Consequences of chemoresistance for the herpes simplex virus thymidine kinase/ganciclovir-induced bystander effect in a human small cell lung cancer cell line model

Anticancer Research

Volumn 25, Issue 1 A, 2005, Pages 255-261

  Van Dillen, Ingrid J ^a   Mulder, Nanno H ^a   Sluiter, Wim J ^a   Meijer, Coby ^a   De Jong, Steven ^a   Loncarek, Jadranka ^b   Mesnil, Marc ^c   De Vries, Erik F J ^a   Vaalburg, Willem ^a   Hospers, Geke A P ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^b UNIVERSITY OF ZAGREB   (Croatia)

^c UNIVERSITÉ DE POITIERS   (France)

Author keywords

Bystander effect; Ganciclovir; Gap junctional intercellular communication; Herpes simplex virus thymidine kinase; Multidrug resistance

Indexed keywords

18ALPHA GLYCYRRHETINIC ACID; CISPLATIN; DOXORUBICIN; GANCICLOVIR; HERPES SIMPLEX VIRUS THYMIDINE KINASE; MITOXANTRONE; MULTIDRUG RESISTANCE PROTEIN 4; MULTIDRUG RESISTANCE PROTEIN 5; NUCLEOSIDE TRANSPORTER; THYMIDINE KINASE; UNCLASSIFIED DRUG;

ARTICLE; BYSTANDER EFFECT; CANCER CELL CULTURE; CELL COMMUNICATION; CHEMOSENSITIVITY; CYTOTOXICITY; GAP JUNCTION; HERPES SIMPLEX VIRUS; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; LUNG CANCER; LUNG SMALL CELL CANCER; MODEL; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; SUICIDE GENE THERAPY; VIRAL GENE THERAPY; WESTERN BLOTTING;

CARCINOMA, SMALL CELL; CELL COMMUNICATION; CELL LINE, TUMOR; CONNEXIN 43; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; GANCICLOVIR; GAP JUNCTIONS; GENE THERAPY; GLYCYRRHETINIC ACID; HUMANS; LUNG NEOPLASMS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; SIMPLEXVIRUS; THYMIDINE KINASE;

