Orthotopic heart transplantation in a transgenic pig-to-primate model

Transplantation

Volumn 65, Issue 12, 1998, Pages 1570-1577

  Schmoeckel, Michael ^a,b   Bhatti, Farah N K ^a,b   Zaidi, Afzal ^a,b   Cozzi, Emanuele ^a,b   Waterworth, Paul D ^a,b   Tolan, Michael J ^a,b   Goddard, Martin ^a,b   Warner, Richard G ^a   Langford, Gillian A ^a   Dunning, John J ^a,b   Wallwork, John ^a,b   White, David J G ^a,b,c  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b PAPWORTH HOSPITAL   (United Kingdom)

^c Imutran Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHOSPHAMIDE; CYCLOSPORIN; DECAY ACCELERATING FACTOR; STEROID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BABOON; CONTROLLED STUDY; GRAFT REJECTION; HEART OUTPUT; HEART TRANSPLANTATION; NONHUMAN; PANCYTOPENIA; PRIORITY JOURNAL; SPECIES DIFFERENCE; SWINE; TRANSGENIC ANIMAL; VASCULAR ENDOTHELIUM; XENOTRANSPLANTATION;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTIGENS, CD55; FEMALE; GRAFT REJECTION; HEART TRANSPLANTATION; IMMUNOSUPPRESSION; MALE; PAPIO; SWINE; TRANSPLANTATION, HETEROLOGOUS;

EID: 0032572261     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/00007890-199806270-00006     Document Type: Article

References (33)

