Recombinant toxins containing human granulocyte-macrophage colony stimulating factor and either pseudomonas exotoxin or diphtheria toxin kill gastrointestinal cancer and leukemia cells

Blood

Volumn 90, Issue 1, 1997, Pages 252-259

  Kreitman, Robert J ^a   Pastan, Ira ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLONY STIMULATING FACTOR RECEPTOR; DIPHTHERIA TOXIN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; PSEUDOMONAS EXOTOXIN; TRANSFERRIN RECEPTOR;

ARTICLE; CANCER CELL CULTURE; COLON CANCER; CONTROLLED STUDY; CYTOTOXICITY; DIGESTIVE SYSTEM CANCER; HUMAN; HUMAN CELL; LEUKEMIA CELL LINE; PRIORITY JOURNAL; RECEPTOR BINDING; STOMACH CANCER;

EID: 0030921452     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v90.1.252     Document Type: Article

References (46)

1. Miyajima A, Mui AL, Ogorochi T, Sakamaki K: Receptors for granulocyte-macrophage colony-stimulating factor, interleukin-3, and interleukin-5. Blood 82:1960, 1993
2. Metcalf D: The granulocyte-macrophage colony-stimulating factors. Science 299:16, 1985
3. Burgess AW, Camakaris J, Metcalf D: Purification and properties of colony-stimulating factor from mouse lung-conditioned medium. J Biol Chem 252:1998, 1977
4. Park LS, Friend D, Gillis S, Urdal DL: Characterization of the cell surface receptor for granulocyte-macrophage colony-stimulating factor. J Biol Chem 261:4177, 1986
5. DiPersio J, Billing P, Kaufman S, Eghtesady P, Williams RE, Gasson JC: Characterization of the human granulocyte-macrophage colony-stimulating factor receptor. J Biol Chem 263:1834, 1988
6. Wong GG, Witek JS, Temple PA, Wilkens KM, Leary AC, Luxenberg DP, Jones SS, Brown EL, Kay RM, Orr EC, Shoemaker C, Golde DW, Kaufman RJ, Hewick RM, Wang EA, Clark SC: Human GM-CSF: Molecular cloning of the complementary DNA and purification of the natural and recombinant proteins. Science 228:810, 1985
7. Cantrell MA, Anderson D, Cerretti DP, Price V, McKereghan K, Tushinski RJ, Mochizuki DY, Larsen A, Grabstein K, Gillis S, Cosman D: Cloning, sequence, and expression of a human granulocyte/macrophage colony-stimulating factor. Proc Natl Acad Sci USA 82:6250, 1985
8. Hayashida K, Kitamura T, German DM, Arai K, Yokota T, Miyajima A: Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): Reconstitution of a high-affinity GM-CSF receptor. Proc Natl Acad Sci USA 87:9655, 1990
9. Fleischman RA: Southwestern Internal Medicine Conference: Clinical use of hematopoietic growth factors. Am J Med Sci 305:248, 1993
10. Foulke RS, Marshall MH, Trotta PP, Hoff DDV: In vitro assessment of the effects of granulocyte-macrophage colony-stimulating factor on primary human tumors and derived lines. Cancer Res 50:6264, 1990
11. Park LS, Waldron PE, Friend D, Sassenfeld HM, Price V, Anderson D, Cosman D, Andrews RG, Bernstein ID, Urdal DL: Interleukin-3, GM-CSF, and G-CSF receptor expression on cell lines and primary leukemia cells: Receptor heterogeneity and relationship to growth factor responsiveness. Blood 74:56, 1989
12. Chiba S, Shibuya K, Piao Y, Tojo A, Sasaki N, Matsuki S, Miyagawa K, Miyazono K, Takaku F: Identification and cellular distribution of distinct proteins forming human GM-CSF receptor. Cell Regul 1:327, 1990
