Qualitative and quantitative requirements for CD4+ T cell-mediated antiviral protection

Journal of Immunology

Volumn 162, Issue 5, 1999, Pages 2867-2874

  Maloy, Kevin J ^a   Burkhart, Christoph ^a   Freer, Giulia ^a   Rülicke, Thomas ^a   Pircher, Hanspeter ^a   Kono, Dwight H ^b   Theofilopoulos, Argyrios N ^b   Ludewig, Burkhard ^a   Hoffmann Rohrer, Urs ^a   Zinkernagel, Rolf M ^a   Hengartner, Hans ^a  

^a INSTITUTE OF EXPERIMENTAL IMMUNOLOGY   (Switzerland)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; IMMUNOGLOBULIN G; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T LYMPHOCYTE RECEPTOR; VIRUS GLYCOPROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIVIRAL ACTIVITY; ARTICLE; B LYMPHOCYTE; CELL DIFFERENTIATION; CELLULAR IMMUNITY; CONTROLLED STUDY; HELPER CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSGENIC MOUSE; VESICULAR STOMATITIS VIRUS;

ADOPTIVE TRANSFER; ANIMALS; ANTIBODIES, VIRAL; CD4-POSITIVE T-LYMPHOCYTES; FEMALE; IMMUNOGLOBULIN CLASS SWITCHING; IMMUNOGLOBULIN G; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; VESICULAR STOMATITIS-INDIANA VIRUS; VIRAL ENVELOPE PROTEINS; VIRUS DISEASES;

EID: 20244387399     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (67)

