Detection of alkaline sphingomyelinase activity in human stool: Proposed role as a new diagnostic and prognostic marker of colorectal cancer

Cancer Epidemiology Biomarkers and Prevention

Volumn 14, Issue 4, 2005, Pages 856-862

  Di Marzio, Luisa ^a   Di Leo, Alfredo ^b,c   Cinque, Benedetta ^d   Fanini, Donatella ^d   Agnifili, Alessio ^e   Berloco, Pasquale ^b   Linsalata, Michele ^b   Lorusso, Dionigi ^b   Barone, Michele ^c   De Simone, Claudio ^d   Cifone, Maria Grazia ^d,e  

^a UNIVERSITY OF CHIETI   (Italy)

^b Laboratory of Biochemistry   (Italy)

^c UNIVERSITY OF BARI   (Italy)

^d UNIVERSITY OF L'AQUILA   (Italy)

^e UNIVERSITY OF L'AQUILA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE SPHINGOMYELINASE; SPHINGOMYELIN PHOSPHODIESTERASE; UNCLASSIFIED DRUG;

ADENOCARCINOMA; ADULT; AGED; ARTICLE; CANCER DIAGNOSIS; CELL DIFFERENTIATION; COLORECTAL CARCINOMA; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME LOCALIZATION; FECES ANALYSIS; FEMALE; HUMAN; INTESTINE MUCOSA; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; SAMPLING; SEX DIFFERENCE; STATISTICAL ANALYSIS;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; CASE-CONTROL STUDIES; COLORECTAL NEOPLASMS; FECES; FEMALE; HUMANS; MALE; MIDDLE AGED; SPHINGOMYELIN PHOSPHODIESTERASE;

EID: 20144386965     PISSN: 10559965     EISSN: None     Source Type: Journal    
DOI: 10.1158/1055-9965.EPI-04-0434     Document Type: Article

References (39)

