Dimemorfan prevents seizures induced by the L-type calcium channel activator BAY k-8644 in mice

Behavioural Brain Research

Volumn 151, Issue 1-2, 2004, Pages 267-276

  Shin, Eun Joo ^a   Nabeshima, Toshitaka ^b   Lee, Phil Ho ^c   Kim, Won Ki ^d   Ko, Kwang Ho ^e   Jhoo, Jin Hyeong ^f   Jhoo, Wang Kee ^a   Cha, Joo Young ^a   Kim, Hyoung Chun ^a  

^a Korea Institute of Drug Abuse   (South Korea)

^b NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c Kangwon National University   (South Korea)

^d Ewha Womans University School of Medicine   (South Korea)

^e Seoul National University   (South Korea)

^f Seoul National University Hospital   (South Korea)

Author keywords

AP 1 DNA binding activity; BAY k 8644; c fos; c jun; Dextromethorphan; Dimemorfan; fos related antigen; Phencyclidine like behavior

Indexed keywords

1,4 DIHYDRO 2,6 DIMETHYL 5 NITRO 4 [2 (TRIFLUOROMETHYL)PHENYL] 3 PYRIDINECARBOXYLIC ACID METHYL ESTER; CALCIUM CHANNEL L TYPE; DEXTRORPHAN; DIMEMORFAN; MORPHINAN DERIVATIVE; PHENCYCLIDINE; PROTEIN C JUN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR DISORDER; CIRCLING BEHAVIOR; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFECT; DRUG POTENCY; EXPERIMENTAL MOUSE; LOCOMOTION; MALE; MOUSE; NONHUMAN; ONCOGENE C FOS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEIZURE; STATISTICAL SIGNIFICANCE;

3-PYRIDINECARBOXYLIC ACID, 1,4-DIHYDRO-2,6-DIMETHYL-5-NITRO-4-(2-(TRIFLUOROMETHYL)PHENYL)-, METHYL ESTER; ANIMALS; ANTICONVULSANTS; BEHAVIOR, ANIMAL; BLOTTING, NORTHERN; BLOTTING, WESTERN; CALCIUM CHANNELS, L-TYPE; CELL COUNT; DENSITOMETRY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED C57BL; MORPHINANS; MOTOR ACTIVITY; PHENCYCLIDINE; PROTO-ONCOGENE PROTEINS C-FOS; PROTO-ONCOGENE PROTEINS C-JUN; REACTION TIME; RNA; SEIZURES;

EID: 16544393829     PISSN: 01664328     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbr.2003.09.004     Document Type: Article

References (56)

