Synthesis of conformationally locked L-iduronic acid derivatives: Direct evidence for a critical role of the skew-boat 2S0 conformer in the activation of antithrombin by heparin

Chemistry - A European Journal

Volumn 7, Issue 22, 2001, Pages 4821-4834

  Das, Sanjoy K ^a   Mallet, Jean Maurice ^a   Esnault, Jacques ^a   Driguez, Pierre Alexandre ^b   Duchaussoy, Philippe ^b   Sizun, Philippe ^b   Herault, Jean Pascal ^b   Herbert, Jean Marc ^b   Petitou, Maurice ^a,b   Sinay, Pierre ^a  

^a ECOLE NORMALE SUPÉRIEURE   (France)

^b SANOFI   (France)

Author keywords

Antithrombin; Carbohydrates; Glycosylation; Heparin; Iduronic acid

Indexed keywords

ACTIVATION ANALYSIS; GLUCOSE; POLYSACCHARIDES; SOLUTIONS; SYNTHESIS (CHEMICAL);

BINDING SITES;

CARBOXYLIC ACIDS;

ANTIBODY; ANTITHROMBIN; BLOOD CLOTTING FACTOR 10A; GLUCOSE; HEPARIN; HYDROGEN; IDURONIC ACID; PENTASACCHARIDE; VINYL DERIVATIVE;

ARTICLE; ASSAY; BINDING SITE; CHEMICAL STRUCTURE; CONFORMATION; COVALENT BOND; METHYLATION; ROTATION; STRUCTURE ANALYSIS; SYNTHESIS;

EID: 0035914639     PISSN: 09476539     EISSN: None     Source Type: Journal    
DOI: 10.1002/1521-3765(20011119)7:22<4821::AID-CHEM4821>3.0.CO;2-N     Document Type: Article

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