Conformational flexibility of a synthetic glycosylaminoglycan bound to a fibroblast growth factor. FGF-1 recognizes both the 1C4 and 2So conformations of a bioactive heparin-like hexasaccharide

Journal of the American Chemical Society

Volumn 127, Issue 16, 2005, Pages 5778-5779

  Canales, Angeles ^a   Angulo, Jesús ^b   Ojeda, Rafael ^b   Bruix, Marta ^c   Fayos, Rosa ^a   Lozano, Rosa ^a   Giménez Gallego, Guillermo ^a   Martín Lomas, Manuel ^b   Nieto, Pedro M ^b   Jiménez Barbero, Jesús ^a  

^a CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^b INSTITUTO DE INVESTIGACIONES QUÍMICAS   (Spain)

^c INSTITUTO DE QUÍMICA FÍSICA ROCASOLANO   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR 1; HEPARIN; POLYSACCHARIDE; SYNTHETIC GLYCOSAMINOGLYCAN; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG;

ARTICLE; CARBOHYDRATE ANALYSIS; CONFORMATIONAL TRANSITION; MOLECULAR RECOGNITION; NUCLEAR MAGNETIC RESONANCE; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; X RAY ANALYSIS;

ANTITHROMBIN III; CARBOHYDRATE CONFORMATION; CARBOHYDRATE SEQUENCE; FIBROBLAST GROWTH FACTOR 1; GLYCOSAMINOGLYCANS; HEPARIN; MOLECULAR SEQUENCE DATA; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; OLIGOSACCHARIDES;

EID: 20244368809     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja043363y     Document Type: Article

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