Increases in CD4+ T Lymphocytes Occur Without Increases in Thymic Size in HIV-Infected Subjects Receiving Interleukin-2 Therapy

Journal of Acquired Immune Deficiency Syndromes

Volumn 34, Issue 3, 2003, Pages 299-303

  Lu, Amy C ^a   Jones, Elizabeth C ^b   Chow, Catherine ^b   Miller, Kirk D ^a   Herpin, Betsey ^a   Rock Kress, Diane ^a   Metcalf, Julia A ^a   Lane, H Clifford ^a   Kovacs, Joseph A ^a,b  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

CD4+ T lymphocytes; Computed tomography; Immunotherapy; Interleukin 2; Longitudinal studies; Thymus gland; X ray

Indexed keywords

INTERLEUKIN 2;

ADULT; ARTICLE; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; FLOW CYTOMETRY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE SUBPOPULATION; MALE; MEMORY CELL; PRIORITY JOURNAL; T LYMPHOCYTE; VIRUS LOAD;

ADULT; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; FLOW CYTOMETRY; HIV INFECTIONS; HIV-1; HUMANS; INTERLEUKIN-2; LONGITUDINAL STUDIES; MALE; PROSPECTIVE STUDIES; THYMUS GLAND; TOMOGRAPHY, X-RAY COMPUTED;

EID: 0242580966     PISSN: 15254135     EISSN: None     Source Type: Journal    
DOI: 10.1097/00126334-200311010-00007     Document Type: Article

References (14)

1. Kovacs JA, Vogel S, Albert JM, et al. Controlled trial of interleukin-2 infusions in patients infected with the human immunodeficiency virus. N Engl J Med. 1996;335:1350-1356.
2. Davey RT Jr, Chaitt DG, Albert JM, et al. A randomized trial of high-versus low-dose subcutaneous interleukin-2 outpatient therapy for early human immunodeficiency virus type 1 infection. J Infect Dis. 1999;179:849-858.
3. Kovacs JA, Vogel S, Metcalf JA, et al. Interleukin-2 induced immune effects in human immunodeficiency virus-infected patients receiving intermittent interleukin-2 immunotherapy. Eur J Immunol. 2001;31:1351-1360.
4. Mackall CL, Fleisher TA, Brown MR, et al. Age, thymopoiesis, and CD4+ T-lymphocyte regeneration after intensive chemotherapy. N Engl J Med. 1995;332:143-149.
5. McCune JM, Loftus R, Schmidt DK, et al. High prevalence of thymic tissue in adults with human immunodeficiency virus-1 infection. J Clin Invest. 1998;101:2301-2308.
6. Haynes BF, Hale LP, Weinhold KJ, et al. Analysis of the adult thymus in reconstitution of T lymphocytes in HIV-1 infection. J Clin Invest. 1999;103:453-460.
7. Miller KD, Spooner K, Herpin BR, et al. Immunotherapy of HIV-infected patients with intermittent interleukin-2: effects of cycle frequency and cycle duration on degree of CD4(+) T-lymphocyte expansion. Clin Immunol. 2001;99:30-42.
8. Hollander M, Wolfe D. Nonparametric Statistical Methods. 2nd ed. New York: John Wiley & Sons; 1999.
9. De Paoli P, Bortolin MT, Zanussi S, et al. Changes in thymic function in HIV-positive patients treated with highly active antiretroviral therapy and interleukin-2. Clin Exp Immunol. 2001;125:440-446.
10. Marchetti G, Meroni L, Varchetta S, et al. Low-dose prolonged intermittent interleukin-2 adjuvant therapy: results of a randomized trial among human immunodeficiency virus-positive patients with advanced immune impairment. J Infect Dis. 2002;186:606-616.
11. Carcelain G, Saint-Mezard P, Altes HK, et al. IL-2 therapy and thymic production of naive CD4 T cells in HIV-infected patients with severe CD4 lymphopenia. AIDS. 2003;17:841-850.
12. Natarajan V, Lempicki RA, Sereti I, et al. Increased peripheral expansion of naive CD4+ T cells in vivo after IL-2 treatment of patients with HIV infection. Proc Natl Acad Sci U S A. 2002;99:10712-10717.
13. De Rosa SC, Herzenberg LA, Roederer M. 11-color, 13-parameter flow cytometry: identification of human naive T cells by phenotype, function, and T-cell receptor diversity. Nat Med. 2001;7:245-248.
14. Smith KY, Valdez H, Landay A, et al. Thymic size and lymphocyte restoration in patients with human immunodeficiency virus infection after 48 weeks of zidovudine, lamivudine, and ritonavir therapy. J Infect Dis. 2000;181:141-147.