EID: 20144389753     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Moolten FL: Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy. Cancer Res 46(10): 5276-5281, 1986.
2. Tomicic MT, Bey E, Wutzler P, Thust R and Kaina B: Comparative analysis of DNA breakage, chromosomal aberrations and apoptosis induced by the anti-herpes purine nucleoside analogues aciclovir, ganciclovir and penciclovir. Mutat Res 505(1-2): 1-11, 2002.
3. Freeman SM, Abboud CN, Whartenby KA, Packman CH, Koeplin DS, Moolten FL and Abraham GN: The "bystander effect": tumor regression when a fraction of the tumor mass is genetically modified. Cancer Res 53(21): 5274-5283, 1993.
4. Mesnil M and Yamasaki H: Bystander effect in herpes simplex virus-thymidine kinase/ganciclovir cancer gene therapy: role of gap-junctional intercellular communication. Cancer Res 60(15): 3989-3999, 2000.
5. Tanaka T, Yamasaki H and Mesnil M: Stimulation of intercellular communication of poor-communicating cells by gap-junction-competent cells enhances the HSV-TK/GCV bystander effect in vitro. Int J Cancer 91(4): 538-542, 2001.
6. Schuetz JD, Connelly MC, Sun D, Paibir SG, Flynn PM, Srinivas RV, Kumar A and Fridland A: MRP4: a previously unidentified factor in resistance to nucleoside- based antiviral drugs. Nat Med 5(9): 1048-1051, 1999.
7. Wijnholds J, Mol CAAM, van Deemter L, de Haas M, Scheffer GL, Baas F, Beijnen JH, Scheper RJ, Hatse S, De Clercq E, Balzarini J and Borst P: Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs. Proc Natl Acad Sci USA 97(13): 7476-7481, 2000.
8. Adachi M, Sampath J, Lan LB, Sun D, Hargrove P, Flatley RM, Tatum A, Ziegelmeier MZ, Wezeman M, Matherly LH, Drake RR and Schuetz JD: Expression of MRP4 confers resistance to ganciclovir and compromises bystander cell killing. J Biol Chem 277(74): 38998-39004, 2002.
9. van Dillen IJ, Mulder NH, Vaalburg W, de Vries EFJ and Hospers GAP: Influence of the bystander effect on HSV-Tk/GCV gene therapy. A Review. Curr Gene Ther 2(3): 307-322, 2002.
10. Hospers GAP, Calogero A, van Waarde A, Doze P, Vaalburg W, Mulder NH and de Vries EFJ: Monitoring of herpes simplex virus thymidine kinase enzyme activity using positron emission tomography. Cancer Res 60(6): 1488-1491, 2000.
11. Zijlstra JG, de Vries EGE and Mulder NH: Multifactorial drug resistance in an adriamycin-resistant human small cell lung carcinoma cell line. Cancer Res 47(7): 1780-1784, 1987.
12. 4. Br J Cancer 74(12): 1869-1876, 1996.
13. Hospers GAP, Mulder NH, de Jong B, de Ley L, Uges DRA, Fichtinger-Schepman AMJ, Scheper RJ and de Vries EGE: Characterization of a human small cell lung carcinoma cell line with acquired resistance to cis-diamminedichloroplatinum(II) in vitro. Cancer Res 48(23): 6803-6807, 1988.
14. Meijer C, Mulder NH, Timmer-Bosscha H, Peters WHM and de Vries EGE: Combined in vitro modulation of adriamycin resistance. Int J Cancer 49(4): 582-586, 1991.
15. Meijer C, Mulder NH, Hospers GAP, Uges DRA and de Vries EGE: The role of glutathione in resistance to cisplatin in a human small cell lung cancer cell line. Br J Cancer 62(1): 72-77, 1990.
16. Lai L and Tan TMC: Role of glutathione in the multidrug resistance protein 4 (MRP4/ABCC4)- mediated efflux of CAMP and resistance to purine analogues. Biochem J 361(Pt 3): 497-503, 2002.
17. Tomicic MT, Thust R, Sobol RW and Kaina B: DNA polymerase beta mediates protection of mammalian cells against ganciclovir-induced cytotoxicity and DNA breakage. Cancer Res 67(20): 7399-7403, 2001.
18. Hamel W, Magnelli L, Chiarugi VP and Israel MA: Herpes simplex virus thymidine kinase/ganciclovir-mediated apoptotic death of bystander cells. Cancer Res 56(12): 2697-2702, 1996.
19. Freeman SM, Ramesh R and Marrogi AJ: Immune system in suicide-gene therapy. Lancet 349(9044): 2-3, 1997.
20. Ruch RJ, Cesen-Cummings K and Malkinson AM: Role of gap junctions in lung neoplasia. Exp Lung Res 24(4): 523-539, 1998.
21. Ruch RJ, Porter S, Koffler LD, Dwyer-Nield LD and Malkinson AM: Defective gap junctional intercellular communication in lung cancer: loss of an important mediator of tissue homeostasis and phenotypic regulation. Exp Lung Res 27(3): 231-243, 2001.
22. Fernstrom MJ, Koffler LD, Abou-Rjaily G, Boucher PD, Shewach DS and Ruch RJ: Neoplastic reversal of human ovarian carcinoma cells transfected with Connexin43. Exp Mol Pathol 73(1): 54-60, 2002.
23. Carystinos GD, Alaoui-Jamali MA, Phipps J, Yen L and Batist G: Upregulation of gap junctional intercellular communication and Connexin 43 expression by Cyclic-AMP and all-trans-retinoic acid is associated with glutathione depletion and chemosensitivity in neuroblastoma cells. Cancer Chemother Pharmacol 47(2): 126-132, 2001.
24. Imaizumi K, Hasegawa Y, Kawabe T, Emi N, Saito H, Naruse K and Shimokata K: Bystander tumoricidal effect and gap junctional communication in lung cancer cell lines. Am J Respir Cell Mol Biol 18(2): 205-212, 1998.
25. Drake RR, Pitlyk K, McMasters RA, Mercer KE, Young H and Moyer MP: Connexin-independent ganciclovir-mediated killing conferred on bystander effect-resistant cell lines by a herpes simplex virus- thymidine kinase-expressing colon cell line. Mol Ther 2(5): 515-523, 2000.