1. Lawson JH, Platt JL. Molecular barriers to xenotransplantation. Transplantation 1996; 62: 303.
2. Zhao Z, Termignon JL, Cardoso J, et al. Hyperacute xenograft rejection in the swine-to-human donor-recipient combination. Transplantation 1994; 57: 245.
3. Makowka L, Cramer DV, Hoffman A, et al. The use of a pig liver xenograft for temporary support of a patient with fulminant hepatic failure. Transplantation 1995; 59: 1654.
4. Atkinson JP, Farries T. Separation of self from non-self in the complement system. Immunol Today 1987; 8: 212.
5. Dalmasso AP, Vercelloti GM, Platt JL, Bach FH. Inhibition of complement-mediated cytotoxicity by decay accelerating factor: potential for prevention of xenograft hyperacute rejection. Transplantation 1991; 52: 530.
6. Atkinson JP, Oglesby TJ, White D, Adams EA, Liszewski MK. Separation of self from non-self in the complement system: a role for membrane cofactor protein and decay accelerating factor. Clin Exp Immunol 1991; 86 (suppl 1): 27.
7. Wang MW, Wright LJ, Sims MJ, White DJG. Presence of human chromosome 1 with expression of human decay-accelerating factor (DAF) prevents lysis of mouse/human hybrid cells by human complement. Scand J Immunol 1991; 34: 771.
8. Dalmasso AP, Vercellotti GM, Fischel RJ, et al. Mechanisms of complement activation in the hyperacute rejection of porcine organs transplanted into primate recipients. Am J Pathol 1992; 140: 1157.
9. White DJG, Langford GA, Cozzi E, Young VK. Production of pigs transgenic for human DAF: a strategy for xenotransplantation. Xenotransplantation 1995; 2: 213.
10. Schmoeckel M, Nollert G, Shahmohammadi M, et al. Prevention of hyperacute rejection by decay accelerating factor in xenogeneic perfused working hearts. Transplantation 1996; 69: 729.
11. Waterworth PD, Cozzi E, Tolan MJ, et al. Pig-to-primate cardiac xenotransplantation and cyclophosphamide therapy. Transplant Proc 1997; 29: 899.
12. White DJG. HDAF transgenic pig organs: are they concordant for human transplantation? Xeno 1996; 4: 50.
13. Cozzi E, White DJG. The generation of transgenic pigs as potential organ donors for humans. Nature Med 1995; 1: 964.
14. Cozzi E, Langford GA, Wright L, et al. Comparative analysis of human DAF expression in tissues of transgenic pigs and man. Transplant Proc 1995; 27: 319.
15. Rosengard AM, Cary NRB, Langford GA, et al. Tissue expression of human complement inhibitor, decay-accelerating factor, in transgenic pigs. Transplantation 1995; 59: 1325.
16. Lower RR, Shumway NE. Studies on the orthotopic homotransplantation of the canine heart. Surg Forum 1960; 11: 18.
17. Stark JH, Smit JA, Gridelli B. Sensitivity of baboon lymphocytes to cyclosporin A and FK 506: relative resistance of alloactivated cells to CyA. Transpl Int 1994; 7: 372.
18. Euler HH, Schroder OJ, Harten P, Zeuner RA, Gutschmidt HJ. Treatment-free remission in severe systemic lupus erythematosus following synchronization of plasmapheresis with subsequent pulse cyclophosphamide. Arthritis Rheum 1994; 12: 1784.
19. Boumpas DT, Austin HA, Vaughn EM, et al. Controlled trial of pulse methylprednisolone versus two regimens of pulse cyclophosphamide in severe lupus nephritis. Lancet 1992; 340: 741.
20. Fukushima N, Gundry SR, Matsumiya G, Bouchart F, Zuppan C, Bailey LL. Histological findings in heart grafts after orthotopic pig to baboon cardiac transplantation. Transplant Proc 1996; 28: 788.
21. Cozzi E, Yannoutsos N, Langford GA, Pino-Chavez G, Wallwork J, White DJG. Effect of transgenic expression of human decay accelerating factor on the inhibition of hyperacute rejection of pig organs. In: Cooper DKC, Kemp E, Platt JL, White DJ, eds. Xenotransplantation: the transplantation of organs and tissues between species, 2nd ed. Berlin, Heidelberg, New York: Springer, 1997: 665.
22. Hasan RI, van den Bogaerde J, Forty J, Wright L, Wallwork J, White DJ. Prolonged survival of hamster to rat heart xenografts with cyclophosphamide therapy. Transplant Proc 1992; 24: 517.
23. Calne RY, White DJG, Rolles K, Smith DP, Herbertson BM. Prolonged survival of pig orthotopic heart grafts treated with cyclosporin A. Lancet 1978; 1: 1183.
24. Müller-Werdan U, Klein D, Zander M, Werdan K, Hammer C. Beating neonatal rat cardiomyocytes as a model to study the role of xenoreactive natural antibodies in Xenotransplantation. Transplantation 1994; 58: 1403.
25. Autenrieth A, Müller-Werdan U, Koidl B, Werdan K, Hammer C. Different action of xenoreactive natural and immune antibodies on functioning cardiomyocytes. Transplant Proc 1996; 28: 576.
26. Hammer C. Evolution: its complexity and impact on xenotransplantation. In: Cooper DKC, Kemp E, Platt JL, White DJG, eds. Xenotransplantation: the transplantation of organs and tissues between species, 2nd Edition. Berlin, Heidelberg, New York: Springer, 1997: 716.
27. Sadeghi AM, Robbins RC, Smith CR, et al. Cardiac xenotransplantation in primates. J Thorac Cardiovasc Surg 1987; 93: 809.
28. Leventhal JR, Matas AJ, Sun LH, et al. The immunopathology of cardiac xenograft rejection in the guinea pig-to-rat model. Transplantation 1993; 56: 1.
29. Blakely ML, van der Werf WJ, Berndt MC, Dalmasso AP, Bach FH, Hancock WW. Activation of intragraft endothelial and mononuclear cells during discordant xenograft rejection. Transplantation 1994; 58: 1059.
30. Byrne GW, McCurry KR, Martin MJ, et al. Transgenic pigs expressing human CD59 and decay-accelerating factor produce an intrinsic barrier to complement mediated damage. Transplantation 1997; 63: 149.
31. Leventhal JR, John R, Fryer JP, Witson JC, et al. Removal of baboon and human antiporcine IgG and IgM natural antibodies by immunoadsorption. Transplantation 1995; 59: 294.
32. Cooper DKC, Human PA, Lexer G, et al. Effects of cyclosporine and antibody adsorption on pig cardiac xenograft survival in the baboon. J Heart Transplant 1988; 7: 238.
33. Roslin MS, Zisbrod Z, Burack JH, et al. 15-day survival in pig-to-baboon heterotopic cardiac xenotransplantation. Transplant Proc 1992; 24: 572.