Canstatin acts on endothelial and tumor cells via mitochondrial damage initiated through interaction with αvβ3 and αvβ5 integrins

Cancer Research

Volumn 65, Issue 10, 2005, Pages 4353-4361

  Magnon, Claire ^a   Galaup, Ariane ^a   Mullan, Brian ^a   Rouffiac, Valérie ^a   Bidart, Jean Michel ^a   Griscelli, Frank ^a   Opolon, Paule ^a   Perricaudet, Michel ^a  

^a INSTITUT GUSTAVE ROUSSY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; ALPHAVBETA5 INTEGRIN; ANGIOGENESIS INHIBITOR; CANSTATIN; CASPASE; CASPASE 8; COLLAGEN TYPE 4; HUMAN SERUM ALBUMIN; HYBRID PROTEIN; INTEGRIN; PROCASPASE 9; RECEPTOR; UNCLASSIFIED DRUG; VITRONECTIN RECEPTOR;

ALPHA CHAIN; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; DRUG PROTEIN BINDING; ENDOTHELIUM CELL; ENZYME ACTIVATION; GENE TRANSFER; HUMAN; HUMAN CELL; IN VIVO STUDY; MITOCHONDRION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; SIGNAL TRANSDUCTION; TUMOR; TUMOR CELL; TUMOR VASCULARIZATION;

ANGIOGENESIS INHIBITORS; ANIMALS; APOPTOSIS; BREAST NEOPLASMS; CASPASES; CELL LINE, TUMOR; COLLAGEN TYPE IV; ENDOTHELIAL CELLS; HUMANS; INTEGRIN ALPHAVBETA3; INTEGRINS; ISOENZYMES; MICE; MITOCHONDRIA; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, VITRONECTIN; RECOMBINANT FUSION PROTEINS; SERUM ALBUMIN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 20144374161     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-04-3536     Document Type: Article

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