13. Berdel WE, Danhauscr-Riedl S, Steinhauser G, Winton EF: Various hematopoietic growth factors (interleukin-3, GM-CSF, G-CSF) stimulate clonal growth of non-hematopoietic tumor cells. Blood 73:80, 1989
14. Baldwin GC, Gasson JC, Kaufman SE, Quan SG, Williams RE, Avalos BR, Gazdar AF, Golde DW, DiPersio JF: Nonhematopoietic tumor cells express functional GM-CSF receptors. Blood 73:1033, 1989
15. Dippold WG, Klingel R, Kerlin M, Schwaeble W, Buschenfelde KMZ: Stimulation of pancreas and gastric carcinoma cell growth by interleukin 3 and granulocyte-macrophage colony stimulating factor. Gastroenterology 100:1338, 1991
16. Hirsch T, Eggstein S, Frank S, Farthmann EH, Specht Bv: Expression of GM-CSF and a functional GM-CSF receptor in the human colon carcinoma line SW403. Biochem Biophys Res Commun 217:138, 1995
17. + bone marrow cells, differentiating monomyeloid progenitors, and mature blood cell subsets. Blood 84:764, 1994
18. Chan C, Blazar BR, Eide CR, Kreitman RJ, Vallera DA: A murine cytokine fusion toxin specifically targeting the murine granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor on normal committed bone marrow progenitor cells and GM-CSF-dependent tumor cells. Blood 86:2732, 1995
19. Lappi DA, Martineau D, Sarmientos P, Garofano L, Aranda AP, Miyajima A, Kitamura T, Baird A: Characterization of a saporin mitotoxin specifically cytotoxic to cells bearing the granulocyte-macrophage colony-stimulating factor receptor. Growth Factors 9:31, 1993
20. Pastan I, FitzGerald D: Recombinant toxins for cancer treatment. Science 254:1173, 1991
21. Murphy JR, vanderSpek JC: Targeting diphtheria toxin to growth factor receptors. Semin Cancer Biol 6:259, 1995
22. Hwang J, FitzGerald DJ, Adhya S, Pastan I: Functional domains of Pseudomonas exotoxin identified by deletion analysis of the gene expressed in E. coli. Cell 48:129, 1987
23. Allured VS, Collier RJ, Carroll SF, McKay DB: Structure of exotoxin A of Pseudomonas aeruginosa at 3.0 Angstrom resolution. Proc Natl Acad Sci USA 83:1320, 1986
24. 194. J Biol Chem 265:20673, 1990
25. Kreitman RJ, Pastan I: Importance of the glutamate residue of KDEL in increasing the cytotoxicity of Pseudomonas exotoxin derivatives and for increased binding to the KDEL receptor. Biochem J 307:29, 1995
26. Kreitman RJ, Batra JK, Seetharam S, Chaudhary VK, FitzGerald DJ, Pastan I: Single-chain immunotoxin fusions between anti-Tac and Pseudomonas exotoxin: Relative importance of the two toxin disulfide bonds. Bioconjug Chem 4:112, 1993
27. Seetharam S, Chaudhary VK, FitzGerald D, Pastan I: Increased cytotoxic activity of Pseudomonas exotoxin and two chimeric toxins ending in KDEL. J Biol Chem 266:17376, 1991
28. Kreitman RJ, Puri RK, Leland P, Lee B, Pastan I: Site-specific conjugation to interleukin 4 containing mutated cysteine residues produces interleukin 4-toxin conjugates with improved binding and activity. Biochemistry 33:11637, 1994
29. Kreitman RJ, Puri RK, Pastan I: A circularly permuted recombinant interleukin 4 toxin with increased activity. Proc Natl Acad Sci USA 91:6889, 1994
30. Chaudhary VK, FitzGerald DJ, Pastan I: A proper amino terminus of diphtheria toxin is important for cytotoxicity. Biochem Biophys Res Commun 180:545, 1991