1. Zinkernagel, R. M. 1996. Immunology taught by viruses. Science 271:173.
2. Kägi, D., B. Ledermann, K. Bürki, P. Seiler, B. Odermatt, K. J. Olsen, E. Podack, R. M. Zinkernagel, and H. Hengartner. 1994. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature 369:31.
3. Seiler, P., M.-A. Bründler, C. Zimmermann, D. Weibel, M. Bruns, H. Hengartner, and R. M. Zinkernagel. 1998. Induction of protective cytotoxic T cell responses in the presence of high titers of virus-neutralizing antibodies: implications for passive and active immunization. J. Exp. Med. 187:649.
4. Ramshaw, I. A., A. J. Ramsay, G. Karupiah, M. S. Rolph, S. Mahalingam, and J. C. Ruby. 1997. Cytokines and immunity to viral infections. Immunol. Rev. 159:119.
5. Czarniecki, C. W., C. W. Fennie, D. B. Powers, and D. A. Estell. 1984. Synergistic antiviral and antiproliferative activities of Escherichia coli-derived human α, β, and γ interferons. J. Virol. 49:490.
6. Wong, G. H. W., and D. Goeddel. 1986. Tumour necrosis factors α and β inhibit virus replication and synergize with interferons. Nature 323:819.
7. + T cells correlating with cytotoxic activity in vitro are more efficient in antivaccinia virus protection than CD4-dependent interleukins. J. Immunol. 146:4301.
8. Kündig, T. M., H. Hengartner, and R. M. Zinkernagel. 1993. T cell dependent interferon γ exerts an antiviral effect in the central nervous system but not ir peripheral solid organs. J. Immunol. 150:2316.
9. Ramshaw, I., J. Ruby, A. Ramsay, G. Ada, and G. Karupiah. 1992. Expression of cytokines by recombinant vaccinia viruses: a model for studying cytokines in virus infections in vivo. Immunol. Rev. 127:157.
10. Ramsay, A. J., J. Ruby, and I. A. Ramshaw. 1993. A case for cytokines as effector molecules in the resolution of virus infection. Immunol. Today 14:155.
11. Leist, T. P., S. P. Cobbold, H. Waldmann, M. Aguet, and R. M. Zinkernagel. 1987. Functional analysis of T lymphocyte subsets in antiviral host defense. J. Immunol. 138:2278.
12. + cells in sustaining lymphocyte proliferation during lymphocytic choriomeningitis virus infection. J. Immunol. 146:1955.
13. Leist, T. P., M. Kohler, and R. M. Zinkernagel. 1989. Impaired generation of antiviral cytotoxicity against lymphocytic choriomeningitis and vaccinia virus in mice treated with CD4-specific monoclonal antibody. Scand. J. Immunol. 30:679.
14. + cytotoxic T cell responses during chronic viral infection. J. Virol. 68:8056.
15. Cousens, L. P., J. S. Orange, and C. A. Biron. 1995. Endogenous IL-2 contributes to T cell expansion and IFN-γ production during lymphocytic choriomeningitis virus infection. J. Immunol. 155:5690.
16. von Herrath, M. G., M. Yokoyama, J. Dockter, M. B. A. Oldstone, and J. L. Whitton. 1996. CD4-deficient mice have reduced levels of memory cytotoxic T lymphocytes after immunization and show diminished resistance to subsequent virus challenge. J. Virol. 70:1072.
17. + T cells. J. Exp. Med. 174:875.
18. Scherle, P. A., G. Palladino, and W. Gerhard. 1992. Mice can recover from pulmonary influenza virus infection in the absence of class I-restricted cytotoxic T cells. J. Immunol. 148:212.
19. + T helper type 2 T lymphocytes do not promote recovery from experimental virus infection. J. Exp. Med. 180:1273.
20. + T-cell-deficient mice survive inoculation with high doses of vaccinia virus and exhibit altered IgG responses. Proc. Natl. Acad. Sci. USA 89:6070.
21. Kägi, D., P. Seiler, J. Pavlovic, B. Ledermann, K. Bürki, R. M. Zinkernagel, and H. Hengartner. 1995. The roles of perform and Fas-dependent cytotoxicity in protection against cytopathic and non-cytopathic viruses. Eur. J. Immunol. 25: 3256.
22. + T cell clones with both cytotoxic and helper activity mediate protective humoral immunity against a lethal poliovirus infection in transgenic mice expressing the human poliovirus receptor. J. Exp. Med. 181:1285.
23. Reddehase, M. J., W. Mutter, and U. H. Koszinowski. 1987. In vivo application of recombinant interleukin 2 in the immunotherapy of established cytomegalovirus infection. J. Exp. Med. 165:650.
