The biochemical mechanisms of the excitotoxicity of Kainic acid - Free radical formation

Molecular and Chemical Neuropathology

Volumn 17, Issue 1, 1992, Pages 51-63

  Sun, Albert Y ^a   Cheng, Yu ^a   Bu, Qun ^a   Oldfield, Fifi ^a  

^a UNIVERSITY OF MISSOURI   (United States)

Author keywords

electron spin resonance; free radical; Kainic acid; lipid peroxidation; neuronal death

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); EXCITOTOXIN; FREE RADICAL; KAINIC ACID; LIPID PEROXIDE; MALONALDEHYDE; THIOBARBITURIC ACID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CEREBELLUM; CONJUGATION; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; GERBIL; HIPPOCAMPUS; HISTOPATHOLOGY; HYPERACTIVITY; LIPID PEROXIDATION; NERVE CELL DEGENERATION; NERVE CELL MEMBRANE; NEUROTOXICITY; NONHUMAN;

ANIMAL; BRAIN CHEMISTRY; FREE RADICALS; GERBILLINAE; HISTOCYTOCHEMISTRY; KAINIC ACID; LIPID PEROXIDATION; MALONDIALDEHYDE; NA(+)-K(+)-EXCHANGING ATPASE; NERVOUS SYSTEM DISEASES; NEURONS; SUPPORT, U.S. GOV'T, P.H.S.; SYNAPTOSOMES; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 0026687022     PISSN: 10447393     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03159981     Document Type: Article

References (49)

1. Detection of free radical formation in various tissues after acute carbon tetrachloride administration in gerbil
2. Replication of the neurochemical characteristics of Huntington’s disease by quinolinic acid
3. Kainate N-methyl aspartate and other excitatory amino acid increases in calcium influx into rat brain cortex cells in vitro
4. Effects of kainic acid on ion distribution and ATP levels of striatal slices incubated in vitro
5. The thiobarbituric acid reaction in relation to fatty livers
6. Reduced neurotoxicity in transgenic mice overexpressing human copper-zinc-superoxide dismutase
7. HPLC procedure for the pharmacokinetic study of the spin-trapping agent, α-phenyl- N-tert-butyl nitrone
8. The biochemical mechanism of the excitotoxicity of kainic acid
9. Glutamate neurotoxicity in cortical cell culture is calcium dependent
10. Ionic dependence of glutamate neurotoxicity in cortical cell culture
11. Calcium-mediated neurotoxicity: Relationship to specific channel types and role in ischemic damage
12. Pharmacology of glutamate neurotoxicity in cortical cell culture: Attenuation by NMDA antagonists
13. Neurotoxic actions of kainic acid
14. Lesion of striatal neurons with kainic acid provides a model for Huntington’s chorea
15. NMDA receptors activate the arachidonate cascade system in striatal neurons
16. Mechanism of kainate toxicity to cerebellar neurons in vitro is analogous to reperfusion tissue injury
17. Free radicals and tissue injury
18. Production of volatile hydrocarbons by isolated hepatocytes: An in vitro model for lipid peroxidation studies
19. Phencyclidine receptor ligands attenuate cortical neuronal injury after N-methyl- d-aspartate exposure or hypoxia
20. The measurement and mechanisms of lipid peroxidation in biological systems
21. Cultured striatal neurons containing NADPH-diaphorase or acetylcholinesterase are selectively sensitive to injury by NMDA receptor agonists
22. Arachidonic acid release from K+-evoked depolarization of brain synaptosomes
23. Effects of kainic acid on brain calcium fluxes studied in vivo and in vitro
24. Activation of N-methyl- d-aspartate sensitive glutamate receptors stimulates arachidonic acid release in primary cultures of cerebellar granular cells
25. N-methyl- d-aspartate sensitive glutamate receptors induce, calcium-mediated arachidonic acid release in primary cultures of cerebellar granule cells
26. Kainic acid induced limbic seizure: Metabolic, behavioral, electroencephalographic and neuropathological correlates
27. Kainate induced degeneration of neostriatal neurons: Dependency upon the corticostriatal tract
28. Excitatory amino acid neurotoxicity and neurodegenerative disease
29. Distribution of3H-kainate binding sites in rat CNS as determined by autoradiography
30. The effects of excitatory amino acids on intracellular calcium in single mouse striatal neurons in vitro
31. Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress
32. The involvement of ethanol in the free radical reaction of 6-hydroxydopamine
33. The role of specific ions in glutamate neurotoxicity
34. MK-801 powerfully protects against N-methyl aspartate neurotoxicity
35. Quantitative estimation of peroxidative degeneration of rat-liver microsomal and mitochondrial lipids after carbon tetrachloride poisoning
36. Reactive free radical generation in vivo in heart and liver of ethanol-fed rats: Correlations with radical formation in vitro
37. The effects of kainic acid on high energy metabolites in the mouse striatum
38. Nordihydroguaiaretic acid attenuates slow excitatory amino acid-induced neuronal degeneration in cortical cultures
39. The neurotoxicity of excitatory amino acids is produced by passive chloride influx
40. Cerebral circulation and metabolism
41. Free-radical mechanisms in tissue injury
42. The specificity of the gallocyanin chromalum stain for nucleic acids as studied by the ribonuclease technique
43. The effect of lipoxidation on synaptosomal (Na+, K+)-ATPase isolated from the cerebral cortex of squirrel monkey
44. The effect of phospholipases on the active uptake of norepinephrine by synaptosomes isolated from the cerebral cortex of guinea pig
45. Functional role of phospholipids of synaptosomal membranes
46. Autoradiographic localization of high-affinity3H-kainate binding sites in the rat forebrain
47. Hypoglycemic-induced neuronal damage is prevented by N-methyl- d-aspartate receptor antagonist
48. Different coupling of excitatory amino acids receptors with Ca2+ channels in primary culture of cerebellar granule cells