Role of reactive oxygen species in transforming growth factor-β1- inuduced fibronectin secretion and α-smooth muscle actin expression in human lung fibroblasts

Tuberculosis and Respiratory Diseases

Volumn 58, Issue 3, 2005, Pages 267-275

  Ha, Hunjoo ^a,b   Yu, Mi Ra ^a   Uh, Soo Taek ^a,c   Park, Choon Sik ^a,c   Lee, Hi Bahl ^a,c  

^a Soonchunhyang University   (South Korea)

^b Ewha Womans University   (South Korea)

^c Soonchunhyang University College of Medicine   (South Korea)

Author keywords

Diphenyleneiodonium; Fibroblast; Fibronectin; Myofibroblast; N acetylcysteine; Pulmonary fibrosis; Reactive oxygen species; Transforming growth factor beta1; Smooth muscle actin

Indexed keywords

ACETYLCYSTEINE; ALPHA SMOOTH MUSCLE ACTIN; DICHLOROFLUORESCEIN; DIPHENYLIODONIUM SALT; FIBRONECTIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; BIOACCUMULATION; CELL ASSAY; CELL DIFFERENTIATION; CELL STIMULATION; CELL STRAIN; CELL STRAIN MRC 5; CELL SYNCHRONIZATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; LUNG FIBROBLAST; LUNG FIBROSIS; MYOFIBROBLAST; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

EID: 20344377188     PISSN: 03780066     EISSN: None     Source Type: Journal    
DOI: 10.4046/trd.2005.58.3.267     Document Type: Article

References (35)

