Role of gap junctions in lung neoplasia

Experimental Lung Research

Volumn 24, Issue 4, 1998, Pages 523-539

  Ruch, Randall J ^a   Cesen Cummings, Kimberley ^a   Malkinson, Alvin M ^b  

^a MEDICAL COLLEGE OF OHIO   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Carcinoma; Connexin; Gap junction; Growth; Lung; Transfection; Tumorigenicity

Indexed keywords

ANIMAL CELL; CARCINOMA CELL; CELL COMMUNICATION; CONFERENCE PAPER; EPITHELIUM CELL; GAP JUNCTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; LUNG CARCINOGENESIS; LUNG TUMOR; MALIGNANT TRANSFORMATION; MOUSE; NONHUMAN; ONCOGENE K RAS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TUMOR GROWTH;

EID: 0031831440     PISSN: 01902148     EISSN: None     Source Type: Journal    
DOI: 10.3109/01902149809087384     Document Type: Conference Paper

References (58)

1. Loewenstein WR. Junctional intercellular communication and the control of growth. Biochim Biophys Acta. 1979;560:1-65.
2. Yamasaki H. Gap junctional intercellular communication and carcinogenesis. Carcinogenesis. 1990;11:1051-1058.
3. Trosko JE, Chang CC, Madhukar BV, Klaunig JE. Chemical, oncogene and growth factor inhibition of gap junctional intercellular communication: an integrative hypothesis of carcinogenesis. Pathobiology. 1990;58:265-278.
4. Ruch RJ. The role of gap junctional intercellular communication in neoplasia. Ann Clin Lab Sci. 1994;24:216-231.
5. Goodenough DA, Goliger JA, Paul DL. Connexins, connexons, and intercellular communication. Annu Rev Biochem. 1996;65:475-502.
6. Beyer EC, Paul DL, Goodenough DA. Connexin43: a protein from rat heart homologous to a gap junction protein from liver. J Cell Biol. 1987;105:2621-2629.
7. Lee YC, Yellowley CE, Li ZY, Donahue HJ, Rannels DE. Expression of functional gap junctions in cultured pulmonary alveolar epithelial cells. Am J Physiol. 1997;272:L1105-L1114.
8. Guan X, Hardenbrook J, Fernstrom MJ, Chaudhuri R, Malkinson AM, Ruch RJ. Downregulation by butylated hydroxytoluene of the number and permeability of gap junctions in cell line derived from mouse lung and rat liver. Carcinogenesis 1995;16:2575-2582.
9. Banoub RW, Fernstrom M, Malkinson AM, Ruch RJ. Enhancement of gap junctional intercellular communication by dibutyryl cyclic AMP in lung epithelial cells. Anticancer Res. 1996;16:3715-3720.
10. Paul DL. Molecular cloning of cDNA for rat liver gap junction protein. J Cell Biol. 1986;103:123-134.
11. Cotran RS, Kumar V, Robbins SL. Robbin's Pathological Basis of Disease, 5th ed. Philadelphia: Saunders; 1994.
12. Malkinson Am. Genetic studies on lung tumor susceptibility and histogenesis in mice. Environ Health Perspect. 1991;93:149-159.
13. McDonagh D, Vollmer RT, Shelburne JD. Intercellular junctions and tumor behavior in lung cancer. Mod Pathol. 1991;4:436-440.
14. Vollmer RT. Intercellular junctions and tumor behavior in lung cancer. Mod Pathol. 1992;5:96-7.
15. Albright CD, Jones RT, Grimley PM, Resau JH. Intercellular communication in bronchial epithelial cells: review of evidence for a possible role in lung carcinogenesis. Toxicol Pathol. 1990;18:324-343.
16. Albright CD, Grimley PM, Jones RT, Fontana JA, Keenan KP, Resau JH. Cell-to-cell communication: a differential response to TGF-β in normal and transformed (BEAS-2B) human bronchial epithelial cells. Carcinogenesis. 1991;12:1993-1999.
17. Heussen GAH, Alink GM. Inhibition of gap-junctional intercellular communication by TPA and airborne particulate matter in primary cultures of rat alveolar type II cells. Carcinogenesis. 1992;13:719-722.