1. Bing G., McMillan M., Kim H.-C., Pennypacker K., Feng Z., Qi Q.et al. Long-term expression of the 35000 mol wt. Fos-related antigen in rat brain after kainic acid treatment. Neuroscience. 73:1996;1159-1174.
2. Bing G., Wilson B., Hudson P., Jin L., Feng Z., Zhang W.et al. A single dose of kainic acid elevates the levels of enkephalins and activator protein-1 transcription factors in the hippocampus for up to 1 year. Proc. Natl. Acad. Sci. U.S.A. 94:1997;9422-9427.
3. Boham D., Bos T.J., Admon A., Nishimura T., Vogt P.K., Tjian R. Human proto-oncogene c-jun encodes a DNA-binding protein with structural and functional properties of transcription factor AP-1. Science. 238:1987;1386-1392.
4. Bolger G.T., Weissman B.A., Skolinick P. The behavioral effects of the calcium channel agonist BAY k-8644 in the mouse: antagonism by the calcium channel antagonist nifedipine. Naunyn-Schmeideberg's Arch. Pharmacol. 328:1985;373-377.
5. Brown A.M., Kunze D.L., Yatani A. The agonist effect of dihydropyridines on Ca channels. Nature. 311:1984;570-572.
6. Chomcznski P., Sacchi N. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:1987;156-159.
7. Chou Y.C., Liao J.F., Chang W.Y., Lin M.F., Chen C.F. Binding of dimemorfan to sigma-1 receptor and its anticonvulsant and locomotor effects in mice, compared with dextromethorphan and dextrorphan. Brain Res. 821:1999;516-519.
8. Clark W.G., Vivonia C.A., Baxter C.F. Accurate free hand injections into the lateral brain ventricle of the conscious mouse. J. Appl. Physiol. 25:1968;319-321.
9. Colado M.I., Ormazabal M.J., Alfaro M.J., Martin M.I. Effect of Bay k-8644 on the synthesis and metabolism of dopamine and 5-hydroxytryptophan in various brain areas of the rat. J. Pharm. Pharmacol. 45:1993;220-222.
10. Curran T., Gordon M.B., Rubino K.L., Sambucetti L.C. Isolation and characterization of c-fos cDNA and analysis of post-translational modification in vitro. Oncogene. 2:1987;79-84.
11. De Sarro G.B., Ascioti C., Donato Di Paola E., Vidal M.J., De Sarro A. Effects of antiepileptic drugs, calcium channel blockers and other compounds on seizures induced by activation of voltage-dependent L-calcium channel in DBA/2 mice. Gen. Pharmacol. 23:1992;1205-1216.
12. Ferkany J.W., Borosky S.A., Clissold D.B., Pontecorvo M.J. Dextromethorphan inhibits NMDA induced convulsions. Eur. J. Pharmacol. 151:1988;151-154.
13. Fort P., Marty L., Piechaczyk M., Sabrouty E., Dani C., Jeanteur P.et al. Various rat adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate dehydrogenase multigenic family. Nucleic Acids Res. 13:1985;1431-1442.
14. 0 during repetitive electrical stimulation and during pentetrazole-induced seizure activity in the sensorimotor cortex of cats. Pflügers Arch. 398:1983;310-317.
15. Heinemann U., Pumain R. Effects of tetradotoxin on changes in extracellular free calcium induced by repetitive electrical stimulation and iontophoretic application of excitatory amino acids in the sensorimotor cortex of cats. Neurosci. Lett. 21:1981;87-91.
16. Holzman S.G. Discriminative stimulus effects of dextromethorphan in the rat. Psychopharmacology. 116:1994;249-254.
17. + potential. Ann. Neurol. 10:1981;11-17.
18. Javitt D.C., Zukin S.R. Recent advances in the phencyclidine model of schizophrenia. Am. J. Psychiatry. 148:1991;1301-1308.
19. Jhoo W.-K., Shin E.-J., Lee Y.H., Cheon M.A., Oh K.W., Kang S.Y.et al. Dual effects of dextromethorphan on cocaine-induced conditioned place preference in mice. Neurosci. Lett. 288:2000;76-80.
20. Kasé Y., Kito G., Miyata T., Uno T., Takahama K., Ida H. Antitussive activity and other related pharmaceutical properties of D-3-methyl-N-methylmorphinan (AT-17). Arzneim-Forsch (Drug Res.). 26:1976;353-360.
21. Kim H.-C., Pennypacker K., Bing G., Bronstein D., McMillian M., Hong J.S. The effect of dextromethorphan on kainic acid-induced seizures in the rat. Neurotoxicology. 17:1996;375-386.
22. Kim H.-C., Suh H.W., Bronstein D., Bing G., Wilson B., Hong J.S. Dextromethorphan blocks opioid peptide gene expression in the rat hippocampus induced by kainic acid. Neuropeptides. 31:1997;105-112.
23. Kim H.-C., Lee P.H., Jhoo W.-K. The complex pharmacological action of dextromethorphan; requirement of development of neuroprotective dextromethorphan analogs with negligible psychotomimetic effects. Int. Symp. Mol. Monitor. Neurosci. Field (Nagoya, Japan). 3:1998;1-2.
24. Kim H.-C., Bing G., Jhoo W.-K., Ko K.H., Kim W.-K., Lee D.C.et al. Dextromethorphan modulates the AP-1 DNA binding activity induced by kainic acid. Brain Res. 824:1999;125-132.
25. Kim H.-C., Ko K.H., Kim W.-K., Shin E.-J., Kang K.S., Shin C.Y.et al. Effects of dextromethorphan on the seizures induced by kainate and the calcium channel angonist BAY k-8644: comparison with the effects of dextrorphan. Behav. Brain Res. 120:2001;169-175.
26. Kim H.-C., Nabeshima T., Jhoo W.-K., Ko K.H., Kim W.-K., Shin E.-J.et al. Anticonvulsant effects of new morphinan derivatives. Bioorg. Med. Chem. Lett. 11:2001;1651-1654.
