Tirapazamine administered as a neoadjuvant to radiotherapy reduces metastatic dissemination

Clinical Cancer Research

Volumn 11, Issue 11, 2005, Pages 4212-4216

  Lunt, Sarah Jane ^a,c   Telfer, Brian A ^a   Fitzmaurice, Richard J ^b   Stratford, Ian J ^a   Williams, Kaye J ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b MANCHESTER ROYAL INFIRMARY   (United Kingdom)

^c PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 BROMOETHYLAMINO) 3 (2 NITRO 1 IMIDAZOLYL) 2 PROPANOL; PIMONIDAZOLE; SODIUM CHLORIDE; TIRAPAZAMINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER ADJUVANT THERAPY; CANCER CONTROL; CANCER GROWTH; CANCER RADIOTHERAPY; CONTROLLED STUDY; DRUG EFFICACY; DRUG TARGETING; FEMALE; HYPOXIA; METASTASIS; MOUSE; NONHUMAN; OXYGEN TENSION; PRIORITY JOURNAL; RADIATION DOSE; RADIOSENSITIVITY; REPRODUCIBILITY; TUMOR VASCULARIZATION;

ANIMALS; ANOXIA; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; COMBINED MODALITY THERAPY; FEMALE; MICE; MICE, INBRED C3H; NEOADJUVANT THERAPY; NEOPLASM METASTASIS; NEOPLASM TRANSPLANTATION; NEOVASCULARIZATION, PATHOLOGIC; NITROIMIDAZOLES; RADIATION-SENSITIZING AGENTS; SARCOMA, EXPERIMENTAL; TREATMENT OUTCOME; TRIAZINES;

EID: 20344382293     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-04-2162     Document Type: Article

References (21)

1. Cairns RA, Kalliomaki T, Hill RP. Acute (Cyclic) hypoxia enhances spontaneous metastases of KHT murine tumors. Cancer Res 2001;60:8903-8.
2. Aznavoorian S, Murphy AN, Stetler-Stevenson WG, Liotta LA. Molecular aspects of tumor cell invasion and metastasis. Cancer 1998;71:1368-83.
3. Subarsky P, Hill RP. The hypoxic tumor microenvironment and metastatic progression. Clin Exp Metastasis 2003;20:237-50.
4. Gatenby RA, Kessler HB, Rosenblum JS, et al. Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy. Int J Radiat Oncol Biol Phys 1988;14:831-8.
5. Okunieff P, Hockel M, Dunphy EP, Schienger K, Knoop C, Vaupel P. Oxygen tension distributions are sufficient to explain the local response of human breast tumors treated with radiation alone. Int J Radiat Oncol Biol Phys 1993;26:631-6.
6. Brizel DM, Scully SP, Harrelson JM, et al. Tumor oxygenation predicts for the likelihood of distant metastasis in human soft tissue sarcoma. Cancer Res 1996;56: 941-3.
7. Hockel M, Schlenger K, Aral B, Mitze M, Schaffer U, Vaupel P. Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res 1996;56:4509-15.
8. Fyles AW, Milosevic M, Wong R, et al. Oxygenation predicts radiation response in patients with cervix cancer. Radiother Oncol 1998;48:149-56.
9. Nordsmark M, Overgaard J. A confirmatory prognostic study on oxygenation status and regional control in advanced head and neck squamous cell carcinoma treated by radiation therapy. Radiother Oncol 2000; 57:39-43.
10. Teicher BA. Hypoxia and drug resistance. Cancer Metastasis Rev 1994;13:139-68.
11. Graeber TG, Osmanian C, Jacks T, et al. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumors. Nature 1996;379: 88-91.
12. Young SD, Marshall RS, Hill RP. Hypoxia induces DNA over-replication and enhances metastatic potential of murine tumor cells. Proc Natl Acad Sci U S A 1988;85:9533-7.
13. Stratford IJ, Adams GE, Bremner JCM, et al. Manipulation and exploitation of the tumor environment for therapeutic benefit. Int J Radiat Biol 1994; 65:85-94.
14. Stratford IJ,Williams KJ, Cowen R, Jaffar M. Combining bioreductive drugs and radiation for the treatment of solid tumors. Semin Radit Oncol 2003;13: 42-52.
15. Koch CJ. Unusual oxygen concentration dependence of toxicity of SR-4233, a hypoxic cell toxin. Cancer Res 1993;53:3992-7.
16. De Jaeger K, Merlo FM, Kavanagh MC, Fyles AW, Hedley D, Hill RP. Heterogeneity of tumor oxygenation: relationship to tumor necrosis, tumor size and metastasis. Int J Radiat Oncol Biol Phys 1998;42: 717-21.
17. De Jaeger K, Kavanagh FM, Hill RP. Relationship of hypoxia to metastatic ability in rodent tumors. Br J Cancer 2001;84:1280-5.
18. Fuchs T, Chowdbury G, Barnes CL, Gates KS. 3-amino-1,2,4-benzotriazine 4-oxide: characterization of a new metabolite arising from bioreductive processing of the anti-tumor agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine). J Org Chem 2001;66: 107-14.
19. Jenkins TC, Naylor MA, O'Neill P, et al. Synthesis and evaluation of α-[[(2-haloethyl)amino]methyl]-2-nitro-1H-imidazole-1-ethanols as prodrugs of α-[(1-aziridinyl)methyl]-2-nitro-1H-imidazole-1-ethanol (RSU-1069) and its analogues which are radiosensitizers and bioreductively activated cytotoxins. J Med Chem 1990;33:2603-10.
20. Cole S, Stratford IJ, Adams GE, Fielden EM, Jenkins TC. Dual-function 2-nitroimidazoles as hypoxic cell radiosensitizers and bioreductive cytotoxins: in vivo evaluation in KHT murine sarcomas. Radiat Res 1990;124:S38-43.
21. Hill RP, Zhang L. Hypoxia enhances metastatic efficiency by up-regulating Mdm2 in KHT cells and increasing resistance to apoptosis. Cancer Res 2004; 64:4180-9.