Malignant progenitors from patients with acute myelogenous leukemia are sensitive to a diphtheria toxin-granulocyte-macrophage colony-stimulating factor fusion protein

Blood

Volumn 92, Issue 2, 1998, Pages 589-595

  Hogge, Donna E ^a,g   Willman, Cheryl L ^b   Kreitman, Robert J ^c   Berger, Marc ^d   Hall, Philip D ^e   Kopecky, Kenneth J ^f   McLain, Chris ^a   Tagge, Edward P ^b   Eaves, Connie J ^c   Frankel, Arthur E ^d  

^a BRITISH COLUMBIA CANCER AGENCY   (Canada)

^b UNIVERSITY OF NEW MEXICO   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^e USA   (United States)

^f WAKE FOREST BAPTIST HEALTH   (United States)

^g NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIPHTHERIA TOXIN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR RECEPTOR; HYBRID PROTEIN;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; AGED; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER GROWTH; FEMALE; HUMAN; HUMAN CELL; MALE; PRIORITY JOURNAL; STEM CELL;

ADULT; AGED; AGED, 80 AND OVER; CELL COUNT; CELL DEATH; DIPHTHERIA TOXIN; FEMALE; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; LEUKEMIA, MYELOCYTIC, ACUTE; MALE; MIDDLE AGED; RECEPTORS, GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; RECOMBINANT FUSION PROTEINS; TUMOR CELLS, CULTURED;