31. Batra JK, FitzGerald DJ, Chaudhary VK, Pastan I: Single-chain immunotoxins directed at the human transferrin receptor containing Pseudomonas exotoxin A or diphtheria toxin: Anti-TFR(Fv)-PE40 and DT388-Anti-TFR(Fv). Mol Cell Biol 11:2200, 1991
32. Kreitman RJ, Bailon P, Chaudhary VK, FitzGerald DJP, Pastan I: Recombinant immunotoxins containing anti-Tac(Fv) and derivatives of Pseudomonas exotoxin produce complete regression in mice of an interleukin-2 receptor-expressing human carcinoma. Blood 83:426, 1994
33. 4E, a recombinant fusion of interleukin 6 with Pseudomonas exotoxin. Bioconjug Chem 4:581, 1993
34. Studier FW, Moffatt BA: Use of bacteriophage T7 polymerase to direct selective expression of cloned genes. J Mol Biol 189:113, 1986
35. Batra JK, Kasprzyk PG, Bird RE, Pastan I, King CR: Recombinant anti-erbB2 immunotoxins containing Pseudomonas exotoxin. Proc Natl Acad Sci USA 89:5867, 1992
36. Kreitman RJ, Siegall CB, FitzGerald DJP, Epstein J, Barlogie B, Pastan I: Interleukin-6 fused to a mutant form of Pseudomonas exotoxin kills malignant cells from patients with multiple myeloma. Blood 79:1775, 1992
37. Batra JK, Jinno Y, Chaudhary VK, Kondo T, Willingham MC, FitzGerald DJ, Pastan I: Antitumor activity in mice of an immunotoxin made with anti-transferrin receptor and a recombinant form of Pseudomonas exotoxin. Proc Natl Acad Sci USA 86:8545, 1989
38. Chaudhary VK, Jinno Y, FitzGerald D, Pastan I: Pseudomonas exotoxin contains a specific sequence at the carboxyl terminus that is required for cytotoxicity. Proc Natl Acad Sci USA 87:308, 1990
39. Kreitman RJ, Hansen HJ, Jones AL, FitzGerald DJP, Goldenberg DM, Pastan I: Pseudomonas exotoxin-based immunotoxins containing the antibody LL2 or LL2-Fab′ induce regression of subcutaneous human B-cell lymphoma in mice. Cancer Res 53:819, 1993
40. Chiron MF, Fryling CM, FitzGerald DJ: Cleavage of Pseudomonas exotoxin and diphtheria toxin by a furin-like enzyme prepared from beef liver. J Biol Chem 269:18167, 1994
41. 280 generates the enzymatically active fragment which translocates to the cytosol. J Biol Chem 267:25396, 1992
42. Zhan H, Choe S, Huynh PD, Finkelstein A, Eisenberg D, Collier RJ: Dynamic transitions of the transmembrane domain of diphtheria toxin: Disulfide trapping and fluorescence proximity studies. Biochemistry 33:11254, 1994
43. Cabiaux V, Mindell J, Collier RJ: Membrane translocation and channel-forming activities of diphtheria toxin are blocked by replacing isoleucine 364 with lysine. Infect Immunity 61:2200, 1993
44. vanderSpek J, Cassidy D, Genbauffe F, Huynh PD, Murphy JR: An intact transmembrane helix 9 is essential for the efficient delivery of the diphtheria toxin catalytic domain to the cytosol of target cells. J Biol Chem 269:21455, 1994
45. Yamaizumi M, Mekada E, Uchida T, Okada Y: One molecule of diphtheria toxin fragment A introduced into a cell can kill the cell. Cell 15:245, 1978
46. Kaushansky K, Shoemaker SG, Alfaro S, Brown C: Hematopoietic activity of granulocyte/macrophage colony-stimulating factor is dependent upon two distinct regions of the molecule: Functional analysis based upon the activities of interspecies hybrid growth factors. Proc Natl Acad Sci USA 86:1213, 1989