1. Phan SH. The myofibroblast in pulmonary fibrosis. Chest 2002;122:286S-9S.
2. Adler KB, Low RB, Leslie KO, Mitchell J, Evans JN. Contratile cells in normal and fibrotic lung. Lab Invest 1989;60:473-85.
3. Mitchell J, Woodcock-Mitchell J, Reynolds S, Low R, Leslie K, Adler K, et al. α-smooth muscle actin in parenchymal cells of bleomycin-injected rat lung. Lab Invest 1989;60:643-50.
4. Kuhn C, McDonald JA. The role of myofibroblast in idiopathic pulmonary fibrosis: ultrastructural and imniunohistochemical features of sites of active extracellular matrix synthesis. Am J Pathol 1991;138:1257-65.
5. Pache JC, Christakos PG, Cannon DE, Mitchell JJ, Low RB, Leslie KO. Myofibroblasts in diffuse alveolar damage of the lung. Mod Pathol 1998;11:1064-70.
6. Zhang K, Rekhter MD, Gordon D, Phan SH. Myofibroblasts and their role in lung collagen gene expression during pulmonary fibrosis: a combined immunohistochemical and in situ hybridization study. Am J Pathol 1994;145:114-25.
7. Zhang K, Flanders KC, Phan SH. Cellular localization of transforming growth factor β expression in bleomycin-induced pulmonary fibrosis. Am J Pathol 1995; 147:352-61.
8. Zhang HY, Gharaee-Kermani M, Zhang K, Karmiol S, Phan SH. Lung fibroblast α-smooth muscle actin expression and contractile phenotype in bleomycin-induced pulmonary fibrosis. Am J Pathol 1996;148: 527-37.
9. Zhang K, Gharaee-Kermani M, Jones ML, Warren JS, Phan SH. Lung monocyte chemoattractant protein-1 gene expression in bleomycin-induced pulmonary fibrosis. J Immunol 1994;153:4733-41.
10. Coker RK, Laurent GJ, Shahzeidi S, Hernandez-Rodriguez NA, Pantelidis P, du Bois RM, et al. Diverse cellular TGF-β1 and TGF-β3 gene expression in normal human and murine lung. Eur Respir J 1996;9:2501-7.
11. Eickelberg O, Kohler E, Reichenberger F, Bertschin S, Woodtli T, Erne P, et al. Extracellular matrix deposition by primary human lung fibroblasts in response to TGF-β1 and TGF-β3. Am J Riysiol 1999; 276:L814-24.
12. Border W, Noble NA. Transforming growth factor-beta in tissue fibrosis. N Engl J Med 1994;331: 1286-92.
13. Yang J, Liu Y. Dissection of key events in tubular epithelial to myofibrcblast transition and its implications in renal interstitial fibrosis. Am J Pathol 2001;159: 1465-75.
14. Hu B, Wu Z, Phan SH. Smad3 mediates transforming growth factor-β-induced α-smooth muscle actin expression. Am J Respir Cell Mol Biol 2003;29:397-404.
15. Li JH, Zhu HJ, Huang XR, Lai KN, Johnson RJ, Lam HY. Smad7 inhibits fibrotic effect of TGF-β on renal tubular epithelial cells by blocking smad2 activation. J Am Soc Nephrol 2002;13:1464-72.
16. Hartsough MT, Mulder KM. Transforming growth factor beta activation of p44MAPK in proliferating cultures of epithelial cells. J Biol Chem 1995;270: 7117-24.
17. Zavadil J, Bitzer M, Liang D, Yang YC, Massimi A, Kneitz S, et al. Genetic programs of epithelial cell plasticity directed by transforming growth factor-beta. Proc Natl Acad Sci U S A 2001;98:6686-91.
18. Ellenrieder V, Hendler SF, Boeck W, Seufferlein T, Menke A, Ruhland C, et al. Transforming growth factor-β1 treatment leads to an epithelial-mesenchymal transdifferentiation of pancreatic cancer cells requiring extracellular signal-regulated kinase 2 activation. Cancer Res 2001;61:4222-8.
19. Janda E, Lehmann K, Killisch I, Jechlinger M, Herzig M, Downward J, et al. Ras and TGF-β cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathway. J Cell Biol 2002;156:299-313.
20. Lafon C, Mathieu C, Guerrin M, Pierre O, Vidal S, Valette A. Transforming growth factor-β1-induced apoptosis in human ovarian carcinoma cells: protection by the antioxidant N-acetylcysteine and bcl-2. Cell Growth Differ 1996;7:1095-104.
21. Hong YH, Peng HB, la Fata V, Liao JK. Hydrogen peroxide-mediated transcriptional induction of macrophage colony-stimulation factor by TGF-β1. J Immunol 1997;159:2418-23.
22. 2+ in TGF-β1-induced IL-6 expression. J Immunol 2000;165:2190-7.
23. Chiu C, Maddock DA, Zhang Q, Souza KP, Townsend AR, Wan Y. TGF-β-induced p38 activation is mediated by Rac1-regulated generation of reactive oxygen species in cultured human keratinocytes. Int J Mol Med 2001;8:251-5.
24. Herrera B, Alvarez AM, Sanchez A, Fernandez M, Roncero C, Benito M, et al. Reactive oxygen species mediates the mitochondrial-dependent apoptosis induced by transforming growth factor-β in fetal hepatocyte. FASEB J 2001;15:741-51.
25. Herrera B, Fernandez M, Roncero C, Ventura JJ, Porras A, Valladares A, et al. Activation of p38MAPK by TGF-β in fetal rat hepatocytes requires radical oxygen production, but is dispensable for cell death. FEBS Lett 2001;499:225-9.
26. Jiang Z, Seo JY, Ha H, Lee EA, Kim YS, Han DC, et al. Reactive oxygen species mediate TGF-β1-induced plasminogen activator inhibitor-1 upregulation in mesangial cells. Biochem Biophys Res Commun 2003;309:961-6.
27. Lee HB, Yu MR, Yang Y, Jiang Z, Ha H. Reactive oxygen species-regulated signaling in diabetic nephropathy. J Am Soc Nephrol 2003;14:S241-5.
28. Rhyu DY, Yang Y, Ha H, Lee GT, Song JS, Uh ST, et al. Role of reactive oxygen species in TGF-β1-induced MAPK activation and epithelial-mesenchymal transition in renal tubular epithelial cells. J Am Soc Nephrol 2005. (In press)
29. Hagiwara S, Ishii Y, Kitamura S. Aerosol administration of N-acetylcysteine attenuates lung fibrosis induced by bleomycin in mice. Am J Respir Crit Care Med 2000;162:225-31.
30. Ha H, Yu MR, Choi HN, Cha MK, Rang HS, Kim MH, et al. Effects of conventional and new peritoneal dialysis solution on human peritoneal mesothelial cell viability and proliferation. Perit Dial Int 2000; 20:S10-8.
31. Oh JH, Ha H, Yu MR, Lee HB. Sequential effect of high glucose on mesangial cell transforming growth facator-β1 and fibronectin synthesis. Kidney Int 1998; 54:1872-8.
32. Thannickal VJ, Day RM, Klinz SG, Bastien MC, Larios JM, Fanburg BL. Ras-dependent and -independent regulation of reactive oxygen species by mitogenic growth factors and TGF-β1. FASEB J 2000;14:1741-8.
33. Larios JM, Budhiraja R, Fanburg BL, Thannickal VJ. Oxidative protein cross-linking reaction involving L-tyrosine in transforming growth factor-β1-stimulated fibroblasts. J Biol Chem 2001;276:17437-41.
34. Bottinger EP, Bitzer M. TGF-β signaling in renal disease. J Am Soc Nephrol 2002;13:2600-10.
35. Hayashida T, deCasestecker M, Schnaper HW. Cross-talk between ERK MAP kinase and Smad-signaling pathways enhances TGF-β dependent responses in human mesangial cells. FASEB J 2003;17:1576-8.