Synthesis of conformationally locked carbohydrates: A skew-boat conformation of L-iduronic acid governs the antithrombotic activity of heparin

Angewandte Chemie - International Edition

Volumn 40, Issue 9, 2001, Pages 1670-1673

  Das, Sanjoy K ^a   Mallet, Jean Maurice ^a   Esnault, Jacques ^a   Driguez, Pierre Alexandre ^b   Duchaussoy, Philippe ^b   Sizun, Philippe ^b   Hérault, Jean Pascal ^b   Herbert, Jean Marc ^b   Petitou, Maurice ^b   Sinaÿ, Pierre ^a  

^a ECOLE NORMALE SUPÉRIEURE   (France)

^b SANOFI   (France)

Author keywords

Blood coagulation; Carbohydrates; Glycosylation; Heparin; Molecular recognition

Indexed keywords

BLOOD; COAGULATION; CONFORMATIONS; SYNTHESIS (CHEMICAL);

CONFORMATIONAL FLEXIBILITY;

CARBOHYDRATES;

ANTITHROMBIN; BLOOD CLOTTING FACTOR 10A; CARBOHYDRATE; HEPARIN; IDURONIC ACID; PENTASACCHARIDE;

ARTICLE; BLOOD CLOTTING; CARBOHYDRATE ANALYSIS; CARBOHYDRATE SYNTHESIS; CONFORMATION; GLYCOSYLATION; MOLECULAR RECOGNITION; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

EID: 0035805327     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-3773(20010504)40:9<1670::AID-ANIE16700>3.0.CO;2-Q     Document Type: Article

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