27. Kim H.-C., Bing G., Shin E.-J., Jhoo H.S., Cheon M.A., Lee S.H.et al. Dextromethorphan affects cocaine-mediated behavioral pattern in parallel with a long-lasting fos-related antigen-immunoreactivity. Life Sci. 69:2001;615-624.
28. Kim H.-C., Bing G., Jhoo W.-K., Kim W.-K., Shin E.-J., Im D.H.et al. Metabolism to dextrorphan is not essential for dextromethorphan's anticonvulsant activity against kainate in mice. Life Sci. 72:2003;769-783.
29. Kim H.-C., Shin C.Y., Seo D.O., Jhoo J.-H., Jhoo W.-K., Kim W.-K.et al. New morphinan derivatives with negligible psychotropic effects attenuate convulsions induced by maximal electroshock in mice. Life Sci. 72:2003;1883-1895.
30. Kopchik T.T., Cullen R., Stacey D.W. Rapid analysis of small nucleic acid samples by gel electrophoresis. Anal. Biochem. 115:1981;419-423.
31. Löscher W., Hönack D. Differences in anticonvulsant potency and adverse effects between dextromethorphan and dextrorphan in amygdala-kindled and non-kindled rats. Eur. J. Pharmacol. 238:1993;191-200.
32. 2+ antagonist. Epilepsia. 8:1987;409-414.
33. Meyer F.B. Calcium, neuronal hyperexcitability and ischemic injury. Brain Res. Rev. 14:1989;227-243.
34. Morgan J.L., Curran T. Proto-oncogene transcription factors and epilepsy. Trends Pharmacol. Sci. 12:1991;343-349.
35. Murakami M., Inukai N., Nagano N. Studies on morphinan derivatives. I. The synthesis of several new 3-substituted derivatives of N-methylmorphinan ring having antitussive activities. Chem. Pharm. Bull. 20:1972;1699-1705.
36. Murphy T.H., Worley P.F., Baraban J.M. L-type voltage-sensitive calcium channels mediate synaptic activation of immediate early genes. Neuron. 7:1991;625-635.
37. Netzer R., Pflimlin P., Trube G. Dextromethorphan blocks N-methyl-D-aspartate-induced currents and voltage-operated inward currents in cultured cortical neurons. Eur. J. Pharmacol. 238:1993;209-216.
38. Noda Y., Yamada K., Furukawa H., Nabeshima T. Enhancement of immobility in a forced swimming test by subacute or repeated treatment with phencyclidine: a new model of schizophrenia. Br. J. Pharmacol. 116:1995;2531-2537.
39. O'Neill S.K., Bolger G.T. The effects of dihydropyridine calcium modulators on pentylenetetrazole convulsions. Brain Res. Bull. 25:1990;211-214.
40. Overweg J., Binnie C.D., Meijer J.W.A., Meinardi H., Nuijfen S.T.M., Schmaltz S.et al. Double-blind, placebo-controlled trial of flunarizine as add-on therapy in epilepsy. Epilepsia. 25:1984;217-222.
41. Park SY, Shin E-J, Jhoo W-K, Ko KH, Kim W-K, Kim H-C. Dimemorfan provides neuroprotection via activation of sigma-1 receptor and blocking L-type calcium channels; models of kainate and BAY k-8644. Society for Neuroscience 2002:32. Program No. 798.5 [abstract].
42. Pennypacker K., Hong J.S., McMillian M. Implications of prolonged expression of Fos-related antigens. Trends Pharmacol. Sci. 16:1995;317-321.
43. Pender E.S., Parks B.R. Toxicity with dextromethorphan-containing preparations: a literature review and report of two additional cases. Pediat. Emerg. Care. 7:1991;163-165.
44. ++ agonist BAY K8644 increases catecholamine synthesis in mouse brain. Neuropharmacology. 26:1987;101-105.
45. Pumain R., Kurcewicz I., Louvel J. Fast extracellular calcium transients: involvement in epileptic processes. Science. 222:1983;177-179.
46. Rammer L., Holmgren P., Sandler H. Fatal intoxication by dextromethorphan: a report on two cases. Forensic Sci. Int. 37:1988;766-768.
47. Shelton R.C., Grebb J.A., Freed W.J. Induction of seizures in mice by intracerebroventricular administration of the calcium channel BAY k-8644. Brain Res. 402:1987;399-402.
48. Szekely J.L., Sharpe L.G., Jaffe J.H. Induction of phencyclidine-like behavior in rats by dextrorphan but not dextromethorphan. Pharmacol. Biochem. Behav. 40:1991;381-386.
49. Thomas J. The effect of nomodipine on picrotoxin-induced seizures. Brain Res. Bull. 24:1990;11-15.
50. Tortella F.C., Pellicano M., Bowery N.G. Dextromethorphan and neuromodulation: old drug coughs up new activities. Trends Pharmacol. Sci. 10:1989;501-507.
51. Tortella F.C., Robles L., Witkin J.M., Newman A.H. Novel anticonvulsant analogs of dextromethorphan: improved efficacy, potency, duration and side-effect profile. J. Pharmacol. Exp. Ther. 268:1994;727-733.
52. Van Luijtelaar E.L., Ates N., Coenen A.M. Role of L-type calcium channel modulation in nonconvulsive epilepsy in rats. Epilepsia. 36:1995;86-92.
53. Vendrell M., Pujol M.J., Tusell J.M., Serratosa J. Effect of different convulsions on calmodulin levels and proto-oncogene c-fos expression in the central nervous system. Mol. Brain Res. 14:1992;285-292.
54. Won J.S., Kim Y.H., Song D.K., Suh H.W. The effects of cycloheximide on the regulation of proenkephalin and prodynorphan gene expressions induced by kainic acid in rat hippocampus. Mol. Brain Res. 47:1997;303-310.
55. Wu D., Otton S.V., Kalow W., Sellers E.M. Effects of route of administration on dextromethorphan pharmakinetics and behavioral response in the rat. J. Pharmacol. Exp. Ther. 274:1995;1431-1437.
56. Young S.T., Porrino L.J., Iadarola M.J. Cocaine induces c-fos immunoreactive proteins via dopaminergic D1 receptors. Proc. Natl. Acad. Sci. U.S.A. 88:1991;1291-1295.