Molecular-modeling based design, synthesis, and activity of substituted piperidines as γ-secretase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 7, 2005, Pages 1891-1894

  Gundersen, Eric ^a   Fan, Kristi ^a   Haas, Kimberly ^a   Huryn, Donna ^a   Jacobsen, J Steven ^a   Kreft, Anthony ^a   Martone, Robert ^a   Mayer, Scott ^a   Sonnenberg Reines, June ^a   Sun, Shaiu Ching ^a   Zhou, Hua ^a  

^a PFIZER INC   (United States)

Author keywords

Alzheimer's; Molecular modeling; Piperidines; Secretase inhibitors

Indexed keywords

AMYLOID BETA PROTEIN; BRAIN PROTEIN; GAMMA SECRETASE INHIBITOR; PIPERIDINE DERIVATIVE;

ALZHEIMER DISEASE; ARTICLE; DRUG ACTIVITY; DRUG DESIGN; DRUG SYNTHESIS; ENZYME INHIBITION; MOLECULAR MODEL;

EID: 20144378610     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.02.006     Document Type: Article

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