Pro- and anti-inflammatory substances modulate expression of the leukotriene B4 receptor, BLT1, in human monocytes

Journal of Leukocyte Biology

Volumn 77, Issue 6, 2005, Pages 1018-1025

  Pettersson, Annika ^a   Sabirsh, Alan ^c   Bristulf, Jesper ^a   Kidd Ljunggren, Karin ^b   Ljungberg, Bengt ^b   Owman, Christer ^a   Karlsson, Ulf ^a,b  

^a LUND UNIVERSITY   (Sweden)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

IFN ; Inflammatory mediators; LTB4; Mononuclear phagocytes

Indexed keywords

CD14 ANTIGEN; CD16 ANTIGEN; CHEMOKINE RECEPTOR CCR2; DEXAMETHASONE; GAMMA INTERFERON; INTERLEUKIN 10; LEUKOTRIENE B4 RECEPTOR; LIPOPOLYSACCHARIDE; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN BLT1; RECEPTOR PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

CHEMOTAXIS; CONCENTRATION (PARAMETERS); CONFERENCE PAPER; CONTROLLED STUDY; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMMUNOMODULATION; IMMUNOREGULATION; IMMUNOSTIMULATION; INFLAMMATION; MONOCYTE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION;

CHEMOTAXIS; DEXAMETHASONE; DOWN-REGULATION; HUMANS; INFLAMMATION MEDIATORS; INTERFERON TYPE II; INTERLEUKIN-10; LIPOPOLYSACCHARIDES; MONOCYTES; RECEPTORS, LEUKOTRIENE; RECEPTORS, LEUKOTRIENE B4; RECEPTORS, PURINERGIC P2; RNA STABILITY; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 20044394027     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.1204740     Document Type: Conference Paper

References (56)