18. Zhu D, Caveney S, Kidder GM, Naus CCG. Transfection of C6 glioma cells with connexin 43 cDNA: analysis of expression, intercellular coupling, and cell proliferation. Proc Natl Acad Sci USA. 1991;88:1883-1887.
19. Naus, CCG, Elisevich K, Zhu D, Belliveau DJ, Del Maestro R. In vivo growth of C6 glioma cells transfected with connexin 43 cDNA. Cancer Res. 1992;52:4208-4213.
20. Eghbali B, Kessler JA, Reid LM, Roy C, Spray DC. Involvement of gap junctions in tumorigenesis: transfection of tumor cells with connexin 32 cDNA retards growth in vivo. Proc Natl Acad Sci USA. 1991;88:10701-10705.
21. Mehta PP, Hotz-Wagenblatt A, Rose B, Shalloway D, Loewenstein WR. Incorporation of the gene for a cell-cell channel protein into transformed cells leads to normalization of growth. J Membr Biol. 1991;124:207-225.
22. Rose B, Mehta PP, Loewenstein WR. Gap-junction protein gene suppresses tumorigenicity. Carcinogenesis. 1993;14:1073-1075.
23. Chen SC, Pelletier D, Ao P, Boynton A. Connexin43 reverses the phenotype of transformed cells and alters their expression of cyclin/cyclin-dependent kinases. Cell Growth Differ. 1995;6:681-690.
24. Hirschi KK, Xu CE, Tsukamoto T, Sager R. Gap junction genes C x 26 and C x 43 individually suppress the cancer phenotype of human mammary carcinoma cells and restore differentiation potential. Cell Growth Differ. 1996;7:861-870.
25. Goldberg GS, Martyn KD, Lau AF. A connexin 43 antisense vector reduces the ability of normal cells to inhibit the foci formation of transformed cells. Mol Carcinog. 1994;11:106-114.
26. Ruch RJ, Guan X, Sigler K. Inhibition of gap junctional intercellular communication and altered growth in Balb/c 3T3 cells treated with connexin43 antisense oligonucleotides. Mol Carcinog. 1995;14:269-274.
27. Reaume A, de Sousa P, Kulkarni S et al. Cardiac malformation in neonatal mice lacking connexin43. Science. 1995;267:1831-1834.
28. Willecke K, Temme A, Gabriel HD et al. Biological functions of gap junctions revealed by targeted inactivation of mouse connexin32 and -26 genes. 1997 International Gap Junction Conference, Key Largo, FL.
29. Chaudhuri R, Sigler K, Dupont E, Trosko JE, Malkinson AM, Ruch RJ. Gap junctional intercellular communication in mouse lung epithelial cell lines: effects of cell transformation and tumor promoters. Cancer Lett. 1993;71:11-18.
30. Cesen-Cummings K, Fernstrom MJ, Malkinson AM, Ruch RJ. Frequent reduction of gap junctional intercellular communication and connexin43 expression in human and mouse lung carcinoma cells. Carcinogenesis. 1998;19:41-47.
31. Cesen-Cummings K, Park IK, Lin B, Malkinson AM, Ruch RJ. Altered growth properties and decreased tumorigenicity of mouse lung carcinoma cells stably transfected with connexin43. Submitted.
32. Malkinson AM, Dwyer-Nield LD, Rice PL, Dinsdale D. Mouse lung epithelial cell lines: tools for the study of differentiation and the neoplastic phenotype. Toxicology. 1997;123:53-100.
33. Pan YH, Nuzum EO, Hanson LA, Beer DG. Ki-ras activation and expression in transformed mouse lung cells. Mol Carcinog. 1990;3:279-286.
34. Bongiorno PF, Whyte RI, Lesser EJ, Moore JH, Orringer MB, Beer DG. Alterations of Ki-ras, p53, and erbB-2/neu in human lung adenocarcinomas. J Thor Cardiovasc Surg. 1994;107:590-595.
35. Mitsudomi T, Viallet J, Mulshine JL, Linnoila RI, Minna JD, Gazdar AF. Mutations of ras genes distinguish a subset of non-small-cell lung cancer cell lines from small-cell lung cancer cell lines. Oncogene. 1991;6:1353-1362.
36. Rodenhuis S, Slebos RJC, Boot AJM, et al. Incidence and possible clinical significance of K-ras oncogene activation in adenocarcinoma of the human lung. Cancer Res. 1988;48:5738-5741.