24. Papadopoulos, E. B., M. Ladanyi, D. Emanuel, S. Mackinnon, F. Boulad, M. H. Carabasi, H. Castro-Malaspina, B. H. Childs, A. P. Gillio, T. N. Small, et al. 1994. Infusions of donor leukocytes to treat Epstein-Barr virus-associated lymphoproliferative disorders after allogeneic bone marrow transplantation. N. Engl. J. Med. 330:1185.
25. Riddell, S. R., and P. D. Greenberg. 1995. Principles for adoptive T cell therapy of human viral diseases. Annu. Rev. Immunol. 13:545.
26. + T cells, and interferons in persistent and acute infections of mice with lymphocytic choriomeningitis virus: implications for adoptive immunotherapy of virus carriers. Proc. Natl. Acad. Sci. USA 94:6874.
27. Selin, L. K., K. Vergilis, R. M. Welsh, and S. R. Nahill. 1996. Reduction of otherwise remarkably stable virus-specific cytotoxic T lymphocyte memory by heterologous viral infections. J. Exp. Med. 183:2489.
28. Burkhart, C., G. Freer, R. Castro, L. Adorini, K. H. Wiesmüller, R. M. Zinkernagel, and H. Hengartner. 1994. Characterization of T helper epitopes of the glycoprotein of vesicular stomatitis virus. J. Virol. 68:1573.
29. Lefrancois, L. 1984. Protection against lethal viral infection by neutralizing and nonneutralizing monoclonal antibodies: distinct mechanisms of action in vivo. J. Virol. 51:208.
30. Gobet, R., A. Cerny, E. Rüedi, H. Hengartner, and R. M. Zinkernagel. 1988. The role of antibodies in natural and acquired resistance of mice to vesicular stomatitis virus. Exp. Cell Biol. 56:175.
31. Bachmann, M. F., A. Althage, T. M. Kündig, C. P. Kalberer, H. Hengartner, and R. M. Zinkernagel. 1994. How many specific B cells are needed to protect against a virus? J. Immunol. 152:4235.
32. Thomsen, A. R., A. Nansen, C. Anderson, J. Johansen, O. Marker, and J. P. Christensen. 1997. Cooperation of B and T cells is required for survival of mice infected with vesicular stomatits virus. Int. Immunol. 9:1757.
33. Kündig, T., I. Castelmur, M. F. Bachmann, D. Abraham, D. Binder, H. Hengartner, and R. M. Zinkernagel. 1993. Fewer protective cytotoxic T cell epitopes than T helper cell epitopes on vesicular stomatitis virus. J. Virol. 67:3680.
34. Oxenius, A., M. F. Bachmann, R. M. Zinkernagel, and H. Hengartner. 1998. Virus-specific MHC class II-restricted TCR-transgenic mice: effects on humoral and cellular immune responses after viral infection. Eur. J. Immunol. 28:390.
35. Philpott, K. L., J. L. Viney, G. Kay, S. Rastan, E. M. Gardiner, S. Chae, A. C. Hayday, and M. J. Owen. 1992. Lymphoid development in mice congenitally lacking T cell receptor αβ-expressing cells. Science 256:1448.
36. Pircher, H. P., K. Bürki, R. Lang, H. Hengartner, and R. M. Zinkernagel. 1989. Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen. Nature 342:559.
37. Freer, G., C. Burkhart, T. Rülicke, E. Ghelardi, U. Hoffmann Rohrer, H. Pircher, R. M. Zinkernagel, and H. Hengartner. 1995. Role of T helper cell precursor frequency on vesicular stomatitis virus neutralizing antibody responses in a T cell receptor β chain transgenic mouse. Eur. J. Immunol. 25:1410.
38. Brinster, R. L., H. Y. Chen, M. Trumbauer, A. W. Senear, R. Warren, and R. D. Palmiter. 1981. Somatic expression of herpes thymidine kinase in mice following injection of a fusion gene into eggs. Cell 27:223.
39. Hogan, B., F. Constantini, and E. Lacy. 1986. Manipulating the Mouse Embryo: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
40. Ludewig, B., S. Ehl, U. Karrer, B. Odermatt, H. Hengartner, and R. M. Zinkernagel. 1998. Dendritic cells efficiently induce protective antiviral immunity. J. Virol. 72:3812.
41. McCaren, L., J. J. Holland, and J. T. Syverton. 1959. The mammalian cell-virus relationship. I. Attachment of poliovirus to cultivated cells of primate and non-primate origin. J. Exp. Med. 109:475.
42. Charan, S., and R. M. Zinkernagel. 1986. Antibody mediated suppression of secondary IgM response in nude mice against vesicular stomatitis virus. J. Immunol. 136:3057.
43. Bachmann, M. F., T. M. Kündig, C. Kalberer, H. Hengartner, and R. M. Zinkernagel. 1993. Formalin inactivation of vesicular stomatitis virus impairs T cell- but not T helper independent B cell responses. J. Virol. 67:3917.