1. Okazaki T, Bell RM, Hannun YA. Sphingomyelin turnover induced by vitamin D3 in HL-60 cells. Role in cell differentiation. J Biol Chem 1989;264:19076-80.
2. Okazaki T, Bielawska A, Bell RM, Hannun YA. Role of ceramide as a lipid mediator of 1 α,25-dihydroxyvitamin D3-induced HL-60 cell differentiation. J Biol Chem 1990;265:15823-31.
3. Hannun YA. The sphingomyelin cycle and the second messenger function of ceramide. J Biol Chem 1994;269:3125-8.
4. Kolesnick RN. Sphingomyelin and derivatives as cellular signals. Prog Lipid Res 1991;30:1-38.
5. Gomez-Munoz A. Modulation of cell signalling by ceramides. Biochim Biophys Acta 1998;1391:92-109.
6. Kronke M. Involvement of sphingomyelinases in TNF signaling pathways. Chem Phys Lipids 1999;102:157-66.
7. Ohanian J, Ohanian V. Sphingolipids in mammalian cell signalling. Cell Mol Life Sci 2001;58:2053-68.
8. Hannun YA, Liberto C, Argraves KM. Enzymes of sphingolipid metabolism: from modular to tntegrative signalling. Biochemistry 2001;40:4893-03.
9. Cinque B, Di Marzio L, Centi C, Di Rocco C, Riccardi C, Cifone MG. Sphingolipids and the immune system. Pharmacol Res 2003;47:421-37.
10. Duan RD, Cheng Y, Hansen G, et al. Purification, localization and expression of human intestinal alkaline sphingomyelinase. J Lipid Res 2003;44:1241-50.
11. Cheng Y, Nilsson A, Tomquist E, Duan RD. Purification, characterization, and expression of rat intestinal alkaline sphingomyelinase. J Lipid Res 2002;43:316-24.
12. Duan RD, Bergman T, Xu N, et al. Identification of human intestinal alkaline sphingomyelinase as a novel ecto-enzyme related to the nucleotide phosphodiesterase family J Biol Chem 2003;278:38528-36.
13. Schmelz EM, Crall KJ, Larocque R, Dillehay DL, Merrill AH Jr. Uptake and metabolism of sphingolipids in isolated intestinal loops of mice. J Nutr 1994;124:702-12.
14. Nyeberg L, Nilsson A, Lundgren P, Duan RD. Localization and capacity of sphingomyelin digestion in the rat intestinal tract. J Nutr Biochem 1997;8:112-8.
15. Duan RD. Sphingomyelin hydrolysis in the gut and clinical implications in colorectal tumourigenesis and other gastrointestinal diseases. Scand J Gastroenterol 1998;33:673-83.
16. Omodeo-Sale F, Lindi C, Marciani P, et al. Postnatal maturation of rat intestinal membrane: lipid composition and fluidity. Comp Biochem Physiol A 1991;100:301-7.
17. Lillienau J, Cheng Y, Nilsson A, Duan RD. Development of intestinal alkaline sphingomyelinase in rat fetus and newborn rat. Lipids 2003;38:545-9.
18. Yellis MB. Human breast milk and facilitation of gastrointestinal development and maturation. Gastroenterol Nurs 1995;18:11-5.
19. Dudeja PK, Dahiya R, Brasitus TA. The role of sphingomyelin synthetase and sphingomyelinase in 1,2-dimethylhydrazine-induced lipid alterations of rat colonie plasma membranes. Biochim Biophys Acta 1986;863:309-12.
20. Dillehay DL, Webb SK, Schmelz EM, Merrill AH Jr. Dietary sphingomyelin inhibits 1,2-dimethylhydrazine-induced colon cancer in CF1 mice. J Nutr 1994;124:615-20.
21. Schmelz EM, Dillehay DL, Webb SK, Reiter A, Adams J, Merrill AH Jr. Sphingomyelin consumption suppresses aberrant colonic crypt foci and increases the proportion of adenomas versus adenocarcinomas in CF1 mice treated with 1,2-dimethylhydrazine: implications for dietary sphingolipids and colon carcinogenesis. Cancer Res 1996;56:4936-41.
22. Schmelz EM, Bushnev AS, Dillehay DL, Liotta DC, Merrill AH Jr. Suppression of aberrant colonic crypt foci by synthetic sphingomyelins with saturated or unsaturated sphingoid base backbones. Nutr Cancer 1997;28:81-5.
23. Hertervig E, Nilsson A, Nyberg L, Duan RD. Alkaline sphingomyelinase activity is decreased in human colorectal carcinoma. Cancer 1997;79:448-53.
24. Hertervig E, Nilsson A, Bjork J, Hultkrantz R, Duan RD. Familial adenomatous polyposis is associated with a marked decrease in alkaline sphingomyelinase activity, a key factor to the unrestrained cell proliferation. Br J Cancer 1999;81:232-6.
25. Hertervig E, Nilsson A, Nilbert M, Duan RD. Reduction in alkaline sphingomyelinase in colorectal tumourigenesis is not related to the APC gene mutation. Int J Colorectal Dis 2003;18:309-13.
26. Sjoqvist U, Hertervig E, Nilsson A, et al. Chronic colitis is associated with a reduction of mucosal alkaline sphingomyelinase activity. Inflamm Bowel Dis 2002;8:258-63.
27. Duan RD, Nyberg L, Nilsson A. Alkaline sphingomyelinase activity in rat gastrointestinal tract: distribution and characteristics. Biochim Biophys Acta 1995;1259:49-55.
28. Cheng Y, Tauschel HD, Nilsson A, Duan RD. Ursodeoxycholic acid increases the activities of alkaline sphingomyelinase and caspase-3 in the rat colon. Scand J Gastroenterol 1999;34:915-20.
29. Cifone MG, Roncaioli P, De Maria R, et al. Multiple pathways originate at the Fas/APO-1 (CD95) receptor: sequential involvement of phosphatidylcholine- specific phospholipase C and acidic sphingomyelinase in the propagation of the apoptotic signal. EMBO J 1995;14:5859-68.
30. Cifone MG, De Maria R, Roncaioli P, et al. Apoptotic signaling through CD95 (Fas/Apo-1) activates an acidic sphingomyelinase. J Exp Med 1994;180:1547-52.
31. Nilsson A, Duan RD. Alkaline sphingomyelinases and ceramidases of the gastrointestinal tract. Chem Phys Lipids 1999;10257-05.
32. Nilsson A. Metabolism of sphingomyelin in the intestinal tract of the rat. Biochim Biophys Acta 1968;164:575-84.
33. Berra B, Colombo I, Sottocornola E, Giocosa A. Dietary sphingolipids in colorectal cancer prevention. Eur J Cancer Prev 2002;11:193-7.
34. Schmelz EM, Sullards MC, Dillehay DL, Merrill AH Jr. Colonic cell proliferation and aberrant crypt foci formation are inhibited by dairy glycosphingolipids in 1,2-dimethylhydrazine-treated CF1 mice. J Nutr 2000;130:522-7.
35. Ciccocioppo R, Di Sabatino A, Parroni R, et al. Increased enterocyte apoptosis and Fas-Fas ligand system in celiac disease. Am J Clin Pathol 2001;115:494-503.
36. Ciccocioppo R, Di Sabatino A, Luinetti O, Rossi M, Cifone MG, Corazza GR. Small bowel enterocyte apoptosis and proliferation are increased in the elderly. Gerontology 2002;48:204-8.
37. Koornstra JJ, de Jong S, Hollema H, de Vries EGE, Kleibeuker JH. Changes in apoptosis during the development of colorectal cancer: a systematic review of the literature. Crit Rev Oncol Hematol 2003;45:37-53.
38. Moss SF, Scholes JV, Holt PR. Abnormalities of epithelial apoptosis in mulristep colorectal neoplasia demonstrated by terminal deoxyuridine nick end labeling. Dig Dis Sci 1999;41:2238-47.
39. Duan RD, Hertervig E, Nyberg L, et al. Distribution of alkaline sphingomyelinase activity in human beings and animals. Tissue and species differences. Dig Dis Sci 1996;41:1801-6.