1. Johnston, B., Butcher, E. C. (2002) Chemokines in rapid leukocyte adhesion triggering and migration. Semin. Immunol. 14, 83-92.
2. Murdoch, C., Finn, A. (2000) Chemokine receptors and their role in inflammation and infectious diseases. Blood 95, 3032-3043.
3. Colotta, F., Borre, A., Wang, J. M., Tattanelli, M., Maddalena, F., Polentarutti, N., Peri, G., Mantovani, A. (1992) Expression of a monocyte chemotactic cytokine by human mononuclear phagocytes. J. Immunol. 148, 760-765.
4. Sica, A., Saccani, A., Borsatti, A., Power, C. A., Wells, T. N., Luini, W., Polentarutti, N., Sozzani, S., Mantovani, A. (1997) Bacterial lipopolysaccharide rapidly inhibits expression of C-C chemokine receptors in human monocytes. J. Exp. Med. 185, 969-974.
5. Sozzani, S., Ghezzi, S., Iannolo, G., Luini, W., Borsatti, A., Polentarutti, N., Sica, A., Locati, M., Mackay, C., Wells, T. N., Biswas, P., Vicenzi, E., Poli, G., Mantovani, A. (1998) Interleukin 10 increases CCR5 expression and HIV infection in human monocytes. J. Exp. Med. 187, 439-444.
6. Tangirala, R. K., Murao, K., Quehenberger, O. (1997) Regulation of expression of the human monocyte chemotactic protein-1 receptor (hCCR2) by cytokines. J. Biol. Chem. 272, 8050-8056.
7. Penton-Rol, G., Polentarutti, N., Luini, W., Borsatti, A., Mancinelli, R., Sica, A., Sozzani, S., Mantovani, A. (1998) Selective inhibition of expression of the chemokine receptor CCR2 in human monocytes by IFN-γ. J. Immunol. 160, 3869-3873.
8. Samuelsson, B. (1983) Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation. Science 220, 568-575.
9. Crooks, S. W., Stockley, R. A. (1998) Leukotriene B4. Int. J. Biochem. Cell Biol. 30, 173-178.
10. Owman, C., Sabirsh, A., Boketoft, A., Olde, B. (1997) Leukotriene B4 is the functional ligand binding to and activating the cloned chemoattractant receptor, CMKRL1. Biochem. Biophys. Res. Commun. 240, 162-166.
11. Yokomizo, T., Izumi, T., Chang, K., Takuwa, Y., Shimizu, T. (1997) A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis. Nature 387, 620-624.
12. Tryselius, Y., Nilsson, N. E., Kotarsky, K., Olde, B., Owman, C. (2000) Cloning and characterization of cDNA encoding a novel human leukotriene B(4) receptor. Biochem. Biophys. Res. Commun. 274, 377-382.
13. Kamohara, M., Takasaki, J., Matsumoto, M., Saito, T., Ohishi, T., Ishii, H., Furuichi, K. (2000) Molecular cloning and characterization of another leukotriene B4 receptor. J. Biol. Chem. 275, 27000-27004.
14. Wang, S., Gustafson, E., Pang, L., Qiao, X., Behan, J., Maguire, M., Bayne, M., Laz, T. (2000) A novel hepatointestinal leukotriene B4 receptor. Cloning and functional characterization. J. Biol. Chem. 275, 40686-40694.
15. Yokomizo, T., Kato, K., Terawaki, K., Izumi, T., Shimizu, T. (2000) A second leukotriene B(4) receptor, BLT2. A new therapeutic target in inflammation and immunological disorders. J. Exp. Med. 192, 421-432.
16. Dasari, V. R., Jin, J., Kunapuli, S. P. (2000) Distribution of leukotriene B4 receptors in human hematopoietic cells. Immunopharmacology 48, 157-163.
17. Yokomizo, T., Izumi, T., Shimizu, T. (2001) Co-expression of two LTB4 receptors in human mononuclear cells. Life Sci. 68, 2207-2212.
18. Friedrich, E. B., Tager, A. M., Liu, E., Pettersson, A., Owman, C., Munn, L., Luster, A. D., Gerszten, R. E. (2003) Mechanisms of leukotriene 154-triggered monocyte adhesion. Arterioscler. Thromb. Vasc. Biol. 23, 1761-1767.
19. Pettersson, A., Richter, J., Owman, C. (2003) Flow cytometric mapping of the leukotriene B4 receptor, BLT1, in human bone marrow and peripheral blood using specific monoclonal antibodies. Int. Immunopharmacol. 3, 1467-1475.
20. Runarsson, G., Liu, A., Mahshid, Y., Feltenmark, S., Pettersson, A., Klein, E., Bjorkholm, M., Claesson, H. E. (2004) Leukotriene B4 plays a pivotal role in CD40 dependent activation of chronic B lymphocytic leukemia cells. Blood 105, 1274-1279.