44. Mackett, M., T. Yilma, J. K. Rose, and B. Moss. 1985. Vaccinia virus recombinants: expression of VSV genes and protective immunization of mice and cattle. Science 227:433.
45. Wagner, R. R., R. M. Snyder, and S. Yamazaki. 1970. Proteins of vesicular stomatitis virus: kinetics and cellular sites of synthesis. J. Virol. 5:548.
46. Scott, D. W., and R. K. Gershon. 1970. Determination of total and mercapto-ethanol-resistant antibody in the same serum sample. Clin. Exp. Immunol. 6:313.
47. Malissen, M., J. Trucy, E. Jouvin-Marche, P. A. Cazenave, R. Scollay, and B. Malissen. 1992. Regulation of TCR α and β gene allelic exclusion during T-cell development. Immunol. Today 13:315.
48. Gallione, C. J., and J. K. Rose. 1983. Nucleotide sequence of a cDNA clone encoding the entire glycoprotein from the New Jersey serotype of vesicular stomatitis virus. J. Virol. 46:162.
49. Mackay, C. R., W. L. Marston, and L. Dudler. 1990. Naive and memory T cells show distinct pathways of lymphocyte recirculation. J. Exp. Med. 171:801.
50. Mackay, C. R. 1993. Homing of naive, memory and effector lymphocytes. Curr. Opin. Immunol. 5:423.
51. Butcher, E. C., and L. J. Picker. 1996. Lymphocyte homing and homeostasis. Science 272:60.
52. Lee, W. T., and E. S. Vitetta. 1991. The differential expression of homing and adhesion molecules on virgin and memory T cells in the mouse. Cell. Immunol. 132:215.
53. Swain, S. L., L. M. Bradley, M. Croft, S. Tonkonogy, G. Atkins, A. D. Weinberg, D. D. Duncan, S. M. Hedrick, R. W. Dutton, and G. Huston. 1991. Helper T cell subsets: phenotype, function and the role of lymphokines in regulating their development. Immunol. Rev. 123:115.
54. + T cells. Annu. Rev. Immunol. 12:635.
55. + T lymphocytes different from unprimed cells? Eur. J. Immunol. 24:1073.
56. Bachmann, M. F., T. M. Kündig, B. Odermatt, H. Hengartner, and R. M. Zinkernagel. 1994. Free recirculation of memory B cells versus antigen-dependent differentiation to antibody forming cells. J. Immunol. 153:3386.
57. Kündig, T. M., M. F. Bachmann, P. S. Ohashi, H. Pircher, H. Hengartner, and R. M. Zinkernagel. 1996. On T cell memory: arguments for antigen-dependence. Immunol. Rev. 150:63.
58. Bachmann, M. F., T. M. Kündig, H. Hengartner, and R. M. Zinkernagel. 1997. Protection against immunopathological consequences of a viral infection by activated but not resting cytotoxic T cells: T cell memory without "memory T cells?" Proc. Natl. Acad. Sci. USA 94:640.
59. Kündig, T. M., M. F. Bachmann, S. Oehen, U. W. Hoffmann, J. J. L. Simard, C. P. Kalberer, H. Pircher, P. S. Ohashi, H. Hengartner, and R. M. Zinkernagel. 1996. On the role of antigen in maintaining cytotoxic T-cell memory. Proc. Natl. Acad. Sci. USA 93:9716.
60. Heath, W. R., and J. F. A. P. Miller. 1993. Expression of two α chains on the surface of T cells in T cell receptor transgenic mice. J. Exp. Med. 178:1807.
61. Lee, W. T., J. Cole-Calkins, and N. E. Street. 1996. Memory T cell development in the absence of specific antigen priming. J. Immunol. 157:5300.
62. Padovan, E., G. Casorati, P. Dellabona, S. Meyer, M. Brockhaus, and A. Lanzavecchia. 1993. Expression of two T cell receptor α chains: dual receptor T cells. Science 262:422.
63. Padovan, E., C. Giachino, M. Cella, S. Valitutti, O. Acuto, and A. Lanzavecchia. 1995. Normal T lymphocytes can express two different T cell receptor β chains: implications for the mechanism of allelic exclusion. J. Exp. Med. 181:1587.
64. Heath, W. R., F. R. Carbone, P. Bertolino, J. Kelly, S. Cose, and J. F. A. P. Miller. 1995. Expression of two T cell receptor α chains on the surface of normal murine T cells. Eur. J. Immunol. 25:1617.
65. + T cells. J. Immunol. 160:4500.
66. + T cells from mice transgenic for an αβ TCR. J. Immunol. 159:2563.
67. Reiner, S. L., D. J. Fowell, N. H. Moskowitz, K. Swier, D. R. Brown, C. R. Brown, C. W. Turck, P. A. Scott, N. Killeen, and R. M. Locksley. 1998. Control of Leishmania major by a monoclonal αβ T cell repertoire. J. Immunol. 160:884.