Recovery of hematopoietic activity in bone marrow from human immunodeficiency virus type 1-infected patients during highly active antiretroviral therapy

AIDS Research and Human Retroviruses

Volumn 16, Issue 15, 2000, Pages 1471-1479

  Isgro, A ^a   Mezzaroma, I ^a   Aiuti, A ^b   De Vita, L ^a   Franchi, F ^a   Pandolfi, F ^c   Alario, C ^a   Ficara, F ^b   Riva, E ^a   Antonelli, G ^a   Aiuti, F ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b SAN RAFFAELE SCIENTIFIC INSTITUTE   (Italy)

^c San Camillo Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; CD16 ANTIGEN; CD19 ANTIGEN; CD3 ANTIGEN; CD34 ANTIGEN; CD38 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGEN; HEMOGLOBIN;

ADULT; BLOOD ANALYSIS; BONE MARROW CELL; CELL CULTURE; CELL PROLIFERATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; ERYTHROCYTE COUNT; FEMALE; HEMATOPOIESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; LEUKOCYTE COUNT; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; STEM CELL; TREATMENT OUTCOME; VIRUS LOAD;

ADULT; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; BONE MARROW; CELLS, CULTURED; DNA, VIRAL; FEMALE; FLOW CYTOMETRY; HEMATOLOGY; HEMATOPOIESIS; HIV INFECTIONS; HIV-1; HUMANS; LEUKOCYTES, MONONUCLEAR; MALE; METHYLCELLULOSE; MIDDLE AGED; POLYMERASE CHAIN REACTION; TIME FACTORS;

EID: 0034633612     PISSN: 08892229     EISSN: None     Source Type: Journal    
DOI: 10.1089/088922200750005994     Document Type: Conference Paper

References (42)

1. Bone marrow examination in patients with AIDS and AIDS-related complex (ARC)
2. Directly measured kinetics of circulating T lymphocytes in normal and HIV-1 infected humans
3. The influence of human immunodeficiency virus-1 on hematopoiesis
4. Defective in vitro growth of the hematopoietic progenitor cells in the acquired immunodeficiency syndrome
5. CD34+ bone marrow cells are infected with HIV in a subset of seropositive individuals
6. Human immunodeficiency virus infection of human bone marrow stromal fibroblasts
7. Involvement of HIV Nef protein in abnormal hematopoiesis in AIDS: In vitro study on bone marrow progenitor cells
8. Impaired in vitro growth of peripheral blood hematopoietic progenitor cells in HIV infected patients: Evidence of an inhibitory effect of autologous T lymphocytes
9. Suppression of in vitro haematopoiesis following human immunodeficiency virus infection
10. Expression of CXCR4, the receptor for stromal cell-derived factor-1 on fetal and adult human limphohematopoietic progenitors
11. Human CD34+ cells express CXCR4 and its ligand stromal cell-derived factor-1. Implication for infection by T cell tropic human immunodeficiency virus
12. Hematopoietic CD34+ progenitor cells are not infected by HIV-1 in vivo but show impaired clonogenesis
13. Infection of human marrow stroma by human immunodeficiency virus-1 (HIV-1) is both required and sufficient for HIV-1 induced hematopoietic suppression in vitro: Demonstration by gene modification of primary human stroma
14. Role of human immunodeficiency virus replication in defective in vitro growth of hematopoietic progenitors
15. Loss of primitive hematopoietic progenitors in patients with human immunodeficiency virus infection
16. Secondary colony formation after long-term bone marrow culture using peripheral blood and bone marrow of HIV-infected patients
17. Neither human immunodeficiency virus-1 (HIV-1) nor HIV-2 infects most primitive human hematopoietic stem cells as assessed in long-term bone marrow cultures
18. Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy
19. Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease
20. Clinical and immunologic response without decrease in virus load in patients with AIDS after 24 months of highly active antiretroviral therapy
21. Functional characterization of individual human hematopoietic stem cells cultured at limiting dilution on supportive marrow stromal layers
22. Cytomegalovirus transcript in peripheral blood leukocytes of actively infected transplant patients detected by reverse transcription polymerase chain reaction
23. Line probe assay detection for rapid detection of drug-selected mutations in the human immunodeficiency virus type 1 reverse transcriptase gene
24. Zidovudine resistance predicted by direct determination of mutations in DNA from HIV-infected lymphocytes
25. In vitro exposure to human immunodeficiency virus type 1 induces apoptotic cell death of the factor-dependent TF-1 hematopoietic cell line
26. Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: A composite of redistribution and proliferation
27. T cell telomere length in HIV-1 infection: No evidence for increase CD4+ T cell turnover
28. Changes in thymic function with age and during the treatment of HIV infection
29. Human immunodeficiency virus type 1 Vpr alters bone marrow cell function
30. Tat protein stimulates production of transforming growth factor-beta 1 by marrow macrophages: A potential mechanism for human immunodeficiency virus-1 induced hematopoietic suppression
31. Peripheral blood-derived CD34+ progenitor cell: CXC chemokine receptor 4 and CC chemokine receptor 5 expression and infection by HIV
32. Lack of evidence for infection of or effect on growth of hematopoietic progenitor cells after in vivo or in vitro exposure to human immunodeficiency virus
33. Depletion of CD34+ CD4+ cells in bone marrow from HIV-1-infected individuals
34. Long-term evaluation of T-cell subsets and T-cell function after HAART in advanced stage HIV-1 disease
35. Uninfected hematopoietic progenitor (CD34+) cells purified from the bone marrow of AIDS patients are committed to apoptotic cell death in culture
36. Expression of chemokine receptors CXCR4 and CCR5 in HIV-1-infected and uninfected individuals
37. CCR5 and CXCR4 chemokine receptors expression and β-chemokines production during early T-cell repopulation induced by highly active antiretroviral therapy
38. Malignant lymphomas in patients with HIV infection
39. Inhibition of purified CD34+ hematopoietic progenitors cells by human immunodeficiency virus 1 or gp 120 mediated by endogenous transforming growth factor beta 1
40. Reduced mobilization of CD34+ stem cells in advanced human immunodeficiency virus type 1 disease
41. Mobilization of CD34+ progenitor cells by granulocyte colony-stimulating factor in human immunodeficiency virus type 1-infected adults
42. Flt 3 ligand, MGDF, Epo and G-CSF enhance ex vivo expansion of hematopoietic cell compartments in the presence of SCF, IL-3 and IL-6