21. Talvani, A., Machado, F. S., Santana, G. C., Klein, A., Barcelos, L., Silva, J. S., Teixeira, M. M. (2002) Leukotriene B(4) induces nitric oxide synthesis in Trypanosoma cruzi-infected murine macrophages and mediates resistance to infection. Infect. Immun. 70, 4247-4253.
22. Sharon, P., Stenson, W. F. (1984) Enhanced synthesis of leukotriene B4 by colonic mucosa in inflammatory bowel disease. Gastroenterology 86, 453-460.
23. Duell, E. A., Ellis, C. N., Voorhees, J. J. (1988) Determination of 5, 12, and 15-lipoxygenase products in keratomed biopsies of normal and psoriatic skin. J. Invest. Dermatol. 91, 446-450.
24. Ahmadzadeh, N., Shingu, M., Nobunaga, M., Tawara, T. (1991) Relationship between leukotriene B4 and immunological parameters in rheumatoid synovial fluids. Inflammation 15, 497-503.
25. Montuschi, P., Barnes, P. J. (2002) Exhaled leukotrienes and prostaglandins in asthma. J. Allergy Clin. Immunol. 109, 615-620.
26. Owman, C., Garzino-Demo, A., Cocchi, F., Popovic, M., Sabirsh, A., Gallo, R. C. (1998) The leukotriene B4 receptor functions as a novel type of coreceptor mediating entry of primary HIV-1 isolates into CD4-positive cells. Proc. Natl. Acad. Sci. USA 95, 9530-9534.
27. Aiello, R. J., Bourassa, P. A., Lindsey, S., Weng, W., Freeman, A., Showell, H. J. (2002) Leukotriene B4 receptor antagonism reduces monocytic foam cells in mice. Arterioscler. Thromb. Vasc. Biol. 22, 443-449.
28. Subbarao, K., Jala, V. R., Mathis, S., Suttles, J., Zacharias, W., Ahamed, J., Ali, H., Tseng, M. T., Haribabu, B. (2004) Role of leukotriene B4 receptors in the development of atherosclerosis: potential mechanisms. Arterioscler. Thromb. Vasc. Biol. 24, 369-375.
29. Boggs, J. M., Koo, C. H., Goetzl, E. J. (1991) Down-regulation of receptor antigen in leukotriene B4-induced chemotactic deactivation of human polymorphonuclear leucocytes. Immunology 73, 212-216.
30. O'Flaherty, J. T., Rossi, A. G., Redman, J. F., Jacobson, D. P. (1991) Tumor necrosis factor-α regulates expression of receptors for formylmethionyl-leucyl-phenylalanine, leukotriene B4, and platelet-activating factor. Dissociation from priming in human polymorphonuclear neutrophils. J. Immunol. 147, 3842-3847.
31. Stankova, J., Turcotte, S., Harris, J., Rola-Pleszczynski, M. (2002) Modulation of leukotriene B4 receptor-1 expression by dexamethasone: potential mechanism for enhanced neutrophil survival. J. Immunol. 168, 3570-3576.
32. Huang, L., Zhao, A., Wong, F., Ayala, J. M., Struthers, M., Ujjainwalla, F., Wright, S. D., Springer, M. S., Evans, J., Cui, J. (2004) Leukotriene B4 strongly increases monocyte chemoattractant protein-1 in human monocytes. Arterioscler. Thromb. Vasc. Biol. 24, 1783-1788.
33. Matsukawa, A., Hogaboam, C. M., Lukacs, N. W., Lincoln, P. M., Strieter, R. M., Kunkel, S. L. (1999) Endogenous monocyte chemoattractant protein-1 (MCP-1) protects mice in a model of acute septic peritonitis: cross-talk between MCP-1 and leukotriene B4. J. Immunol. 163, 6148-6154.
34. Repnik, U., Knezevic, M., Jeras, M. (2003) Simple and cost-effective isolation of monocytes from buffy coats. J. Immunol. Methods 278, 283-292.
35. Pettersson, A., Boketoft, A., Sabirsh, A., Nilsson, N. E., Kotarsky, K., Olde, B., Owman, C. (2000) First-generation monoclonal antibodies identifying the human leukotriene B(4) receptor-1. Biochem. Biophys. Res. Commun. 279, 520-525.
36. Saccani, A., Saccani, S., Orlando, S., Sironi, M., Bernasconi, S., Ghezzi, P., Mantovani, A., Sica, A. (2000) Redox regulation of chemokine receptor expression. Proc. Natl. Acad. Sci. USA 97, 2761-2766.
37. Xu, L., Rahimpour, R., Ran, L., Kong, C., Biragyn, A., Andrews, J., Devries, M., Wang, J. M., Kelvin, D. J. (1997) Regulation of CCR2 chemokine receptor mRNA stability. J. Leukoc. Biol. 62, 653-660.
38. Boraschi, D., Censini, S., Bartalini, M., Ghiara, P., Di Simplicio, P., Tagliabue, A. (1987) Interferons inhibit LTC4 production in murine macrophages. J. Immunol. 138, 4341-4346.
