E. Smith, and M.J. Welsh Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitive Nature 358 1992 761 764
-
(1992)
Nature
, vol.358
, pp. 761-764
-
-
Denning, G.M.1
Anderson, M.P.2
Amara, J.F.3
Marshall, J.4
Smith, A.E.5
Welsh, M.J.6
-
11
-
-
0034750942
-
Phenanthrolines-a new class of CFTR chloride channel openers
-
M. Duszyk, L.J. MacVinish, and A.W. Cuthbert Phenanthrolines-a new class of CFTR chloride channel openers Br. J. Pharmacol. 134 2001 853 864
-
(2001)
Br. J. Pharmacol.
, vol.134
, pp. 853-864
-
-
Duszyk, M.1
MacVinish, L.J.2
Cuthbert, A.W.3
-
12
-
-
0026951303
-
Submucosal glands are the predominant site of CFTR expression in human bronchus
-
J.F. Engelhardt, J.R. Yankaskas, S.A. Ernst, Y. Yang, C.R. Marino, R.C. Boucher, J.A. Cohn, and J.M. Wilson Submucosal glands are the predominant site of CFTR expression in human bronchus Nat. Genet. 2 1992 240 248
-
(1992)
Nat. Genet.
, vol.2
, pp. 240-248
-
-
Engelhardt, J.F.1
Yankaskas, J.R.2
Ernst, S.A.3
Yang, Y.4
Marino, C.R.5
Boucher, R.C.6
Cohn, J.A.7
Wilson, J.M.8
-
13
-
-
0035827680
-
Novel CFTR chloride channel activators identified by screening of combinatorial libraries based on flavone and benzoquinolizinium lead compounds
-
L.J.V. Galietta, M.F. Springsteel, M. Eda, E.J. Niedzinski, K. By, M.J. Haddadin, M.J. Kurth, M.H. Nantz, and A.S. Verkman Novel CFTR chloride channel activators identified by screening of combinatorial libraries based on flavone and benzoquinolizinium lead compounds J. Biol. Chem. 276 2001 19723 19728
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 19723-19728
-
-
Galietta, L.J.V.1
Springsteel, M.F.2
Eda, M.3
Niedzinski, E.J.4
By, K.5
Haddadin, M.J.6
Kurth, M.J.7
Nantz, M.H.8
Verkman, A.S.9
-
14
-
-
0037020097
-
High affinity activators of cystic fibrosis transmembrane conductance regulator (CFTR) chloride conductance identified by high-throughput screening
-
T. Ma, L. Vetrivel, H. Yang, N. Pedemonte, O. Zegarra-Moran, L.J.V. Galietta, and A.S. Verkman High affinity activators of cystic fibrosis transmembrane conductance regulator (CFTR) chloride conductance identified by high-throughput screening J. Biol. Chem. 277 2002 37235 37241
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 37235-37241
-
-
Ma, T.1
Vetrivel, L.2
Yang, H.3
Pedemonte, N.4
Zegarra-Moran, O.5
Galietta, L.J.V.6
Verkman, A.S.7
-
15
-
-
10744229649
-
Synthesis, SAR, crystal structure and biological activation of benzoquinoliziniums as activators of wild-type and mutant cystic fibrosis transmembrane conductance regulator channels
-
C. Marivingt-Mounir, C. Norez, R. Derand, L. Bulteau-Pignoix, D. Nguyen-Huy, B. Viossat, G. Morgant, F. Becq, J.-M. Vierfond, and Y. Mettey Synthesis, SAR, crystal structure and biological activation of benzoquinoliziniums as activators of wild-type and mutant cystic fibrosis transmembrane conductance regulator channels J. Med. Chem. 47 2004 962 972
-
(2004)
J. Med. Chem.
, vol.47
, pp. 962-972
-
-
Marivingt-Mounir, C.1
Norez, C.2
Derand, R.3
Bulteau-Pignoix, L.4
Nguyen-Huy, D.5
Viossat, B.6
Morgant, G.7
Becq, F.8
Vierfond, J.-M.9
Mettey, Y.10
-
17
-
-
0041589194
-
Benzoflavone activators of the cystic fibrosis transmembrane conductance regulator: Towards a pharmacophore model for the nucleotide-binding domain
-
M.F. Springsteel, L.J.V. Galietta, T. Ma, K. By, G.O. Berger, H. Yang, C.W. Dicus, W. Choung, C. Quan, A.A. Shelat, R.K. Guy, A.S. Verkman, M.J. Kuth, and M.H. Nantz Benzoflavone activators of the cystic fibrosis transmembrane conductance regulator: Towards a pharmacophore model for the nucleotide-binding domain Bioorg. Med. Chem. 11 2003 4113 4120
-
(2003)
Bioorg. Med. Chem.
, vol.11
, pp. 4113-4120
-
-
Springsteel, M.F.1
Galietta, L.J.V.2
Ma, T.3
By, K.4
Berger, G.O.5
Yang, H.6
Dicus, C.W.7
Choung, W.8
Quan, C.9
Shelat, A.A.10
Guy, R.K.11
Verkman, A.S.12
Kuth, M.J.13
Nantz, M.H.14
-
18
-
-
3042700158
-
4-Chloro-benzo[F]isoquinoline (CBIQ) activates CFTR chloride channels and KCNN4 potassium channels in Calu-3 human airway epithelial cells
-
A.J. Szkotak, M. Murthy, L.J. MacVinish, M. Duszyk, and A.W. Cuthbert 4-Chloro-benzo[F]isoquinoline (CBIQ) activates CFTR chloride channels and KCNN4 potassium channels in Calu-3 human airway epithelial cells Br. J. Pharmacol. 142 2004 531 542
-
(2004)
Br. J. Pharmacol.
, vol.142
, pp. 531-542
-
-
Szkotak, A.J.1
Murthy, M.2
MacVinish, L.J.3
Duszyk, M.4
Cuthbert, A.W.5
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