EID: 20244379085     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Schiffer C: Acute myeloid leukemia in adults, in Holland J, Frei E, Bast R, Kufe D, Manon D, Weichselbaum R (eds): Cancer Medicine. Philadelphia, PA, Lea & Febiger, 1997, p 2617
2. Rohatiner A, Lister TA: Acute myeloid leukemia in adults, in Henderson ES, Lister TA, Greaves MF (eds): Leukemia. Philadelphia, PA,Saunders, 1996, p 479
3. List A: Role of multidrug resistance and its pharmacological modulation in acute myeloid leukemia. Leukemia 10:937, 1996
4. Pirker R, Wallner J, Geissler K, Kinkesch W, Haas O, Bettelheim P, Hopfner M, Scherrer R, Valent P, Havelec L, Ludwig H, Lechner K: MDR1 gene expression and treatment outcome in acute myeloid leukemia. J Natl Cancer Inst 83:708, 1991
5. Russo D, Marie JP, Zhou DC, Faussat AM, Melli C, Damiani D, Michelutti A, Michieli M, Fanin R, Baccarani M: Evaluation of the clinical relevance of the anionic glutathione S-transferase (GST pi) and multidrug resistance (mdr-1) gene coexpression in leukemias and lymphomas. Leuk Lymphoma 15:453, 1994
6. Maung Z, MacLean F, Reid M, Pearson A, Proctor S, Hamilton P, Hall A: The relationship between bcl-2 expression and response to chemotherapy in acute leukaemia. Br J Haematol 88:105, 1994
7. List A, Spier C, Grogan T, Johnson C, Roe D, Greer J, Wolff S, Broxterman H, Scheffer G, Scheper R, Dalton W: O verexpression of the major vault transporter protein lung-resistance protein predicts treatment outcome in acute myeloid leukemia. Blood 87:2464, 1996
8. Leith CP, Kopecky KJ, Godwin J, McConnell T, Slovak M, Chen IM, Head DR, Appelbaum F, Willman CL: Acute myeloid leukemia in the elderly: Assessment of multidrug resistance (MDR1) and cytogenetics distinquishes biological subgroups with remarkably distinct responses to standard chemotherapy. A Southwest Oncology Group study. Blood 89:3323, 1997
9. Solary E, Witz B, Caillot D, Moreau P, Desablens B, Cahn JY, Sadoun A, Pignon B, Berthou C, Maloisel F, Guyotat D, Casassus P, Ifrah N, Lamy Y, Audhuy B, Colombat P, Harousseau JL: Combination of quinine as a potential reversing agent with mitoxantrone and cytarabine for the treatment of acute leukemias: A randomized multicenter study. Blood 88:1198, 1996
10. Sievers EL, Bernstein ID, Spielberger RT, Forman SJ, Berger MS, Shannon-Dorcy K, Appelbaum FR: Dose escalation phase I study of recombinant engineered human anti-CD33 antibody-calicheamicin drug conjugate (CMA-676) in patients with relapsed or refractory acute myeloid leukemia (AML). Blood (in press)
11. Roy DC, Griffin JD, Belvin M. Blattler WA, Lambert JM, Ritz J: Anti-MY9-blocked ricin: An immunotoxin for selective targeting of acute myeloid leukemia cells. Blood 77:2404, 1991
12. McGraw KJ, Rosenblum MG, Cheung L, Scheinberg DA: Characterization of murine and humanized anti-CD33, gelonin immunotoxins reactive against myeloid leukemias Cancer Immunol Immunother 39:367, 1994
13. Xu Y, Xu Q, Rosenblum MG, Scheinberg DA: Antileukemic activity of recombinant humanized M195-gelonin immunotoxin in nude mice. Leukemia 10:321, 1996
14. Engert A, Brown A, Thorpe P: Resistance of myeloid leukaemia cell lines to ricin A-chain immunotoxins. Leuk Res 15:1079, 1991
15. Frankel AE, Hall PD, Burbage C, Vesely J, Willingham M, Bhalla K, Kreitman RJ: Modulation of the apoptotic response of human myeloid leukemia cells to a diphtheria toxin-granulocyte-macrophage colony stimulating factor (GM-CSF) fusion protein. Blood 90:3654, 1997
16. Perentesis JP, Waddick KG, Bendel AE, Shao Y, Warman BE, Chandan-Langlie M, Uckun F: Induction of apoptosis in multidrugresistant and radiation-resistant acute myeloid leukemia cells by a recombinant fusion protein directed against the human granulocyte macrophage colony-stimulating factor receptor. Clin Cancer Res 3:347, 1997
17. Kreitman RJ, Pastan I: Recombinant toxins containing human granulocyte-macrophage colony-stimulating factor and either Pseudomonas exotoxin or diphtheria toxin kill gastrointestinal cancer and leukemia cells. Blood 90:242, 1997
18. Chan CH, Blazar BR, Eide CR, Greenfield L, Kreitman RJ, Vallera DA: Reactivity of murine cytokine fusion toxin, DT390-mIL-3, with bone marrow progenitor cells. Blood 88:1445, 1996
19. Chan CH, Blazar BR, Eide CR, Kreitman RJ, Vallera DA: A murine cytokine fusion toxin specifically targeting the murine granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor on normal committed bone marrow progenitor cells and GM-CSFdependent tumor cells. Blood 86:2732, 1995