37. Schneider PM, Hung M-C, Chiocca SM, et al. Differential expression of the c-erbB-2 gene in human small cell and non-small cell lung cancer. Cancer Res. 1989;49:4968-4971.
38. neu) in human non-small cell carcinomas of the lung. Cancer Res. 1990;50:421-425.
39. Yamamoto Y, Ikawa S, Akiyama T, et al. Similarity of protein encoded by the human c-erbB-2 gene to epidermal growth factor. Nature. 1986;319:230-234.
40. Yu D, Wang S, Dulski KM, Tsai C, Nicolson GC, Hung MC. c-erbB-2/neu overexpression enhances metastatic potential of human lung cancer cells by induction of metastasis-associated properties. Cancer Res. 1994;54:3260-3266.
41. Mitsudomi T, Steinberg SM, Nau MM, et al. p53 gene mutations in non-small-cell lung cancer cell lines and their correlation with the presence of ras mutations and clinical features. Oncogene. 1992;7:171-180.
42. Mukhopadyhay T, Roth JA. Induction of apoptosis in human lung cancer cells after wild-type p53 activation by methoxyestradiol. Oncogene. 1997;14:379-384.
43. Horowitz JM, Yandell DW, Park S-H, et al. Point mutational inactivation of the retinoblastoma antitoncogene. Science. 1989;243:937-940.
44. INK4 expression in primary lung cancers and cell lines. Cancer Res. 1995;55:505-509.
45. Shimizu E, Coxon A, Otterson GA, et al. Rb protein status and clinical correlation from 171 cell lines representing lung cancer, extrapulmonary small cell carcinoma, and mesothelioma. Oncogene. 1994;9:2411-2418.
46. INK4 protein is restricted to the subset of lung cancer lines that retains wildtype Rb. Oncogene. 1994;9:3375-3378.
47. INK6/MTS2, and p18 genes in primary and metastatic lung cancer. Cancer Res. 1995;55:1448-1451.
48. Veenstra RD. Size and selectivity of gap junction channels formed from different connexins. J Bioenerg Biomembr. 1996;28:327-337.
49. Steinberg TH, Civitelli R, Geist ST, et al. Connexin43 and connexin45 form gap junctions with different molecular permeabilities in osteoblastic cells. EMBO J. 1994;13:744-750.
50. Elfgang C, Eckert R, Lichtenberg-Frate H, et al. Specific permeability and selective formation of gap junction channels in connexin-transfected HeLa cells. J Cell Biol. 1995;129:805-817.
51. Mehta PP, Bertram JS, Loewenstein WR. Growth inhibition of transformed cells correlates with their junctional communication with normal cells. Cell. 1986;44:187-196.
52. Dodge AB, Lu X, D'Amore PA. Density-dependent endothelial production of an inhibitor of smooth muscle cell growth. J Cell Biochem. 1993;53:21-31.
53. Wieser RJ, Oesch F. Contact inhibition of human diploid fibroblasts by immortalized plasma glycoproteins. J Cell Biol. 1986;103:361-367.
54. Takeichi M. Cadherin cell adhesion receptors as a morphogenetic regulator. Science. 1991;251:1451-1455.
55. Rubin H. Cellular epigenetics: control of the size, shape, and spatial distribution of transformed foci by interactions between the transformed and nontransformed cells. Proc Natl Acad Sci USA. 1994;91:1039-1043.
56. Paludan K, Duch M, Jorgensen P, Kjeldgaard NO, Pedersen FS. Graduated resistance to G418 leads to differentiated selection of cultured mammalian cells expressing the neo gene. Gene. 1989;85:421-426.
57. Mesnil M, Krutovskikh V, Piccoli C, et al. Negative growth control of HeLa cells by connexin genes: connexin species specificity. Cancer Res. 1995;55:629-639.
58. Rae RS, Mehta PP, Trosko JE, Ruch RJ. Altered phenotypes of gap junctional intercellular communication-deficient rat liver epithelial cells and reversal by forced connexin32 expression. Mol. Carcinog. In press.