39. Ito, M., Ishida, E., Tanabe, F., Shigela, S., Watanabe, Y., Kawade, Y. (1987) Interferon-α enhances the production of leukotriene B4 in murine peritoneal macrophages stimulated by opsonized zymosan. Immunology 60, 617-619.
40. Meslier, N., Aldrich, A. J., Bigby, T. D. (1992) Effect of interferon-γ on the 5-lipoxygenase pathway of rat lung macrophages. Am. J. Respir. Cell Mol. Biol. 6, 93-99.
41. D'Amico, G., Frascaroli, G., Bianchi, G., Transidico, P., Doni, A., Vecchi, A., Sozzani, S., Allavena, P., Mantovani, A. (2000) Uncoupling of inflammatory chemokine receptors by IL-10: generation of functional decoys. Nat. Immunol. 1, 387-391.
42. Ziegler-Heitbrock, H. W., Strobel, M., Fingerle, G., Schlunck, T., Pforte, A., Blumenstein, M., Haas, J. G. (1991) Small (CD14+/CD16+) monocytes and regular monocytes in human blood. Pathobiology 59, 127-130.
43. Passlick, B., Flieger, D., Ziegler-Heitbrock, H. W. (1989) Identification and characterization of a novel monocyte subpopulation in human peripheral blood. Blood 74, 2527-2534.
44. Weber, C., Belge, K. U., von Hundelshausen, P., Draude, G., Steppich, B., Mack, M., Frankenberger, M., Weber, K. S., Ziegler-Heitbrock, H. W. (2000) Differential chemokine receptor expression and function in human monocyte subpopulations. J. Leukoc. Biol. 67, 699-704.
45. Kawanaka, N., Yamamura, M., Aita, T., Morita, Y., Okamoto, A., Kawashima, M., Iwahashi, M., Ueno, A., Ohmoto, Y., Makino, H. (2002) CD14+,CD16+ blood monocytes and joint inflammation in rheumatoid arthritis. Arthritis Rheum. 46, 2578-2586.
46. Fingerle, G., Pforte, A., Passlick, B., Blumenstein, M., Strobel, M., Ziegler-Heitbrock, H. W. (1993) The novel subset of CD14+/CD16+ blood monocytes is expanded in sepsis patients. Blood 82, 3170-3176.
47. Blumenstein, M., Boekstegers, P., Fraunberger, P., Andreesen, R., Ziegler-Heitbrock, H. W., Fingerle-Rowson, G. (1997) Cytokine production precedes the expansion of CD14+CD16+ monocytes in human sepsis: a case report of a patient with self-induced septicemia. Shock 8, 73-75.
48. Thieblemont, N., Weiss, L., Sadeghi, H. M., Estcourt, C., Haeffner-Cavaillon, N. (1995) CD14lowCD16high: a cytokine-producing monocyte subset, which expands during human immunodeficiency virus infection. Eur. J. Immunol. 25, 3418-3424.
49. Reape, T. J., Groot, P. H. (1999) Chemokines and atherosclerosis. Atherosclerosis 147, 213-225.
50. Geissmann, F., Jung, S., Littman, D. R. (2003) Blood monocytes consist of two principal subsets with distinct migratory properties. Immunity 19, 71-82.
51. Zhou, Y., Yang, Y., Warr, G., Bravo, R. (1999) LPS down-regulates the expression of chemokine receptor CCR2 in mice and abolishes macrophage infiltration in acute inflammation. J. Leukoc. Biol. 65, 265-269.
52. Matthys, P., Vermeire, K., Heremans, H., Billiau, A. (2000) The protective effect of IFN-γ in experimental autoimmune diseases: a central role of mycobacterial adjuvant-induced myelopoiesis. J. Leukoc. Biol. 68, 447-454.
53. de Boer, O. J., van der Wal, A. C., Verhagen, C. E., Becker, A. E. (1999) Cytokine secretion profiles of cloned T cells from human aortic atherosclerotic plaques. J. Pathol. 188, 174-179.
54. Rus, H. G., Niculescu, F., Vlaicu, R. (1991) Tumor necrosis factor-α in human arterial wall with atherosclerosis. Atherosclerosis 89, 247-254.
55. Mehrabian, M., Allayee, H., Wong, J., Shi, W., Wang, X. P., Shaposhnik, Z., Funk, C. D., Lusis, A. J. (2002) Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice. Circ. Res. 91, 120-126.
56. Helgadottir, A., Manolescu, A., Thorleifsson, G., Gretarsdottir, S., Jonsdottir, H., Thorsteinsdottir, U., Samani, N. J., Gudmundsson, G., Grant, S. F., Thorgeirsson, G., Sveinbjornsdottir, S., Valdimarsson, E. M., Matthiasson, S. E., Johannsson, H., Gudmundsdottir, O., Gurney, M. E., Sainz, J., Thorhallsdottir, M., Andresdottir, M., Frigge, M. L., Topol, E. J., Kong, A., Gudnason, V., Hakonarson, H., Gulcher, J. R., Stefansson, K. (2004) The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. Nat. Genet. 36, 233-239.