20. Bendel AE, Shao Y, Davies SM, Warman B, Yang CH, Waddick KG, Uckun FM, Perentesis JP: A recombinant fusion toxin targeted to the granulocyte-macrophage colony-stimulating factor receptor. Leuk Lymphoma 25:257, 1997
21. Perentesis JP, Bendel AE, Shao Y, Warman B, Davies SM, Yang CH, Chandan-Langlie M, Waddick KG, Uckun FM: Granulocyte-macrophage colony-stimulating factor receptor-targeted therapy of chemotherapy- and radiation-resistant human myeloid leukemias. Leuk Lymphoma 25:247, 1997
22. Hertler A, Schlossman D, Borowitz M, Blythman H, Casellas P, Frankel AE: An anti-CD5 immunotoxin for chronic lymphocytic leukemia: Enhancement of cytotoxicity with human serum albuminmonensin. IntJ Cancer 43:215, 1989
23. Kreitman RJ, Chaudhary VK, Waldmann T, Willingham MC, FitzGerald DJ, Pastan I: The recombinant immunotoxin anti-Tac(Fv)Pseudomonas exotoxin 40 is cytotoxic toward peripheral blood malignant cells from patients with adult T-cell leukemia. Proc Natl Acad Sei USA 87:8291, 1990
24. Hogge D, Fanning S, Bockhold K, Petzer A, Lambie K, Lansdorp P, Eaves A, Eaves C: Quantitäten and characterization of human megakaryocyte colony-forming cells using a standardized serum-free agarose assay. Br J Haematol 96:790, 1997
25. Lowenberg B, Suciu S, Archimbaud E, Ossenkoppele G, Verhoef G, Vellenga E, Wijermans P, Berneman Z, Dekker A, Stryckmans P, Schouten H., Jehn U, Muus P, Sonneveld P, Dordeune M, Zittoun R: Use of recombinant granulocyte-macrophage colony-stimulating factor during and after remission induction chemotherapy on patients aged 61 years and older with acute myeloid leukemia (AML): Final report of AML-11, a phase III randomized study of the leukemia cooperative group of European Oranisation for the Research and Treatment of Cancer (EROTC-LCG) and the Dutch Belgian Hemato-Oncology Cooperative Group (HOVON). Blood 90:2952, 1997
26. Harousseau JL, Cuhn JY, Pignon B, Witz F, Milpied N, Delain M, Lioure B, Lamy T, Desablens B, Guilhot F, Caillot D, Abgrall JF, Francois S, Briere J, Guyotat D, Casassus P, Audhuy B, Tellier Z, Hurteloup P, Herve P: Comparison of autologous bone marrow transplantation and intensive chemotherapy as post-remission therapy in adult myeloid leukemia. Blood 90:2978, 1997
27. Hall PD, Kreitman RJ, Willingham MC, Frankel AE: Toxicology and pharmacology of DT388-GMCSF, a fusion toxin consisting of a truncated diphtheria toxin (DT388) linked to human granulocyte-macrophage colony stimulating factor (GM-CSF), in C57B1/6 mice. Toxicol Appl Pharm (in press)
28. Onetto-Pothier N, Aumont N, Haman A, Bigras C, Wong G, Clark S, DeLean A, Hoang T: Characterization of granulocytemacrophage colony-stimulating factor receptor on the blast cells of acute myeloblastic leukemia. Blood 75:59, 1990
29. Park LS, Waldron PE, Friend D, Sassenfeld HM, Price V, Anderson D, Cosman D, Andrews RG, Bernstein ID, Urdal DL: Interleukin-3, GM-CSF, and G-CSF receptor expression on cell lines and primary leukemia cells: Receptor heterogeneity and relationship to growth factor responsiveness. Blood 74:56, 1989
30. Kelleher C, Wong G, Clark S, Schendel P, Minden M, McCuIloch E: Binding of iodinated recombinant human GM-CSF to the blast cells of acute myeloblastic leukemia. Leukemia 2:211, 1988
31. Buick RN, Till JE, McCulloch EA: Colony assay for proliferative blast cells circulating in myeloblastic leukemia. Lancet 1:862, 1997
32. Ailles LE, Gerhard B, Hogge DE: Detection and characterization of primitive malignant and normal progenitors in patients with acute myelogenous leukemia using long-term coculture with supportive feeder layers and cytokines. Blood 90:2555, 1997
33. Delmar A, Marie JP, Thevenin D, Cadiou M, Viguie F, Zittoun R: Multivariate analysis of prognostic factors in acute myeloid leukemia: Value of clonogenic leukemia cell properties. J Clin Oncol 7:738, 1989
34. Sakamaki K, Miyajima Kitarnura T, Miyajima A: Critical cytoplasmic domains of the common beta subunit of the human GM-CSF, IL-3 and IL-5 receptors for growth signal transduction and tyrosine phosphorylation. EMBO J 11:3541, 1992
35. Frankel AE, Hall PD, McLain C, Safa AR, Tagge EP, Kreitman RJ: Cell-specific modulation of drug resistance in acute myeloid leukemic blasts by targeted toxins. Bioconjug Chem (submitted)
36. Terpstra W, Rozemuller H, Breems DA, Rombouts EJC, Prins A, FitzGerald DJP, Kreitman RJ, Wielenga JJ, Ploemacher RE, Löwenberg B, Hagenbeek A, Martens ACM: Diphtheria toxin fused to granulocytemacrophage colony-stimulating factor eliminates acute myeloid leukemia cells with the potential to initiate leukemia in immunodeficient mice, but spares normal hemopoietic stem cells. Blood 90:3735, 1997